The approach to the adult with newly diagnosed adrenal insufficiency

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 4, 2009, Pages 1059-1067

  Arlt, Wiebke ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROCORTISONE; MINERALOCORTICOID; TETRACOSACTIDE;

ADRENAL INSUFFICIENCY; ADULT; ANAMNESIS; CASE REPORT; CLINICAL FEATURE; CONTINUOUS INFUSION; DOSE RESPONSE; HUMAN; LABORATORY TEST; MALE; PHYSICAL EXAMINATION; PRIORITY JOURNAL; REVIEW;

EID: 65249111733     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-0032     Document Type: Article

References (72)

1. Arlt W, Allolio B 2003 Adrenal insufficiency. Lancet 361:1881-1893
2. Perry R, Kecha O, Paquette J, Huot C, Van Vliet G, Deal C 2005 Primary adrenal insufficiency in children: twenty years experience at the Sainte-Justine Hospital, Montreal. J Clin Endocrinol Metab 90:3243-3250
3. Agha A, Tomlinson JW, Clark PM, Holder G, Stewart PM 2006 The long-term predictive accuracy of the short synacthen (corticotropin) stimulation test for assessment of the hypothalamic-pituitary-adrenal axis. J Clin Endocrinol Metab 91:43-47
4. Stewart PM, Corrie J, Seckl JR, Edwards CR, Padfield PL 1988 A rational approach for assessing the hypothalamo-pituitary-adrenal axis. Lancet 1:1208-1210
5. Clark PM, Neylon I, Raggatt PR, Sheppard MC, Stewart PM 1998 Defining the normal cortisol response to the short synacthen test: implications for the investigation of hypothalamic-pituitary disorders. Clin Endocrinol (Oxf) 49: 287-292
6. Inder WJ, Hunt PJ 2002 Glucocorticoid replacement in pituitary surgery: guidelines for perioperative assessment and management. J Clin Endocrinol Metab 87:2745-2750
7. Arlt W, Justl HG, Callies F, Reincke M, Hubler D, Oettel M, Ernst M, Schulte HM, Allolio B 1998 Oral dehydroepiandrosterone for adrenal androgen replacement: pharmacokinetics and peripheral conversion to androgens and estrogens in young healthy females after dexamethasone suppression. J Clin Endocrinol Metab 83:1928-1934
8. Betterle C, Dal Pra C, Mantero F, Zanchetta R 2002 Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, au-toantigens, and their applicability in diagnosis and disease prediction. Endocr Rev 23:327-364
9. Ahonen P, Myllarniemi S, Sipila I, Perheentupa J 1990 Clinical variation of au-toimmunepolyendocrinopathy-candidiasis- ectodermaldystrophy(APECED) ina series of 68 patients. N Engl J Med 322:1829-1836
10. Finnish-German APECED Consortium 1997 An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat Genet 17:399 -403
11. Nagamine K, Peterson P, Scott HS, Kudoh J, Minoshima S, Heino M, Krohn KJ, Lalioti MD, Mullis PE, Antonarakis SE, Kawasaki K, Asakawa S, Ito F, Shimizu N 1997 Positional cloning of the APECED gene. Nat Genet 17:393 398
12. Mathis D, Benoist C 2007 A decade of AIRE. Nat Rev Immunol 7:645-650
13. Kemp EH, Ajjan RA, Husebye ES, Peterson P, Uibo R, Imrie H, Pearce SH, Watson PF, Weetman AP 1998 A cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism is associated with autoimmune Addison's disease in English patients. Clin Endocrinol (Oxf) 49:609-613
14. Skinningsrud B, Husebye ES, Gervin K, Løvås K, Blomhoff A, Wolff AB, Kemp EH, Egeland T, Undlien DE 2008 Mutation screening of PTPN22: association of the 1858T-allele with Addison's disease. Eur J Hum Genet 16:977-982
15. Skinningsrud B, Husebye ES,PearceSH,McDonaldDO,BrandalK, Wolff AB, Loslash;vås K, Egeland T, Undlien DE 2008 Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency. J Clin En- docrinol Metab 93:3310-3317
16. Hangaard J, Andersen M, Grodum E, Koldkjaer O, Hagen C 1996 Pulsatile
17. thyrotropin secretion in patients with Addison's disease during variable glucocorticoid therapy. J Clin Endocrinol Metab 81:2502-2507
18. Topliss DJ, White EL, Stockigt JR 1980 Significance of thyrotropin excess in untreated primary adrenal insufficiency. J Clin Endocrinol Metab 50: 52-56
19. Allolio B, Kaulen D, Deuss U, Hipp FX, Winkelmann W 1985 Comparison between hydrocortisone and cortisone acetate as replacement therapy in adrenocortical insufficiency. Akt Endokr Stoffw 6:35-39
20. Lutz A, Stojkovic M, Schmidt M, Arlt W, Allolio B, Reincke M 2000 Adre- nocortical function in patients with macrometastases of the adrenal gland. Eur J Endocrinol 143:91-97
21. Lam KY, Lo CY 2002 Metastatic tumours of the adrenal glands: a 30-year experience in a teaching hospital. Clin Endocrinol (Oxf) 56:95-101
22. PresottoF,FornasiniF,BetterleC,FederspilG,RossatoM2005 Acuteadrenal failure as the heralding symptom of primary antiphospholipid syndrome: report of a case and review of the literature. Eur J Endocrinol 153:507-514
23. Moser HW, Mahmood A, Raymond GV 2007 X-linked adrenoleukodystro- phy. Nat Clin Pract Neurol 3:140-151
24. Agha A, Rogers B, Sherlock M, O'Kelly P, Tormey W, Phillips J, Thompson CJ 2004 Anterior pituitary dysfunction in survivors of traumatic brain injury. J Clin Endocrinol Metab 89:4929-4936
25. Giordano G, Aimaretti G, Ghigo E 2005 Variations of pituitary function over time after brain injuries: the lesson from a prospective study. Pituitary8:227- 231
26. Chanson P, Lepeintre JF, Ducreux D 2004 Management of pituitary apoplexy. Expert Opin Pharmacother 5:1287-1298
27. Schwedt TJ, Matharu MS, DodickDW 2006 Thunderclap headache. Lancet Neurol 5:621-631
28. Caturegli P, Lupi I, Landek-Salgado M, Kimura H, Rose NR 2008 Pituitary autoimmunity: 30 years later. Autoimmun Rev 7:631-637
29. Kasperlik-Zaluska AA, Czarnocka B, Czech W 2003 Autoimmunity as the most frequent cause of idiopathic secondary adrenal insufficiency: report of 111 cases. Autoimmunity 36:155-159
30. Manetti L, Lupi I, Morselli LL, Albertini S, Cosottini M, Grasso L, Genovesi M, Pinna G, Mariotti S, Bogazzi F, Bartalena L, Martino E 2007 Prevalence and functional significance of antipituitary antibodies in patients with autoimmune and non-autoimmune thyroid diseases. J Clin Endocrinol Metab 92: 2176-2181
31. EstebanNV, LoughlinT, Yergey AL,ZawadzkiJK,BoothJD,WintererJC, Loriaux DL 1991 Daily cortisol production rate in man determined by stable isotope dilution/mass spectrometry. J Clin Endocrinol Metab 72: 39-45
32. Mah PM, Jenkins RC, Rostami-Hodjegan A, Newell-Price J, Doane A, Ibbotson V, Tucker GT, Ross RJ 2004 Weight-related dosing, timing and monitoring hydrocortisone replacement therapy in patients with adrenal insufficiency. Clin Endocrinol (Oxf) 61:367-375
33. KriegerDT, Allen W, RizzoF,Krieger HP 1971 Characterization of the normal temporal pattern of plasma corticosteroid levels. J Clin Endocrinol Metab 32:266-284
34. Plat L, Leproult R, L'Hermite-Baleriaux M, Fery F, Mockel J, Polonsky KS, Van Cauter E 1999 Metabolic effects of short-term elevations of plasma cor- tisol are more pronounced in the evening than in the morning. J Clin Endo- crinol Metab 84:3082-3092
35. Lovas K, Loge JH, Husebye ES 2002 Subjective health status in Norwegian patients with Addison's disease. Clin Endocrinol (Oxf) 56:581-588
36. Lovas K, Husebye ES, Holsten F, Bjorvatn B 2003 Sleep disturbances in patients with Addison's disease. Eur J Endocrinol 148:449 -456
37. Merza Z, Rostami-Hodjegan A, Memmott A, Doane A, Ibbotson V, Newell- Price J, Tucker GT, Ross RJ 2006 Circadian hydrocortisone infusions in patients with adrenal insufficiency and congenital adrenal hyperplasia. Clin En- docrinol (Oxf) 65:45-50
38. Lovas K, Husebye ES 2007Continuous subcutaneous hydrocortisone infusion in Addison's disease. Eur J Endocrinol 157:109-112
39. Newell-PriceJ,WhitemanM,Rostami-HodjeganA,DarzyK,ShaletS,Tucker GT, Ross RJ 2008 Modified-release hydrocortisone for circadian therapy: a proof-of-principle study in dexamethasone- suppressed normal volunteers. Clin Endocrinol (Oxf) 68:130-135
40. Debono M, Ghobadi C, Rostami-Hodjegan A, Huatan H, Campbell MJ, Newell-Price J, Darzy K, Merke DP, Arlt W, Ross RJ Modified-release hydro- cortisone to provide circadian cortisol profiles. JClin Endocrinol Metab. 2009 Feb 17 [Epub ahead of print]
41. Kehlet H, Binder C, Blichert-Toft M 1976 Glucocorticoid maintenance therapy following adrenalectomy: assessment of dosage and preparation. Clin Endocrinol (Oxf) 5:37-41
42. Jodar E, Valdepenas MP, Martinez G, Jara A, Hawkins F 2003 Long-term follow-up of bone mineral density in Addison's disease. ClinEndocrinol(Oxf) 58:617-620
43. Feek CM, Ratcliffe JG, Seth J, Gray CE, Toft AD, Irvine WJ 1981 Patterns of plasma cortisol and ACTH concentrations in patients with Addison's disease treated with conventional corticosteroid replacement. Clin Endocrinol (Oxf) 14:451-458
44. ScottRS, DonaldRA, EspinerEA1978 Plasma ACTH and cortisol profilesin Addisonian patients receiving conventional substitution therapy. Clin Endo- crinol (Oxf) 9:571-576
45. HowlettTA1997An assessment of optimal hydrocortisone replacement ther- apy. Clin Endocrinol (Oxf) 46:263-268
46. Peacey SR,Guo CY, Robinson AM,Price A,Giles MA,Eastell R,Weetman AP 1997 Glucocorticoid replacement therapy: are patients over treated and does it matter? Clin Endocrinol (Oxf) 46:255-261
47. Arlt W, Rosenthal C, Hahner S, Allolio B 2006 Quality of glucocorticoid replacement in adrenal insufficiency: clinical assessment vs. timed serum cor- tisol measurements. Clin Endocrinol (Oxf) 64:384-389
48. Zelissen PM, Croughs RJ, van Rijk PP, Raymakers JA 1994 Effect of glu- cocorticoid replacement therapy on bone mineral density in patients with Ad- dison disease. Ann Intern Med 120:207-210
49. Florkowski CM, Holmes SJ, Elliot JR, Donald RA, Espiner EA 1994 Bone mineral density is reduced in female but not male subjects with Addison's disease. N Z Med J 107:52-53
50. Braatvedt GD,Joyce M,Evans M,Clearwater J,Reid IR 1999 Bonemineral density in patients with treated Addison's disease. Osteoporos Int 10:435 440
51. Oelkers W, Diederich S, Bahr V 1992 Diagnosis and therapy surveillance in Addison's disease: rapid adrenocorticotropin (ACTH) test and measurement of plasma ACTH, renin activity, and aldosterone. J Clin Endocrinol Metab 75:259-264
52. Ehrlich EN, Lindheimer MD 1972 Effect of administered mineralocorticoids or ACTH in pregnant women. Attenuation of kaliuretic influence of miner- alocorticoids during pregnancy. J Clin Invest 51:1301-1309
53. Erichsen MM, Løvås K, Fougner KJ, Svartberg J, Hauge ER, Bollerslev J, Berg JP, Mella B, Husebye ES 2009 Normal overall mortality rate in Addison's disease, but young patients are at risk of premature death. Eur J Endocrinol 160:233-237
54. Glowniak JV, Loriaux DL 1997 A double-blind study of perioperative steroid requirements in secondary adrenal insufficiency. Surgery 121:123-129
55. Nicholas JA, Burstein CL, Umberger CJ, Wilson PD 1955 Management of adrenocortical insufficiency during surgery. AMA Arch Surg 71:737-742
56. Arlt W, Callies F, van Vlijmen JC, Koehler I, Reincke M, Bidlingmaier M, Huebler D, Oettel M, Ernst M, Schulte HM, Allolio B 1999 Dehydroepi- androsterone replacement in women with adrenal insufficiency. N Engl J Med 341:1013-1020
57. Miller KK, Sesmilo G, Schiller A, Schoenfeld D, Burton S, Klibanski A 2001 Androgen deficiency in women with hypopituitarism. JClin Endocrinol Metab 86:561-567
58. Brooke AM, Kalingag LA, Miraki-Moud F, Camacho-Hiibner C, Maher KT, Walker DM, Hinson JP, Monson JP 2006 Dehydroepiandrosterone improves psychological well-being in male and female hypopituitary patients on maintenance growth hormone replacement. J Clin Endocrinol Metab 91:3773-3779
59. Gurnell EM, Hunt PJ, Curran SE, Conway CL, Pullenayegum EM, Huppert FA, Compston JE, Herbert J, Chatterjee VK 2008 Long-term DHEA replacement in primary adrenal insufficiency: a randomized, controlled trial. J Clin Endocrinol Metab 93:400-409
60. Hunt PJ,Gurnell EM,Huppert FA,Richards C,Prevost AT,Wass JA,Herbert J, ChatterjeeVK2000 Improvement in mood and fatigue after dehydroepiandro- sterone replacement in Addison's disease in a randomized, double blind trial. J Clin Endocrinol Metab 85:4650-4656
61. Johannsson G, Burman P, Wirtén L, Engströim BE, Nilsson AG, Ottosson M, Jonsson B, Bengtsson BA, Karlsson FA 2002 Low dose dehydroepiandros- terone affects behavior in hypopituitary androgen- deficientwomen:aplacebo- controlled trial. J Clin Endocrinol Metab 87:2046-2052
62. Binder G, Weber S, Ehrismann M, Zaiser N, Meisner C, Ranke MB, Maier L, Wudy SA, Hartmann MF, Heinrich U,Bettendorf M, Doerr HG, Pfaeffle RW,Keller E; the South German Working Group for Pediatric Endocrinology 2009 Effects of dehydroepiandrosterone therapy on pubic hair growth and psychological well-being in adolescent girls and young women with central adrenal insufficiency: a double-blind, randomized, placebo-controlled phase III trial. J Clin Endocrinol Metab 94:1182-1190
63. Miller KK,Biller BM,Beauregard C,Lipman JG,Jones J,Schoenfeld D,Sherman JC, Swearingen B, Loeffler J, Klibanski A 2006 Effects of testosterone replacement in androgen- deficient women with hypopituitarism: a randomized, double-blind, placebo-controlled study. JClin Endocrinol Metab 91:1683-1690
64. Arlt W 2006 Androgen therapy in women. Eur J Endocrinol 154:1-11
65. Parasrampuria J, Schwartz K, Petesch R 1998 Quality control of dehydroepi- androsterone dietary supplement products. JAMA 280:1565
66. Hahner S, Loeffler M, Fassnacht M, Weismann D, Koschker AC, Quinkler M, Decker O, Arlt W, Allolio B 2007 Impaired subjective health status in 256 patients with adrenal insufficiency on standard therapy based on cross-sectional analysis. J Clin Endocrinol Metab 92:3912-3922
67. Thomsen AF, Kvist TK, Andersen PK, Kessing LV 2006 The risk of affective disorders in patients with adrenocortical insufficiency. Psychoneuroendocri- nology 31:614 -622
68. BleickenB, HahnerS, LoefflerM, VentzM, Allolio B, QuinklerM2008 Impaired subjective health status in chronic adrenal insufficiency: impact of different glu- cocorticoid replacement regimens. Eur JEndocrinol 159:811-817
69. Tomlinson JW, Holden N, Hills RK, Wheatley K, Clayton RN, Bates AS, Sheppard MC, Stewart PM 2001 Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group. Lancet 357:425-431
70. Bergthorsdottir R, Leonsson-Zachrisson M, Oden A, Johannsson G 2006 Premature mortality in patients with Addison's disease: a population-based study. J Clin Endocrinol Metab 91:4849 -4853
71. Bensing S, Brandt L, Tabaroj F, Sjöberg O, NilssonB, Ekbom A,Blomqvist P, Kämpe O 2008 Increased death risk and altered cancer incidence pattern in patients with isolated or combined autoimmune primary adrenocortical insufficiency. Clin Endocrinol (Oxf) 69:697-704
72. Addison T 1855 On the constitutional and local effects of diseases of the supra-renal capsules. London: Warren and Son