Models to predict changes in serum IGF1 and body composition in response to GH replacement therapy in GH-deficient adults

European Journal of Endocrinology

Volumn 162, Issue 5, 2010, Pages 869-878

  Barbosa, Edna J L ^a,b   Koranyi, Josef ^a   Filipsson, Helena ^a   Bengtsson, Bengt Åke ^a   Boguszewski, Cesar Luiz ^b   Johannsson, Gudmundur ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CORTISONE ACETATE; ESTROGEN; HYDROCORTISONE; INSULIN; LEVOTHYROXINE; RECOMBINANT GROWTH HORMONE; SOMATOMEDIN C;

ADULT; ARTICLE; BLOOD SAMPLING; BODY COMPOSITION; BODY FAT; BODY HEIGHT; BODY MASS; DUAL ENERGY X RAY ABSORPTIOMETRY; EVENING DOSAGE; FEMALE; GROWTH HORMONE DEFICIENCY; HORMONAL THERAPY; HUMAN; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MATHEMATICAL MODEL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TREATMENT DURATION; TREATMENT RESPONSE;

ADULT; BODY COMPOSITION; FEMALE; HUMAN GROWTH HORMONE; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LOGISTIC MODELS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; PREDICTIVE VALUE OF TESTS; TREATMENT OUTCOME;

EID: 77951653489     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-09-0973     Document Type: Article

References (49)

1. Cohen P, Bright GM, Rogol AD, Kappelgaard AM, Rosenfeld RG & American Norditropin Clinical Trials Group. Effects of dose and gender on the growth and growth factor response to GH in GH-deficient children: implications for efficacy and safety. Journal of Clinical Endocrinology and Metabolism 2002 87 90-98.
2. Johannsson G, Bjarnason R, Bramnert M, Carlsson LM, Degerblad M, Manhem P, Rośen T, Thorén M & Bengtsson BA. The individual responsiveness to growth hormone (GH) treatment in GH-deficient adults is dependent on the level of GH-binding protein, body mass index, age, and gender. Journal of Clinical Endocrinology and Metabolism 1996 81 1575-1581.
3. Salomon F, Cuneo RC, Hesp R & Sonksen PH. The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. New England Journal of Medicine 1989 321 1797-1803.
4. Binnerts A, Swart GR, Wilson JH, Hoogerbrugge N, Pols HA, Birkenhager JC & Lamberts SW. The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body composition. Clinical Endocrinology 1992 37 79-87.
5. Johannsson G, Rosén T, Lindstedt G, Bosaeus I & Bengtsson B-Å. Effects of 2 years of growth hormone treatment on body composition and cardiovascular risk factors in adults with growth hormone deficiency. Endocrinology and Metabolism 1996 3 3-12.
6. Götherström G, Svensson J, Koranyi J, Alpsten M, Bosaeus I, Bengtsson B & Johannsson G. A prospective study of 5 years of GH replacement therapy in GH-deficient adults: sustained effects on body composition, bone mass and metabolic indices. Journal of Clinical Endocrinology and Metabolism 2001 86 4657-4665.
7. Boguszewski CL, Meister LH, Zaninelli DC & Radominski RB. One year of GH replacement therapy with a fixed low-dose regimen improves body composition, bone mineral density and lipid profile of GH-deficient adults. European Journal of Endocrinology 2005 152 67-75.
8. Götherström G, Bengtsson BA, Bosaeus I, Johannsson G & Svensson J. A 10-year, prospective study of the metabolic effects of growth hormone replacement in adults. Journal of Clinical Endocrinology and Metabolism 2007 92 1442-1445.
9. Sjogren K, Liu JL, Blad K, Skrtic S, Vidal O, Wallenius V, LeRoith D, Törnell J, Isaksson OG, Jansson JO & Ohlsson C. Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice. PNAS 1999 96 7088-7092.
10. Gibney J & Johannsson G. Long-term monitoring of insulin-like growth factor I in adult growth hormone deficiency: a critical appraisal. Hormone Research 2004 62 66-72.
11. Johannsson G, Rosen T & Bengtsson BA. Individualized dose titration of growth hormone (GH) during GH replacement in hypopituitary adults. Clinical Endocrinology 1997 47 571-581.
12. Burman P, Johansson AG, Siegbahn A, Vessby B & Karlsson FA. Growth hormone (GH)-deficient men are more responsive to GH replacement therapy than women. Journal of Clinical Endocrinology and Metabolism 1997 82 550-555. (Pubitemid 27068627)
13. Bengtsson BA, Abs R, Bennmarker H, Monson JP, Feldt-Rasmussen U, Hernberg-Stahl E, Westberg B, Wilton P & Wüster C. The effects of treatment and the individual responsiveness to growth hormone (GH) replacement therapy in 665 GH-deficient adults. KIMS Study Group and the KIMS International Board. Journal of Clinical Endocrinology and Metabolism 1999 84 3929-3935.
14. Span JP, Pieters GF, Sweep CG, Hermus AR & Smals AG. Gender difference in insulin-like growth factor I response to growth hormone (GH) treatment in GH-deficient adults: role of sex hormone replacement. Journal of Clinical Endocrinology and Metabolism 2000 85 1121-1125.
15. Span JP, Pieters GF, Sweep FG, Hermus AR & Smals AG. Gender differences in rhGH-induced changes in body composition in GH-deficient adults. Journal of Clinical Endocrinology and Metabolism 2001 86 4161-4165.
16. Wolthers T, Hoffman DM, Nugent AG, Duncan MW, Umpleby M & Ho KK. Oral estrogen antagonizes the metabolic actions of growth hormone in growth hormone-deficient women. American Journal of Physiology. Endocrinology and Metabolism 2001 281 1191-1196.
17. Jorge AA, Marchisotti FG, Montenegro LR, Carvalho LR, Mendonca BB & Arnhold IJ. Growth hormone (GH) pharmacogenetics: influence of GH receptor exon 3 retention or deletion on first-year growth response and final height in patients with severe GH deficiency. Journal of Clinical Endocrinology and Metabolism 2006 91 1076-1080.
18. Räz B, Janner M, Petkovic V, Lochmatter D, Eblé A, Dattani MT, Hindmarsh PC, Flück CE & Mullis PE. Influence of growth hormone (GH) receptor deletion of exon 3 and full-length isoforms on GH response and final height in patients with severe GH deficiency. Journal of Clinical Endocrinology and Metabolism 2008 93 974-980.
19. van der Klaauw AA, van der Straaten T, Baak-Pablo R, Biermasz NR, Guchelaar HJ, Pereira AM, Smit JW & Romijn JA. Influence of the d3-growth hormone (GH) receptor isoform on short-term and long-term treatment response to GH replacement in GH-deficient adults. Journal of Clinical Endocrinology and Metabolism 2008 93 2828-2834.
20. Pilotta A, Mella P, Filisetti M, Felappi B, Prandi E, Parrinello G, Notarangelo LD & Buzi F. Common polymorphisms of the growth hormone (GH) receptor do not correlate with the growth response to exogenous recombinant human GH in GH-deficient children. Journal of Clinical Endocrinology and Metabolism 2006 91 1178-1180.
21. Blum WF, Machinis K, Shavrikova EP, Keller A, Stobbe H, Pfaeffle RW & Amselem S. The growth response to growth hormone (GH) treatment in children with isolated GH deficiency is independent of the presence of the exon 3-minus isoform of the GH receptor. Journal of Clinical Endocrinology and Metabolism 2006 91 4171-4174.
22. Barbosa EJ, Palming J, Glad CA, Filipsson H, Koranyi J, Bengtsson BA, Carlsson LM, Boguszewski CL & Johannsson G. Influence of the exon 3-deleted/full-length growth hormone (GH) receptor polymorphism on the response to GH replacement therapy in adults with severe GH deficiency. Journal of Clinical Endocrinology and Metabolism 2009 94 639-644.
23. Ranke MB, Lindberg A, Martin DD, Bakker B, Wilton P, Albertsson-Wikland K, Cowell CT, Price DA & Reiter EO. The mathematical model for total pubertal growth in idiopathic growth hormone (GH) deficiency suggests a moderate role of GH dose. Journal of Clinical Endocrinology and Metabolism 2003 88 4748-4753.
24. Dahlgren J, Kriström B, Niklasson A, Nierop AF, Rosberg S & Albertsson-Wikland K. Models predicting the growth response to growth hormone treatment in short children independent of GH status, birth size and gestational age. BMC Medical Informatics and Decision Making 2007 12 7-40.
25. Svensson J, Johannsson G & Bengtsson B-Å. Insulin-like growth factor-I in growth hormone-deficient adults: relationship to population-based normal values, body composition and insulin tolerance test. Clinical Endocrinology 1997 46 579-586.
26. Bosaeus I, Johannsson G, Rosén T, Hallgren P, Tölli J, Sjöström L & Bengtsson B-Å. Comparison of methods to estimate body fat in growth hormone deficient adults. Clinical Endocrinology 1996 44 395-402.
27. Hosmer DW & Lemeshow S. Applied Logistic Regression. edn 2. New York, USA: John Wiley & Sons, 2000.
28. Landin-Wilhelmsen K, Wilhelmsen L, Lappas G, Rosén T, Lindstedt G, Lundberg PA & Bengtsson B-Å. Serum insulin-like growth factor I in a random population sample of men and women: relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid and osteocalcin. Clinical Endocrinology 1994 41 351-357.
29. Hiding A, Hall K, Wivall-Helleryd IL, Saaf M, Melin AL & Thoren M. Serum levels of insulin-like growth factor I in 152 patients with growth hormone deficiency, aged 19-82 years, in relation to those in healthy subjects. Journal of Clinical Endocrinology and Metabolism 1999 84 2013-2019.
30. Aimaretti G, Corneli G, Rovere S, Granata R, Baldelli R, Grottoli S & Ghigo Ezio. Insulin-like growth I levels and the diagnosis of adult growth hormone deficiency. Hormone Research 2004 62 26-33.
31. Murray RD, Howell SJ, Lissett CA & Shalet SM. Pre-treatment IGF-I level is the major determinant of GH dosage in adult GH deficiency. Clinical Endocrinology 2000 52 537-542.
32. Filipsson H, Monson JP, Koltowska-Häggström M, Mattsson A & Johannsson G. The impact of glucocorticoid replacement regimens on metabolic outcome and comorbidity in hypopituitary patients. Journal of Clinical Endocrinology and Metabolism 2006 91 3954-3961.
33. Meyer S, Haist M, Schaefer S, Ivan D, Ittner JR, Nawroth PP, Plöckinger U, Stalla GK, Tuschy U, Weber MM, Weise A, Pfutzner A, Habbe N & Kann PH. Association of COLIA1 Sp1 polymorphism with the effect of subcutaneously injected recombinant hGH in GH-deficient adults. Pharmacogenomics 2008 9 1017-1026.
34. Thangavel C & Shapiro BH. A molecular basis for the sexually dimorphic response to growth hormone. Endocrinology 2007 148 2894-2903.
35. Leung KC, Doyle N, Ballesteros M, Waters MJ & Ho KK. Insulin regulation of human hepatic growth hormone receptors: divergent effects on biosynthesis and surface translocation. Journal of Clinical Endocrinology and Metabolism 2000 85 4712-4720. (Pubitemid 32157657)
36. Kaytor EN, Zhu JL, Pao CI & Phillips LS. Insulin-responsive nuclear proteins facilitate Sp1 interactions with the insulin-like growth factor-I gene. Journal of Biological Chemistry 2001 276 36896-36901. (Pubitemid 37384098)
37. Carrol PV, Christ ER, Bengtsson B-Å, Carlsson L, Christiansen JS, Clemmons D, Hintz R, Ho K, Laron Z, Sizonenko P, Sönksen PH, Tanaka T & Thorner M. Growth hormone deficiency in adulthood and the effects of growth hormone replacement therapy: a review. Growth Hormone Research Society Scientific Committee. Journal of Clinical Endocrinology and Metabolism 1998 83 382-395.
38. Ezzat S, Fear S, Gaillard R-C, Gayle C, Marcovitz S, Mattioni T, Nussey S, Rees A & Svanberg E. Circulating IGF-I levels in monitoring and predicting efficacy during long-term GH treatment of GH-deficient adults. European Journal of Endocrinology 2003 149 499-509. (Pubitemid 38054693)
39. Abrahamsen B, Nielsen TL, Hangaard J, Gregersen G, Vahl N, Korsholm L, Hansen TB, Andersen M & Hagen C. Dose-, IGF-I- and sex-dependent changes in lipid profile and body composition during GH replacement therapy in adult onset GH deficiency. European Journal of Endocrinology 2004 150 671-679. (Pubitemid 38786537)
40. Lucidi P, Lauteri M, Laureti S, Celleno R, Santoni S, Volpi E, Angeletti G, Santeusanio F & De Feo P. A dose-response study of growth hormone (GH) replacement on whole body protein and lipid kinetics in GH-deficient adults. Journal of Clinical Endocrinology and Metabolism 1998 83 353-357. (Pubitemid 28496505)
41. Hansen TK, Gravholt CH, Ørskov H, Rasmussen MH, Christiansen JS & Jorgensen JO. Dose dependency of the pharmacokinetics and acute lipolytic actions of growth hormone. Journal of Clinical Endocrinology and Metabolism 2002 87 4691-4698.
42. Deurenberg P, Weststrate JA & Seidell JC. Body mass index as a measure of body fatness: age-and sex-specific prediction formulas. British Journal of Nutrition 1991 65 105-114.
43. Bruce Å, Andersson M, Arvidsson B & Isaksson B. Body composition. Prediction of normal body potassium, body water and body fat in adults on the basis of body height, body weight and age. Scandinavian Journal of Clinical and Laboratory Investigation 1980 40 461-473. (Pubitemid 10030662)
44. Mukherjee A, Adams JE, Smethurst L & Shalet SM. Interdependence of lean body mass and total body water, but not quality of life measures, during low dose GH replacement in GH-deficient adults. European Journal of Endocrinology 2005 153 661-668. (Pubitemid 41672412)
45. Svensson J, Finer N, Bouloux P, Bevan J, Jonsson B, Mattsson AE, Lundberg M, Harris PE, Koltowska-Häggström M, Monson JP & KIMS International Board. Growth hormone (GH) replacement therapy in GH deficient adults: predictors of one-year metabolic and clinical response. Growth Hormone & IGF Research 2007 17 67-76. (Pubitemid 46313080)
46. Webb SM & Badia X. Quality of life in growth hormone deficiency and acromegaly. Endocrinology and Metabolism Clinics of North America 2007 36 221-232. (Pubitemid 46335847)
47. Moock J, Albrecht C, Friedrich N, Völzke H, Nauck M, Koltowska-Häggström M, Kohlmann T & Wallaschofski H. Health-related quality of life and IGF-I in GH-deficient adult patients on GH replacement therapy: analysis of the German KIMS data and the study of Health in Pomerania. European Journal of Endocrinology 2009 160 17-24.
48. Jorgensen JO, Moller L, Krog M, Billerstrup N & Christiansen JS. Effects of growth hormone on glucose and fat metabolism in human subjects. Endocrinology and Metabolism Clinics of North America 2007 36 75-87. (Pubitemid 46335844)
49. Nilsson AG, Svensson J & Johannsson G. Management of growth hormone deficiency in adults. Growth Hormone & IGF Research 2007 17 441-462. (Pubitemid 350063727)