Reversibility of the effects of the chemotherapeutic regimen for non-Hodgkin lymphoma, cyclophosphamide, doxorubicin, vincristine, and prednisone, on the male rat reproductive system and progeny outcome

Reproductive Toxicology

Volumn 29, Issue 3, 2010, Pages 332-338

  Delbès, Geraldine ^a   Vaisheva, Farida ^a   Luu, Trang ^a   Marcon, Ludovic ^a   Hales, Barbara F ^a   Robaire, Bernard ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

DNA damage; Male reproductive toxicity; Spermatozoa

Indexed keywords

CYCLOPHOSPHAMIDE; DNA; DOXORUBICIN; PREDNISONE; VINCRISTINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; DRUG EXPOSURE; EPIDIDYMIS; FEMALE; GERM CELL; HISTOLOGY; MALE; MALE GENITAL SYSTEM; MULTIPLE CYCLE TREATMENT; NIDATION; NONHODGKIN LYMPHOMA; NONHUMAN; PREGNANCY OUTCOME; PROGENY; RAT; REPRODUCTIVE TOXICITY; SPERMATOZOON COUNT; TESTIS WEIGHT;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CLINICAL PROTOCOLS; CYCLOPHOSPHAMIDE; DOXORUBICIN; EPIDIDYMIS; FEMALE; HUMANS; LITTER SIZE; LYMPHOMA, NON-HODGKIN; MALE; PREDNISONE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCTION; SPERM COUNT; SPERMATOZOA; TESTIS; TREATMENT OUTCOME; VINCRISTINE;

RATTUS;

EID: 77951620505     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2010.01.007     Document Type: Article

References (33)

1. Horner MJ, Ries LAG, Krapcho M, Neyman N, Aminou R, Howlader N, et al. SEER Cancer Statistics Review, 1975-2006. In: Edwards BK (ed.). National Cancer Institute, Bethesda, MD, 2008.
2. Elias L., Portlock C.S., Rosenberg S.A. Combination chemotherapy of diffuse histiocytic lymphoma with cyclophosphamide, adriamycin, vincristine and prednisone (CHOP). Cancer 1978, 42:1705-1710.
3. Bernard M., Cartron G., Rachieru P., LeMevel A., Branger B., Le Maignan C., et al. Long-term outcome of localized high-grade non-Hodgkin's lymphoma treated with high dose CHOP regimen and involved field radiotherapy: results of a GOELAMS study. Haematologica 2005, 90:802-809.
4. Gregory S.A., Trumper L. Chemotherapy dose intensity in non-Hodgkin's lymphoma: is dose intensity an emerging paradigm for better outcomes?. Ann Oncol 2005, 16:1413-1424.
5. Meistrich M.L. Male gonadal toxicity. Pediatr Blood Cancer 2009, 53:261-266.
6. Howell S.J., Shalet S.M. Spermatogenesis after cancer treatment: damage and recovery. J Natl Cancer Inst Monogr 2005, 12-17.
7. Van Thiel D.H., Sherins R.J., Myers G.H., De V.V. Evidence for a specific seminiferous tubular factor affecting follicle-stimulating hormone secretion in man. J Clin Invest 1972, 51:1009-1019.
8. Shetty G., Meistrich M.L. Hormonal approaches to preservation and restoration of male fertility after cancer treatment. J Natl Cancer Inst Monogr 2005, 36-39.
9. Hales B.F., Barton T.S., Robaire B. Impact of paternal exposure to chemotherapy on offspring in the rat. J Natl Cancer Inst Monogr 2005, 28-31.
10. O'Flaherty C., Vaisheva F., Hales B.F., Chan P., Robaire B. Characterization of sperm chromatin quality in testicular cancer and Hodgkin's lymphoma patients prior to chemotherapy. Hum Reprod 2008, 23:1044-1052.
11. Codrington A.M., Hales B.F., Robaire B. Exposure of male rats to cyclophosphamide alters the chromatin structure and basic proteome in spermatozoa. Hum Reprod 2007, 22:1431-1442.
12. Delbes G., Hales B.F., Robaire B. Effects of the chemotherapy cocktail used to treat testicular cancer on sperm chromatin integrity. J Androl 2007, 28:241-249.
13. Adachi T, Nishimura T, Imahie H, Yamamura T. Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats 9). Testicular toxicity in male rats given adriamycin for two or four weeks. J Toxicol Sci 2000;25 Spec No:95-101.
14. Dobrzynska M.M., Czajka U., Slowikowska M.G. Reproductive effects after exposure of male mice to vincristine and to a combination of X-rays and vincristine. Reprod Fertil Dev 2005, 17:759-767.
15. Hacker-Klom U.B., Meistrich M.L., Gohde W. Effect of doxorubicin and 4′-epi-doxorubicin on mouse spermatogenesis. Mutat Res 1986, 160:39-46.
16. Kato M., Makino S., Kimura H., Ota T., Furuhashi T., Nagamura Y. Sperm motion analysis in rats treated with adriamycin and its applicability to male reproductive toxicity studies. J Toxicol Sci 2001, 26:51-59.
17. Stanley A., Akbarsha M.A. Ultrastructural changes in the Leydig cell on treatment with vincristine. Cytobios 1994, 79:51-58.
18. Vaisheva F., Delbes G., Hales B.F., Robaire B. Effects of the chemotherapeutic agents for non-Hodgkin lymphoma, cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), on the male rat reproductive system and progeny outcome. J Androl 2007, 28:578-587.
19. Bieber A.M., Marcon L., Hales B.F., Robaire B. Effects of chemotherapeutic agents for testicular cancer on the male rat reproductive system, spermatozoa, and fertility. J Androl 2006, 27:189-200.
20. Delbes G., Chan D., Pakarinen P., Trasler J.M., Hales B.F., Robaire B. Impact of the chemotherapy cocktail used to treat testicular cancer on the gene expression profile of germ cells from male Brown-Norway rats. Biol Reprod 2009, 80:320-327.
21. Marcon L., Hales B.F., Robaire B. Reversibility of the effects of subchronic exposure to cancer chemotherapeutics, bleomycin, etoposide and cisplatin (BEP), on spermatogenesis, fertility and progeny outcome in the male rat. J Androl 2008, 29:408-417.
22. Robb G.W., Amann R.P., Killian G.J. Daily sperm production and epididymal sperm reserves of pubertal and adult rats. J Reprod Fertil 1978, 54:103-107.
23. Kirk K.M., Lyon M.F. Induction of congenital malformations in the offspring of male mice treated with X-rays at pre-meiotic and post-meiotic stages. Mutat Res 1984, 125:75-85.
24. Pryzant R.M., Meistrich M.L., Wilson G., Brown B., McLaughlin P. Long-term reduction in sperm count after chemotherapy with and without radiation therapy for non-Hodgkin's lymphomas. J Clin Oncol 1993, 11:239-247.
25. Bokemeyer C., Schmoll H.J., van Rhee J., Kuczyk M., Schuppert F., Poliwoda H. Long-term gonadal toxicity after therapy for Hodgkin's and non-Hodgkin's lymphoma. Ann Hematol 1994, 68:105-110.
26. Kaur F., Sangha G.K., Bilaspuri G.S. Cyclophosphamide-induced structural and biochemical changes in testis and epididymidis of rats. Indian J Exp Biol 1997, 35:771-775.
27. Trasler J.M., Robaire B. Effects of cyclophosphamide on selected cytosolic and mitochondrial enzymes in the epididymis of the rat. J Androl 1988, 9:142-152.
28. Trasler J.M., Hermo L., Robaire B. Morphological changes in the testis and epididymis of rats treated with cyclophosphamide: a quantitative approach. Biol Reprod 1988, 38:463-479.
29. Meistrich M.L. Potential genetic risks of using semen collected during chemotherapy. Hum Reprod 1993, 8:8-10.
30. O'Flaherty C, Hales BF, Chan P, Robaire B. Impact of chemotherapeutics and advanced testicular cancer or Hodgkin lymphoma on sperm deoxyribonucleic acid integrity. Fertil Steril July 8, 2009 [Epub ahead of print] PMID: 19591994 [PubMed].
31. Sabanegh E.S., Ragheb A.M. Male fertility after cancer. Urology 2009, 73:225-231.
32. Aitken R.J., De Iuliis G.N., McLachlan R.I. Biological and clinical significance of DNA damage in the male germ line. Int J Androl 2009, 32:46-56.
33. Lin M.H., Kuo-Kuang L.R., Li S.H., Lu C.H., Sun F.J., Hwu Y.M. Sperm chromatin structure assay parameters are not related to fertilization rates, embryo quality, and pregnancy rates in in vitro fertilization and intracytoplasmic sperm injection, but might be related to spontaneous abortion rates. Fertil Steril 2008, 90:352-359.