Effects of Aroclors and individual PCB congeners on activation of the human androgen receptor in vitro

Reproductive Toxicology

Volumn 17, Issue 1, 2003, Pages 15-23

  Schrader, Timothy J ^a   Cooke, Gerard M ^a,b  

^a TOXICOLOGY RESEARCH DIVISION   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Androgen; Human; Polychlorinated biphenyl; Receptor

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; AROCLOR; LUCIFERASE; POLYCHLORINATED BIPHENYL; POLYCHLORINATED TERPHENYL;

ARTICLE; BREAST MILK; CELL CULTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; HUMAN; HUMAN CELL; MALE GENITAL SYSTEM; PROTEIN EXPRESSION; PROTEIN INTERACTION; REPORTER GENE; REPRODUCTIVE TOXICITY; SPERMATOGENESIS;

ANDROGEN ANTAGONISTS; AROCLORS; CARCINOMA; CELL SURVIVAL; DIHYDROTESTOSTERONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; ENVIRONMENTAL POLLUTANTS; FEMALE; GENES, REPORTER; HUMANS; LUCIFERASES; MALE; MILK, HUMAN; POLYCHLOROTERPHENYL COMPOUNDS; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0037219663     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0890-6238(02)00076-X     Document Type: Article

References (40)

1. Sharpe RM. Regulation of spermatogenesis. In: Knobil E, Neill JD, editors. The physiology of reproduction, vol. 1. 2nd ed. New York: Raven Press Ltd.; 1994, p. 1363-1434.
2. Luke MC, Coffey DS. The male sex accessory tissues. In: Knobil E, Neill JD, editors. The physiology of reproduction, vol. 1. 2nd ed. New York: Raven Press Ltd.; 1994, p. 1435-87.
3. Husmann DA, McPhaul MJ. Time-specific androgen blockade with flutamide inhibits testicular descent in the rat. Endocrinology (Baltimore) 1991;129:1409-16.
4. Spencer JR, Torrado T, Sanchez RS, Darracot Vaughn Jr. E, Imperato-McGinley J. Effects of flutamide and finasteride on rat testicular descent. Endocrinology (Baltimore) 1991;129:741-8.
5. van der Schoot P. Disturbed testicular descent in the rat after prenatal exposure to the antiandrogen flutamide. J Reprod Fertil 1992;96:483-96.
6. Silversides DW, Price CA, Cooke GM. Effects of short-term exposure to hydroxyflutamide in utero on the development of the reproductive tract in male mice. Can J Physiol Pharmacol 1995;73:1582-8.
7. Gray Jr. LE, Wolf C, Lambright C, Mann P, Price M, Cooper RL, et al. Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p′-DDE and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169 and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat. Toxicol Ind Health 1999;15:94-118.
8. Colborn T, vom Saal FS, Soto AM. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect 1993;101:378-84.
9. Safe S. Enviromental and dietary estrogens and human health: is there a problem? Environ Health Perspect 1995;103:346-51.
10. Cooper RL, Kavlok RJ. Endocrine disrupters and reproductive development: a weight-of-evidence overview. J Endocrinol 1997;152: 159-66.
11. Turner KJ, Sharpe RM. Environmental oestrogens - present understanding. Rev Reprod 1997;2:69-73.
12. Gray Jr. LE, Ostby JM, Kelce WR. Developmental effects of an environmental antiandrogen: the fungicide vinclozolin alters sex differentiation of the male rat. Toxicol Appl Pharmacol 1994;129: 46-52.
13. Kelce WR, Stone CR, Laws SC, Gray Jr. LE, Kemppainen JA, Wilson EM. Persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist. Nature (Lond) 1995;375:581-5.
14. Kelce WR, Lambright CR, Gray Jr. LE, Roberts KP. Vinclozolin and p,p′-DDE alter androgen-dependent gene expression: in vivo confirmation of an androgen receptor-mediated mechanism. Toxicol Appl Pharmacol 1997;142:192-200.
15. Sohoni P, Sumpter JP. Several environmental oestrogens are also anti-androgens. J Endocrinol 1998;158:327-39.
16. Ryan JJ, Norstrom RJ. Occurrence of polychlorinated dibenzo-p-dioxins and dibenzofurans in humans and major exposure routes. In: Rappe C, Buser HR, Dodet B, O'Neill IK, editors. Environmental carcinogens: methods of analysis and exposure measurement, vol. 11: polychlorinated dioxins and dibenzofurans. WHO-IARC Scientific Publications and Oxford, UK: Oxford University Press; 1991, p. 51-104 [chapter 4].
17. Jensen AA, Slorach SA. Assessment of infant intake of chemicals via breast milk. In: Jensen AA, Slorach SA, editors. Chemical contaminants in human milk. Boca Raton, Ann Arbor, Boston: CRC Press Inc.; 1991, p. 215-22 [chapter 8].
18. Jensen AA, Slorach SA. Factors affecting the levels of residues in human milk. In: Jensen AA, Slorach SA, editors. Chemical contaminants in human milk. Boca Raton, Ann Arbor, Boston: CRC Press Inc.; 1991, p. 199-207 [chapter 6].
19. Abraham K, Papke O, Gross A, Kordonouri O, Wiegand S, Wahn U, et al. Time course of PCDD/PCDF/PCB concentrations in breast-feeding mothers and their infants. Chemosphere 1998;37: -1731-41.
20. Sager DB, Girard DM, Nelson D. Early postnatal exposure to PCBs: sperm function in rats. Environ Toxicol Chem 1991;10:737-46.
21. Sager DB, Girard DM. Long-term effects on reproductive parameters in female rats after translactational exposure to PCBs. Environ Res 1994;66:52-76.
22. Brouwer A, Ahlborg UG, van der Berg M, Birnbaum LS, Boersma ER, Bosveld B, et al. Functional aspects of developmental toxicity of polyhalogenated aromatic hydrocarbons in experimental animals and human infants. Eur J Pharmacol 1995;293:1-40.
23. Faqi AS, Dalsenter PR, Mathar W, Heinrich-Hirsch B, Chahoud I. Reproductive toxicity and tissue concentrations of 3,3′,4,4′-tetrachlorobiphenyl (PCB 77) in male adult rats. Hum Exp Toxicol 1998;17:151-6.
24. Krogenæes AK, Nafstad I, Skåre U, Farstad W, Hafne A-L. In vitro reproductive toxicity of polychlorinated biphenyl congeners 153 and 126. Reprod Toxicol 1998;12:575-80.
25. Tilson HA, Jacobson JL, Rogan WJ. Polychlorinated biphenyls and the developing nervous system: cross-species comparisons. Neurotoxicol Teratol 1990;12:239-48.
26. Jacobson JL, Jacobson SW. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med 1996;335:783-9.
27. Sonnenschein C, Soto AM. An updated review of environmental estrogen and androgen mimics and antagonists. J Steroid Biochem Mol Biol 1998;65:143-50.
28. Johansson M, Nilsson S, Lund B-O. Interactions between methylsulphonyl PCBs and the glucocorticoid receptor. Environ Health Perspect 1998;106:769-72.
29. Cheek AO, Kow K, Chen J, McLachlan JA. Potential mechanisms of thyroid disruption in humans: interaction of organochlorine compounds with thyroid receptor, transthyretin and thyroid-binding globulin. Environ Health Perspect 1999;107:273-8.
30. Schrader TJ, Cooke GM. Examination of selected food additives and organochlorine food contaminants for androgenic activity in vitro. Toxicol Sci 2000;53:278-88.
31. Mes J, Turton D, Davies D, Sun WF, Lau PY, Weber D. The routine analysis of some specific isomers of polychlorinated biphenyl congeners in human milk. Int J Environ Anal Chem 1987;28:197-205.
32. Borras M, Hardy L, Lempreur F, El Khissiin AH, Legros N, Gol-Winkler R, et al. Estradiol-induced down-regulation of estrogen receptor: effect of various modulators of protein synthesis and expression. J Steroid Biochem Mol Biol 1994;48:325-36.
33. Denizot F, Lang R. Rapid colorimetric assay for cell growth and survival - modification to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 1986;89:271-7.
34. Forest MG, Sizonenko PC, Cathiard AM, Bertrand J. Hypophysogonadal function in humans during the first year of life: 1. Evidence for testicular activity in early infancy. J Clin Invest 1974;53:819-28.
35. Bolton NJ, Tapanainen J, Koivisto M, Vihko R. Circulating sex hormone-binding globulin and testosterone in newborns and infants. Clin Endocrinol 1989;31:201-7.
36. Roehrborn CG, Lange JL, George FW, Wilson JD. Changes in amount and intracellular distribution of androgen receptor in human foreskin as a function of age. J Clin Invest 1987;79:44-7.
37. Sachs BD, Meisel RL. The physiology of male sexual behaviour. In: Knobil E, Neill J, editors. The physiology of reproduction, vol. 2. 1st ed. New York: Raven Press Ltd.; 1988, p. 1444-7 [chapter 34].
38. Atuma SS, Hansson L, Johnsson H, Slorach S, de Wit CA, Lindstrom G. Organochlorine pesticides, polychlorinated biphenyls and dioxins in human milk from Swedish mothers. Food Addit Contam 1998;15:142-50.
39. Fitzgerald EF, Hwang SA, Bush B, Cook K, Worswick P. Fish consumption and breast milk PCB concentrations among Mohawk women at Akwesasne. Am J Epidemiol 1998;148:164-72.
40. Newsome WH, Ryan JJ. Toxaphene and other chlorinated compounds in human milk from northern and southern Canada: a comparison. Chemosphere 1999;39:519-26.