Synergistic effect of vasoactive intestinal peptides on TNF-α-induced IL-6 synthesis in osteoblasts: Amplification of p44/p42 MAP kinase activation

International Journal of Molecular Medicine

Volumn 25, Issue 5, 2010, Pages 813-817

  Natsume, Hideo ^a,b   Tokuda, Haruhiko ^b,c   Mizutani, Jun ^a   Adachi, Seiji ^b   Matsushima Nishiwaki, Rie ^b   Minamitani, Chiho ^a,b   Kato, Kenji ^a,b   Kozawa, Osamu ^b   Otsuka, Takanobu ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

Author keywords

Interleukin 6; Osteoblast; p44 p42 mitogen activated protein kinase; Tumor necrosis factor ; Vasoactive intestinal peptide

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 8 BROMO CYCLIC AMP; ADENYLATE CYCLASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA; VASOACTIVE INTESTINAL POLYPEPTIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CELL STRAIN 3T3; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE AMPLIFICATION; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

3T3 CELLS; 8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANIMALS; CELLS, CULTURED; ENZYME ACTIVATION; FLAVONOIDS; FORSKOLIN; INTERLEUKIN-6; ISOQUINOLINES; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; OSTEOBLASTS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; SULFONAMIDES; TUMOR NECROSIS FACTOR-ALPHA; VASOACTIVE INTESTINAL PEPTIDE;

EID: 77951728722     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm-00000409     Document Type: Article

References (31)

1. Blair HC, Robinson LJ and Zaidi M: Osteoclast signalling pathways. Biochem Biophys Res Commun 328: 728-738, 2005.
2. Kwan Tat S, Padrines M, Theoleyre S, Heymann D and Fortun Y: IL-6, RANKL, TNF-α/IL-1: interrelations in bone resorption pathophysiology. Cytokine Growth Factor Rev 15: 49-60, 2004.
3. Nijweide PJ, Burger EH and Feyen JH: Cells of bone: proliferation, differentiation, and hormonal regulation. Physiol Rev 66: 855-886, 1986. (Pubitemid 17181295)
4. Helle M, Brakenhoff JP, De Groot ER and Aarden LA: Interleukin 6 is involved in interleukin 1-induced activities. Eur J Immunol 18: 957-959, 1988.
5. Ishimi Y, Miyaura C, Jin CH, Akatsu T, Abe E, Nakamura Y, Yamaguchi A, Yoshiki S, Matsuda T and Hirano T: IL-6 is produced by osteoblasts and induces bone resorption. J Immunol 145: 3297-3303, 1990.
6. Littlewood AJ, Russell J, Harvey GR, Hughes DE, Russell RG and Gowen M: The modulation of the expression of IL-6 and its receptor in human osteoblasts in vitro. Endocrinology 129: 1513-1520, 1991.
7. Akira S, Taga T and Kishimoto T: Interleukin-6 in biology and medicine. Adv Immunol 54: 1-78, 1993.
8. Heymann D and Rousselle AV: gp130 Cytokine family and bone cells. Cytokine 12: 1455-1468, 2000.
9. Roodman GD: Interleukin-6: an osteotropic factor? J Bone Miner Res 7: 475-478, 1992.
10. Kozawa O, Suzuki A, Kaida T, Tokuda H and Uematsu T: Tumor necrosis factor-α autoregulates interleukin-6 synthesis via activation of protein kinase C. Function of sphingosine 1-phosphate and phosphatidylcholine-specific phospholipase C. J Biol Chem 272: 25099-25104, 1997. (Pubitemid 27415692)
11. Kozawa O, Tokuda H, Matsuno H and Uematsu T: Activation of mitogen-activated protein kinase is involved in sphingosine 1-phosphate- stimulated interleukin-6 synthesis in osteoblasts. FEBS Lett 418: 149-151, 1997. (Pubitemid 27514435)
12. Takai S, Tokuda H, Hanai Y and Kozawa O: Phosphatidylinositol 3-kinase/Akt plays a part in tumor necrosis factor-α-induced interleukin-6 synthesis in osteoblasts. Horm Metab Res 38: 563-569, 2006. (Pubitemid 44569139)
13. Arimura A: Perspectives on pituitary adenylate cyclase activating polypeptide (PACAP) in the neuroendocrine, endocrine, and nervous systems. Jpn J Physiol 48: 301-331, 1998.
14. Said SI: Vasoactive intestinal polypeptide biologic role in health and disease. Trends Endocrinol Metab 2: 107-112, 1991.
15. Bjurholm A, Kreicbergs A, Schultzberg M and Lerner UH: Neuroendocrine regulation of cyclic AMP formation in osteoblastic cell lines (UMR-106-01, ROS 17/2.8, MC3T3-E1, and Saos-2) and primary bone cells. J Bone Miner Res 7: 1011-1019, 1992.
16. Suzuki A, Kotoyori J, Oiso Y and Kozawa O: Pituitary adenylate cyclase-activating polypeptide induces cAMP production independently from vasoactive intestinal polypeptide in osteoblast-like cells. Cell Signal 6: 11-16, 1994. (Pubitemid 24110324)
17. Hohmann EL, Levine L and Tashjian AH Jr: Vasoactive intestinal peptide stimulates bone resorption via a cyclic adenosine 3′,5′- monophosphate-dependent mechanism. Endocrinology 112: 1233-1239, 1983.
18. Sudo H, Kodama HA, Amagai Y, Yamamoto S and Kasai S: In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. J Cell Biol 96: 191-198, 1983.
19. 2 in osteoblast-like cells. Exp Cell Res 198: 130-134, 1992.
20. Kato K, Ito H, Hasegawa K, Inaguma Y, Kozawa O and Asano T: Modulation of the stress-induced synthesis of hsp27 and αB-crystallin by cyclic AMP in C6 rat glioma cells. J Neurochem 66: 946-950, 1996. (Pubitemid 26065890)
21. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
22. Persson E, Voznesensky OS, Huang YF and Lerner UH: Increased expression of interleukin-6 by vasoactive intestinal peptide is associated with regulation of CREB, AP-1 and C/EBP, but not NF-kappaB, in mouse calvarial osteoblasts. Bone 37: 513-529, 2005. (Pubitemid 41317325)
23. Seamon K and Daly JW: Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein. J Biol Chem 256: 9799-9801, 1981. (Pubitemid 12176176)
24. Alessi DR, Cuenda A, Cohen P, Dudley DT and Saltiel AR: PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270: 27489-27494, 1995.
25. Kanno Y, Ishisaki A, Yoshida M, Tokuda H, Numata O and Kozawa O: SAPK/JNK plays a role in transforming growth factor-b-induced VEGF synthesis in osteoblasts. Horm Metab Res 37: 140-145, 2005. (Pubitemid 40547820)
26. Chijiwa T, Mishima A, Hagiwara M, Sano M, Hayashi K, Inoue T, Naito K, Toshioka T and Hidaka H: Inhibition of forskolininduced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5- isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem 265: 5267-5272, 1990. (Pubitemid 20117183)
27. Widmann C, Gibson S, Jarpe MB and Johnson GL: Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev 79: 143-180, 1999. (Pubitemid 29056951)
28. Lerner UH and Persson E: Osteotropic effects by the neuropeptides calcitonin gene-related peptide, substance P and vasoactive intestinal peptide. J Musculoskelet Neuronal Interact 8: 154-165, 2008.
29. Delgado M, Pozo D and Ganea D: The significance of vasoactive intestinal peptide in immunomodulation. Pharmacol Rev 56: 249-290, 2004. (Pubitemid 38720831)
30. Raisz LG: Primer on the metabolic bone diseases and disorders of mineral metabolism. In: Overview of Pathogenesis. Rosen CJ (eds). 7th edition. The American Society for Bone and Mineral Research, pp203-206, 2008.
31. Charatcharoenwitthaya N, Khosla S, Atkinson EJ, McCready LK and Riggs BL: Effect of blockade of TNF-α and interleukin-1 action on bone resorption in early postmenopausal women. J Bone Miner Res 22: 724-729, 2007. (Pubitemid 351339101)