Shape-memory polymers as a technology platform for biomedical applications

Expert Review of Medical Devices

Volumn 7, Issue 3, 2010, Pages 357-379

  Lendlein, Andreas ^a   Behl, Marc ^a   Hiebl, Bernhard ^a   Wischke, Christian ^a  

^a INSTITUTE OF MATERIALS RESEARCH   (Germany)

Author keywords

Biocompatibility; Biofunctionality; Drug release; Polymer; Shape memory; Sterilization

Indexed keywords

BIOMATERIAL; POLYMER; SHAPE MEMORY POLYMER; UNCLASSIFIED DRUG;

BIODEGRADABLE IMPLANT; BIOMEDICAL TECHNOLOGY ASSESSMENT; CHEMICAL BINDING; CONTROLLED DRUG RELEASE; COVALENT BOND; CROSS LINKING; CYTOTOXICITY TEST; DEVICE; DEVICE INFECTION; HISTOCOMPATIBILITY; IMPLANT; INSTRUMENT STERILIZATION; LITHOTRIPSY; MATERIAL STATE; MEDICAL TECHNOLOGY; NONHUMAN; PARTICLE SIZE; POLYMERIZATION; POROSITY; REVIEW; ROOM TEMPERATURE; SURGICAL TECHNIQUE; TRANSITION TEMPERATURE;

ANIMALS; BIOMEDICAL TECHNOLOGY; DRUG DELIVERY SYSTEMS; EQUIPMENT AND SUPPLIES; HUMANS; MATERIALS TESTING; POLYMERS; STERILIZATION;

EID: 77951832882     PISSN: 17434440     EISSN: 17452422     Source Type: Journal    
DOI: 10.1586/erd.10.8     Document Type: Review

References (174)

1. Weigel T, Schinkel G, Lendlein A. Design and preparation of polymeric scaffolds for tissue engineering. Expert Rev. Med. Devices 3 (6), 835-851 (2006). (Pubitemid 46017623)
2. Lendlein A, Kelch S. Shape-memory polymers. Angew. Chem. Int. Ed. Engl. 41 (12), 2034-2057 (2002). (Pubitemid 34746904)
3. Beloshenko VA, Varyukhin VN, Voznyak Y V. The shape memory effect in polymers. Russ. Chem. Rev. 74 (3), 265-283 (2005).
4. Saroop M, Sarkar A. Shape memory polymers - materials of the future. Popular Plast. Packag. 51 (9), 73-78 (2006).
5. Behl M, Lendlein A. Actively moving polymers. Soft Matter 3, 58-67 (2007). (Pubitemid 44925790)
6. Liu C, Qin H, Mather PT. Review of progress in shape-memory polymers. J. Mater. Chem. 17 (16), 1543-1558 (2007). (Pubitemid 46584580)
7. Behl M, Lendlein A. Shape-memory polymers. Mater. Today 10 (4), 20-28 (2007). (Pubitemid 46603074)
8. Ratna D, Karger-Kocsis J. Recent advances in shape memory polymers and composites: a review. J. Mater. Sci. 43 (1), 254-269 (2008). (Pubitemid 350212195)
9. Gunes IS, Jana SC. Shape memory polymers and their nanocomposites: a review of science and technology of new multifunctional materials. J. Nanosci. Nanotechnol. 8 (4), 1616-1637 (2008).
10. Mondal S. Recent developments in temperature responsive shape memory polymers. Mini-Reviews in Organic Chemistry 6, 114-119 (2009).
11. Mather PT, Luo XF, Rousseau IA. Shape memory polymer research. Annu. Rev. Mater. Res. 39, 445-471 (2009).
12. Meng QH, Hu JL. A review of shape memory polymer composites and blends. Compos. Appl. Sci. Manuf. 40 (11), 1661-1672 (2009).
13. Behl M, Zotzmann J, Lendlein A. Shape-memory polymers and shapechanging polymers. Adv. Polym. Sci. DOI:10.1007/12-2009-26 (2010) (Epub ahead of print).
14. Kim BK, Lee SY, Xu M. Polyurethanes having shape memory effects. Polymer 37 (26), 5781-5793 (1996). (Pubitemid 126396665)
15. Gall K, Dunn ML, Liu Y P, Stefanic G, Balzar D. Internal stress storage in shape memory polymer nanocomposites. Appl. Phys. Lett. 85 (2), 290-292 (2004).
16. Wagermaier W, Kratz K, Heuchel M, Lendlein A. Characterization methods for shape-memory polymers. Adv. Polym. Sci. DOI:10.1007/12-2009-25 (2010) (Epub ahead of print).
17. Lendlein A, Kelch S. Shape-memory polymers as stimuli-sensitive implant materials. Clin. Hemorheol. Micro. 32 (2), 105-116 (2005). (Pubitemid 40529071)
18. ® induced by electron beam irradiation: characterization and evaluation. Nucl. Instrum. Meth. B 185, 100-107 (2001). (Pubitemid 33142295)
19. Mohr R, Kratz K, Weigel T, Lucka-Gabor M, Moneke M, Lendlein A. Initiation of shape-memory effect by inductive heating of magnetic nanoparticles in thermoplastic polymers. Proc. Natl Acad. Sci. USA 103 (10), 3540-3545 (2006). (Pubitemid 43376591)
20. Lendlein A, Langer R. Biodegradable, elastic shape-memory polymers for potential biomedical applications. Science 296 (5573), 1673-1676 (2002). (Pubitemid 34580574)
21. Grablowitz H, Lendlein A. Synthesis and characterization of α, Ω-dihydroxytelechelic oligo (p-dioxanone). J. Mater. Chem. 17 (38), 4050-4056 (2007).
22. Knight PT, Lee KM, Qin H, Mather PT. Biodegradable thermoplastic polyurethanes incorporating polyhedral oligosilsesquioxane. Biomacromolecules 9 (9), 2458-2467 (2008).
23. Pretsch T, Jakob I, Müller W. Hydrolytic degradation and functional stability of a segmented shape memory poly (ester urethane). Polymer Degrad. Stabil. 94 (1), 61-73 (2009).
24. Feng Y, Behl M, Kelch S, Lendlein A. Biodegradable multiblock copolymers based on oligodepsipeptides with shapememory properties. Macromol. Biosci. 9 (1), 45-54 (2009).
25. Gall K, Yakacki CM, Liu Y P, Shandas R, Willett N, Anseth KS. Thermomechanics of the shape memory effect in polymers for biomedical applications. J. Biomed. Mater. Res. A 73A (3), 339-348 (2005). (Pubitemid 40664300)
26. Yakacki CM, Shandas R, Lanning C, Rech B, Eckstein A, Gall K. Unconstrained recovery characterization of shape-memory polymer networks for cardiovascular applications. Biomaterials 28 (14), 2255-2263 (2007). (Pubitemid 46282928)
27. Yakacki CM, Shandas R, Safranski D, Ortega AM, Sassaman K, Gall K. Strong, tailored, biocompatible shape-memory polymer networks. Adv. Funct. Mater. 18 (16), 2428-2435 (2008).
28. Yakacki CM, Willis S, Luders C, Gall K. Deformation limits in shape-memory polymers. Adv. Eng. Mater. 10 (1-2), 112-119 (2008). (Pubitemid 351315536)
29. Ortega AM, Kasprzak SE, Yakacki CM, Diani J, Greenberg AR, Gall K. Structureproperty relationships in photopolymerizable polymer networks: effect of composition on the crosslinked structure and resulting thermomechanical properties of a (meth) acrylate-based system. J. Appl. Polymer Sci. 110 (3), 1559-1572 (2008).
30. 4 nanoparticles for remote activation. J. Appl. Polymer Sci. 112 (5), 3166-3176 (2009).
31. Xie T, Rousseau IA. Facile tailoring of thermal transition temperatures of epoxy shape memory polymers. Polymer 50 (8), 1852-1856 (2009).
32. Alteheld A, Feng YK, Kelch S, Lendlein A. Biodegradable, amorphous copolyesterurethane networks having shape-memory properties. Angew. Chem. Int. Ed. Engl. 44 (8), 1188-1192 (2005). (Pubitemid 40394733)
33. Migneco F, Huang YC, Birla RK, Hollister SJ. Poly (glycerol-dodecanoate), a biodegradable polyester for medical devices and tissue engineering scaffolds. Biomaterials 30 (33), 6479-6484 (2009).
34. Lendlein A, Zotzmann J, Feng Y, Alteheld A, Kelch S. Controlling the switching temperature of biodegradable, amorphous, shape-memory poly (raclactide) urethane networks by incorporation of different comonomers. Biomacromolecules 10 (4), 975-982 (2009).
35. Zotzmann J, Alteheld A, Behl M, Lendlein A. Amorphous phase-segregated copoly (ether) esterurethane thermoset networks with oligo (propylene glycol) and oligo[(rac-lactide)-co-glycolide] segments: synthesis and characterization. J. Mater. Sci. Mater. Med. 20 (9), 1815 (2009).
36. Lendlein A, Neuenschwander P, Suter U W. Hydroxy-telechelic copolyesters with well defned sequence structure through ring-opening polymerization. Macromol. Chem. Phys. 201 (11), 1067-1076 (2000).
37. Bertmer M, Buda A, Blomenkamp-Hofges I, Kelch S, Lendlein A. Biodegradable shape-memory polymer networks: characterization with solid-state NMR. Macromolecules 38 (9), 3793-3799 (2005). (Pubitemid 40672511)
38. Choi NY, Lendlein A. Degradable shapememory polymer networks from oligo[(llactide)-ran-glycolide]dimethacrylates. Soft Matter 3 (7), 901-909 (2007). (Pubitemid 46946214)
39. Kelch S, Choi NY, Wang Z, Lendlein A. Amorphous, elastic AB copolymer networks from acrylates and poly[(llactide)-ran-glycolide]dimethacrylates. Adv. Eng. Mater 10 (5), 494-502 (2008).
40. Choi NY, Kelch S, Lendlein A. Synthesis, shape-memory functionality and hydrolytical degradation studies on polymer networks from poly (rac-lactide) b-poly (propylene oxide)-b-poly (rac-lactide) dimethacrylates. Adv. Eng. Mater. 8 (5), 439-445 (2006). (Pubitemid 43875793)
41. Lendlein A, Schmidt AM, Schroeter M, Langer R. Shape-memory polymer networks from oligo (epsilon-caprolactone) dimethacrylates. J. Polymer Sci. Polymer Chem. 43 (7), 1369-1381 (2005). (Pubitemid 40496612)
42. Razzaq MY, Behl M, Kratz K, Lendlein A. Controlled actuation of shape-memory nanocomposites by application of an alternating magnetic feld. Mat. Res. Soc. Symp. Proc. 1140, 185-190 (2009).
43. Yu XJ, Zhou SB, Zheng XT, Xiao Y, Guo T. Infuence of in vitro degradation of a biodegradable nanocomposite on its shape memory effect. J. Phys. Chem. 113 (41), 17630-17635 (2009).
44. Liu CD, Chun SB, Mather PT, Zheng L, Haley EH, Coughlin EB. Chemically cross-linked polycyclooctene: synthesis, characterization, and shape memory behavior. Macromolecules 35 (27), 9868-9874 (2002).
45. Kunzelman J, Chung T, Mather PT, Weder C. Shape memory polymers with built-in threshold temperature sensors. J. Mater. Chem. 18 (10), 1082-1086 (2008). (Pubitemid 351311823)
46. Neffe AT, Hanh BD, Steuer S, Lendlein A. Polymer networks combining controlled drug release, biodegradation, and shape memory capability. Adv. Mater. 21, 3394-3398 (2009).
47. Lendlein A, Schmidt AM, Langer R. AB-polymer networks based on oligo (epsilon-caprolactone) segments showing shape-memory properties. Proc. Natl Acad. Sci. USA 98 (3), 842-847 (2001). (Pubitemid 32121149)
48. Kirkpatrick CJ, Bittinger F, Wagner M et al. Current trends in biocompatibility testing. Proc. Inst. Mech. Eng. H 212 (2), 75-84 (1998). (Pubitemid 128769984)
49. Hanks CT, Wataha JC, Sun Z. In vitro models of biocompatibility: a review. Dent. Mater. 12 (3), 186-193 (1996). (Pubitemid 126758820)
50. Pizzoferrato A, Ciapetti G, Stea S et al. Cell culture methods for testing biocompatibility. Clin. Mater. 15 (3), 173-190 (1994). (Pubitemid 24127786)
51. Block SA.sDesinfection, Sterilization, and Preservation. tBlock SA (Ed.). Williams & Williams, Lippincott, PA, USAy (2000).
52. 52tFDA.sUpdated 510 (k) Sterility Review Guidance K90-1; Guidance for Industry and FDA.tUS Department Of Health and Human Services, Food and Drug Administration, Center for Devices and Radiological Health, Offce of Device Evaluation, Rockville, MD, USAy (2002).
53. Nair PD.aCurrently practised sterilization methods - some inadvertent consequences.sJ. Biomater. Appl. 10 (2), 121-135 (1995).
54. Rozema FR, Bos RR, Boering G, van Asten JA, Nijenhuis AJ, Pennings AJ.aThe effects of different steam-sterilization programs on material properties of poly (l-lactide). J. Appl. Biomater. 2 (1), 23-28 (1991).
55. Freeman MA, Barwell CF. Ethylene oxide sterilization in hospital practice. J. Hyg. (Lond.) 58, 337-345 (1960).
56. Filipczak K, Wozniak M, Ulanski P et al. Poly (epsilon-caprolactone) biomaterial sterilized by E-beam irradiation. Macromol Biosci. 6 (4), 261-273 (2006).
57. Loo SC, Ooi CP, Boey YC. Infuence of electron-beam radiation on the hydrolytic degradation behaviour of poly (lactide-coglycolide) (PLGA). Biomaterials 26 (18), 3809-3817 (2005).
58. Williams H, Huxley J, Claybourn M et al. The effect of γ-irradiation and polymer composition on the stability of PLG polymer and microspheres. Polym. Degrad. Stab. 91, 2171 (2006). (Pubitemid 43817140)
59. Carrascosa C, Espejo L, Torrado S, Torrado JJ. Effect of γ-sterilization process on PLGA microspheres loaded with insulin-like growth factor-I (IGF-I). J. Biomater. Appl. 18 (2), 95-108 (2003).
60. Montanari L, Costantini M, Signoretti EC et al. γ irradiation effects on poly (dllactictide-co-glycolide) microspheres. J. Control. Release 56 (1-3), 219-229 (1998). (Pubitemid 28511142)
61. Leonard D, Buchanan F, Farrar D. Investigation into depth dependence of effect of e-beam radiation on mechanical and degradation properties of polylactide. Plast. Rubber Compos. 53, 303 (2006).
62. Lerouge S, Tabrizian M, Wertheimer MR, Marchand R, Yahia L. Safety of plasmabased sterilization: surface modifcations of polymeric medical devices induced by Sterrad and Plazlyte processes. Biomed. Mater. Eng. 12 (1), 3-13 (2002). (Pubitemid 34177339)
63. De Nardo L, Alberti R, Cigada A, Yahia L, Tanzi MC, Fare S. Shape memory polymer foams for cerebral aneurysm reparation: effects of plasma sterilization on physical properties and cytocompatibility. Acta Biomater. 5 (5), 1508-1518 (2009).
64. Ikarashi Y, Tsuchiya T, Nakamura A. Cytotoxicity of medical materials sterilized with vapour-phase hydrogen peroxide. Biomaterials 16 (3), 177-183 (1995).
65. Yakacki CM, Lyons MB, Rech B, Gall K, Shandas R. Cytotoxicity and thermomechanical behavior of biomedical shape-memory polymer networks post-sterilization. Biomed. Mater. 3 (1), 15010 (2008). (Pubitemid 351366835)
66. Goveia VR, Pinheiro SM, Graziano KU. Low-temperature sterilization and new technologies. Rev. Lat. Am. Enfermagem 15 (3), 373-376 (2007).
67. Lucas AD, Merritt K, Hitchins VM et al. Residual ethylene oxide in medical devices and device material. J. Biomed. Mater. Res. B Appl. Biomater. 66 (2), 548-552 (2003). (Pubitemid 37517127)
68. Kelch S, Steuer S, Schmidt AM et al. Shape-memory polymer networks from oligo[(epsilon-hydroxycaproate)-coglycolate]dimethacrylates and n-butyl acrylate with adjustable hydrolytic degradation rate. Biomacromolecules 8 (3), 1018-1027 (2007). (Pubitemid 46488487)
69. Rickert D, Lendlein A, Schmidt AM et al. In vitro cytotoxicity testing of AB-polymer networks based on oligo (ε-caprolactone) segments after different sterilization techniques. J. Biomed. Mater. Res. B Appl. Biomater. 67 (2), 722-731 (2003). (Pubitemid 37526678)
70. Rickert D, Scheithauer MO, Coskun S, Kelch S, Lendlein A, Franke R P. The infuence of a multifunctional, polymeric biomaterial on the concentration of acute phase proteins in an animal model. Clin. Hemorheol. Microcirc. 36 (4), 301-311 (2007). (Pubitemid 46868440)
71. Rickert D, Lendlein A, Peters I, Moses MA, Franke R P. Biocompatibility testing of novel multifunctional polymeric biomaterials for tissue engineering applications in head and neck surgery: an overview. Eur. Arch. Otorhinolaryngol. 263 (3), 215-222 (2006).
72. Grapski JA, Cooper SL. Synthesis and characterization of non-leaching biocidal polyurethanes. Biomaterials 22 (16), 2239-2246 (2001).
73. Meng Q, Hu J, Liu B, Zhu Y. A lowtemperature thermoplastic anti-bacterial medical orthotic material made of shape memory polyurethane ionomer: infuence of ionic group. J. Biomater. Sci. Polym. Ed. 20 (2), 199-218 (2009).
74. Lendlein A, Kelch S. Degradable, multifunctional polymeric biomaterials with shape-memory. Materials Science Forum 492-493, 219-223 (2005). (Pubitemid 47543809)
75. Rickert D, Lendlein A, Kelch S, Franke R P, Moses MA. Cell proliferation and cellular activity of primary cell cultures of the oral cavity after cell seeding on the surface of a degradable, thermoplastic block copolymer. Biomed. Tech. (Berl.) 50 (4), 92-99 (2005). (Pubitemid 41783067)
76. Rickert D, Lendlein A, Kelch S, Moses MA, Franke R P. Expression of MMPs and TIMPs in primary epithelial cell cultures of the upper aerodigestive tract seeded on the surface of a novel polymeric biomaterial. Clin. Hemorheol. Microcirc. 32 (2), 117-128 (2005). (Pubitemid 40529072)
77. Sigurdson L, Carney DE, Hou Y et al. A comparative study of primary and immortalized cell adhesion characteristics to modifed polymer surfaces: toward the goal of effective re-epithelialization. J. Biomed. Mater. Res. 59 (2), 357-365 (2002).
78. Singer AJ, Clark RA. Cutaneous wound healing. N. Engl. J. Med. 341 (10), 738-746 (1999).
79. Wang YX, Robertson JL, Spillman WB Jr, Claus RO. Effects of the chemical structure and the surface properties of polymeric biomaterials on their biocompatibility. Pharm. Res. 21 (8), 1362-1373 (2004).
80. Rickert D, Moses MA, Lendlein A, Kelch S, Franke R P. The importance of angiogenesis in the interaction between polymeric biomaterials and surrounding tissue. Clin. Hemorheol. Microcirc. 28 (3), 175-181 (2003). (Pubitemid 36718257)
81. Cabanlit M, Maitland D, Wilson T et al. Polyurethane shape-memory polymers demonstrate functional biocompatibility in vitro. Macromol. Biosci. 7 (1), 48-55 (2007). (Pubitemid 46191959)
82. Coury A, Levy R, McMillin C et al. Biomaterials Science: An Introduction to Materials in Medicine. Ratner B, Hoffman A, Schoen F, Lemons J (Eds). Academic Press, NY, USA (1996).
83. Silver JH, Myers CW, Lim F, Cooper SL. Effect of polyol molecular weight on the physical properties and haemocompatibility of polyurethanes containing polyethylene oxide macroglycols. Biomaterials 15 (9), 695-704 (1994). (Pubitemid 24230610)
84. Lelah MD, Grasel TG, Pierce JA, Cooper SL. The measurement of contact angles on circular tubing surfaces using the captive bubble technique. J. Biomed. Mater. Res. 19 (9), 1011-1015 (1985).
85. Lelah MD, Lambrecht LK, Young BR, Cooper SL. Physicochemical characterization and in vivo blood tolerability of cast and extruded Biomer. J. Biomed. Mater. Res. 17 (1), 1-22 (1983).
86. Neuss S, Blomenkamp I, Stainforth R et al. The use of a shape-memory poly (ε-caprolactone) dimethacrylate network as a tissue engineering scaffold. Biomaterials 30 (9), 1697-1705 (2009).
87. Belanger MC, Marois Y. Hemocompatibility, biocompatibility, infammatory and in vivo studies of primary reference materials low-density polyethylene and polydimethylsiloxane: a review. J. Biomed. Mater. Res. 58 (5), 467-477 (2001). (Pubitemid 32899901)
88. Browne RM. Animal tests for biocompatibility of dental materials - relevance, advantages and limitations. J. Dent. 22 (Suppl. 2) S21-S24 (1994).
89. Pearce AI, Richards RG, Milz S, Schneider E, Pearce SG. Animal models for implant biomaterial research in bone: a review. Eur. Cell. Mater. 13, 1-10 (2007). (Pubitemid 46890447)
90. Clark R. The Molecular and Cellular Biology of Wound Repair. Plenum Press, NY, USA (1995).
91. Nicosia RF, Villaschi S. Autoregulation of angiogenesis by cells of the vessel wall. Int. Rev. Cytol. 185, 1-43 (1999). (Pubitemid 129751071)
92. Binzen E, Lendlein A, Kelch S, Rickert D, Franke RP. Biomaterial- microvasculature interaction on polymers after implantation in mice. Clin. Hemorheol. Microcirc. 30 (3-4), 283-288 (2004). (Pubitemid 38951516)
93. Sieminski AL, Gooch KJ. Biomaterial-microvasculature interactions. Biomaterials 21 (22), 2232-2241 (2000).
94. Bakker D, van Blitterswijk CA, Hesseling SC, Daems W T, Grote JJ. Tissue/biomaterial interface characteristics of four elastomers. A transmission electron microscopical study. J. Biomed. Mater. Res. 24 (3), 277-293 (1990). (Pubitemid 20132800)
95. van Blitterswijk CA, Bakker D, Hesseling SC, Koerten HK. Reactions of cells at implant surfaces. Biomaterials 12 (2), 187-193 (1991).
96. Williams DF. On the mechanisms of biocompatibility. Biomaterials 29 (20), 2941-2953 (2008).
97. Hiebl B, Kratz K, Fuhrmann R, Jung F, Lendlein A, Franke R. In vivo degradation behavior of in vivo multiblock copolymers containing poly (p-dioxanone) hard segments and crystallizable poly (ε-caprolactone) switching segments. Mat. Res. Soc. Symp. Proc. 1190, 113-118 (2009).
98. Hiebl B, Rickert D, Fuhrmann R, Jung F, Lendlein A, Franke R. Tissue integration of two different shape-memory polymers with poly (ε-caprolactone) switching segment in rats. Mat. Res. Soc. Symp. Proc. 1140, 143-149 (2009).
99. Binzen E, Rickert D, Kelch S, Fuhrmann R. Angiogenesis around new AB-polymer networks after one week of implantation in mice. Clin. Hemorheol. Microcirc. 28 (3), 183-188 (2003). (Pubitemid 36718258)
100. N39F-54: 20 Medical Device Technologies Changing Healthcare. Frost & Sullivan, TX, USA (2008).
101. Wache HM, Tartakowska DJ, Hentrich A, Wagner MH. Development of a polymer stent with shape memory effect as a drug delivery system. J. Mater. Sci. Mater. Med. 14 (2), 109-112 (2003). (Pubitemid 36337564)
102. Bellin I, Kelch S, Langer R, Lendlein A. Polymeric triple-shape materials. Proc. Natl Acad. Sci. USA 103 (48), 18043-18047 (2006). (Pubitemid 44871609)
103. Baer G, Wilson T, Maitland D, Matthews D. Shape memory polymer neurovascular stents. J. Investig. Med. 54 (1), S162-S162 (2006).
104. Yakacki CM, Shandas R, Lanning C, Gall K. Free recovery effects of shapememory polymers for cardiovascular stents. In: Mechanical Behavior of Biological and Biomimetic Materials. Bushby AJ, Ferguson VL, Ko C-C, Oyen ML (Eds). Material Research Society, PA, USA (2006). (Pubitemid 46884547)
105. Baer GM, Small W, Wilson TS et al. Fabrication and in vitro deployment of a laser-activated shape memory polymer vascular stent. Biomed. Eng. Online 6, 8 (2007).
106. Baer GM, Wilson TS, Small W et al. Thermomechanical properties, collapse pressure, and expansion of shape memory polymer neurovascular stent prototypes. J. Biomed. Mater. Res. B Appl. Biomater. 90B (1), 421-429 (2009).
107. Metcalfe A, Desfaits AC, Salazkin I, Yahia L, Sokolowski WM, Raymond J. Cold hibernated elastic memory foams for endovascular interventions. Biomaterials 24 (9), 491-497 (2003). (Pubitemid 35287520)
108. Hampikian JM, Heaton BC, Tong FC, Zhang ZQ, Wong CP. Mechanical and radiographic properties of a shape memory polymer composite for intracranial aneurysm coils. Mater. Sci. Eng. C 26 (8), 1373-1379 (2006).
109. Ortega J, Maitland D, Wilson T, Tsai W, Savas O, Saloner D. Vascular dynamics of a shape memory polymer foam aneurysm treatment technique. Ann. Biomed. Eng. 35 (11), 1870-1884 (2007). (Pubitemid 47631058)
110. Maitland DJ, Small W, Ortega JM et al. Prototype laser-activated shape memory polymer foam device for embolic treatment of aneurysms. J. Biomed. Opt. 12 (3), 030504 (2007).
111. Small W, Buckley PR, Wilson TS et al. Shape memory polymer stent with expandable foam: A new concept for endovascular embolization of fusiform aneurysms. IEEE Trans. Biomed. Eng. 54 (6), 1157-1160 (2007).
112. Metzger MF, Wilson TS, Schumann D, Matthews DL, Maitland DJ. Mechanical properties of mechanical actuator for treating ischemic stroke. Biomedical Microdevices 4 (2), 89-96 (2002). (Pubitemid 34449935)
113. Maitland DJ, Metzger MF, Schumann D, Lee A, Wilson TS. Photothermal properties of shape memory polymer micro-actuators for treating stroke. Lasers Surg. Med. 30 (1), 1-11 (2002). (Pubitemid 34101495)
114. Small W, Metzger MF, Wilson TS, Maitland DJ. Laser-activated shape memory polymer microactuator for thrombus removal following ischemic stroke: Preliminary in vitro analysis. IEEE J. Sel. Top. Quant. Electron. 11 (4), 892-901 (2005).
115. Small W, Wilson TS, Benett WJ, Loge JM, Maitland DJ. Laser-activated shape memory polymer intravascular thrombectomy device. Optics Express 13 (20), 8204-8213 (2005).
116. Wilson TS, Small W, Benett WJ, Bearinger JP, Maitland D. Shape memory polymer therapeutic devices for stroke. In: Smart Medical and Biomedical Sensor Technology III. Cullum BM, Carter JC (Eds). SPIE, WA, USA, 60070R (2005). (Pubitemid 43331162)
117. Small W, Wilson TS, Buckley PR et al. Prototype fabrication and preliminary in vitro testing of a shape memory endovascular thrombectomy device. IEEE Trans. Biomed. Eng. 54 (9), 1657-1666 (2007).
118. Hartman J, Small Wt, Wilson TS et al. Embolectomy in a rabbit acute arterial occlusion model using a novel electromechanical extraction device. AJNR Am. J. Neuroradiol. 28 (5), 872-874 (2007). (Pubitemid 46776065)
119. Maitland DJ, Wilson T, Metzger M, Schumann DL. Laser-activated shape memory polymer microactuators for treating stroke. In: Proceedings of SPIE - The International Society for Optical Engineering. tBornhop DJ, Dunn DA, Mariella JRP et al. (Eds). Biomedical Nanotechnology Architectures and Applications, 394 (2002). (Pubitemid 34101495)
120. Ortega JM, Small W, Wilson TS, Benett WJ, Loge JM, Maitland DJ. A shape memory polymer dialysis needle adapter for the reduction of hemodynamic stress within arteriovenous grafts. sIEEE Trans. Biomed. Eng. 54 (9), 1722-1724 (2007).
121. Sharp AA, Panchawagh HV, Ortega A et al. Toward a self-deploying shape memory polymer neuronal electrode. J. Neural Eng. 3 (4), L23-L30 (2006). (Pubitemid 46063914)
122. Jung YC, Cho JW. Application of shape memory polyurethane in orthodontic. J. Mater. Sci. Mater. Med. (2008) (Epub ahead of print).
123. Sokolowski W, Metcalfe A, Hayashi S, Yahia L, Raymond J. Medical applications of shape memory polymers. Biomed. Mater. 2 (1), S23-S27 (2007). (Pubitemid 47007469)
124. Yackaki CM, Gall K. Shape-memory polymers for biomedical applications. In: Advances in Polymer Science. Lendlein A (Ed.). Springer, NY, USA, DOI: 10.1007/12-2009-23 (2010) (Epub ahead of print).
125. Koebbe CJ, Veznedaroglu E, Jabbour P, Rosenwasser RH. Endovascular management of intracranial aneurysms: current experience and future advances. Neurosurgery 59 (5 Suppl. 3), S93-S102; discussion S3-S13 (2006). (Pubitemid 44622722)
126. Ferns SP, Sprengers ME, van Rooij WJ et al. Coiling of intracranial aneurysms: a systematic review on initial occlusion and reopening and retreatment rates. Stroke 40 (8), e523-e529 (2009).
127. Lederle FA. In the clinic. Abdominal aortic aneurysm. Ann. Intern. Med. 150 (9), ITC5-1-15 (2009).
128. Duarte MP, Maldjian CT, Laskowski I. Comparison of endovascular versus open repair of abdominal aortic aneurysms: a review. Cardiol. Rev. 17 (3), 112-114 (2009).
129. Gobin YP, Starkman S, Duckwiler GR et al. MERCI 1: a Phase 1 study of mechanical embolus removal in cerebral ischemia. Stroke 35 (12), 2848-2854 (2004). (Pubitemid 39565182)
130. Hayashi S. Properties and applications of polyurethane-series shape-memory polymer. In: International Progress in Urethanes. Technomic Publishing Co., PA, USA, 90-150 (1993).
131. Wischke C, Neffe AT, Steuer S, Lendlein A. Evaluation of a degradable shape-memory polymer network as matrix for controlled drug release. J. Control. Release 138 (3), 243-250 (2009).
132. Nagahama K, Ueda Y, Ouchi T, Ohya Y. Biodegradable shape-memory polymers exhibiting sharp thermal transitions and controlled drug release. Biomacromolecules 10, 1789 (2009).
133. Wischke C, Neffe AT, Lendlein A. Controlled drug release from shapememory polymers. Adv. Polym. Sci. DOI: 10.1007/12-2009-29 (2010) (Epub ahead of print).
134. Woodland JH, Yolles S. Long-acting delivery systems for narcotic antagonists 1. J. Med. Chem. 16 (8), 897-901 (1973).
135. Yolles S, Leafe TD, Woodland JH, Meyer FJ. Long-acting delivery systems for narcotic-antagonists II: release rates of naltrexone from poly (lactic acid) composites. J. Pharm. Sci. 64 (2), 348-349 (1975).
136. Chiang CN, Hollister LE, Kishimoto A, Barnett G. Kinetics of a naltrexone sustained-release preparation. Clin. Pharm. Ther. 36 (5), 704-708 (1984). (Pubitemid 15224677)
137. Neffe AT, Hanh BD, Steuer S, Wischke C, Lendlein A. Thermomechanical properties and shape-memory capability of drug loaded semi-crystalline polyestermethacrylate networks. Mat. Res. Soc. Symp. Proc. 1190, 105-111 (2009).
138. Wischke C, Neffe AT, Steuer S, Lendlein A. Amorphous polymer networks combining three functionalities - shapememory, biodegradability, and drug release. Mat. Res. Soc. Symp. Proc. 1190, 131-136 (2009) Patents
139. Lendlein A, Langer R. Biodegradable shape memory polymeric sutures. United States Patent Application Publication
140. US 2004/0015187 A1 (2004).
141. Goraltchouk A, Lai J, Herrmann RA. Shape-memory self retaining sutures, methods of manufacture, and methods of use. International Publication
142. WO 2009/132284 A2 (2009).
143. Bettuchi M, Heinrich R. Novel surgical fastener. sUnited States Patent Application Publication, US 2009/0118747 A1 (2009).
144. Simon P, Lendlein A, Schnitter B. Temporäre bioabbaubare Stents. German Patent Application Publication
145. DE 10357744 A1 (2005).
146. Simon P, Kratz K, Lendlein A, Schnitter B. Temporäre Stents. German Patent Application Publication, DE 10357743 A1 (2005).
147. Shandas R, Yakacki CM, Gall K et al. Shape memory medical devices. International Publication
148. WO 2007/115208 A2 (2007).
149. Jordan G. Shape memory polymeric stent. United States Patent Application Publication, US 2008/0312733 (2008).
150. Wilson TS, Maitland DJ. Shape memory polymer foams for endovascular therapies. United States Patent Application Publication, US 2005/0075405 A1 (2005).
151. Shaolian SM, Shaoulian E, Henson MR, Moaddeb S. Externally adjustable endovascular graft implant. United States Patent Application Publication
152. US 2006/0212113 A1 (2006).
153. Wilson TS, Maitland DJ, Small W et al. Stent with expandable foam. United States Patent Application Publication
154. US 2007/0135907 A1 (2007).
155. Lee JA, Calabria MF, Bertelson AJ, Boock R. Aneurysm embolization material and device. United States Patent Application Publication, US 2007/0104752 A1 (2007).
156. Moaddeb S, Shaolian S, Shaoulian E, Lenker JA. Adjustable prosthetic valve implant. United States Patent Application Publication, US 2007/0142907 A1 (2007).
157. Maitland D, Lee A, Schumann D, Da Silva L. Shape memory polymer (SMP) gripper with a release system. tUnited States Patent, US 6102917 (2000)
158. Lee A P, Fitch JP. Microdevices using shape memory patches for mated connections. United States Patent, US 6086599 (2000).
159. Notter M. Inderwelling catheter. International Publication, WO 2007/147894 (2007).
160. Sung J. Access port using shape memory polymer. United States Patent Application Publication, US 2009/0105691 A1 (2009).
161. Teague JA. Light responsive medical retrieval devices. International Publication, WO 2007/145800 (2007).
162. Feldmann T, Wang W. Lumen occluders made from thermodynamic materials. United States Patent Application Publication, US 2002/0129819 A1 (2002).
163. Shandas R, Yakacki CM, Nair DP, Gall K, Lyons M. Shape memory polymer-based transcervical device for permanent or temporary sterilization. International Publication, WO 2008/077123 A1 (2008).
164. Simon P, Lendlein A, Schnitter B. Temporäre bioabbaubare stents zur nicht-vaskulären anwendung [Temporary biodegradable stents for non-vascular application]. German Patent Application Publication, DE 10357747 A1 (see also US 2006/0287710 A1) (2005).
165. Simon P, Kratz K, Lendlein A, Schnitter B. Temporäre stents zur nicht-vaskulären anwendung [Temporary stents for non-vascular application]. German Patent Application Publication, DE 10357742 A1 (see also US 2007/0129784 A1) (2005).
166. Shadduck JH. Implants for treating ocular hypertension, methods of use and methods of fabrication. United States Patent Application Publication, US 2004/0193095 A1 (2004).
167. Shadduck J. Implants for treating ocular hypertension, methods of use and methods of fabrication. United States Patent Application Publication, US 2004/0193262 A1 (2004).
168. Lendlein A, Langer R. Self-expandiong device for the gastrointestinal or urogenital area. International Publication, WO 2004/073690 A1 (2004).
169. Mather PT. Mechanically activated shape memory device. United States Patent, US 7151157 B2 (2006).
170. Langer R, Lendlein A, Schmidt A, Grablowitz H. Biodegradable shape memory polymers. United States Patent Publication, US 6160084 (2000).
171. Shikinami Y. Shape-memory, biodegradable and absorbable material. European Patent Publication, EP 1 000 958 B1 (2004).
172. Mather PT, Liu C, Ge Q. Shape memory polymers based on semicrystalline thermoplastic polyurethanes bearing nanostructured hard segments. United States Patent, US 7524914 B2 (2009).
173. Stankus J, Trollsas M, Ngo M. Polymers for implantable devices exhibiting shape-memory effects. United States Patent Application Publication, US 2009/0035350 A1 (2009).
174. Lendlein A, Steuer S, Tuleweit A. Systems for releasing active ingredients based on biodegradable or biocompatible polymers with a shape memory effect. International Publication, WO 2004/006885 (2004).