Acute pancreatitis induced by activated polyamine catabolism is associated with coagulopathy: Effects of α-methylated polyamine analogs on hemostasis

Pancreatology

Volumn 10, Issue 2-3, 2010, Pages 208-221

  Hyvonen M T ^a   Sinervirta, R ^a   Keinanen T A ^a   Fashe, T ^a   Grigorenko, N ^c   Khomutov, A R ^c   Vepsalainen J ^b   Alhonen, L ^a  

^a AI Virtanen Institute for Molecular Sciences   (United States)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

Author keywords

Acute pancreatitis; Coagulation; Fibrinolysis; Lipopolysaccharide; Polyamines; Transgenic rats

Indexed keywords

ALPHA METHYLSPERMIDINE; FIBRINOGEN; LIPOPOLYSACCHARIDE; POLYAMINE DERIVATIVE; UNCLASSIFIED DRUG; 1-METHYLSPERMIDINE; ACYLTRANSFERASE; DIAMINE N-ACETYLTRANSFERASE; POLYAMINE; SPERMIDINE;

ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING DISORDER; BLOOD CLOTTING TIME; CATABOLISM; CONTROLLED STUDY; DOSE RESPONSE; FIBRINOGEN BLOOD LEVEL; FIBRINOLYSIS; HEMOSTASIS; IN VITRO STUDY; MULTIPLE ORGAN FAILURE; NONHUMAN; PRIORITY JOURNAL; RAT; THROMBOCYTE COUNT; TRANSGENIC RAT; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD CLOTTING; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; GENETICS; METABOLISM; PANCREATITIS; PATHOLOGY;

ACETYLTRANSFERASES; ANIMALS; BLOOD COAGULATION; BLOOD COAGULATION DISORDERS; DISEASE MODELS, ANIMAL; FIBRINOLYSIS; HEMOSTASIS; PANCREATITIS; POLYAMINES; RATS; RATS, TRANSGENIC; SPERMIDINE;

EID: 77951963527     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1159/000243730     Document Type: Article

References (45)

1. Thomas T, Thomas TJ: Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications. Cell Mol Life Sci 2001; 58: 244-258.
2. Thomas T, Thomas TJ: Polyamine metabolism and cancer. J Cell Mol Med 2003; 7: 113-126.
3. Kagramanova AT, Tishchenko LD, Berezov TT: The ornithine decarboxylase activity of the epidermis in psoriasis as a biochemical index of the hyperproliferative process. Biull Eksp Biol Med 1993; 115: 618-620.
4. Li J, Doyle KM, Tatlisumak T: Polyamines in the brain: distribution, biological interactions, and their potential therapeutic role in brain ischaemia. Curr Med Chem 2007; 14: 1807-1813.
5. Sugimoto H, Sakurai S, Abe T, Takagi H, Takahashi H, Takezawa J, Nagamine T, Matsuzaki S: Elevation of N 1 -acetylspermidine and putrescine in hepatic tissues of patients with fulminant hepatitis and liver cirrhosis. J Gastroenterol 1994; 29: 159-163.
6. Han L, Xu C, Guo Y, Li H, Jiang C, Zhao Y: Polyamine metabolism in rat myocardial ischemia-reperfusion injury. Int J Cardiol 2009; 132: 142-144.
7. Zahedi K, Wang Z, Barone S, Prada AE, Kelly CN, Casero RA, Yokota N, Porter CW, Rabb H, Soleimani M: Expression of SSAT, a novel biomarker of tubular cell damage, increases in kidney ischemia-reperfusion injury. Am J Physiol Renal Physiol 2003; 284: F1046-F1055.
8. Frossard JL, Steer ML, Pastor CM: Acute pancreatitis. Lancet 2008; 371: 143-152.
9. Bhatia M, Wong FL, Cao Y, Lau HY, Huang J, Puneet P, Chevali L: Pathophysiology of acute pancreatitis. Pancreatology 2005; 5: 132-144.
10. Gukovskaya AS, Pandol SJ: Cell death pathways in pancreatitis and pancreatic cancer. Pancreatology 2004; 4: 567-586.
11. Alhonen L, Parkkinen JJ, Keinänen T, Sinervirta R, Herzig KH, Jänne J: Activation of polyamine catabolism in transgenic rats induces acute pancreatitis. Proc Natl Acad Sci USA 2000; 97: 8290-8295.
12. Räsänen TL, Alhonen L, Sinervirta R, Uimari A, Kaasinen K, Keinänen T, Herzig KH, Jänne J: Gossypol activates pancreatic polyamine catabolism in normal rats and induces acute pancreatitis in transgenic rats overexpressing spermidine/spermine N 1 -acetyltransferase. Scand J Gastroenterol 2003; 38: 787-793.
13. Herzig KH, Jänne J, Alhonen L: Acute pancreatitis induced by activation of the polyamine catabolism in gene-modified mice and rats overexpressing spermidine/spermine N 1 -acetyltransferase. Scand J Gastroenterol 2005; 40: 120-121.
14. Räsänen TL, Alhonen L, Sinervirta R, Keinänen T, Herzig KH, Suppola S, Khomutov AR, Vepsäläinen J, Jänne J: A polyamine analogue prevents acute pancreatitis and restores early liver regeneration in transgenic rats with activated polyamine catabolism. J Biol Chem 2002; 277: 39867-39872.
15. Hyvönen MT, Merentie M, Uimari A, Keinänen TA, Jänne J, Alhonen L: Mechanisms of polyamine catabolism-induced acute pancreatitis. Biochem Soc Trans 2007; 35: 326-330.
16. Hyvönen MT, Herzig KH, Sinervirta R, Albrecht E, Nordback I, Sand J, Keinänen TA, Vepsäläinen J, Grigorenko N, Khomutov AR, Kruger B, Jänne J, Alhonen L: Activated polyamine catabolism in acute pancreatitis: alpha-methylated polyamine analogues prevent trypsinogen activation and pancreatitis- associated mortality. Am J Pathol 2006; 168: 115-122.
17. Lakanen JR, Coward JK, Pegg AE: alpha- Methyl polyamines: metabolically stable spermidine and spermine mimics capable of supporting growth in cells depleted of polyamines. J Med Chem 1992; 35: 724-734.
18. Jin HT, Lämsä T, Merentie M, Hyvönen MT, Sand J, Räty S, Herzig KH, Alhonen L, Nordback I: Polyamine levels in the pancreas and the blood change according to the severity of pancreatitis. Pancreatology 2008; 8: 15-24.
19. Perin A, Sessa A: Polyamine acetylation in rat liver following long-term ethanol ingestion. Biochim Biophys Acta 1993; 1156: 113-116.
20. Diehl AM, Wells M, Brown ND, Thorgeirsson SS, Steer CJ: Effect of ethanol on polyamine synthesis during liver regeneration in rats. J Clin Invest 1990; 85: 385-390.
21. Aoki Y, Suzuki H, Itoh H: Changes in polyamine metabolism in rat liver after oral administration of alpha-naphthylisothiocyanate. J Toxicol Sci 1986; 11: 95-104.
22. Crowther RC, Pritchard CM, Qiu SM, Soloway RD: Inhibition of calcium hydroxyapatite formation by polyamines. Liver 1993; 13: 141-145.
23. Grigorenko NA, Vepsäläinen J, Järvinen A, Keinänen TA, Alhonen L, Jänne J, Khomutov AR: New syntheses of alpha-methyland alpha,alpha'-dimethylspermine. Bioorg Khim 2005; 31: 200-205.
24. Grigorenko N, Khomutov AR, Keinänen TA, Järvinen A, Alhonen L, Jänne J, Vepsäläinen J: Synthesis of novel optical isomers of alphamethylpolyamines. Tetrahedron 2007; 63: 2257-2262.
25. Smith AA, Jacobson LJ, Miller BI, Hathaway WE, Manco-Johnson MJ: A new euglobulin clot lysis assay for global fibrinolysis. Thromb Res 2003; 112: 329-337.
26. Millar HR, Simpson JG, Stalker AL: An evaluation of the heat precipitation method for plasma fibrinogen estimation. J Clin Pathol 1971; 24: 827-830.
27. Hyvönen T, Keinänen TA, Khomutov AR, Khomutov RM, Eloranta TO: Monitoring of the uptake and metabolism of aminooxy analogues of polyamines in cultured cells by high-performance liquid chromatography. J Chromatogr 1992; 574: 17-21.
28. Koike K, Moore EE, Moore FA, Read RA, Carl VS, Banerjee A: Gut ischemia/reperfusion produces lung injury independent of endotoxin. Crit Care Med 1994; 22: 1438-1444.
29. Merentie M, Uimari A, Pietilä M, Sinervirta R, Keinänen TA, Vepsäläinen J, Khomutov A, Grigorenko N, Herzig KH, Jänne J, Alhonen L: Oxidative stress and inflammation in the pathogenesis of activated polyamine catabolism- induced acute pancreatitis. Amino Acids 2007; 33: 323-330.
30. Lasson A, Ohlsson K: Consumptive coagulopathy, fibrinolysis and protease-antiprotease interactions during acute human pancreatitis. Thromb Res 1986; 41: 167-183.
31. Salomone T, Tosi P, Palareti G, Tomassetti P, Migliori M, Guariento A, Saieva C, Raiti C, Romboli M, Gullo L: Coagulative disorders in human acute pancreatitis: role for the Ddimer. Pancreas 2003; 26: 111-116.
32. Kakafika A, Papadopoulos V, Mimidis K, Mikhailidis DP: Coagulation, platelets, and acute pancreatitis. Pancreas 2007; 34: 15-20.
33. Warzecha Z, Dembinski A, Ceranowicz P, Dembinski M, Cieszkowski J, Kusnierz-Cabala B, Naskalski JW, Jaworek J, Konturek SJ, Pawlik WW, Tomaszewska R: Influence of ischemic preconditioning on blood coagulation, fibrinolytic activity and pancreatic repair in the course of caerulein-induced acute pancreatitis in rats. J Physiol Pharmacol 2007; 58: 303-319.
34. Rydzewska G, Kosidlo S, Gabryelewicz A, Rydzewski A: Tissue plasminogen activator, plasminogen activator inhibitor, and other parameters of fibrinolysis in the early stages of taurocholate acute pancreatitis in rats. Int J Pancreatol 1992; 11: 161-168.
35. Zhang M, Wang H, Tracey KJ: Regulation of macrophage activation and inflammation by spermine: a new chapter in an old story. Crit Care Med 2000; 28:N60-N66.
36. Alhonen L, Räsänen TL, Sinervirta R, Parkkinen JJ, Korhonen VP, Pietilä M, Jänne J: Polyamines are required for the initiation of rat liver regeneration. Biochem J 2002; 362: 149-153.
37. Homma R, Mase A, Toida T, Kashiwagi K, Igarashi K: Modulation of blood coagulation and fibrinolysis by polyamines in the presence of glycosaminoglycans. Int J Biochem Cell Biol 2005; 37: 1911-1920.
38. de la Pena NC, Sosa-Melgarejo JA, Ramos RR, Mendez JD: Inhibition of platelet aggregation by putrescine, spermidine, and spermine in hypercholesterolemic rabbits. Arch Med Res 2000; 31: 546-550.
39. Pakala R: Effect of polyamines on in vitro platelet aggregation and in vivo thrombus formation. Cardiovasc Radiat Med 2002; 3: 213-220.
40. Corona-de-la-Pena N, Uribe-Carvajal S, Barrientos-Rios R, Matias-Aguilar L, Montiel- Manzano G, Majluf-Cruz A: Polyamines inhibit both platelet aggregation and glycoprotein IIb/IIIa activation. J Cardiovasc Pharmacol 2005; 46: 216-221.
41. Leviant MI, Bylinkina VS, Orekhovich VN: Inhibitors of cathepsin R (ribosomal proteinase): polyamines as natural inhibitors of the proteinase. Biokhimiia 1979; 44: 1454-1459.
42. de Vera N, Camon L, Martinez E: Blood polyamines in the rat. J Pharm Pharmacol 1995; 47: 204-205.
43. Lundgren DW, Farrell PM, Di Sant'Agnese PA: Polyamine alterations in blood of male homozygotes and heterozygotes for cystic fibrosis. Clin Chim Acta 1975; 62: 357-362.
44. Campbell RA, Grettie DP, Bartos F, Bartos D, Marton LJ: Uremic polyamine dysmetabolism. Proc Clin Dial Transplant Forum 1978; 8: 194-198.
45. Natta CL, Kremzner LT: Polyamines and membrane proteins in sickle cell disease. Blood Cells 1982; 8: 273-280.