T cell proliferation, MHC class II restriction and cytokine products of gliadin-stimulated peripheral blood mononuclear cells (PBMC)

Clinical and Experimental Immunology

Volumn 117, Issue 2, 1999, Pages 269-276

  O'Keeffe, Joan ^a   Mills, K ^a,b   Jackson, J ^a   Feighery, C ^a  

^a ST JAMES S HOSPITAL   (Ireland)

^b ST PATRICK S COLLEGE   (Ireland)

Author keywords

Coeliac disease; Cytokines; Gliadin; Peripheral blood

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GLIADIN; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ADULT; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CELIAC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOPOIESIS; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ADOLESCENT; ADULT; ANTIGENS, CD3; CELIAC DISEASE; CYTOKINES; EPITOPES, T-LYMPHOCYTE; FEMALE; GLIADIN; HLA-DR ANTIGENS; HUMANS; INTERLEUKIN-10; INTERLEUKIN-4; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTES;

EID: 0032816864     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1999.00973.x     Document Type: Article

References (37)

1. 1 Marsh MN. Mucosal pathology in gluten sensitivity. In: Marsh MN, eds. Coeliac disease. Oxford: Blackwell Scientific Publications, 1992; 136-91.
2. 2 Marsh MN. The morphology and immunopathology of the jejunal lesion in gluten sensitivity. Eur J Gastroenterol Hepatol 1991; 3:163-8.
3. 3 MacDonald T, Spencer J. Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine. J Exp Med 1988; 167:1341-9.
4. 4 Halstensen TS, Scott H, Fausa O, Brandtzaeg P. Gluten stimulation of coeliac mucosa in vitro induces activation (CD25) of lamina propria CD4+ T cells but no crypt hyperplasia. Scand J Immunol 1993; 38:581-90.
5. 5 Holmes GKT, Asquith P, Cook WT. Cell mediated immunity to gluten fraction III in adult coeliac disease. Clin Exp Immunol 1976; 24:259-65.
6. 6 Sikora BS, Truelove SC, Ciclitira PS, Offord RC. Stimulation of lymphocytes from patients with coeliac disease by a subfraction of gluten. Lancet 1976; 2:389-91.
7. 7 Gjertsen HA, Sollid LM, Ek J, Thorsby E, Lundin KEA. T cells from the peripheral blood of coeliac patients recognise gluten antigens when presented by HLA-DR, DQ or DP molecules. Scand J Immunol 1994; 37:567-74.
8. 8 Mosmann TR, Sad S. The expanding universe of T cell subsets: Th1, Th2 and more. Immunol Today 1996; 17:138-46.
9. 9 Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996; 383:787-93.
10. 10 Mosmann TR, Coffman RL. Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv Immunol 1989; 46:11-47.
11. 11 Romagnani S. Lymphokine production by human T cells in disease states. Annu Rev Immunol 1989; 7:145-73.
12. 12 Lundin KEA, Scott H, Hanson T et al. Gliadin-specific T cells isolated from the small intestinal mucosa of coeliac disease patients. J Exp Med 1993; 178:187-96.
13. 13 Nilsen EM, Lundin KEG, Krajci P, Scott H, Sollid LM, Brandtzaeg P. Gluten specific, HLA-DQ restricted T cells from the coeliac mucosa produce cytokines with a Th1 or Th0 profile dominated by interferon-γ. Gut 1995; 37:766-76.
14. 14 Nilsen EM, Gjertsen HA, Jensen K, Brandtzaeg P, Lundin KEA. Gluten activation of peripheral blood T cells induces a Th0 like cytokine pattern in both coeliac patients and controls. Clin Exp Immunol 1996; 103:295-303.
15. 15 Maggi E, Parronchi P, Manetti R et al. Reciprocal regulatory effects of IFN-γ and IL-4 on the in vitro development of human Th1 and Th2 clones. J Immunol 1993; 148:2142.
16. 16 Del Prete GF, De Carli M, D'Elios MM, Maestelli P, Ricci M, Fabbri L, Romagnani S. Allergen exposure induces the activation of allergen-specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders. Eur J Immunol 1993; 23:1145.
17. 17 Frew AJ, Bright S, Shrewry PR, Munro A. Proliferative response of lymphocytes of normal individuals to wheat proteins (gliadins). Int Arch Allergy Appl Immunol 1980; 62:162-7.
18. 18 Jensen K, Sollid LM, Scott H, Paulsen G, Kett K, Thorsby E, Lundin KEA. Gliadin-specific T cell responses in peripheral blood of healthy individuals involve T cells restricted by the coeliac disease associated DQ2 heterodimer. Scand J Immunol 1995; 42:166-70.
19. 19 Molberg Ø, Kett K, Scott H, Thorsby E, Sollid LM, Lundin KEA. Gliadin-specific, HLA DQ2 restricted T cells are commonly found in small intestinal biopsies from coeliac disease patients, but not from controls. Scand J Immunol 1997; 46:103-8.
20. 20 Baker BS, Garioch JJ, Bokth S, Thomas H, Walker MM, Leonard JN, Fry L. Lack of proliferative response by gluten-specific T cells in the blood and gut of patients with dermatitis herpetiformis. J Autoimmun 1995; 8:561-74.
21. 21 Penttila IA, Gibson CE, Forrest BD, Cummins AG, Labrooy JT. Lymphocyte activation as measured by interleukin-2 receptor expression to gluten fraction III in coeliac disease. Immunol Cell Biol 1990; 68:155-60.
22. 22 Liblau RS, Singer SM, McDevitt HO. Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune disease. Immunol Today 1995; 16:34-38.
23. 23 Farrar JJ, Benjamin WR, Hilfiker ML, Howard M, Farrae WL, Fuller-Farrar J. The biochemistry, biology and role of interleukin-2 in the induction of cytotoxic T cell and antibody forming B cell responses. Immunol Rev 1982; 63:150-62.
24. 24 ElGhazali GEB, Paulie S, Andersson G, Hansson Y, Sun JB, Olsson T, Ekre HP, Blomberg MT. Number of interleukin 4 and interferon-γ secreting human T cells reactive with tetanus toxoid and the mycobacterial antigen PPD or phythemagglutinin: distinct response profiles depending on the type of antigen used for activation. Eur J Immunol 1993; 23:2740-5.
25. 25 Shimojo N, Kohono Y, Katsuki T, Honma K, Saito K, Niimi H. Diminished interferon-gamma (IFN-γ) production by bacterial antigen-specific T cells in atopic patients. Clin Exp Immunol 1996; 106:62-66.
26. 26 Breese EJ, Kumar P, Farthing MJ, MacDonald TT. Interleukin-2 and interferon-γ producing cells in the lamina propria in coeliac disease. Dig Dis Sci 1994; 39:2243.
27. 27 Nilsen EM, Frode LJ, Lundin KEA et al. Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with coeliac disease. Gastroenterol 1998; 115:551-63.
28. 28 Hirano T, Akira S, Taga T, Kishimoto T. Biological and clinical aspects of interleukin 6. Immunol Today 1990; 11:443-9.
29. 29 McManus RM, Wilson AG, Mansfield J, Weir DG, Duff GW, Kelleher D. TNF2, a polymorphism of the tumour necrosis-alpha gene promoter, is a component of the coeliac disease major histocompatibility complex haplotype. Eur J Immunol 1996; 26:2113-8.
30. 30 Stordeur P, Schandene L, Durez P, Gerard C, Goldman M, Velu T. Spontaneous and cycloheximide induced interleukin-10 expression in human mononuclear cells. Mol Immunol 1995; 32:233-9.
31. 31 Chomarat P, Rissoan M, Banchereau J, Miossec P. Interferon-γ inhibits interleukin 10 production by monocytes. J Exp Med 1993; 177:523-7.
32. 32 Schwartz M, Majdic O, Knapp W, Holter W. High-level IL-10 production by monoclonal antibody-stimulated human T cells. Immunol 1995; 86:364-71.
33. 33 Clerici M, Wynn TA, Berzofsky JA, Blatt SP, Hendrix CW, Sher A, Coffman RL, Shearer GM. Role of Interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus. J Clin Invest 1994; 93:768-75.
34. 34 Mahanty S, Ravichandran M, Raman U, Jayaraman K, Kumaraswami V, Nutman TB. Regulation of parasite antigen-driven immune responses by interleukin-10 (IL-10) and IL-12 in lymphatic filariasis. Int Immunol 1997; 65:1742-6.
35. 35 Weiner HL. Oral tolerance. Proc Natl Acad Sci USA 1994; 91:10762-5.
36. 36 Molberg Ø, McAdam SW, Korner R et al. Tissue transglutaminase selectively modifies gliadin peptides that are recognised by gut derived T cells in coeliac disease. Nat Med 1998; 4:713-7.
37. 37 Lundin KE, Sollid LM, Anthonsen D, Noren O, Molberg Ø, Thorsby E, Sjostrom H. Heterogeneous reactivity patterns of HLA-DQ restricted, small intestinal T cell clones from patients with coeliac disease. Gastroenterol 1997; 112:752-9 .