NNINspm, naphthalimide-polyamine conjugate, induces hepatoma HepG2 cell apoptosis via PI3K/Akt pathways

Chinese Pharmacological Bulletin

Volumn 26, Issue 2, 2010, Pages 169-174

  Xie, Song Qiang ^a,b   Li, Qian ^b   Zhang, Ya Hong ^b   Wang, Jian Hong ^b   Zhao, Jin ^b   Wang, Chao Jie ^b  

^a HENAN UNIVERSITY   (China)

^b Key Laboratory of Natural Medicine and Immuno Engineering   (China)

Author keywords

Akt; Apoptosis; Cell cycle; mTOR; Polyamine conjugate; Polyamine transporter

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CASPASE 3; CASPASE 9; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYTOCHROME C; MAMMALIAN TARGET OF RAPAMYCIN; NAPHTHALIMIDE DERIVATIVE; NAPHTHALIMIDE NORSPERMINE CONJUGATE; PHOSPHATIDYLINOSITOL 3 KINASE; POLYAMINE; PROTEIN 14 3 3; PROTEIN BAD; PROTEIN BCL XL; PROTEIN KINASE B; S6 KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE ARREST; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOTOXICITY; DISSOCIATION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME RELEASE; FLOW CYTOMETRY; GENE TRANSLOCATION; HEPATOMA CELL; HUMAN; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

EID: 77951859441     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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