Dexamethasone suppression test predicts later development of an impaired adrenal function after a 14-day course of prednisone in healthy volunteers

European Journal of Endocrinology

Volumn 162, Issue 5, 2010, Pages 943-949

  Neidert, Stefanie ^a   Schuetz, Philipp ^a   Mueller, Beat ^b   Christ Crain, Mirjam ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b Kantonsspital Aarau ^*  (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; DEXAMETHASONE; HYDROCORTISONE; PREDNISONE;

ADRENAL CORTEX DISEASE; ADRENAL FUNCTION; ADULT; AREA UNDER THE CURVE; ARTICLE; CORTICOTROPIN TEST; DEXAMETHASONE SUPPRESSION TEST; DISEASE COURSE; EVENING DOSAGE; FUNCTIONAL ASSESSMENT; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; LOW DRUG DOSE; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; STEROID THERAPY;

ADRENAL INSUFFICIENCY; ADRENOCORTICOTROPIC HORMONE; ADULT; DEXAMETHASONE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; PITUITARY-ADRENAL SYSTEM; PREDNISONE; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 77951653292     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-09-0930     Document Type: Article

References (36)

1. van Staa TP, Leufkens HG, Abenhaim L, Begaud B, Zhang B & Cooper C. Use of oral corticosteroids in the United Kingdom. Quarterly Journal of Medicine 2000 93 105-111. (Pubitemid 30098773)
2. Bornstein SR. Predisposing factors for adrenal insufficiency. New England Journal of Medicine 2009 360 2328-2339.
3. Oelkers W. Adrenal insufficiency. New England Journal of Medicine 1996 335 1206-1212.
4. Grinspoon SK & Biller BM. Clinical review 62: laboratory assessment of adrenal insufficiency. Journal of Clinical Endocrinology and Metabolism 1994 79 923-931. (Pubitemid 24342224)
5. Henzen C, Suter A, Lerch E, Urbinelli R, Schorno XH & Briner VA. Suppression and recovery of adrenal response after short-term, high-dose glucocorticoid treatment. Lancet 2000 355 542-545. (Pubitemid 30088675)
6. Schlaghecke R, Kornely E, Santen RT & Ridderskamp P. The effect of long-term glucocorticoid therapy on pituitary-adrenal responses to exogenous corticotropin-releasing hormone. New England Journal of Medicine 1992 326 226-230.
7. Salassa RM, Bennett WA, Keating FR Jr & Sprague RG. Post-operative adrenal cortical insufficiency; occurrence in patients previously treated with cortisone. Journal of the American Medical Association 1953 152 1509-1515.
8. Schuetz P, Christ-Crain M, Schild U, Suess E, Facompre M, Baty F, Nusbaumer C, Brutsche M & Muller B. Effect of a 14-day course of systemic corticosteroids on the hypothalamic-pituitary-adrenalaxis in patients with acute exacerbation of chronic obstructive pulmonary disease. BMC Pulmonary Medicine 2008 8 1. (Pubitemid 351285303)
9. Werbel SS & Ober KP. Acute adrenal insufficiency. Endocrinology and Metabolism Clinics of North America 1993 22 303-328.
10. Arlt W. The approach to the adult with newly diagnosed adrenal insufficiency. Journal of Clinical Endocrinology and Metabolism 2009 94 1059-1067.
11. Bouillon R. Acute adrenal insufficiency. Endocrinology and Metabolism Clinics of North America 2006 35 767-775.
12. Cooper MS & Stewart PM. Corticosteroid insufficiency in acutely ill patients. New England Journal of Medicine 2003 348 727-734.
13. Mortimer KJ, Tata LJ, Smith CJ, West J, Harrison TW, Tattersfield AE & Hubbard RB. Oral and inhaled corticosteroids and adrenal insufficiency: a case-control study. Thorax 2006 61 405-408. (Pubitemid 43723323)
14. Huizenga NA, Koper JW, de Lange P, Pols HA, Stolk RP, Grobbee DE, de Jong FH & Lamberts SW. Interperson variability but intraperson stability of baseline plasma cortisol concentrations, and its relation to feedback sensitivity of the hypothalamo-pituitary-adrenal axis to a low dose of dexamethasone in elderly individuals. Journal of Clinical Endocrinology and Metabolism 1998 83 47-54.
15. Nugent CA, Nichols T & Tyler FH. Diagnosis of Cushing's syndrome; single dose dexamethasone suppression test. Archives of Internal Medicine 1965 116 172-176.
16. Gaab J, Huster D, Peisen R, Engert V, Schad T, Schurmeyer TH & Ehlert U. Low-dose dexamethasone suppression test in chronic fatigue syndrome and health. Psychosomatic Medicine 2002 64 311-318.
17. Carroll BJ. Dexamethasone suppression test for depression. Advances in Biochemical Psychopharmacology 1984 39 179-188.
18. Widmer IE, Puder JJ, Konig C, Pargger H, Zerkowski HR, Girard J & Muller B. Cortisol response in relation to the severity of stress and illness. Journal of Clinical Endocrinology and Metabolism 2005 90 4579-4586.
19. Pasquali R, Ambrosi B, Armanini D, Cavagnini F, Uberti ED, Del Rio G, de Pergola G, Maccario M, Mantero F, Marugo M, Rotella CM & Vettor R. Cortisol and ACTH response to oral dexamethasone in obesity and effects of sex, body fat distribution, and dexamethasone concentrations: a dose-response study. Journal of Clinical Endocrinology and Metabolism 2002 87 166-175.
20. Arlt W, Rosenthal C, Hahner S & Allolio B. Quality of glucocorticoid replacement in adrenal insufficiency: clinical assessment vs timed serum cortisol measurements. Clinical Endocrinology 2006 64 384-389.
21. Abdu TA, Elhadd TA, Neary R & Clayton RN. Comparison of the low dose short synacthen test (1 μg), the conventional dose short synacthen test (250 μg), and the insulin tolerance test for assessment of the hypothalamo-pituitary-adrenal axis in patients with pituitary disease. Journal of Clinical Endocrinology and Metabolism 1999 84 838-843.
22. Dorin RI, Qualls CR & Crapo LM. Diagnosis of adrenal insufficiency. Annals of Internal Medicine 2003 139 194-204.
23. Suliman AM, Smith TP, Labib M, Fiad TM & McKenna TJ. The lowdose ACTH test does not provide a useful assessment of the hypothalamic-pituitary-adrenal axis in secondary adrenal insufficiency. Clinical Endocrinology 2002 56 533-539.
24. Reimondo G, Bovio S, Allasino B, Terzolo M & Angeli A. Secondary hypoadrenalism. Pituitary 2008 11 147-154.
25. Clayton RN. Short synacthen test versus insulin stress test for assessment of the hypothalmo-pituitary-adrenal axis: controversy revisited. Clinical Endocrinology 1996 44 147-149.
26. DeLong ER, DeLong DM & Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 1988 44 837-845.
27. Charmandari E, Kino T, Ichijo T & Chrousos GP. Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder. Journal of Clinical Endocrinology and Metabolism 2008 93 1563-1572.
28. Arlt W & Allolio B. Adrenal insufficiency. Lancet 2003 361 1881-1893.
29. Russcher H, Smit P, van Rossum EF, van den Akker EL, Brinkmann AO, de Heide LJ, de Jong FH, Koper JW & Lamberts SW. Strategies for the characterization of disorders in cortisol sensitivity. Journal of Clinical Endocrinology and Metabolism 2006 91 694-701.
30. Rasmuson S, Olsson T & Hagg E. A low dose ACTH test to assess the function of the hypothalamic-pituitary-adrenal axis. Clinical Endocrinology 1996 44 151-156.
31. Nye EJ, Grice JE, Hockings GI, Strakosch CR, Crosbie GV, Walters MM & Jackson RV. Comparison of adrenocorticotropin (ACTH) stimulation tests and insulin hypoglycemia in normal humans: low dose, standard high dose, and 8-hour ACTH-(1-24) infusion tests. Journal of Clinical Endocrinology and Metabolism 1999 84 3648-3655.
32. Mayenknecht J, Diederich S, Bahr V, Plockinger U & Oelkers W. Comparison of low and high dose corticotropin stimulation tests in patients with pituitary disease. Journal of Clinical Endocrinology and Metabolism 1998 83 1558-1562.
33. Dickstein G & Saiegh L. Low-dose and high-dose adrenocorticotropin testing: indications and shortcomings. Current Opinion in Endocrinology, Diabetes and Obesity 2008 15 244-249.
34. Dickstein G. High-dose and low-dose cosyntropin stimulation tests for diagnosis of adrenal insufficiency. Annals of Internal Medicine 2004 140 312-313.
35. Kazlauskaite R, Evans AT, Villabona CV, Abdu TA, Ambrosi B, Atkinson AB, Choi CH, Clayton RN, Courtney CH, Gonc EN, Maghnie M, Rose SR, Soule SG & Tordjman K. Corticotropin tests for hypothalamic-pituitary-adrenal insufficiency: a metaanalysis. Journal of Clinical Endocrinology and Metabolism 2008 93 4245-4253.
36. Tordjman K, Jaffe A, Grazas N, Apter C & Stern N. The role of the low dose (1 μg) adrenocorticotropin test in the evaluation of patients with pituitary diseases. Journal of Clinical Endocrinology and Metabolism 1995 80 1301-1305.