Isolation and characterization of circulating tissue transglutaminase- specific T cells in coeliac disease

International Journal of Immunopathology and Pharmacology

Volumn 23, Issue 1, 2010, Pages 179-191

  Ciccocioppo, Rachele ^a   Finamore, A ^b   Mengheri, E ^b   Millimaggi, D ^c   Esslinger, B ^d   Dieterich, W ^d   Papola, F ^c   Colangeli, S ^c   Tombolino, V ^c   Schuppan, D ^e   Corazza, G R ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b ISTITUTO NAZIONALE DELLA NUTRIZIONE   (Italy)

^c UNIVERSITY OF L'AQUILA   (Italy)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Coeliac disease; Cytokines; T cells; Tissue transglutaminase

Indexed keywords

CYTOKINE; GAMMA INTERFERON; HLA DQ2 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANTIGEN SPECIFICITY; ARTICLE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELIAC DISEASE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; FLOW CYTOMETRY; HAPLOTYPE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INTESTINE INJURY; MALE; MOLECULAR CLONING; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; SERODIAGNOSIS; T LYMPHOCYTE;

EID: 77951744913     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463201002300116     Document Type: Article

References (41)

1. Sollid LM. Celiac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol 2002; 2:647-655
2. Lundin KEA, Scott H, Hansen T, Paulsen G, Halstensen TS, Fausa O, Thorsby E, Sollid LM. Gliadin-specific, HLA-DQ (α1*0501,β1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med 1993; 178:187-196
3. Vader W, Kooy Y, van Veelen P, et al. The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides. Gastroenterology 2002; 122:1729-1737 (Pubitemid 34651415)
4. Arentz-Hansen H, Fleckenstein B, Molberg Ø, Scott H, Koning F, Jung G, Roepstorff P, Lundin KEA, Sollid LM. The molecular basis for oat intolerance in patients with celiac disease. PLOS Med 2004; 1:84-92.
5. + memory T cells in patients with celiac disease: linkage between memory function, gut homing and Th1 polarization. J Leukoc Biol 2006; 79:676-685 (Pubitemid 44835600)
6. Bargetzi MJ, Schönenberger A, Tichelli A, Fried R, Cathomas G, Signer E, Speck B, Gratwohl A. Celiac disease transmitted by allogenic non-T cell-depleted bone marrow transplantation. Bone Marrow Transpl 1997; 20:607-609 (Pubitemid 27464570)
7. Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, Schuppan D. Identification of tissue transglutaminase as the autoantigen in celiac disease. Nat Med 1997: 3:797-801. (Pubitemid 27298728)
8. Dieterich W, Laag E, Schopper H, Volta U, Ferguson A, Gillett H, Riecken EO, Schuppan D. Autoantibodies to tissue transglutaminase as predictors of celiac disease. Gastroenterology 1998; 115:1317-1321 (Pubitemid 28545979)
9. Freitag T, Schulze-Koops H, Niedobitek G, Melino G, Schuppan D. The role of the immune response against tissue transglutaminase in the pathogenesis of coeliac disease. Autoimmun Rev 2004; 3:13-20. (Pubitemid 38293361)
10. van de Wal Y, Kooy YMC, van Veelen P, Peña S, Mearin L, Papadopoulos G, Koning F. Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity. J Immunol 1998; 161:1585-1588 (Pubitemid 28387571)
11. Arentz-Hansen H, Körner R, Molberg Ø, et al. The intestinal T cell response to α-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase. J Exp Med 2000; 191:603-612
12. Maiuri L, Ciacci C, Ricciardelli I, et al. Unexpected role of surface transglutaminase type II in celiac disease. Gastroenterology 2005; 129:1400-1413 (Pubitemid 41597382)
13. Koskinen O, Collin P, Korponay-Szabo I, Salmi T, Iltanen S, Haimila K, Partanen J, Mäki M, Kaukinen K. Gluten-dependent small bowel mucosal transglutaminase 2-specific IgA deposits in overt and mild enteropathy coeliac disease. J Pediatr Gastroenterol Nutr 2008; 47:436-442
14. + T cell transendothelial migration. J Immunol 2003; 171:3179-3186 (Pubitemid 37093543)
15. Halttunen T, Mäki M. Serum immunoglobulin A from patients with celiac disease inhibits human T84 intestinal crypt epithelial cell differentiation. Gastroenterology 1999; 116: 566-572 (Pubitemid 29106764)
16. Wong CP, Stevens R, Long B, Li L, Wang Y, Wallet MA, Goudy KS, Frelinger JA, Tisch R. Identical beta cell-specific CD8(+) T cell clonotypes typically reside in both peripheral blood lymphocyte and pancreatic islets. J Immunol 2007; 178:1388-1395 (Pubitemid 46154609)
17. Ferguson A, Arranz E, O'Mahony S. Clinical and pathological spectrum of coeliac disease-active, silent, latent, potential. Gut 1993; 34:150-151 (Pubitemid 23049101)
18. Marsh MN, Crowe PT. Morphology of the mucosal lesion in gluten sensitivity. Baillieres Clin Gastroenterol 1995; 9:273-293
19. Dieterich W, Trapp D, Esslinger B, Leidenberger M, Piper J, Hahn E, Schuppan D. Autoantibodies of patients with coeliac disease are insufficient to block tissue transglutaminase activity. Gut 2003; 52:1562-1566 (Pubitemid 37363438)
20. Dieterich W, Esslinger B, Trapp D, Hahn E, Huff T, Seilmeier W, Wieser H, Schuppan D. Cross linking to tissue transglutaminase and collagen favours gliadin toxicity in coeliac disease. Gut 2006; 55:478-484
21. Peakman M, Tree TI, Endl J, van Endert P, Atkinson MA, Roep BO. Characterization of preparations of GAD65, proinsulin, and the islet tyrosine phosphatase IA-2 for use in detection of autoreactive T-cells in type-1 diabetes. Report of phase II of the Second International Immunology of Diabetes Society Workshop for standardization of T-cell assays in type 1 diabetes. Diabetes 2001; 50:1749-1754
22. Neitzel H. A routine method for the establishment of permanent growing lymphoblastoid cell lines. Human Genetics 1986; 73:320-326 (Pubitemid 16047212)
23. Howdle PD, Corazza GR, Bullen AW, Losowsky MS. In vitro diagnosis of coeliac disease: an assessment. Gut 1981; 22:939-947
24. Barton SH, Murray JA. Celiac disease and autoimmunity in the gut and elsewhere. Gastroenterol Clin North Am 2008; 37:411-428
25. Saltzman JR, Clifford BD. Identification of the triggers of celiac disease. Nutr Rev 1994; 52:317-319
26. Sollid LM, Jabri B. Is celiac disease an autoimmune disorder? Curr Opin Immunol 2005; 17:595-600.
27. Molberg Ø, McAdam SN, Lundin KE, Kristiansen C, Arentz-Hansen H, Kett K, Sollid LM. T cells from celiac disease lesions recognize gliadin epitopes deamidated in situ by endogenous tissue transglutaminase. Eur J Immunol 2001; 31: 1317-1323
28. Granzotto M, Dal Bo S, Quaglia S, et al. Regulatory T-cell function is impaired in celiac disease. Dig Dis Sci 2009; 54:1513-1519
29. Fraser JS, Engel W, Ellis HJ, Moodie SJ, Pollock EL, Wieser H, Ciclitira PJ. Coeliac disease: in vivo toxicity of the putative immunodominant epitope. Gut 2003; 52:1698-1702
30. Nilsen EM, Lundin KE, Krajci P, Scott H, Sollid LM, Brandtzaeg P. Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma. Gut 1995; 37:766-776
31. Nilsen EM, Gjertsen HA, Jensen K, Brandtzaeg P, Lundin KE. Gluten activation of peripheral blood T cells induces a Th0-like cytokine pattern in both celiac patients and controls. Clin Exp Immunol 1996; 103:295-303. (Pubitemid 26045370)
32. Przemioslo RT, Lundin KE, Sollid LM, Nelufer J, Ciclitira PJ. Histological changes in small bowel mucosa induced by gliadin sensitive T lymphocytes can be blocked by anti-interferon gamma antibody. Gut 1995; 36:874-879
33. Forsberg G, Hernell O, Melgar S, Israelsson A, Hammarstrom S, Hammarstrom ML. Paradoxical coexpression of proinflammatory and downregulatory cytokines in intestinal T cells in childhood celiac disease. Gastroenterology 2002; 123:667-678 (Pubitemid 34977072)
34. O'Keeffe JO, Mills K, Jackson J, Feighery C. T cell proliferation, MHC class II restriction and cytokine products of gliadin-stimulated peripheral blood mononuclear cells (PBMC). Clin Exp Immunol 1999; 117:269-276
35. Kamimura D, Ishihara K, Hirano T. IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev Physiol Biochem Pharmacol 2003; 149:1-38.
36. Nakachi K, Powell M, Swift G, et al. Epitopes recognised by tissue transglutaminase antibodies in coeliac disease. J Autoimmun 2004; 22:53-63. (Pubitemid 38050213)
37. Honeyman MC, Stone N, de Aizpurua H, Rowley MJ, Harrison LC. High T cell responses to the Glutamic Acid Decarboxylase (GAD) isoform 67 reflect a hyperimmune state that precedes the onset of insulin-dependent diabetes. J Autoimmunity 1997; 10:165-173 (Pubitemid 27242457)
38. Matzinger P. The danger model: a renewed sense of self. Science 2002; 296:301-305 (Pubitemid 34303674)
39. Fleckenstein B, Qiao SW, Larsen MR, Jung G, Roepstorff P, Sollid LM. Molecular characterization of covalent complexes between tissue transglutaminase and gliadin peptides. J Biol Chem 2004; 279:17607-16. (Pubitemid 38560525)
40. Ciccocioppo R, Di Sabatino A, Ara C, Biagi F, Perilli M, Amicosante G, Cifone MG, Corazza GR. Gliadin and tissue transglutaminase complexes in normal and coeliac duodenal mucosa. Clin Exp Immunol 2003; 134:516-524 (Pubitemid 37542094)
41. Korponay-Szabo I, Vecsei Z, Kiraly R, Dahlbom I, Chirdo F, Nemes E, Fésüs L, Mäki M. Deamidated gliadin peptides form epitopes that transglutaminase antibodies recognize. J Pediatr Gastroenterol Nutr 2008; 46:253-261