Investigating the spectral characteristics of backscattering from heterogeneous spherical nuclei using broadband finite-difference time-domain simulations

Journal of Biomedical Optics

Volumn 15, Issue 1, 2010, Pages

  Chao, Guo Shan ^a   Sung, Kung Bin ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Dysplasia; Finite difference time domain; Light scattering spectroscopy; Mie theory; Nucleus

Indexed keywords

DYSPLASIA; FINITE DIFFERENCE TIME DOMAINS; LIGHT SCATTERING SPECTROSCOPY; MIE THEORY; NUCLEUS;

BACKSCATTERING; FINITE DIFFERENCE TIME DOMAIN METHOD; LIGHT SCATTERING; LIGHT SOURCES; NUCLEAR PHYSICS; PLANTS (BOTANY); REFRACTION; REFRACTIVE INDEX; SPHERES; THREE DIMENSIONAL; TISSUE;

TIME DOMAIN ANALYSIS;

ARTICLE; AUTOMATED PATTERN RECOGNITION; BIOLOGICAL MODEL; CELL NUCLEUS; CHEMISTRY; CHROMATIN; COMPUTER SIMULATION; CYTOPLASM; ELECTROMAGNETIC FIELD; METHODOLOGY; RADIATION SCATTERING; SPECTROSCOPY;

CELL NUCLEUS; CHROMATIN; COMPUTER SIMULATION; CYTOPLASM; ELECTROMAGNETIC FIELDS; MODELS, BIOLOGICAL; PATTERN RECOGNITION, AUTOMATED; SCATTERING, RADIATION; SPECTRUM ANALYSIS;

EID: 77951762184     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.3324838     Document Type: Article

References (39)

1. J. R. Mourant, J. P. Freyer, A. H. Hielscher, A. A. Eick, D. Shen, and T. M. Johnson, "Mechanisms of light scattering from biological cells relevant to noninvasive optical-tissue diagnostics", Appl. Opt. 37(16), 3586-3593 (1998). (Pubitemid 128658703)
2. J. R. Mourant, T. M. Johnson, S. Carpenter, A. Guerra, T. Aida, and J. P. Freyer, "Polarized angular dependent spectroscopy of epithelial cells and epithelial cell nuclei to determine the size scale of scattering structures", J. Biomed. Opt. 7(3), 378-387 (2002).
3. L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, "Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution", Phys. Rev. Lett. 80(3), 627-630 (1998). (Pubitemid 128622229)
4. V. Backman, R. Gurjar, K. Badizadegan, L. Itzkan, R. R. Dasari, L. T. Perelman, and M. S. Feld, "Polarized light scattering spectroscopy for quantitative measurement of epithelial cellular structures in situ", IEEE J. Sel. Top. Quantum Electron. 5(4), 1019-1026 (1999). (Pubitemid 30544900)
5. V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Muller, Q. Zhang, G. Zonios, E. Kline, T. McGillican, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, "Detection of preinvasive cancer cells", Nature 406(6791), 35-36 (2000). (Pubitemid 30460198)
6. K. Sokolov, R. Drezek, K. Gossage, and R. Richards-Kortum, "Reflectance spectroscopy with polarized light: is it sensitive to cellular and nuclear morphology", Opt. Express 5(13), 302-317 (1999).
7. A. Wax, C. H. Yang, V. Backman, K. Badizadegan, C. W. Boone, R. R. Dasari, and M. S. Feld, "Cellular organization and substructure measured using angle-resolved low-coherence interferometry", Biophys. J. 82(4), 2256-2264 (2002). (Pubitemid 34280836)
8. R. Drezek, M. Guillaud, T. Collier, I. Boiko, A. Malpica, C. Macaulay, M. Follen, and R. Richards-Kortum, "Light scattering from cervical cells throughout neoplastic progression: influence of nuclear morphology, DNA content, and chromatin texture", J. Biomed. Opt. 8(1), 7-16 (2003).
9. C. Mujat, C. Greiner, A. Baldwin, J. M. Levitt, F. Tian, L. A. Stucenski, M. Hunter, Y. L. Kim, V. Backman, M. Feld, K. Muenger, and I. Georgakoudi, "Endogenous optical biomarkers of normal and human papillomavirus immortalized epithelial cells", Int. J. Cancer 122(2), 363-371 (2008). (Pubitemid 350234722)
10. A. Dunn and R. Richards-Kortum, "Three-dimensional computation of light scattering from cells", IEEE J. Sel. Top. Quantum Electron. 2(4), 898-905 (1996). (Pubitemid 126543830)
11. R. Drezek, A. Dunn, and R. Richards-Kortum, "Light scattering from cells: finite-difference time-domain simulations and goniometric measurements", Appl. Opt. 38(16), 3651-3661 (1999). (Pubitemid 129568245)
12. D. Arifler, M. Guillaud, A. Carraro, A. Malpica, M. Follen, and R. Richards-Kortum, "Light scattering from normal and dysplastic cervical cells at different epithelial depths: finite-difference time-domain modeling with a perfectly matched layer boundary condition", J. Biomed. Opt. 8(3), 484-494 (2003).
13. R. S. Brock, X. H. Hu, D. A. Weidner, J. R. Mourant, and J. Q. Lu, "Effect of detailed cell structure on light scattering distribution: FDTD study of a B-cell with 3D structure constructed from confocal images", J. Quant. Spectrosc. Radiat. Transf. 102(1), 25-36 (2006).
14. X. T. Su, C. Capjack, W. Rozmus, and C. Backhouse, "2D light scattering patterns of mitochondria in single cells", Opt. Express 15(17), 10562-10575 (2007). (Pubitemid 47296111)
15. R. Drezek, A. Dunn, and R. Richards-Kortum, "A pulsed finitedifference time-domain (FDTD) method for calculating light scattering from biological cells over broad wavelength ranges", Opt. Express 6(7), 147-157 (2000).
16. X. Li, Z. G. Chen, A. Taflove, and V. Backman, "Equiphase-sphere approximation for light scattering by stochastically inhomogeneous microparticles", Phys. Rev. E 70(5), 056610 (2004).
17. X. Li, Z. G. Chen, J. M. Gong, A. Taflove, and V. Backman, "Analytical techniques for addressing forward and inverse problems of light scattering by irregularly shaped particles", Opt. Lett. 29(11), 1239-1241 (2004).
18. X. Li, A. Taflove, and V. Backman, "Recent progress in exact and reduced-order modeling of light-scattering properties of complex structures", IEEE J. Sel. Top. Quantum Electron. 11(4), 759-765 (2005). (Pubitemid 41805931)
19. K. B. Sung, R. Richards-Kortum, M. Follen, A. Malpica, C. Liang, and M. R. Descour, "Fiber optic confocal reflectance microscopy: a new real-time technique to view nuclear morphology in cervical squamous epithelium in vivo", Opt. Express 11(24), 3171-3181 (2003).
20. K. S. Yee, "Numerical solution of initial boundary value problems involving Maxwell's equations in isotropic media", IEEE Trans. Antennas Propag. AP14(3), 302-307 (1966).
21. J. P. Berenger, "Three-dimensional perfectly matched layer for the absorption of electromagnetic waves", J. Comput. Phys. 127(2), 363-379 (1996).
22. D. W. Fawcett, "Nucleus", Chap. 4 in The Cell, pp. 195-292, W. B. Saunders Co., West Washington Square Philadelphia, PA (1981).
23. J. M. Schmitt and G. Kumar, "Turbulent nature of refractive-index variations in biological tissue", Opt. Lett. 21(16), 1310-1312 (1996). (Pubitemid 126569103)
24. A. J. Einstein, H. S. Wu, and J. Gil, "Self-affinity and lacunarity of chromatin texture in benign and malignant breast epithelial cell nuclei", Phys. Rev. Lett. 80(2), 397-400 (1998). (Pubitemid 128621966)
25. Y. L. Kim, Y. Liu, R. K. Wali, H. K. Roy, M. J. Goldberg, A. K. Kromin, K. Chen, and V. Backman, "Simultaneous measurement of angular and spectral properties of light scattering for characterization of tissue microarchitecture and its alteration in early precancer", IEEE J. Sel. Top. Quantum Electron. 9(2), 243-256 (2003).
26. M. Hunter, V. Backman, G. Popescu, M. Kalashnikov, C. W. Boone, A. Wax, V. Gopal, K. Badizadegan, G. D. Stoner, and M. S. Feld, "Tissue self-affinity and polarized light scattering in the Born approximation: A new model for precancer detection", Phys. Rev. Lett. 97(13), 138102 (2006).
27. K. J. Chalut, J. H. Ostrander, M. G. Giacomelli, and A. Wax, "Light scattering measurements of subcellular structure provide noninvasive early detection of chemotherapy-induced apoptosis", Cancer Res. 69(3), 1199-1204 (2009).
28. A. Brunstin and P. F. Mullaney, "Differential light-scattering from spherical mammalian-cells", Biophys. J. 14(6), 439-453 (1974).
29. K. E. Handwerger, J. A. Cordero, and J. G. Gall, "Cajal bodies, nucleoli, and speckles in the Xenopus oocyte nucleus have a lowdensity, sponge-like structure", Mol. Biol. Cell 16(1), 202-211 (2005). (Pubitemid 40024303)
30. R. Barer, "Refractometry and interferometry of living cells", J. Opt. Soc. Am. A 47(6), 545-556 (1957).
31. Z. G. Chen, A. Taflove, and V. Backman, "Equivalent volumeaveraged light scattering behavior of randomly inhomogeneous dielectric spheres in the resonant range", Opt. Lett. 28(10), 765-767 (2003).
32. C. Lau, O. Scepanovic, J. Mirkovic, S. McGee, C. C. Yu, S. Fulghum, M. Wallace, J. Tunnell, K. Bechtel, and M. Feld, "Reevaluation of model-based light-scattering spectroscopy for tissue spectroscopy", J. Biomed. Opt. 14(2), 024031 (2009).
33. C. Kortun, Y. R. Hijazi, and D. Arifler, "Combined Monte Carlo and finite-difference time-domain modeling for biophotonic analysis: implications on reflectance-based diagnosis of epithelial precancer", J. Biomed. Opt. 13(3), 034014 (2008).
34. C. Y. Xu, C. Vinegoni, T. S. Ralston, W. Luo, W. Tan, and S. A. Boppart, "Spectroscopic spectral-domain optical coherence microscopy", Opt. Lett. 31(8), 1079-1081 (2006). (Pubitemid 43837458)
35. I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, L. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. H. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, and L. T. Perelman, "Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels", Proc. Natl. Acad. Sci. U. S. A. 104(44), 17255-17260 (2007). (Pubitemid 350219824)
36. P. Huang, M. Hunter, and I. Georgakoudi, "Confocal light scattering spectroscopic imaging system for in situ tissue characterization", Appl. Opt. 48(13), 2595-2599 (2009).
37. I. R. Capoglu, A. Taflove, and V. Backman, "Generation of an incident focused light pulse in FDTD", Opt. Express 16(23), 19208-19220 (2008).
38. M. S. Starosta and A. K. Dunn, "Three-dimensional computation of focused beam propagation through multiple biological/Cells", Opt. Express 17(15), 12455-12469 (2009).
39. Y. J. Sung, W. Choi, C. Fang-Yen, K. Badizadegan, R. R. Dasari, and M. S. Feld, "Optical diffraction tomography for high resolution live cell imaging", Opt. Express 17(1), 266-277 (2009).