Sensitivity of breast cancer cell lines to recombinant thiaminase I

Cancer Chemotherapy and Pharmacology

Volumn 66, Issue 1, 2010, Pages 171-179

  Liu, Shuqian ^a   Monks, Noel R ^a   Hanes, Jeremiah W ^b   Begley, Tadhg P ^b   Yu, Hui ^a   Moscow, Jeffrey A ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

Doxorubicin; Paclitaxel; THTR2; Unfolded protein response

Indexed keywords

ADENOSINE TRIPHOSPHATE; BACTERIAL ENZYME; CARRIER PROTEIN; DOXORUBICIN; GLUCOSE REGULATED PROTEIN 78; GLYCOGEN SYNTHASE KINASE 3BETA; INITIATION FACTOR 2ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; PACLITAXEL; PROTEIN KINASE B; RECOMBINANT ENZYME; RECOMBINANT THIAMINASE I; THIAMINE TRANSPORTER 2; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; HEAT SHOCK PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MOLECULAR CHAPERONE GRP78; RECOMBINANT PROTEIN; SLC19A3 PROTEIN, HUMAN; THIAMIN PYRIDINYLASE; TRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACILLUS; BACILLUS THIAMINOLYTICUS; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL STRAIN MCF 7; CELL VIABILITY; CELLULAR STRESS RESPONSE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG INTERACTION; DRUG MECHANISM; DRUG PURIFICATION; DRUG SENSITIVITY; ENDOPLASMIC RETICULUM STRESS; ENZYME PURIFICATION; FEMALE; HUMAN; HUMAN CELL; IC 50; IMMUNOBLOTTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; TUMOR CELL LINE; ANIMAL; CELL SURVIVAL; DRUG EFFECT; DRUG POTENTIATION; DRUG SCREENING; ISOLATION AND PURIFICATION; METABOLISM; NUDE MOUSE; THIAMINE DEFICIENCY; UNFOLDED PROTEIN RESPONSE;

ADENOSINE TRIPHOSPHATE; ALKYL AND ARYL TRANSFERASES; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL LINE, TUMOR; CELL SURVIVAL; DOXORUBICIN; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; FEMALE; GLYCOGEN SYNTHASE KINASE 3; HEAT-SHOCK PROTEINS; HUMANS; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, NUDE; PACLITAXEL; PROTO-ONCOGENE PROTEINS C-AKT; RECOMBINANT PROTEINS; THIAMINE DEFICIENCY; UNFOLDED PROTEIN RESPONSE;

EID: 77951933094     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-009-1148-9     Document Type: Article

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