Quantitative analysis of safranal in saffron extract and nanoparticle formulation by a validated high-performance thin-layer chromatographic method

Phytochemical Analysis

Volumn 21, Issue 3, 2010, Pages 219-223

  Pathan, Shadab Ahmad ^a   Alam, Sanjar ^a   Jain, Gaurav K ^a   Zaidi, Syed M A ^b   Akhter, Sohail ^a   Vohora, Divya ^a   Khar, Roop K ^a   Ahmad, Farhan J ^a,b  

^a HAMDARD UNIVERSITY   (India)

^b HAMDARD UNIVERSITY   (India)

Author keywords

Controlled release; Crocus sativus; Densitometric analysis; Epilepsy; Nanotechnology

Indexed keywords

CHROMATOGRAPHIC ANALYSIS; CONTROLLED DRUG DELIVERY; DRUG PRODUCTS; HEXANE; LIQUID CHROMATOGRAPHY; NANOPARTICLES; TARGETED DRUG DELIVERY;

BRAIN DELIVERY; CHROMATOGRAPHIC METHODS; CONTROLLED RELEASE; CROCUS SATIVUS; DENSITOMETRIC ANALYSIS; EPILEPSY; GABAA RECEPTORS; NANOPARTICLE FORMULATION; PERFORMANCE; THIN LAYERS;

SILICA GEL;

ACETIC ACID ETHYL ESTER; HEXANE; NANOPARTICLE; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; SAFFRON EXTRACT; SAFRANAL; TERPENE; UNCLASSIFIED DRUG;

ANALYTICAL EQUIPMENT; ARTICLE; CHEMICAL PARAMETERS; CONTROLLED STUDY; DRUG FORMULATION; DRUG IMPURITY; DRUG RELEASE; DRUG SOLUBILITY; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; VALIDATION STUDY;

CROCUS SATIVUS;

EID: 77951785787     PISSN: 09580344     EISSN: 10991565     Source Type: Journal    
DOI: 10.1002/pca.1184     Document Type: Article

References (17)

1. Castellar MR, Montijano H, Manjón A,Iborra JL. 1993. Preparative high-performance liquid chromatography purifi cation of saffron secondary metabolites. J Chromatogr 648: 187-190. (Pubitemid 23294651)
2. Hosseinzadeh H,Khosravan V. 2002. Anticonvulsant effects of aqueous and ethanolic extracts of Crocus sativus L. stigmas in mice. Arch Intern Med 5: 44-47. (Pubitemid 34591502)
3. Hosseinzadeh H, Sadeghnia HR. 2007. Protective effect of safranal, an active constituent of Crocus sativus, on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems. Phytomed 14: 256-262.
4. Hosseinzadeh H, Younesi HM. 2002. Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacol 2: 1-8. (Pubitemid 38729257)
5. Iborra JL, Castellar MR, Canovas M, Manjón A. 1992. TLC preparative purification of picrocrocin, HTCC and crocin from saff ron. J Food sci 57: 714-716.
6. Kanakis CD, Daferera DJ, Tarantilis PA, Polissiou MG. 2004. Qualit ative determination of volatile compounds and quantitative evaluation of safranal and 4-hydroxy-2,6,6-thimethyl-1-cyclohexene-1-carboxaldehyde (HTCC) in Greek saff ron. J Agric Food chem 52: 4515-4521.
7. Karimi G, Hosseinzadeh H, Khaleghpanah P. 2001. Study of antidepressant effect of aqueous and ethanolic extract of Crocus sativus in mice. Iranian J Basic Med Sci 4: 11-15.
8. Narasimhan H, Chand H, Rajalakshmi D. 1992. Saffron: quality evaluation by sensory profile and gas chromatography. J Food Qual 15: 303-314.
9. Perucca E. 2006. The new generation of antiepileptic drugs: advantages and disadvantages. Br J Clin Pharmacol 42: 531-543.
10. Rodel W, Petrzika M. 1991. Analysis of the volatile components of saffron, J High-Resolution Chromatogr 14: 771-774.
11. Sabers A, Gram L. 2000. Newer anticonvulsants: comparative review of drug interactions and adverse effects. Drugs 60: 23-33. (Pubitemid 30598818)
12. Salinas MR, Alonso G, Esteban-Infantes FJ. 1994. Adsorption thermal desorption-gas chromatography applied to the determination of wine aromas. J Agric Food Chem 42: 1328-1331.
13. Sujata V, Ravishankar GA, Venkataraman LV. 1992. Methods for the analysis of the saff ron metabolites crocin, crocetin, picrocrocin and safranal for the determination of the quality of spice using thin-layer chromatography, HPLC and GC. J Chromatogr A 624: 497-502.
14. Tarantilis PA, Tsoupras G, Polissiou M. 1995. Determination of saffron (Crocus sativus L.) components in crude plant extract using high-performance liquid chromatography-UV-vis photodiode array detection-mass spectrometry. J Chromatogr A 699: 107-118.
15. Winterhalter P, Straubinger M. 2000. Antitumor effect of saffron (Crocus sativus L.): overview and perspectives. Food Rev Int 16: 39-59.
16. Yan W, Wuli Y, Changchun W, Jianhua H, Shoukuan F. 2005. Chitosan nanoparticles as a novel delivery system for ammonium glycyrrhizinate. Int J Pharm 295: 235-324
17. Zougagh M, Ríos A, Valcárcel M. 2006. Determination of total safranal by in situ acid hydrolysis in supercritical fluid media: Application to the quality control of commercial saffron. Anal Chim Acta 578: 117-121. (Pubitemid 44396918)