A pharmacokinetic model for ocular drug delivery

Chemical and Pharmaceutical Bulletin

Volumn 52, Issue 11, 2004, Pages 1290-1294

  Tojo, Kakuji ^a  

^a KYUSHU INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Distribution; Drug diffusion; Elimination; Ocular drug delivery; Ocular pharmacokinetics; Virtual eye

Indexed keywords

POLYMER; TERAZOSIN; DRUG; EYE DROPS;

ANIMAL EXPERIMENT; ANTERIOR EYE CHAMBER; AQUEOUS HUMOR FLOW; ARTICLE; CATARACT EXTRACTION; CELL MEMBRANE FLUIDITY; CHOROID; CONTROLLED STUDY; DIFFUSION COEFFICIENT; DRUG BINDING; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG METABOLISM; DRUG TRANSPORT; LENS; MATHEMATICAL MODEL; MOLECULAR WEIGHT; NONHUMAN; PARTITION COEFFICIENT; POSTERIOR EYE CHAMBER; PREDICTION; RETINA; SCLERA; VITREOUS BODY; ANIMAL; CATTLE; CHEMICAL MODEL; DIFFUSION; DRUG EFFECT; EYE; METABOLISM; METHODOLOGY; PHYSIOLOGY; PROTEIN BINDING; RABBIT; SWINE; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ANIMALS; CATTLE; DIFFUSION; DRUG DELIVERY SYSTEMS; EYE; MODELS, CHEMICAL; OPHTHALMIC SOLUTIONS; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; RABBITS; SWINE;

EID: 21644459439     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.52.1290     Document Type: Article

References (18)

1. Maurice D. M., Mishima S., "Pharmacology of the Eye," ed. by Sears M. L., Springer, Berlin, 1984, pp. 19-116.
2. Ohtori A., Deguchi T., Tojo K., J. Eye (Atarashii Ganka), 13, 1263-1266 (1996).
3. Uno K., Ohtori A., Tojo K., J. Eye, 11, 607-609 (1994).
4. Kurita T., Nakagawa K., Yamashita A., Tojo K., J. Eye, 15, 391-394 (1998).
5. Ohtori A., Tojo K., J. Eye, 10, 589-593 (1993).
6. Tojo K., Drug News Pers., 3, 409-416 (1990).
7. Tojo K., J. Jpn. Soc. Cataract. Res., 13, 5-12 (2001).
8. Aoyagi H., Isowaki A. Tojo K., J. Chem. Eng. Jpn., 35, 450-455 (2002).
9. Tojo K., Isowaki A., Adv. Drug Del. Rev., 52, 17-24 (2001).
10. Crank J., "The Mathematics of Diffusion," 2nd ed., Oxford Univ. Press, Oxford, 1975, pp. 89-103.
11. Kaiser R. J., Maurice D. M., Exp. Eye Res., 3, 156-165 (1964).
12. Kinsey V. E., Circulation, 21, 968-987 (1960).
13. Tojo K., Nakagawa K., Morita Y., Ohtori A., Eur. J. Pharm. Biopharm., 47, 99-104 (1999).
14. Tojo K., "Drug Delivery Systems," Biocom Systems Inc., Fukuoka, 2002.
15. Tojo K., Fujikawa Y., Jpn. Patent Application 2001-53035 (2001).
16. Mishima S., Invest. Ophthalmol. Vis. Sci., 21, 504-541 (1981).
17. Vieth W. R., "Membrane Systems, Analysis and Design," Chapt. 2, Oxford Univ. Press, New York, 1988.
18. Tojo K., "Mathematical Models of Transdermal and Topical Drug Delivery," Biocom Systems Inc., Fukuoka, 2003.