The impact of quercetin on cisplatin-induced clastogenesis and apoptosis in murine marrow cells

Mutagenesis

Volumn 25, Issue 3, 2010, Pages 281-288

  Attia, Sabry M ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; DNA; GLUTATHIONE; LIPOCORTIN 5; PROPIDIUM IODIDE; QUERCETIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BONE MARROW; BONE MARROW CELL; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CONTROLLED STUDY; LIPID PEROXIDATION; MALE; METAPHASE CHROMOSOME; MICRONUCLEUS; MICRONUCLEUS TEST; MITOSIS RATE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SINGLE DRUG DOSE;

ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; BONE MARROW CELLS; CHROMOSOMES, MAMMALIAN; CISPLATIN; GLUTATHIONE; LIPID PEROXIDATION; MALE; MICE; MICRONUCLEUS TESTS; MUTAGENS; OXIDATIVE STRESS; QUERCETIN;

MURINAE; MUS;

EID: 77951965597     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/geq004     Document Type: Article

References (58)

1. Fram, R. J. (1992) Cisplatin and platinum analogues: recent advances. Curr. Opin. Oncol., 4, 1073-1079.
2. Kartalou, M. and Essigmann, J. M. (2001) Recognition of cisplatin adducts by cellular proteins. Mutat. Res., 478, 1-21.
3. Kharbangar, A., Khynriam, D. and Prasad, S. B. (2000) Effect of cisplatin on mitochondrial protein, glutathione, and succinate dehydrogenase in Dalton lymphoma-bearing mice. Cell Biol. Toxicol., 16, 363-373.
4. Osanto, S., Thijssen, J. C., Woldering, V. M., van Rijn, J. L., Natarajan, A. T. and Tates, A. D. (1991) Increased frequency of chromosomal damage in peripheral blood lymphocytes up to 9 years following curative chemotherapy of patients with testicular carcinoma. Environ. Mol. Mutagen., 17, 71-78.
5. Elsendoorn, T. J., Weijl, N. I., Mithoe, S., Zwinderman, A. H., Van Dam, F., De Zwart, F. A., Tates, A. D. and Osanto, S. (2001) Chemotherapy-induced chromosomal damage in peripheral blood lymphocytes of cancer patients supplemented with antioxidants or placebo. Mutat. Res., 498, 145-158.
6. DeMas, P., Daudin, M., Vincent, M. C., Bourrouillou, G., Calvas, P., Mieusset, R. and Bujan, L. (2001) Increased aneuploidy in spermatozoa from testicular tumour patients after chemotherapy with cisplatin, etoposide and bleomycin. Hum. Reprod., 16, 1204-1208.
7. Weijl, N. I., Elsendoorn, T. J., Lentjes, E. G., Hopman, G. D., Wipkink-Bakker, A., Zwinderman, A. H., Cleton, F. J. and Osanto, S. (2004) Supplementation with antioxidant micronutrients and chemotherapyinduced toxicity in cancer patients treated with cisplatin-based chemotherapy: a randomised, double-blind, placebo-controlled study. Eur. J. Cancer, 40, 1713-1723.
8. Lamson, D. W. and Brignall, M. S. (2000) Antioxidants and cancer, part 3: quercetin. Altern. Med. Rev., 5, 196-208.
9. Conklin, K. A. (2004) Cancer chemotherapy and antioxidants. J. Nutr., 134, 3201S-3204S.
10. Liesveld, J. L., Abbound, C. N., Lu, C., McNair, C., Menon, A., Smith, A., Rosell, K. and Rapoport, A. P. (2003) Flavonoid effect on normal and leukemic cells. Leukemia Res., 27, 517-527.
11. Piantelli, M., Rossi, C., Iezzi, M., La Sorda, R., Iacobelli, S., Alberti, S. and Natali, P. G. (2006) Flavonoids inhibit melanoma lung metastasis by impairing tumor cells endothelium interactions. J. Cell Physiol., 207, 23-39.
12. Sharma, H., Sen, S. and Singh, N. (2005) Molecular pathways in the chemosensitization of cisplatin by quercetin in human head and neck cancer. Cancer Biol. Ther., 4, 949-955.
13. Kuhar, M., Imran, S. and Singh, N. (2007) Curcumin and quercetin combined with cisplatin to induce apoptosis in human laryngeal carcinoma Hep-2 cells through the mitochondrial pathway. J. Cancer Mol., 3, 121-128.
14. Molnár, J., Béládi, I., Domonkos, K., Földeák, S., Boda, K. and Veckenstedt, A. (1981) Antitumor activity of flavonoids on NK/Ly ascites tumor cells. Neoplasma, 28, 11-18.
15. Scambia, G., Ranelletti, F. O., Panici, P. B. et al. (1990) Inhibitory effect of quercetin on OVCA 433 cells and presence of type II oestrogen binding sites in primary ovarian tumours and cultured cells. Br. J. Cancer, 62, 942-946.
16. Scambia, G., Ranelletti, F. O., Benedetti, P. et al. (1992) Inhibitory effect of quercetin on primary ovarian and endometrial cancers and synergistic activity with cis-diamminedichloroplatinum (II). Gynecol. Oncol., 45, 13-19.
17. Choi, J. A., Kim, J. Y., Lee, J. Y., Kang, C. M., Kwon, H. J., Yoo, Y. D., Kim, T. W., Lee, Y. S. and Lee, S. J. (2001) Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin. Int. J. Oncol., 19, 837-844.
18. Hofmann, J., Fiebig, H. H., Winterhalter, B. R., Berger, D. P. and Grunicke, H. (1990) Enhancement of the antiproliferative activity of cisdiamminedichloroplatinum (II) by quercetin. Int. J. Cancer, 45, 536-539.
19. Giri, A., Khynriam, D. and Prasad, S. B. (1998) Vitamin C mediated protection on cisplatin induced mutagenicity in mice. Mutat. Res., 421, 139-148.
20. USDA. (2000) 1994-1996, 1998 Continuing Survey of Food Intakes by Individuals (CSFII) and Diet and Health Knowledge Survey (DHKS) (On CD-ROM). US Department of Agriculture (USDA), Riverdale, Maryland. [PB2000-500027]. Cited in MacRae and Mefferd (2006).
21. Adler, I.-D. (1984) Cytogenetic tests inmammals. In Venitt, S.and Parry, J. M. (eds), Mutagenicity Testing: A Practical Approach. IRI Press, Oxford, pp. 275-306.
22. Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F. and Riccardi, C. (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods, 139, 271-279.
23. Ohkawa, H., Ohishi, N. and Yagi, K. (1979) Assay of lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 95, 351-358.
24. Ellman, G. L. (1959) Tissue sulfhydryl groups. Arch. Biochem. Biophys., 82, 70-77.
25. Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J. (1951) Protein measurement with Folin phenol reagent. J. Biol. Chem., 193, 265-275.
26. Cierniak, A., Papiez, M. and Kapiszewska, M. (2004) Modulatory effect of quercetin on the DNA damage-induced by etoposide in bone marrow cells and on the changes in the activity of antioxidant enzymes in rats. Roczk. Akad. Med. Bialys, 49, 167-169.
27. Kapiszewska, M., Cierniak, A., Papiez, M. A., Pietrzycka, A., Stepniewski, M. and Lomnicki, A. (2007) Prolonged quercetin administration diminishes the etoposide-induced DNA damage in bone marrow cells of rats. Drug Chem. Toxicol., 30, 67-81.
28. Harwood, M., Danielewska-Nikiel, B., Borzelleca, J. F., Flamm, G. W., Williams, G. M. and Lines, T. C. (2007) A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem. Toxicol., 45, 2179-2205.
29. Utesch, D., Feige, K., Dasenbrock, J., Broschard, T. H., Harwood, M., Danielewska-Nikiel, B. and Lines, T. C. (2008) Evaluation of the potential in vivo genotoxicity of quercetin. Mutat. Res., 654, 38-44.
30. Papiez, M. A., Cierniak, A., Krzysciak, W., Bzowska, M., Taha, H. M., Jozkowicz, A. and Piskula, M. (2008) The changes of antioxidant defense system caused by quercetin administration do not lead to DNA damage and apoptosis in the spleen and bone marrow cells of rats. Food Chem. Toxicol., 46, 3053-3058.
31. Wätjen, W., Michels, G., Steffan, B., Niering, P., Chovolou, Y., Kampkotter, A., Tran-Thi, Q. H., Proksch, P. and Kahl, R. (2005) Low concentrations of flavonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis. J. Nutr., 135, 525-531.
32. Boersma, M. G., van der Woude, H., Bogaards, J., Boeren, S., Vervoort, J., Cnubben, N. H., van Iersel, M. L., van Bladere, P. J. and Rietjens, I. M. (2002) Regioselectivity of phase II metabolism of luteolin and quercetin by UDP-glucuronosyl transferases. Chem. Res. Toxicol., 15, 662-670.
33. Zhu, B. T., Ezell, E. L. and Liehr, J. G. (1994) Catechol-O- methyltransferaasecatalyzed rapid O-methylation of mutagenic flavonoids. J. Biol. Chem., 269, 292-299.
34. Garcia-Sagredo, J. M. (2008) Fifty years of cytogenetics: a parallel view of the evolution of cytogenetics and genotoxicology. Biochim. Biophys. Acta, 1779, 363-375.
35. Kliesch, U. and Adler, I.-D. (1987) Micronucleus test in bone marrow of mice treated with 1-nitropropane, 2-nitropropane and cisplatin. Mutat. Res., 192, 181-184.
36. Adler, I.-D. and el-Tarras, A. (1989) Clastogenic effects of cisdiamminedichloroplatinum. I. Induction of chromosomal aberrations in somatic and germinal cells of mice. Mutat. Res., 211, 131-137.
37. Edelweiss, M. I., Trachtenberg, A. and Pinheiro, E. X., da-Silva, J., Riegel, M., Lizardo-Daudt, H. M. and Mattevi, M. S. (1995) Clastogenic effect of cisplatin on Wistar rat bone marrow cells. Braz. J. Med. Biol. Res, 28, 679-683.
38. Choudhury, R. C., Jagdale, M. B. and Misra, S. (2000) Cytogenetic toxicity of cisplatin in bone marrow cells of Swiss mice. J. Chemother., 12, 173-182.
39. Hayashi, M., Sofuni, T. and Ishidate, M., Jr. (1984) Kinetics of micronucleus formation in relation to chromosomal aberrations in mouse bone marrow. Mutat. Res., 127, 129-137.
40. Sorenson, C. M. and Eastman, A. (1988) Influence of cisdiamminedichloroplatinum (II) on DNA synthesis and cell cycle progression in excision repair proficient and deficient Chinese hamster ovary cells. Cancer Res., 48, 6703-6707.
41. Savage, J. R. (1988) A comment on the quantitative relationship between micronuclei and chromosomal aberrations. Mutat. Res., 207, 33-36.
42. Miyazawa, M. and Hisama, M. (2003) Antimutagenic activity of flavonoids from Chrysanthemum morifolium. Biosci. Biotechnol. Biochem., 67, 2091-2099.
43. Geetha, T., Malhotra, V., Chopra, K. and Kaur, I. P. (2005) Antimutagenic and antioxidant/prooxidant activity of quercetin. Indian J. Exp. Biol., 43, 61-67.
44. Oliveira, N. G., Neves, M., Rodrigues, A. S., Monteiro Gil, O., Chaveca, T. and Rueff, J. (2000) Assessment of the adaptive response induced by quercetin using the MNCB peripheral blood human lymphocytes assay. Mutagenesis, 15, 77-83.
45. Lautraite, S., Musonda, A. C., Doehmer, J., Edwards, G. O. and Chipman, J. K. (2002) Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1. Mutagenesis, 17, 45-53.
46. Malaveille, C., Hautefeuille, A., Pignatelli, B., Talaska, G., Vineis, P. and Bartsch, H. (1996) Dietary phenolics as anti-mutagens and inhibitors of tobacco-related DNA adduction in the urothelium of smokers. Carcinogenesis, 17, 2193-2200.
47. Tamaki, T., Naomoto, Y., Kimura, S. et al. (2003) Apoptosis in normal tissues induced by anti-cancer drugs. J. Int. Med. Res., 31, 6-16.
48. Lee, J. C., Kim, J., Park, J. K., Chung, G. H. and Jang, Y. S. (2003) The antioxidant, rather than prooxidant, activities of quercetin on normal cells: quercetin protects mouse thymocytes from glucose oxidase-mediated apoptosis. Exp. Cell Res., 291, 386-397.
49. Ishikawa, Y. and Kitamura, M. (2000) Bioflavonoid quercetin inhibits mitosis and apoptosis of glomerular cells in vitro and in vivo. Biochem. Biophys. Res. Commun., 279, 629-634.
50. Jozkowicz, A., Was, H. and Dulak, J. (2007) Heme oxygenase-1 in tumors. Antioxid Redox Signal., 9, 2099-2118.
51. Yao, P., Nussler, A., Liu, L., Hao, L., Song, F., Schirmeier, A. and Nussler, N. (2007) Quercetin protects human hepatocytes from ethanolderived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways. J. Hepatol., 47, 253-261.
52. Masuda, H., Tanaka, T. and Takahama, U. (1994) Cisplatin generates superoxide anion by interaction with DNA in a cell-free system. Biochem. Biophys. Res. Commun., 203, 1175-1180.
53. Baliga, R., Zhang, Z., Baliga, M., Ueda, N. and Shah, S. V. (1998) In vitro and in vivo evidence suggesting a role for iron in cisplatin-induced nephrotoxicity. Kidney Int., 53, 394-401.
54. Fiorani, M., De Sanctis, R., Menghinello, P., Cucchiarini, L., Cellini, B. and Dachà, M. (2001) Quercetin prevents glutathione depletion induced by dehydroascorbic acid in rabbit red blood cells. Free Radic. Res., 34, 639-648.
55. Behling, E. B., Sendão, M. C., Francescato, H. D., Antunes, L. M., Costa, R. S. and Bianchi Mde, L. (2006) Comparative study of multiple dosage of quercetin against cisplatin-induced nephrotoxicity and oxidative stress in rat kidneys. Pharmacol. Rep., 58, 526-532.
56. Weijl, N. I., Hopman, G. D., Wipkink-Bakker, A., Lentjes, E. G., Berger, H. M., Cleton, F. J. and Osanto, S. (1998) Cisplatin combination chemotherapy induces a fall in plasma antioxidants of cancer patients. Ann. Oncol., 9, 1331-1337.
57. Suzuki, C. A. M. and Cherian, M. G. (1990) The interactions of cisdiamminedichloroplatinum with met al.lothionein and glutathione in rat liver and kidney. Toxicology, 64, 113-127.
58. Nakagawa, I., Nishi, E., Naganuma, A. and Imura, N. (1995) Effect of preinduction of met al.lothionein synthesis on clastogenicity of anticancer drugs in mice. Mutat. Res., 348, 37-43.