Structural elucidation of N-oxidized clemastine metabolites by liquid chromatography/tandem mass spectrometry and the use of Cunninghamella elegans to facilitate drug metabolite identification

Rapid Communications in Mass Spectrometry

Volumn 24, Issue 10, 2010, Pages 1447-1456

  Åberg, Annica Tevell ^a,b   Löfgren, Helena ^a,c   Bondesson, Ulf ^a,b   Hedeland, Mikael ^a,b  

^a NATIONAL VETERINARY INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUNDS; ATMOSPHERIC IONIZATION; ATMOSPHERIC PRESSURE; BIOMOLECULES; HYDROXYLATION; ISOMERS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; OXIDATION;

AROMATIC RINGS; CLEMASTINE; CUNNINGHAMELLA ELEGANS; DRUG METABOLITES; ELEGANS; HYDROGEN/DEUTERIUM EXCHANGE; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; METABOLITE IDENTIFICATION; STRUCTURAL ELUCIDATION;

METABOLITES;

EID: 77951935161     PISSN: 09514198     EISSN: 10970231     Source Type: Journal    
DOI: 10.1002/rcm.4535     Document Type: Article

References (29)

1. Torneke K, Ingvast-Larsson C, Pettersson K, Bergvall K, Hedeland M, Bondesson U, Brostrom H. J. Vet. Pharmacol. Ther. 2003; 26: 151.
2. Tevell A, Bondesson U, Torneke K, Hedeland M. Rapid Commun. Mass Spectrom. 2004; 18: 2267.
3. Gober B, Al Mardini MA, Franke P. Pharmazie 1989; 44: 847.
4. Krueger SK, Vandyke JE, Williams DE, Hines RN. Drug Metab. Rev. 2006; 38: 139.
5. Bickel MH. Pharmacol. Rev. 1969; 21: 325.
6. Chen G, Daaro I, Pramanik BN, Piwinski JJ. J. Mass Spectrom. 2009; 44: 203.
7. Holcapek M, Kolarova L, Nobilis M. Anal. Bioanal. Chem. 2008; 391: 59.
8. Ma S, Chowdhury SK, Alton KB. Anal. Chem. 2005; 77: 3676.
9. Peiris DM, Lam W, Michael S, Ramanathan R. J. Mass Spectrom. 2004; 39: 600.
10. Penner NA, Zgoda-Pols J, Ramanathan R, Chowdhury SK, Alton KB. Mass Spectrometry in Drug Metabolism and Pharmacokinetics. John Wiley: Hoboken, New Jersey, 2009.
11. Ohashi N, Furuuchi S, Yoshikawa M. J. Pharm. Biomed. Anal. 1998; 18: 325.
12. Ramanathan R, Su AD, Alvarez N, Blumenkrantz N, Chowdhury SK, Alton K, Patrick J. Anal. Chem. 2000; 72: 1352.
13. Tong W, Chowdhury SK, Chen JC, Zhong R, Alton KB, Patrick JE. Rapid Commun. Mass Spectrom. 2001; 15: 2085.
14. Wang Y, Chen X, Li Q, Zhong D. Rapid Commun. Mass Spectrom. 2008; 22: 1843.
15. Zhang D, Yang Y, Leakey JE, Cerniglia CE. FEMS Microbiol. Lett. 1996; 138: 221.
16. Moody JD, Freeman JP, Fu PP, Cerniglia CE. Drug Metab. Dispos. 2002; 30: 1274.
17. Zhang D, Evans FE, Freeman JP, Duhart B Jr, Cerniglia CE. Drug Metab. Dispos. 1995; 23: 1417.
18. Pilard S, Caradec F, Jackson P, Luijten W. Rapid Commun. Mass Spectrom. 2000; 14: 2362.
19. Zhang D, Zhang H, Aranibar N, Hanson R, Huang Y, Cheng PT, Wu S, Bonacorsi S, Zhu M, Swaminathan A, Humphreys WG. Drug Metab. Dispos. 2006; 34: 267.
20. Tevell Aberg A, Olsson C, Bondesson U, Hedeland M. J. Mass Spectrom. 2009; 44: 1026.
21. Hansen EB Jr, Cho BP, Korfmacher WA, Cerniglia CE. Xenobiotica 1995; 25: 1081.
22. Hansen EB Jr, Cerniglia CE, Korfmacher WA, Miller DW, Heflich RH. Drug Metab. Dispos. 1987; 15: 97.
23. Zhang D, Hansen EB Jr, Deck J, Heinze TM, Henderson A, Korfmacher WA, Cerniglia CE. Xenobiotica 1997; 27: 301.
24. Chen G, Daaro I, Pramanik BN, Piwinski JJ. J. Mass Spectrom. 2009; 44: 203.
25. Fandino AS, Nagele E, Perkins PD. J. Mass Spectrom. 2006; 41: 248.
26. Mauriala T, Chauret N, Oballa R, Nicoll-Griffith DA, Bateman KP. Rapid Commun. Mass Spectrom. 2005; 19: 1984.
27. Lappenberg-Pelzer M. J. Anal. Toxicol. 1998; 22: 215.
28. Park SB, Jacob P III, Benowitz NL, Cashman JR. Chem. Res. Toxicol. 1993; 6: 880.
29. Schepers G, Rustemeier K, Walk RA, Hackenberg U. Eur. J. Drug Metab. Pharmacokinet. 1993; 18: 187.