Cages augmented with mineralized collagen and platelet-rich plasma as an osteoconductive/Inductive combination for interbody fusion

Spine

Volumn 35, Issue 7, 2010, Pages 740-746

  Scholz, Matti ^a   Schleicher, Philipp ^a   Eindorf, Tanja ^b   Friedersdorff, Frank ^b   Gelinsky, Michael ^c   König, Ulla ^c   Sewing, Andreas ^d   Haas, Norbert P ^b   Kandziora, Frank ^a  

^a Center for Spinal Surgery and Neurotraumatology   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d Biomet Deutschland GmbH   (Germany)

Author keywords

Animal model; Autologous bone graft; Cervical spine; Interbody fusion; Mineralized collagen matrix; PRP; Sheep

Indexed keywords

COLLAGEN TYPE 1; TITANIUM;

ANIMAL EXPERIMENT; ARTICLE; BONE CONDUCTION; BONE DENSITY; BONE GRAFT; CANCELLOUS BONE; CARTILAGE; CERVICAL SPINE; COMPUTER ASSISTED TOMOGRAPHY; FEMALE; FRACTURE HEALING; ILIAC CREST; IN VIVO STUDY; INTERVERTEBRAL DISKECTOMY; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; SHEEP; SPINE FUSION; THROMBOCYTE RICH PLASMA;

ANIMALS; BIOMECHANICS; BONE SUBSTITUTES; BONE TRANSPLANTATION; CERVICAL VERTEBRAE; COLLAGEN; DISKECTOMY; FEMALE; ILIUM; PLATELET-RICH PLASMA; SHEEP; SPINAL FUSION;

EID: 77951666068     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e3181bdc6cc     Document Type: Article

References (46)

1. Weiner BK, Fraser RD. Spine update lumbar interbody fusion cages. Spine 1998;23:634-640
2. Anitua E. Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants 1999;14:529-535
3. Goulet JA, Senunas LE, DeSilva GL, et al. Autogenous iliac crest bone graft. Complications and functional assessment. Clin Orthop Relat Res 1997;339: 76-81
4. Hill NM, Horne JG, Devane PA. Donor site morbidity in the iliac crest bone graft. Aust N Z J Surg 1999;69:726-728
5. Bradt JH, Mertig M, Teresiak A, et al. Biomimetic mineralization of collagen by combined fibril assembly and calcium phosphate formation. Chem Mater 1999;11:2694-2701
6. Koster K, Ehard H, Kubicek J, et al. Experimental application of calcium phosphate granulate for the substitution of conventional bone transplants. Z Orthop Ihre Grenzgeb 1979;117:398-403
7. Mimatsu K, Kishi S, Hashizume Y. Experimental chronic compression on the spinal cord of the rabbit by ectopic bone formation in the ligamentum flavum with bone morphogenetic protein. Spinal Cord 1997;35:740-746
8. Spiro RC, Thompson AY, Poser JW. Spinal fusion with recombinant human growth and differentiation factor-5 combined with a mineralized collagen matrix. Anat Rec 2001;263:388-395
9. Tay BK, Le AX, Heilman M, et al. Use of a collagen-hydroxyapatite matrix in spinal fusion. A rabbit model. Spine 1998;23:2276-2281
10. Yokoyama A, Gelinsky M, Kawasaki T, et al. Biomimetic porous scaffolds with high elasticity made from mineralized collagen-an animal study. J Biomed Mater Res B Appl Biomater 2005;75:464-472
11. Nizard M. Knochengewebsneubildung durch Collagen-Apatit- Implantation. Homburg/Saar, Germany: Habilitationsschrift aus der orthopädischen Universitätsklinik und Poliklinik
12. Gelinsky M, König U, Sewing A, et al. Poröse Scaffolds from mineralized collagen-a biomimetic bone substitute. Mat Wiss Werkstofftechnik 2004; 35:229-233
13. Weibrich G, Hansen T, Kleis W, et al. Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration. Bone 2004;34: 665-671
14. Carlson ER. Bone grafting the jaws in the 21st century: the use of plateletrich plasma and bone morphogenetic protein. Alpha Omegan 2000;93: 26-30
15. Marx RE, Carlson ER, Eichstaedt RM, et al. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85:638-646
16. Knighton DR, Ciresi K, Fiegel VD, et al. Stimulation of repair in chronic, nonhealing, cutaneous ulcers using platelet-derived wound healing formula. Surg Gynecol Obstet 1990;170:56-60
17. Hood AG, Hill AG, Reeder GD, et al. Perioperative autologues sequestration III: a new physiologic glue with wound healing properties. Proc Am Acad Cardiovasc Perfusion 14:126-129
18. Marx RE. Platelet-rich plasma (PRP): What is PRP and what is not PRP? Implant Dent 2001;10:225-228
19. Rodriguez A, Anastassov GE, Lee H, et al. Maxillary sinus augmentation with deproteinated bovine bone and platelet rich plasma with simultaneous insertion of endosseous implants. J Oral Maxillofac Surg 2003;61:157-163
20. Kovacs K, Velich N, Huszar T, et al. Comparative study of betatricalcium phosphate mixed with platelet-rich plasma versus betatricalcium phosphate, a bone substitute material in dentistry. Acta Vet Hung 2003;51:475-484
21. Korinth MC, Hero T, Pandorf T, et al. Application of a stand-alone interbody fusion cage based on a novel porous TiO2/glass ceramic-2: biomechanical evaluation after implantation in the sheep cervical spine. Biomed Tech (Berl) 2005;50:111-118
22. Wilke HJ, Kettler A, Claes LE. Are sheep spines a valid biomechanical model for human spines? Spine 1997;22:2365-2374
23. Kandziora F, Pflugmacher R, Scholz M, et al. Comparison between sheep and human cervical spines: an anatomic, radiographic, bone mineral density, and biomechanical study. Spine 20011;26:1028-1037
24. Kandziora F, Schollmeier G, Scholz M, et al. Influence of cage design on interbody fusion in a sheep cervical spine model. J Neurosurg 2002;96 (3 suppl):321-332
25. Boden SD, Schimandle JH. Biologic enhancement of spinal fusion. Spine 1995;20(24 suppl):113S-23S
26. Boden SD, Martin Jr GJ, Horton WC, et al. Laparoscopic anterior spinal arthrodesis with rhBMP-2 in a titanium interbody threaded cage. J Spinal Disord 1998;11:95-101
27. David SM, Gruber HE, Mayer Jr RA, et al. Lumbar spinal fusion using recombinant human bone morphogenetic protein in the canine. A comparison of three dosages and two carriers. Spine 1999;24:1973-1979
28. Martin Jr GJ, Boden SD, Marone MA, et al. Posterolateral intertransverse process spinal arthrodesis with rhBMP-2 in a nonhuman primate: important lessons learned regarding dose, carrier, and safety. J Spinal Disord 1999;12: 179-186
29. Takaoka K, Koezuka M, Nakahara H. Telopeptide-depleted bovine skin collagen as a carrier for bone morphogenetic protein. J Orthop Res 1991;9: 902-907
30. Sorensen TS, Sorensen AI, Merser S. Rapid release of gentamicin from collagen sponge. In vitro comparison with plastic beads. Acta Orthop Scand 1990;61:353-356
31. Sandhu HS, Kanim LE, Kabo JM, et al. Effective doses of recombinant human bone morphogenetic protein-2 in experimental spinal fusion. Spine 1996;21:2115-2122
32. Boden SD, Zdeblick TA, Sandhu HS, et al. The use of rhBMP-2 in interbody fusion cages. Definitive evidence of osteoinduction in humans: a preliminary report. Spine 2000;25:376-381
33. Cook SD, Rueger DC: Osteogenic protein-1: biology and applications. Clin Orthop Relat Res 1996;324:29-38
34. Grauer JN, Patel TC, Erulkar JS, et al. 2000 Young Investigator Research Award winner. Evaluation of OP-1 as a graft substitute for intertransverse process lumbar fusion. Spine 2001;26:127-133
35. Dolder JV, Mooren R, Vloon AP. Platelet-rich plasma: quantification of growth factor levels and the effect on growth and differentiation of rat bone marrow cells. Tissue Eng 2006;12:3067-3073
36. Graziani F, Ivanovski S, Cei S. The in vitro effect of different PRP concentrations on osteoblasts and fibroblasts. Clin Oral Implants Res 2006; 12:212-219
37. Meury T. Effect of platelet-rich plasma on bone marrow stromal cell differentiation. ASBMR 26th Annual Meeting. 2006
38. Annunziata M, Oliva A, Buonaiuto C. In vitro cell-type specific biological response of human piridontally related cells to platelet-rich plasma. J Peridontal Res 2005;40:489-495
39. Lucarelli E, Beccheroni A, Donati D. Platelet-derived growth factor enhance proliferation of human stromal stem cells. Biomaterials 2003;24:3095-3100
40. Gruber R, Varga F, Fischer MB. Platelets stimulate proliferation f bone cell: involvement of platelet-derived growth factor, microparticles and membranes. Clinical Oral Implant Res 2002;13:529-535
41. Oprea WE, Karp JM, Hosseini MM. Effect on platelet releasate on bone cell migration and recruitment in vitro. J Craniofac Surg 2003;14:292-300
42. Lowery GL, Kulkarni S, Pennisi AE. Use of autologous growth factors in lumbar spinal fusion. Bone 1999;25(2 suppl):47S-50S
43. Hee HT, Majd ME, Holt RT, et al. Do autologous growth factors enhance transforaminal lumbar interbody fusion? Eur Spine J 2003;12:400-407
44. Ranly DM, Lohmann CH, Andrecchio D. Platelet rich plasma inhibits demineralised bone matrix-induce bone formation in nude mice. J Bone Joint Surg Am 2007;89:139-147
45. Li H, Zou X, Xue Q, et al. Anterior lumbar interbody fusion with carbon fiber cage loaded with bioceramics and platelet-rich plasma. An experimental study on pigs. Eur Spine J 2004;13:354-358
46. Pryor ME, Yang J, Polimeni G. Analysis of rat calvaria defects implanted with a platelet-rich plasma preparation: radiographic observations. J Peridontol 2005;76:1287-1292 (Pubitemid 41245772)