Treatment of chronic nonhealing neurotrophic corneal epithelial defects with thymosin β4

Annals of the New York Academy of Sciences

Volumn 1194, Issue , 2010, Pages 199-206

  Dunn, Steven P ^a,b   Heidemann, David G ^b   Chow, Christopher Y C ^b   Crockford, David ^c   Turjman, Nabila ^c   Angel, Janet ^c   Allan, Christian B ^c   Sosne, Gabriel ^d  

^a WAYNE STATE UNIVERSITY   (United States)

^b WILLIAM BEAUMONT HOSPITAL   (United States)

^c RegeneRx Biopharmaceuticals Inc   (United States)

^d WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Corneal ulceration; Diabetes; Herpes zoster ophthalmicus; Neurotrophic keratitis; Neurotrophic keratopathy; Thymosin beta 4; T 4

Indexed keywords

THYMOSIN BETA4;

ADULT; AGED; CHRONIC NONHEALING NEUROTROPHIC CORNEAL EPITHELIAL DEFECT; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; CORNEA DISEASE; CORNEA STROMA; EYE IRRITATION; FEMALE; FOLLOW UP; HUMAN; KERATITIS; MALE; TREATMENT DURATION; TREATMENT RESPONSE; WOUND HEALING;

GEOCORIS; HERPES ZOSTER;

EID: 77951835077     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2010.05471.x     Document Type: Conference Paper

References (16)

1. Lambiase, A., P. Rama, L. Aloe & S. Bonini. 1999. Management of neurotrophic keratopathy. Curr. Opin. Ophthalmol. 10: 270-276.
2. Sosne, G., C.C. Chan, K. Thai, et al. 2001. Thymosin beta 4 promotes corneal wound healing and modulates inflammatory mediators in vivo. Exp. Eye Res. 72: 605-608.
3. Sosne, G., E.A. Szliter, R. Barrett, et al. 2002. Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury. Exp. Eye Res. 74: 293-299.
4. Sosne, G., P.L. Christopherson, R.P. Barrett & R. Fridman. 2005. Thymosin-beta4 modulates corneal matrix metalloproteinase levels and polymorphonuclear cell infiltration after alkali injury. Invest. Ophthalmol. Vis. Sci. 46: 2388-2395.
5. Qiu, P.,M. Kurpakus-Wheater & G. Sosne. 2007.Matrix metalloproteinase activity is necessary for thymosin beta 4 promotion of epithelial cell migration. J. Cell. Physiol. 212: 165-173.
6. Lambiase, A., P. Rama, S. Bonini, et al. 1998. Topical treatment with nerve growth factor for corneal neurotrophic ulcers. N. Engl. J. Med. 338: 1174-1180.
7. Safer, D., R. Golla & V.T. Nachmias. 1990. Isolation of a 5-kilodalton actin-sequestering peptide from human blood platelets. Proc. Natl. Acad. Sci. USA 87: 2536-2540.
8. 4: Actin-sequestering protein moonlights to repair injured tissues. Trends Mol. Med. 11: 421-429.
9. 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids. Nat. Med. 5: 1424-1427.
10. Sosne, G., P. Qiu, P.L. Christopherson & M.K. Wheater. 2007. Thymosin beta 4 suppression of corneal NFkappaB: A potential anti-inflammatory pathway. Exp. Eye Res. 84: 663-669.
11. 4 inhibits corneal epithelial cell apoptosis after ethanol exposure in vitro. Invest. Ophthalmol. Vis. Sci. 45: 1095-1100.
12. 4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature 432: 466-472.
13. 4 stimulates directional migration of human umbilical vein endothelial cells. FASEB J. 11: 474-481.
14. 4 accelerates wound healing. J. Invest. Dermatol. 113: 364-368.
15. Yang, H., X. Cheng, Q. Yao, et al. 2008. The promotive effects of thymosin beta 4 on neuronal survival and neurite outgrowth by upregulating L1 expression. Neurochem. Res. 33: 2269-2280.
16. Sosne G., L. Xu, L. Prach, et al. 2004. Thymosin beta 4 stimulates laminin-5 production independent of TGFbeta. Exp. Cell. Res. 293: 175-183.