A kiss of a prion: New implications for oral transmissibility

Journal of Infectious Diseases

Volumn 201, Issue 11, 2010, Pages 1615-1616

  Da Costa Dias, Bianca ^a   Weiss, Stefan F T ^a  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN;

DISEASE TRANSMISSION; FECES; FOOD INTAKE; MEAT; MILK; NOTE; PRION; PRION DISEASE; PRIORITY JOURNAL; SALIVA;

ANIMALS; HUMANS; PRION DISEASES; PRIONS;

EID: 77951896047     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/652458     Document Type: Note

References (17)

1. Vana K, Zuber C, Nikles D, Weiss S. Novel aspects of prions, their receptor molecules, and innovative approaches for TSE therapy. Cell Mol Neurobiol 2007; 27: 107-128. (Pubitemid 46169898)
2. Zuber C, Ludewigs H, Weiss S. Therapeutic approaches targeting the prion receptor LRP/ LR. Vet Microbiol 2007; 123: 387-393. (Pubitemid 47088870)
3. Ludewigs H, Zuber C, Vana K, Nikles D, Zerr I, Weiss S. Therapeutic approaches for prion disorders. Expert Rev Anti Infect Ther 2007; 5: 613-630.
4. Lasmézas CI, Weiss S. Molecular biology of prion diseases. In: Cary JW, Linz JE, Bhatnagar D, eds. Microbial foodborne diseases: mechanisms of pathogenicity and toxin synthesis. 1st ed. Lancaster, PA: Technomic Publishing, 2000: 495-537.
5. Sc accumulation in muscles of hamsters orally infected with scrapie. EMBO Rep 2003; 4: 530-533.
6. Tamguney G, Miller MW, Wolfe LL, et al. Asymptomatic deer excrete infectious prions in faeces. Nature 2009; 461: 529-532.
7. Mathiason CK, Powers JG, Dahmes SJ, et al. Infectious prions in the saliva and blood of deer with chronic wasting disease. Science 2006; 314: 133-136.
8. Haley NJ, Seelig DM, Zabel MD, Telling GC, Hoover EA. Detection of CWD prions in urine and saliva of deer by transgenic mouse bioassay. PLoS One 2009; 4: e4848.
9. Sc in salivary glands of scrapie-affected sheep. J Virol 2007; 81: 4872-11876
10. Maddison BC, Rees HC, Baker CA, et al. Prions are secreted into the oral cavity in sheep with preclinical scrapie. J Infect Dis 2010; 201(10): 1672-1676 (in this issue).
11. Saborio GP, Permanne B, Soto C. Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding. Nature 2001; 411: 810-813. (Pubitemid 32588105)
12. Castilla J, Saa P, Hetz C, Soto C. In vitro generation of infectious scrapie prions. Cell 2005; 121: 195-206.
13. Castilla J, Saa P, Soto C. Detection of prions in blood. Nat Med 2005; 11: 982-985.
14. Saa P, Castilla J, Soto C. Presymptomatic detection of prions in blood. Science 2006; 313: 92-94.
15. van Keulen LJ, Schreuder BE, Vromans ME, Langeveld JP, Smits MA. Pathogenesis of natural scrapie in sheep. Arch Virol Suppl 2000; 16: 57-71.
16. Heppner FL, Christ AD, Klein MA, et al. Transepithelial prion transport by M cells. Nat Med 2001; 7: 976-977.
17. Morel E, Andrieu T, Casagrande F, et al. Bovine prion is endocytosed by human enterocytes via the 37 kDa/67 kDa laminin receptor. Am J Pathol 2005; 167: 1033-1042. (Pubitemid 41416255)