메뉴 건너뛰기




Volumn 264, Issue 2, 2010, Pages 287-300

A biomathematical model of human thrombopoiesis under chemotherapy

Author keywords

Thrombopheresis; Thrombopoietin; TPO

Indexed keywords

CYCLOPHOSPHAMIDE; DOXORUBICIN; ETOPOSIDE; PREDNISONE; THROMBOPOIETIN; VINCRISTINE;

EID: 77951652489     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2009.12.032     Document Type: Article
Times cited : (26)

References (74)
  • 3
    • 0037676141 scopus 로고    scopus 로고
    • Dose-intense chemotherapy every 2 weeks with dose-intense cyclophosphamide, doxorubicin, vincristine, and prednisone may improve survival in intermediate- and highgrade lymphoma: a phase II study of the Southwest Oncology Group (SWOG 9349)
    • Blayney D.W., LeBlanc M.L., Grogan T., Gaynor E.R., Chapman R.A., Spiridonidis C.H., Taylor S.A., Bearman S.I., Miller T.P., Fisher R.I. Dose-intense chemotherapy every 2 weeks with dose-intense cyclophosphamide, doxorubicin, vincristine, and prednisone may improve survival in intermediate- and highgrade lymphoma: a phase II study of the Southwest Oncology Group (SWOG 9349). Journal of Clinical Oncology 2003, 21:2466-2473.
    • (2003) Journal of Clinical Oncology , vol.21 , pp. 2466-2473
    • Blayney, D.W.1    LeBlanc, M.L.2    Grogan, T.3    Gaynor, E.R.4    Chapman, R.A.5    Spiridonidis, C.H.6    Taylor, S.A.7    Bearman, S.I.8    Miller, T.P.9    Fisher, R.I.10
  • 4
    • 13844312616 scopus 로고    scopus 로고
    • Increasing chemotherapy dose density and intensity: phase I trials in non-small cell lung cancer and non-Hodgkin's lymphoma
    • Blayney D.W., McGuire B.W., Cruickshank S.E., Johnson D.H. Increasing chemotherapy dose density and intensity: phase I trials in non-small cell lung cancer and non-Hodgkin's lymphoma. Oncologist 2005, 10:138-149.
    • (2005) Oncologist , vol.10 , pp. 138-149
    • Blayney, D.W.1    McGuire, B.W.2    Cruickshank, S.E.3    Johnson, D.H.4
  • 5
    • 0030968519 scopus 로고    scopus 로고
    • Human platelets display high-affinity receptors for thrombopoietin
    • Broudy V.C., Lin N.L., Sabath D.F., Papayannopoulou T., Kaushansky K. Human platelets display high-affinity receptors for thrombopoietin. Blood 1997, 89(6):1896-1904.
    • (1997) Blood , vol.89 , Issue.6 , pp. 1896-1904
    • Broudy, V.C.1    Lin, N.L.2    Sabath, D.F.3    Papayannopoulou, T.4    Kaushansky, K.5
  • 7
    • 0029835344 scopus 로고    scopus 로고
    • Constitutive expression of Mpl ligand transcripts during thrombocytopenia or thrombocytosis
    • Cohen-Solal K., Villeval J.L., Titeux M., Lok S., Vainchenker W., Wendling F. Constitutive expression of Mpl ligand transcripts during thrombocytopenia or thrombocytosis. Blood 1996, 88(7):2578-2584.
    • (1996) Blood , vol.88 , Issue.7 , pp. 2578-2584
    • Cohen-Solal, K.1    Villeval, J.L.2    Titeux, M.3    Lok, S.4    Vainchenker, W.5    Wendling, F.6
  • 8
    • 0024528096 scopus 로고
    • The relationship between megakaryocyte ploidy and platelet volume
    • Corash L. The relationship between megakaryocyte ploidy and platelet volume. Blood Cells 1989, 15:81-107.
    • (1989) Blood Cells , vol.15 , pp. 81-107
    • Corash, L.1
  • 9
    • 0036389484 scopus 로고    scopus 로고
    • Pegfilgrastim administered once per cycle reduces incidence of chemotherapy-induced neutropenia
    • Crawford J. Pegfilgrastim administered once per cycle reduces incidence of chemotherapy-induced neutropenia. Drugs 2002, 62(Suppl. 1):89-98.
    • (2002) Drugs , vol.62 , Issue.SUPPL. 1 , pp. 89-98
    • Crawford, J.1
  • 10
    • 0141813695 scopus 로고    scopus 로고
    • Current management of chemotherapy-induced neutropenia: the role of colony-stimulating factors
    • Dale D. Current management of chemotherapy-induced neutropenia: the role of colony-stimulating factors. Seminars in Oncology 2003, 30:3-9.
    • (2003) Seminars in Oncology , vol.30 , pp. 3-9
    • Dale, D.1
  • 11
    • 0018198259 scopus 로고
    • Use of [75Se]-methionine as a tracer of thrombocytopoiesis. II-Kinetics in normal rats and in platelet disorders in man: a new approach
    • Dassin E., Ardaillou N., Eberlin A., Bourebia J., Najean Y. Use of [75Se]-methionine as a tracer of thrombocytopoiesis. II-Kinetics in normal rats and in platelet disorders in man: a new approach. Biochemical and Biophysical Research Communications 1978, 81(2):329-335.
    • (1978) Biochemical and Biophysical Research Communications , vol.81 , Issue.2 , pp. 329-335
    • Dassin, E.1    Ardaillou, N.2    Eberlin, A.3    Bourebia, J.4    Najean, Y.5
  • 14
    • 0013939902 scopus 로고
    • Megakaryocytopoiesis in the rat with transfusion-induced thrombocytosis. Proceedings of the Society for Experimental Biology and Medicine
    • Ebbe, S., Stohlman, F., Donovan, J., Howard, D.,1966. Megakaryocytopoiesis in the rat with transfusion-induced thrombocytosis. Proceedings of the Society for Experimental Biology and Medicine 122 (4), 1053-1057.
    • (1966) , vol.122 , Issue.4 , pp. 1053-1057
    • Ebbe, S.1    Stohlman, F.2    Donovan, J.3    Howard, D.4
  • 15
    • 0014360461 scopus 로고
    • Megakaryocyte maturation rate in thrombocytopenic rats
    • Ebbe S., Stohlman F., Donovan J., Overcash J. Megakaryocyte maturation rate in thrombocytopenic rats. Blood 1968, 32(5):787-795.
    • (1968) Blood , vol.32 , Issue.5 , pp. 787-795
    • Ebbe, S.1    Stohlman, F.2    Donovan, J.3    Overcash, J.4
  • 16
    • 0023851481 scopus 로고
    • Megakaryocytes increase in size within ploidy groups in response to the stimulus of thrombocytopenia
    • Ebbe S., Yee T., Carpenter D., Phalen E. Megakaryocytes increase in size within ploidy groups in response to the stimulus of thrombocytopenia. Experimental Hematology 1988, 16:55-61.
    • (1988) Experimental Hematology , vol.16 , pp. 55-61
    • Ebbe, S.1    Yee, T.2    Carpenter, D.3    Phalen, E.4
  • 17
    • 0029881744 scopus 로고    scopus 로고
    • Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction
    • Emmons R.V.B., Reid D.M., Cohen R.L., Meng G., Young N.S., Dunbar C.E., Shulman N.R. Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood 1996, 87(10):4068-4071.
    • (1996) Blood , vol.87 , Issue.10 , pp. 4068-4071
    • Emmons, R.V.B.1    Reid, D.M.2    Cohen, R.L.3    Meng, G.4    Young, N.S.5    Dunbar, C.E.6    Shulman, N.R.7
  • 19
    • 4944219924 scopus 로고    scopus 로고
    • A computational model of human granulopoiesis to simulate the hematotoxic effects of multicycle polychemotherapy
    • Engel C., Scholz M., Loeffler M. A computational model of human granulopoiesis to simulate the hematotoxic effects of multicycle polychemotherapy. Blood 2004, 104(8):2323-2331.
    • (2004) Blood , vol.104 , Issue.8 , pp. 2323-2331
    • Engel, C.1    Scholz, M.2    Loeffler, M.3
  • 21
    • 0017712709 scopus 로고
    • Kinetics of the formed elements of human blood
    • Finch C.A., Harker L.A., Cook J.D. Kinetics of the formed elements of human blood. Blood 1977, 50(4):699-707.
    • (1977) Blood , vol.50 , Issue.4 , pp. 699-707
    • Finch, C.A.1    Harker, L.A.2    Cook, J.D.3
  • 22
    • 0016750188 scopus 로고
    • Heterogeneity of rabbit platelets. V. Preferential splenic sequestration of megathrombocytes
    • Freedman M.L., Karpatkin S. Heterogeneity of rabbit platelets. V. Preferential splenic sequestration of megathrombocytes. British Journal of Haematology 1975, 31:255-262.
    • (1975) British Journal of Haematology , vol.31 , pp. 255-262
    • Freedman, M.L.1    Karpatkin, S.2
  • 23
    • 0017698622 scopus 로고
    • Presence of a nonsplenic platelet pool
    • Freedman M., Altszuler N., Karpatkin S. Presence of a nonsplenic platelet pool. Blood 1977, 50(3):419-425.
    • (1977) Blood , vol.50 , Issue.3 , pp. 419-425
    • Freedman, M.1    Altszuler, N.2    Karpatkin, S.3
  • 24
    • 66749131902 scopus 로고    scopus 로고
    • The regulation of proplatelet production
    • Geddis A.E. The regulation of proplatelet production. Haematologica 2009, 94(6):756-759.
    • (2009) Haematologica , vol.94 , Issue.6 , pp. 756-759
    • Geddis, A.E.1
  • 25
    • 0015320432 scopus 로고
    • Pooling and destruction of platelets in the spleen in hypersplenism
    • Gehrmann G., Elbers C., Berninger F.S. Pooling and destruction of platelets in the spleen in hypersplenism. Klinische Wochenschrift 1972, 50:379-382.
    • (1972) Klinische Wochenschrift , vol.50 , pp. 379-382
    • Gehrmann, G.1    Elbers, C.2    Berninger, F.S.3
  • 26
    • 34547232294 scopus 로고    scopus 로고
    • Lineage specification of hematopoietic stem cells: mathematical modeling and biological implications
    • Glauche I., Cross M., Loeffler M., Roeder I. Lineage specification of hematopoietic stem cells: mathematical modeling and biological implications. Stem Cells 2007, 25(7):1791-1799.
    • (2007) Stem Cells , vol.25 , Issue.7 , pp. 1791-1799
    • Glauche, I.1    Cross, M.2    Loeffler, M.3    Roeder, I.4
  • 27
    • 77951652946 scopus 로고
    • Platelet production and its regulation
    • North-Holland Publishing Company, J.M. Paulus (Ed.)
    • Harker L.A. Platelet production and its regulation. Platelet Kinetics 1971, 202-211. North-Holland Publishing Company. J.M. Paulus (Ed.).
    • (1971) Platelet Kinetics , pp. 202-211
    • Harker, L.A.1
  • 28
    • 0034656323 scopus 로고    scopus 로고
    • Effects of megakaryocyte growth and development factor on platelet production, platelet life span, and platelet function in healthy human volunteers
    • Harker L.A., Roskos L.K., Marzec U.M., Carter R.A., Cherry J.K., Sundell B., Cheung E.N., Terry D., Sheridan W. Effects of megakaryocyte growth and development factor on platelet production, platelet life span, and platelet function in healthy human volunteers. Blood 2000, 95:2514-2522.
    • (2000) Blood , vol.95 , pp. 2514-2522
    • Harker, L.A.1    Roskos, L.K.2    Marzec, U.M.3    Carter, R.A.4    Cherry, J.K.5    Sundell, B.6    Cheung, E.N.7    Terry, D.8    Sheridan, W.9
  • 29
    • 0031057949 scopus 로고    scopus 로고
    • Action of thrombopoietin at the megakaryocyte progenitor level is critical for the subsequent proplatelet production
    • Horie K., Miyazaki H., Hagiwara T., Tahara E., Matsumoto A., Kadoya T., Ogami K., Kato T. Action of thrombopoietin at the megakaryocyte progenitor level is critical for the subsequent proplatelet production. Experimental Hematology 1997, 25(2):169-176.
    • (1997) Experimental Hematology , vol.25 , Issue.2 , pp. 169-176
    • Horie, K.1    Miyazaki, H.2    Hagiwara, T.3    Tahara, E.4    Matsumoto, A.5    Kadoya, T.6    Ogami, K.7    Kato, T.8
  • 31
    • 34248649315 scopus 로고    scopus 로고
    • Pharmacokinetic model of target-mediated disposition of thrombopoietin
    • Jin F., Krzyzanski W. Pharmacokinetic model of target-mediated disposition of thrombopoietin. The AAPS Journal 2004, 6(1):86-93.
    • (2004) The AAPS Journal , vol.6 , Issue.1 , pp. 86-93
    • Jin, F.1    Krzyzanski, W.2
  • 33
    • 0029864161 scopus 로고    scopus 로고
    • Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice
    • Kaushansky K., Lin N., Grossmann A., Humes J., Sprugel K.H., Broudy V.C. Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice. Experimental Hematology 1996, 24(2):265-269.
    • (1996) Experimental Hematology , vol.24 , Issue.2 , pp. 265-269
    • Kaushansky, K.1    Lin, N.2    Grossmann, A.3    Humes, J.4    Sprugel, K.H.5    Broudy, V.C.6
  • 34
    • 0030711568 scopus 로고    scopus 로고
    • Thrombopoietin: more than a lineage-specific megakaryocyte growth factor
    • Kaushansky K. Thrombopoietin: more than a lineage-specific megakaryocyte growth factor. Stem Cells 1997, 15(Suppl. 1):97-102.
    • (1997) Stem Cells , vol.15 , Issue.SUPPL. 1 , pp. 97-102
    • Kaushansky, K.1
  • 36
    • 77951652954 scopus 로고    scopus 로고
    • Entwicklung eines mathematischen Kompartmentmodells zur Regulation der murinen Thrombopoese auf der Basis von Stoerungsmustern der thrombopoetischen Zellreihe. Dissertation, Universitaet Leipzig.
    • Kliem, C., 2001. Entwicklung eines mathematischen Kompartmentmodells zur Regulation der murinen Thrombopoese auf der Basis von Stoerungsmustern der thrombopoetischen Zellreihe. Dissertation, Universitaet Leipzig.
    • (2001)
    • Kliem, C.1
  • 37
    • 33646379875 scopus 로고    scopus 로고
    • Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients
    • Kuderer N.M., Dale D.C., Crawford J., Cosler L.E., Lyman G.H. Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients. Cancer 2006, 106:2258-2266.
    • (2006) Cancer , vol.106 , pp. 2258-2266
    • Kuderer, N.M.1    Dale, D.C.2    Crawford, J.3    Cosler, L.E.4    Lyman, G.H.5
  • 38
    • 0028117771 scopus 로고
    • The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production. Proceedings of the National Academy of Science USA
    • Kuter, D.J., Beeler, D.L., Rosenberg, R.D., 1994. The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production. Proceedings of the National Academy of Science USA 91(23), 11104-11108.
    • (1994) , vol.91 , Issue.23 , pp. 11104-11108
    • Kuter, D.J.1    Beeler, D.L.2    Rosenberg, R.D.3
  • 39
    • 0037111558 scopus 로고    scopus 로고
    • Recombinant human thrombopoietin: basic biology and evaluation of clinical studies
    • Kuter D.J., Begley C.G. Recombinant human thrombopoietin: basic biology and evaluation of clinical studies. Blood 2002, 100(10):3457-3469.
    • (2002) Blood , vol.100 , Issue.10 , pp. 3457-3469
    • Kuter, D.J.1    Begley, C.G.2
  • 40
    • 0032842829 scopus 로고    scopus 로고
    • Interaction of thrombopoietin with the platelet c-mpl receptor in plasma: binding, internalization, stability and pharmacokinetics
    • Li J., Xia Y., Kuter D.J. Interaction of thrombopoietin with the platelet c-mpl receptor in plasma: binding, internalization, stability and pharmacokinetics. British Journal of Haematology 1999, 106(2):345-356.
    • (1999) British Journal of Haematology , vol.106 , Issue.2 , pp. 345-356
    • Li, J.1    Xia, Y.2    Kuter, D.J.3
  • 42
    • 0028892286 scopus 로고
    • Murine thrombopoietin mRNA levels are modulated by platelet count
    • McCarty J.M., Sprugel K.H., Fox N.E., Sabath D.E., Kaushansky K. Murine thrombopoietin mRNA levels are modulated by platelet count. Blood 1995, 86(10):3668-3675.
    • (1995) Blood , vol.86 , Issue.10 , pp. 3668-3675
    • McCarty, J.M.1    Sprugel, K.H.2    Fox, N.E.3    Sabath, D.E.4    Kaushansky, K.5
  • 44
    • 0032945856 scopus 로고    scopus 로고
    • The relationship between carboplatin AUC and serum thrombopoietin kinetics in patients with lung cancer
    • Miyazaki M., Fujiwara Y., Isobe T., Yamakido M., Kato T., Miyazaki H. The relationship between carboplatin AUC and serum thrombopoietin kinetics in patients with lung cancer. Anticancer Research 1999, 19:667-670.
    • (1999) Anticancer Research , vol.19 , pp. 667-670
    • Miyazaki, M.1    Fujiwara, Y.2    Isobe, T.3    Yamakido, M.4    Kato, T.5    Miyazaki, H.6
  • 47
    • 3242683136 scopus 로고    scopus 로고
    • A mathematical model of haematopoiesis as exemplified by CD34 cell mobilization into the peripheral blood
    • Obeyesekere M.N., Berry R.W., Spicer P.P., Korbling M. A mathematical model of haematopoiesis as exemplified by CD34 cell mobilization into the peripheral blood. Cell Proliferation 2004, 37:279-294.
    • (2004) Cell Proliferation , vol.37 , pp. 279-294
    • Obeyesekere, M.N.1    Berry, R.W.2    Spicer, P.P.3    Korbling, M.4
  • 50
    • 40149102666 scopus 로고    scopus 로고
    • German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL). Dose-escalated CHOEP for the treatment of young patients with aggressive non-Hodgkin's lymphoma: II. Results of the randomized high-CHOEP trial of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL). Annals of Oncology
    • Pfreundschuh, M., Zwick, C., Zeynalova, S., Duehrsen, U., Pflueger, K.H., Vrieling, T., Mesters, R., Mergenthaler, H.G., Einsele, H., Bentz, M., Lengfelder, E., Truemper, L., Ruebe, C., Schmitz, N., Loeffler, M., German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL) (2008). Dose-escalated CHOEP for the treatment of young patients with aggressive non-Hodgkin's lymphoma: II. Results of the randomized high-CHOEP trial of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL). Annals of Oncology 19 (3), 545-552.
    • (2008) , vol.19 , Issue.3 , pp. 545-552
    • Pfreundschuh, M.1    Zwick, C.2    Zeynalova, S.3    Duehrsen, U.4    Pflueger, K.H.5    Vrieling, T.6    Mesters, R.7    Mergenthaler, H.G.8    Einsele, H.9    Bentz, M.10    Lengfelder, E.11    Truemper, L.12    Ruebe, C.13    Schmitz, N.14    Loeffler, M.15
  • 51
    • 0034699773 scopus 로고    scopus 로고
    • Regulation of platelet production: the normal response to perturbation and cyclical platelet disease
    • Santillan M., Mahaffy J.M., Belair J., Mackey M.C. Regulation of platelet production: the normal response to perturbation and cyclical platelet disease. Journal of Theoretical Biology 2000, 206(4):585-603.
    • (2000) Journal of Theoretical Biology , vol.206 , Issue.4 , pp. 585-603
    • Santillan, M.1    Mahaffy, J.M.2    Belair, J.3    Mackey, M.C.4
  • 53
  • 54
    • 17444368098 scopus 로고    scopus 로고
    • Modelling human granulopoiesis under polychemotheraphy with G-CSF support
    • Scholz M., Engel C., Loeffler M. Modelling human granulopoiesis under polychemotheraphy with G-CSF support. Journal of Mathematical Biology 2005, 50(4):397-493.
    • (2005) Journal of Mathematical Biology , vol.50 , Issue.4 , pp. 397-493
    • Scholz, M.1    Engel, C.2    Loeffler, M.3
  • 55
    • 33644906922 scopus 로고    scopus 로고
    • Model-based design of chemotherapeutic regimens that account for heterogeneity in leucopoenia
    • Scholz M., Engel C., Loeffler M. Model-based design of chemotherapeutic regimens that account for heterogeneity in leucopoenia. British Journal of Haematology 2006, 132:723-735.
    • (2006) British Journal of Haematology , vol.132 , pp. 723-735
    • Scholz, M.1    Engel, C.2    Loeffler, M.3
  • 56
    • 70350482446 scopus 로고    scopus 로고
    • Pharmacokinetic and Pharmacodynamic modelling of the novel human G-CSF derivative Maxy-G34 and Pegfilgrastim in the rat. Cell Proliferation, in press.
    • Scholz, M., Engel, C., Apt, D., Sankar, S.L., Goldstein, E., Loeffler, M., 2009. Pharmacokinetic and Pharmacodynamic modelling of the novel human G-CSF derivative Maxy-G34 and Pegfilgrastim in the rat. Cell Proliferation, in press.
    • (2009)
    • Scholz, M.1    Engel, C.2    Apt, D.3    Sankar, S.L.4    Goldstein, E.5    Loeffler, M.6
  • 57
    • 0036753566 scopus 로고    scopus 로고
    • The effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on platelet recovery in breast cancer patients undergoing autologous bone marrow transplantation
    • Schuster M.W., Beveridge R., Frei-Lahr D., Abboud C.N., Cruickshank S., Macri M., Menchaca D., Holden J., Waller E.K. The effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on platelet recovery in breast cancer patients undergoing autologous bone marrow transplantation. Experimental Hematology 2002, 30:1044-1050.
    • (2002) Experimental Hematology , vol.30 , pp. 1044-1050
    • Schuster, M.W.1    Beveridge, R.2    Frei-Lahr, D.3    Abboud, C.N.4    Cruickshank, S.5    Macri, M.6    Menchaca, D.7    Holden, J.8    Waller, E.K.9
  • 58
    • 0013445810 scopus 로고
    • Evolution strategies: a family of nonlinear optimization techniques based on imitating some principles of organic evolution
    • Schwefel H.P. Evolution strategies: a family of nonlinear optimization techniques based on imitating some principles of organic evolution. Annals of Operations Research 1984, 1:65-167.
    • (1984) Annals of Operations Research , vol.1 , pp. 65-167
    • Schwefel, H.P.1
  • 60
    • 0022716145 scopus 로고
    • Mathematical model study of megakaryocytopoiesis. 1. The simulation model, cell steady-state distribution and the number of divisions in a proliferating population
    • Selivanov V.A., Lanin V.N. Mathematical model study of megakaryocytopoiesis. 1. The simulation model, cell steady-state distribution and the number of divisions in a proliferating population. Ontogenez 1986, 17:270-277.
    • (1986) Ontogenez , vol.17 , pp. 270-277
    • Selivanov, V.A.1    Lanin, V.N.2
  • 61
    • 0028793717 scopus 로고
    • High-dose CHOP as initial therapy for patients with poor prognosis aggressive non-Hodgkin's lymphoma: a dose-finding pilot study
    • Shipp M.A., Neuberg D., Janicek M., Canellos G.P., Shulman L.N. High-dose CHOP as initial therapy for patients with poor prognosis aggressive non-Hodgkin's lymphoma: a dose-finding pilot study. Journal of Clinical Oncology 1995, 13:2916-2923.
    • (1995) Journal of Clinical Oncology , vol.13 , pp. 2916-2923
    • Shipp, M.A.1    Neuberg, D.2    Janicek, M.3    Canellos, G.P.4    Shulman, L.N.5
  • 63
    • 0021320445 scopus 로고
    • Etoposide: a semisynthetic epipodophyllotoxin. Chemistry, pharmacology, pharmacokinetics, adverse effects and use as an antineoplastic agent
    • Sinkule J.A. Etoposide: a semisynthetic epipodophyllotoxin. Chemistry, pharmacology, pharmacokinetics, adverse effects and use as an antineoplastic agent. Pharmacotherapy 1984, 4(2):61-73.
    • (1984) Pharmacotherapy , vol.4 , Issue.2 , pp. 61-73
    • Sinkule, J.A.1
  • 65
    • 0030970642 scopus 로고    scopus 로고
    • Metabolism of thrombopoietin (TPO) in vivo: determination of the binding dynamics for TPO in mice
    • Stefanich E., Senn T., Widmer R., Fratino C., Keller G.A., Fielder P.J. Metabolism of thrombopoietin (TPO) in vivo: determination of the binding dynamics for TPO in mice. Blood 1997, 89(11):4063-4070.
    • (1997) Blood , vol.89 , Issue.11 , pp. 4063-4070
    • Stefanich, E.1    Senn, T.2    Widmer, R.3    Fratino, C.4    Keller, G.A.5    Fielder, P.J.6
  • 66
    • 0024530858 scopus 로고
    • Mechanisms of platelet production
    • Stenberg P.E., Levin J. Mechanisms of platelet production. Blood Cells 1989, 15:23-47.
    • (1989) Blood Cells , vol.15 , pp. 23-47
    • Stenberg, P.E.1    Levin, J.2
  • 67
    • 0021467172 scopus 로고
    • Kinetics and distribution of platelets in man
    • Tsan M.F. Kinetics and distribution of platelets in man. American Journal of Hematology 1984, 17(1):97-104.
    • (1984) American Journal of Hematology , vol.17 , Issue.1 , pp. 97-104
    • Tsan, M.F.1
  • 70
    • 0033360884 scopus 로고    scopus 로고
    • The influence of automated plateletpheresis on systemic levels of hematopoietic growth factors
    • Weisbach V., Friedlein H., Glaser A., Zingsem J., Zimmermann R., Eckstein R. The influence of automated plateletpheresis on systemic levels of hematopoietic growth factors. Transfusion 1999, 39:889-894.
    • (1999) Transfusion , vol.39 , pp. 889-894
    • Weisbach, V.1    Friedlein, H.2    Glaser, A.3    Zingsem, J.4    Zimmermann, R.5    Eckstein, R.6
  • 73
    • 0038350303 scopus 로고    scopus 로고
    • Practicability and acute haematological toxicity of 2- and 3-weekly CHOP and CHOEP chemotherapy for aggressive non-Hodgkin's lymphoma: results from the NHL-B trial of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL)
    • Wunderlich A., Kloess M., Reiser M., Rudolph C., Truemper L., Bittner S., Schmalenberg H., Schmits R., Pfreundschuh M., Loeffler M. Practicability and acute haematological toxicity of 2- and 3-weekly CHOP and CHOEP chemotherapy for aggressive non-Hodgkin's lymphoma: results from the NHL-B trial of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL). Annals of Oncology 2003, 14:881-893.
    • (2003) Annals of Oncology , vol.14 , pp. 881-893
    • Wunderlich, A.1    Kloess, M.2    Reiser, M.3    Rudolph, C.4    Truemper, L.5    Bittner, S.6    Schmalenberg, H.7    Schmits, R.8    Pfreundschuh, M.9    Loeffler, M.10
  • 74
    • 41549124023 scopus 로고    scopus 로고
    • Prognostic factors for hematotoxicity of chemotherapy in aggressive non-Hodgkin's lymphoma
    • Ziepert M., Schmits R., Truemper L., Pfreundschuh M., Loeffler M. Prognostic factors for hematotoxicity of chemotherapy in aggressive non-Hodgkin's lymphoma. Annals of Oncology 2008, 19(4):752-762.
    • (2008) Annals of Oncology , vol.19 , Issue.4 , pp. 752-762
    • Ziepert, M.1    Schmits, R.2    Truemper, L.3    Pfreundschuh, M.4    Loeffler, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.