Testosterone concentrations and male genital organ morphology in Greenland sledge dogs (Canis familiaris) dietary exposed to organohalogen contaminants

Toxicological and Environmental Chemistry

Volumn 92, Issue 5, 2010, Pages 955-967

  Kirkegaard, Maja ^a,b   Sonne, Christian ^a,b   Dietz, Rune ^b   Jenssen, Bjørn Munro ^c   Leifsson, Pall S ^d   Jensen, Jens Erik Bech ^e   Letcher, Robert J ^f  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b NATIONAL ENVIRONMENTAL RESEARCH INSTITUTE   (Denmark)

^c NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e HVIDOVRE HOSPITAL   (Denmark)

^f CARLETON UNIVERSITY   (Canada)

Author keywords

DDT; PCB; Sledge dog; Testis; Testosterone

Indexed keywords

ADIPOSE TISSUE; BONE MINERAL DENSITY; CHRONIC EXPOSURE; COMPLEX MIXTURE; DIETARY INTAKES; GREENLAND; LOW CONCENTRATIONS; MALE REPRODUCTIVE ORGANS; MARINE MAMMALS; MINKE WHALES; ORGANOHALOGEN CONTAMINANTS; ORGANOHALOGEN POLLUTANTS; SLEDGE DOG; TOP PREDATOR;

MAMMALS; MARINE POLLUTION; MORPHOLOGY; POLYCHLORINATED BIPHENYLS;

CONCENTRATION (PROCESS);

CANID; CHEMICAL POLLUTANT; DDT; DIETARY SHIFT; FUNCTIONAL MORPHOLOGY; HORMONE; MODELING; ORGANOHALOGEN; PCB; PREDATOR-PREY INTERACTION; SECONDARY SEXUAL CHARACTERISTICS; WHALE;

ANIMALIA; BACULUM; BALAENOPTERA; BALAENOPTERA ACUTOROSTRATA; CANIS FAMILIARIS; MAMMALIA;

EID: 77951829641     PISSN: 02772248     EISSN: 10290486     Source Type: Journal    
DOI: 10.1080/02772240903143836     Document Type: Article

References (50)

1. Ahmad, S.U., S. Tariq, S. Jalali, and M.M. Ahmad. 2003. Environmental pollutant Aroclor 1242 (PCB) disrupts reproduction in adult male rhesus monkeys (Macaca mulatta). Environmental Research 93: 272-8.
2. Anas, M-K.I., C. Guillemette, P. Ayotte, D. Pereg, F. Giguere, and L.J. Bailey. 2005. In utero and lactational exposure to an environmentally relevant organochlorine mixture disrupts reproductive development and function in male rats. Biology of Reproduction 73: 414-26.
3. Andersen, H.R., I.M. Schmidt, P. Grandjean, T.K. Jensen, E. Budtz-Jørgensen, M.B. Kjærstad, J. Bælum, J.B. Nielsen, N.E. Skakkebæk, and K.M. Main. 2008. Impaired reproductive development in sons of women occupationally exposed to pesticides during pregnancy. Environmental Health Perspectives 116: 566-72.
4. Andric, S.A., T.S. Kostic, S.S. Stojilkovic, and R.Z. Kovacevic. 2000. Inhibition of rat testicular androgenesis by a polychlorinated biphenyl mixture Aroclor 1248. Biology of Reproduction 62: 1882-8.
5. Bonefeld-Jørgensen, E.C., H.R. Andersen, T.H. Rasmussen, and A.M. Vinggaard. 2001. Effect of highly bioaccumulated polychlorinated biphenyl congeners on estrogen and androgen receptor activity. Toxicology 158: 141-53.
6. Born, E.W., I. Kraul, and T. Kristensen. 1981. Mercury, DDT and PCB in the Atlantic Walrus (Odobenus rosmarus rusmarus) from the Thule District, North Greenland. Arctic 34: 255-80.
7. Colciago, A., P. Negri-Cesi, A. Pravettoni, O. Mornati, L. Casati, and F. Celotti. 2006. Prenatal Aroclor 1254 exposure and brain sexual differentiation: Effect on the expression of testosterone metabolizing enzymes and androgen receptors in the hypothalamus of male and female rats. Reproductive Toxicology 22: 738-45.
8. Dallinga, J.W., E.J.C. Moonen, J.C.M. Dumoulin, J.L.H. Evers, J.P.M. Geraedts, and J.C.S. Kleinjans. 2002. Decreased human semen quality and organochlorine compounds in blood. Human Reproduction 17: 1973-9.
9. Derocher, A.E., H. Wolkers, T. Colborn, M. Schlabach, T.S. Larsen, and O. Wiig. 2003. Contaminants in Svalbard polar bear samples archived since 1967 and possible population level effects. Science of the Total Environment 301: 163-74.
10. Dietz, R., F.F. Riget, C. Sonne, R.J. Letcher, E.W. Born, and D.C.G. Muir. 2004. Seasonal and temporal trends in polychlorinated biphenyls and organochlorine pesticides in East Greenland polar bears (Ursus maritimus), 1990-2001. Science of the Total Environment 331: 107-24.
11. Faqi, A.S., P.R. Dalsenter, H-J. Merker, and I. Chahoud. 1998. Effects on developmental landmarks and reproductive capability of 3,30,4,40-tetrachlorobiphenyl and 3,30,4,40,5-pentacholorobiphenyl in pup of rats exposed during pregnancy. Human Experimental Toxicology 17: 365-72.
12. Fielden, M.R., R.G. Halgren, C.H.M. Tashiro, B.R. Yeo, B. Chittim, K. Chou, and T.R. Zacharewski. 2001. Effects of gestational and lactational exposure to aroclor 1242 on sperm quality and in vitro fertility in early adult and middle-aged mice. Reproductive Toxicology 15: 281-92.
13. Fuglei, E., J.O. Bustnes, H. Hop, T. Mork, H. Bjornfoth, and B. van Bavel. 2007. Environmental contaminants in arctic foxes (Alopex lagopus) in Svalbard: Relationships with feeding ecology and body condition. Environmental Pollution 146: 128-38.
14. Gebbink, W.A., C. Sonne, R. Dietz, M. Kirkegaard, E.W. Born, D.C.G. Muir, and R.J. Letcher. 2008a. Target tissue selectivity and burdens of diverse classes of brominated and chlorinated contaminants in polar bears (Ursus maritimus) from East Greenland. Environal Science and Technology 42: 752-9.
15. Gebbink, W.A., C. Sonne, R. Dietz, M. Kirkegaard, F.F. Riget, E.W. Born, D.C.G. Muir, and R.J. Letcher. 2008b. Tissue-specific congener composition of organohalogen and metabolite contaminants in East Greenland polar bears (Ursus maritimus). Environmental Pollution 152: 621-9.
16. Gray Jr, L.E., J. Ostby, J. Furr, C.J. Wolf, C. Lambright, L. Parks, D.N. Veeramachaneni, et al. 2001. Effects of environmental antiandrogens on reproductive development in experimental animals. Human Reproduction Update 7: 248-64.
17. Gray Jr, L.E., V.S. Wilson, T. Stoker, C. Lambright, J. Furr, N. Noriega, K. Howdeshell, G.T. Ankley, and L. Guillette. 2006. Adverse effects of environmental antiandrogens and androgens on reproductive development in mammals. International Journal of Andrology 29: 96-104.
18. Hany, J., H. Lilienthal, A. Sarasin, A. Roth-Härer, A. Fastabend, L. Dunemann, W. Lichtensteiger, and G Winneke. 1999. Developmental Exposure of rats to a reconstituted PCB mixture or aroclor 1254: Effects on organ weights; aromatase activity; sex hormone levels and sweet preference behavior. Toxicology an Applied Pharmacology 158: 231-43.
19. Kuriyama, S.N., and I. Chahould. 2004. In utero exposure to low-dose 2,3',4',5-pentachlorobiphenyl (PCB 118) impairs male fertility and alters neurobehavior in rat pup. Toxicology 202: 185-97.
20. Lundkvist, U. 1990. Clinical and reproductive effects of Clophen A50 (PCB) administered during gestation on pregnant guinea pigs and their pup. Toxicology 61: 249-57.
21. Mialot, J.P., M. Thibier, J.E. Toublanc, M. Castanier, and R Scholler. 1988. Plasma concentration of luteinizing hormone, testosterone, dehydroepiandrosterone, androstenedione between birth and one year in the male dog: Longitudinal study and hCG stimulation. Andrologia 20: 145-54.
22. Oskam, I.C., E. Ropstad, E. Dahl, E. Lie, A.E. Derocher, and O. Wiig. 2003. Organochlorines affect the major androgenic hormone, testosterone, in male polar bears (Ursus maritimus) at Svalbard. Journal of Toxicology and Environmental Health Part A 66: 2119-39.
23. Palmer, J.S., C.M. Kane, T.T. Higuchi, K.J. Bodensteiner, K-Y.F. Pau, and D.N.R. Veeramachaneni. 2000. Gestational and lactational exposure to antiandrogenic pesticides, p,p'DDT and Vinclozolin, impairs reproductive function in male rabbits [Abstract]. Biology of Reproduction 62, Suppl no. 1: 185.
24. Pfleiger-Bruss, S., V. Hanf, P. Behnisch, H. Hagenmaier, and G.M. Rune. 1999. Effects of single polychlorinated biphenyls on the morphlogy of cultured rat tubuli seminiferi. Andrologia 31: 77-82.
25. Polischuk, S.C., R.J. Letcher, R.J. Nordstrom, and M.A. Ramsay. 1995. Preliminary results of fasting on kinetics of organochlorines in polar bears (Ursus maritimus). Science of the Total Environment 160/161: 456-72.
26. Prestrud, P., and K. Nilssen. 1992. Fat Deposition and Seasonal Variation in Body Composition of Arctic Foxes in Svalbard. Journal of Wildlife Management 56: 221-33.
27. Reijnders, P.J.H. 1986. Reproductive failure in common seals feeding on fish from polluted coastal waters. Nature 324: 456-7.
28. Restum, J.C., J.P. Giesy, E.A. Render, D.B. Shipp, R.A. Verbrugge, and J. Aulerich. 1998. Multigenerational study of the effects of consumption of PCB-contaminated carp from Saginaw Bay, Lake Huron, on mink. 1. Effects on mink reproduction, kit growth and survival, and selected biological parameters. Journal of Toxicology and Environmental Health Part A 54: 343-75.
29. Royal Canin (Royal Canin A/S) 2008. Size Health Nutrition - Hund: Gennemsnitlig analyse. http://www.royalcanin.dk (accessed January 1, 2009).
30. Rune, G.M., P. DeSouza, R. Krowke, H.J. Merker, and D. Neubert. 1991a. Morphological and histochemical pattern of response in rat testes after adminstration of 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD). Histological Histopathology 6: 459-67.
31. Rune, G.M., P. DeSouza, R. Krowke, H.J. Merker, and D. Neubert. 1991b. Morphological and histochemical effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on marmoset (Callithrix jacchus) testes. Archhives of Andrology 26: 143-154.
32. Schrader, T.J., and G.M. Cooke. 2003. Effects of Aroclors and individual PCB congeners on activation of the human androgen receptor in vitro. Reproductive Toxicology 17: 15-23.
33. Skakkebaek, N.E., E. Rajpert-De Meytz, and K.E. Main. 2001. Testicular dysgenesis syndrome: An increasingly common developmental disorder with environmental aspects. Human Reproduction 16: 972-78.
34. Skinner, M.K., and M.D. Anway. 2006. Seminiferous cord formation and germ-cell, programming epigenetic transgenerational actions of endocrine disruptors. Annals of New York Academy of Science 1061: 18-32.
35. Sonne, C. 2010. Health effects from long-range transported contaminants in Arctic top predators: An integrated review based on studies of polar bears and relevant model species. Enviornment International (forthcoming) DOI: 10.1016/j.envint.2010.03.002.
36. Sonne, C., R. Dietz, M. Kirkegaard, R.J. Letcher, S. Shahmiri, S. Andersen, P. Møller, A.K. Olsen, and A.L. Jensen. 2008b. Effects of organohalogen pollutants on haematological and urine clinical-chemical parameters in Greenland Sledge dogs (Canis familiaris). Ecotoxicology and Environmental Safety 69: 381-90.
37. Sonne, C., R. Dietz, H.J.S. Larsen, K.E. Loft, M. Kirkegaard, R.J. Letcher, S. Shahmiri, and P. Møller. 2006b. Impairment of cellular immunity in West Greenland sledge dogs (Canis familiaris) dietary exposed to polluted minke whale (Balaenoptera acutorostrata) blubber. Environmental Science and Technology 40: 2056-62.
38. Sonne, C., S. Fonfara, R. Dietz, M. Kirkegaard, R.J. Letcher, S. Shahmiri, S. Andersen, and P. Moller. 2007b. Multiple cytokine and acute-phase protein gene transcription in West Greenland sledge dogs (Canis familiaris) dietary exposed to organic environmental pollutants. Archives of Environmental Contamination and Toxicology 53: 110-18.
39. Sonne, C., P.L. Leifsson, R. Dietz, E.W. Born, R.J. Letcher, L. Hyldstrup, F.F. Riget, M. Kirkegaard, and D.C.G. Muir. 2006a. Xenoendocrine pollutants may decrease size of sexual organs in East Greenland polar bears (Ursus maritimus). Environmental Science and Technology 40: 5668-74.
40. Sonne, C., P.S. Leifsson, R. Dietz, M. Kirkegaard, A.L. Jensen, S. Shahmiri, and R.J. Letcher. 2008a. Greenland sledge dogs (Canis familiaris) develop liver lesions when exposed to a chronic and dietary low dose of an environmental organohalogen cocktail. Environmental Research 106: 72-80.
41. Sonne, C., P.S. Leifsson, R. Dietz, M. Kirkegaard, P. Møller, A.J. Jensen, R.J. Letcher, and S. Shahmiri. 2007a. Renal lesions in Greenland sledge dogs (Canis familiaris) exposed to a natural dietary cocktail of persistent organic pollutants. Toxicology of Environmental Chemistry 89: 563-76.
42. Sonne, S., F.F. Rigét, J-E.B. Jensen, L. Hyldstrup, J. Teilmann, R. Dietz, M. Kirkegaard, S. Andersen, R.J. Letcher, and J. Jakobsen. 2008c. Does the nutrition profile of vitamins, fatty acids and microelements counteract the negative impact from organohalogen pollutants on bone mineral density in Greenland sledge dogs (Canis familiaris)? Environment International 34: 811-20.
43. Sonne, C., H. Wolkers, F.F. Rigé t, J.E. Beck Jensen, J. Teilmann, B.M. Jenssen, E. Fuglei, O. Ahlstroøm, R. Dietz, D.C.G. Muir, and E. JoØrgensen. 2009. Composition and biomechanical properties of bone tissue from male arctic foxes (Vulpes lagopus) exposed to organochlorines and emaciation. Comparative Biochemistry and Physiology Part C 149: 97-103.
44. Toft, G., L. Hagmar, A. Giwercman, and J.P. Bonde. 2004. Epidemiological evidence on reproductive effects of persistent organochlorines in humans. Reproductive Toxicology 19: 5-26.
45. van Duursen, M.B.M., J.T. Sanderson, M. van der Bruggen, J. van der Linden, and M. van den Berg. 2003. Effects of several dioxin-like compounds on estrogen metabolism in the malignant MCF-7 and nontumorigenic MCF-10A human mammary epithelial cell lines. Toxicology and Applied Pharmacology 190: 241-50.
46. Verreault, J., R. Dietz, C. Sonne, W.A. Gebbink, S. Shahmiri, and R.J. Letcher. 2008. Comparative fate of organohalogen contaminants in two top carnivores in Greenland: Captive sledge dogs and free-ranging polar bears. Comparative Biochemistry and Physiology Part C 147: 306-15.
47. Verreault, J., F. Maisonneuve, R. Dietz, C. Sonne, and R.J. Letcher. 2009a. Dietary, age and trans-generational effects on the fate of organohalogen contaminants in captive sledge dogs in Greenland. Environment International 35: 56-62.
48. Verreault, J., F. Maisonneuve, R. Dietz, C. Sonne, and R.J. Letcher. 2009b. Comparative hepatic activity of xenobiotic-metabolizing enzymes and concentrations of organohalogens and their hydroxylated analogues in captive Greenland sledge dogs. Environmental Toxicology and Chemistry 28: 162-72.
49. Wolf, C.J., G.A. LeBlanc, J.S. Ostby, and L.E. Gray. 2000. Characterization of the period of sensitivity of fetal male sexual development to vinclozolin. Toxicological Science 55: 152-61.
50. You, L., M. Casanova, S. Archibeque-Engle, M. Sar, L-Q. Fan, and H.d'A. Heck. 1998. Impaired male sexual development in perinatal Sprague Dawley and Long Evans hooded rats exposed in utero and lactationally to p,ṕ-DDE. Toxicological Science 45: 162-73.