Phosphatidylinositol 3-kinase/Akt plays a part in tumor necrosis factor-α-induced interleukin-6 synthesis in osteoblasts

Hormone and Metabolic Research

Volumn 38, Issue 9, 2006, Pages 563-569

  Takai, S ^a   Tokuda, H ^a,b   Hanai, Y ^a,b   Kozawa, Osamu ^a  

^a GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

Author keywords

Akt; IL 6; Osteoblast; Phosphatidylinositol 3 kinase; TNF

Indexed keywords

1LEVO 6 HYDROXYMETHYL CHIRO INOSITOL 2 2 O METHYL 3 O OCTADECYLCARBONATE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; GLYCOPROTEIN GP 130; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; RAPAMYCIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL STRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA MICROARRAY; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; DRUG POTENTIATION; MOUSE; NEWBORN; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; CELLS, CULTURED; CHROMONES; CYTOKINE RECEPTOR GP130; FLAVONOIDS; GENE EXPRESSION REGULATION; INTERLEUKIN-6; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MORPHOLINES; OSTEOBLASTS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; SIROLIMUS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33750034174     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-950502     Document Type: Article

References (31)

1. Kwan Tat S, Padrines M, Theoleyre S, Heymann D, Fortun Y. IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology. Cytokine Growth Factor Rev 2004; 15: 49-60
2. Blair HC, Robinson LJ, Zaidi M. Osteoclast signalling pathways. Bicohem Biophys Res Commun 2005; 328: 728-738
3. Nijweide PJ, Burger EH, Feyen JHM. Cells of bone: proliferation, differentiation, and humoral regulation. Physiol Rev 1986; 66: 855-886
4. Ishimi Y, Miyaura C, Jin CH, Akatsu T, Abe E, Nakamura Y, Yamaguchi Y, Yoshiki S, Matsuda T, Hirano T, Kishimoto T, Suda T. IL-6 is produced by osteoblasts and induces bone resorption. J Immunol 1990; 145: 3297-3303
5. Helle M, Brakenhoff JPJ, DeGroot ER, Aarden LA. Interleukin-6 is involved in interleukin-1-induced activities. Eur J Immunol 1988; 18: 957-959
6. Littlewood AJ, Russil J, Harvey GR, Hughes DE, Russel RGG, Gowen M. The modulation of the expression of IL-6 and its receptor in human osteoblasts in vitro. Endocrinology 1991; 129: 1513-1520
7. Akira S, Taga T, Kishimoto T. Interleukin-6 in biology and medicine. Adv Immunol 1993; 54: 1-78
8. Heymann D, Rousselle AV. gp130 Cytokine family and bone cells. Cytokine 2000; 12: 1455-1468
9. Roodman GD. Interleukin-6: an osteotropic factor? J Bone Miner Res 1992; 7: 475-478
10. Kozawa O, Suzuki A, Kaida T, Tokuda H, Uematsu T. Tumor necrosis factor-α autoregulates interleukin-6 synthesis via activation of protein kinase C: Function of sphingosine 1-phosphate and phosphatidylcholine-specific phospholipase C. J Biol Chem 1997; 272: 25099-25104
11. Kozawa O, Tokuda H, Matsuno H, Uematsu T. Activation of mitogen-activated protein kinase is involved in sphingosine 1-phosphate-stimulated interleukin-6 synthesis in osteoblasts. FEBS Lett 1997; 418: 149-151
12. Coffer PJ, Jin J, Woodgett JR. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J 1998; 335: 1-13
13. Chan TO, Rittenhouse SE, Tsichlis PN. AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide- dependent phosphorylation. Annu Rev Biochem 1999; 68: 965-1014
14. Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002; 296: 1655-1657
15. Borgatti P, Martelli AM, Bellacosa A, Casto R, Massari L, Capitani S, Neri LM. Translocation of Akt/PKB to the nucleus of osteoblast-like MC3T3-E1 cells exposed to proliferative growth factors. FEBS Lett 2000; 477: 27-32
16. Danciu TE, Adam RM, Naruse K, Freeman MR, Hauschka PV. Calcium regulates the PI3K-Akt pathway in stretched osteoblasts. FEBS Lett 2003; 536: 193-197
17. Kang HY, Cho CL, Huang KL, Wang JC, Hu YC, Lin HK, Chang C, Huang KE. Nongenomic Androgen Activation of Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in MC3T3-E1 Osteoblasts. J Bone Miner Res 2004; 19: 1181-1190
18. Noda T, Tokuda H, Yoshida M, Yasuda E, Hanai Y, Takai S, Kozawa O. Possible involvement of phosphatidylinositol 3-kinase/Akt pathway in insulin-like growth factor-I-induced alkaline phosphatase activity in osteoblasts. Horm Metab Res 2005; 37: 270-274
19. Sudo H, Kodama H, Amagai Y, Yamamoto S, Kasai S. In vivo differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. J Cell Biol 1983; 96: 191-198
20. 2 in osteoblast-like cells. Exp Cell Res 1992; 198: 130-134
21. Yoshida M, Niwa M, A, Hirade K, Ito H, Shimizu K, Kato K, Kozawa O. Methotrexate enhances prostaglandin D2-stimulated heat shock protein 27 induction in osteoblast. Prostaglandins Leukot Essent Fatty Acids 2004; 71: 351-362
22. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-685
23. Kato K, Ito H, Hasegawa K, Inaguma Y, Kozawa O, Asano T. Modulation of the stress-induced synthesis of hsp27 and αB-crystallin by cyclic AMP in C6 glioma cells. J Neurochem 1996; 66: 946-950
24. Hu Y, Qiao L, Wang S, Rong SB, Meuillet EJ, Berggren M, Gallegos A, Powis G, Kozikowski AP. 3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth. J Med Chem 2000; 43: 3045-3451
25. Vlahos CJ, Matter WF, Hui KY, Brown RF. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 1994; 269: 5241-5248
26. Arcaro A, Wymann MP. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem J 1993; 296: 297-301
27. Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR. PD98059 is a specific inhibitor of the activation of mitogen-activated protein kinase in vitro and in vivo. J Biol Chem 1995; 270: 27489-27494
28. Kanno Y, Ishisaki A, Yoshida M, Tokuda H, Numata O, Kozawa O. SAPK/JNK plays a role in transforming growth factor-β-induced VEGF synthesis in osteoblast. Horm Metab Res 2005; 37: 140-145
29. Kurokouchi K, Kambe F, Yasukawa K, Izumi R, Ishiguro N, Iwata H, Seo H. TNF-alpha increase expression of IL-6 and ICAM-1 genes through activation of NF-kappaB in osteoblast-like ROS17/2.8 cells. J Bone Miner Res 1998; 13: 1290-1299
30. Marchetti L, Klein M, Schlett K, Pfizenmaier K, Eisel UM. Tumor Necrosis Factor by N-Methyl-D-aspartate Receptor Activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway. J Biol Chem 2004; 279: 32869-32881
31. Weitzmann MN, Pacifici R. The role of T lymphocytes in bone metabolism. Immunol Rev 2005; 208: 154-168