Impact of the chemotherapy cocktail used to treat testicular cancer on the gene expression profile of germ cells from male brown-norway rats

Biology of Reproduction

Volumn 80, Issue 2, 2009, Pages 320-327

  Delbès, Geraldine ^a   Chan, Donovan ^a   Pakarinen, Pirjo ^e   Trasler, Jacquetta M ^a,b,c   Hales, Barbara F ^a   Robaire, Bernard ^a,d,f  

^a Pharmacology and Therapeutics   (Canada)

^b Pediatrics   (Canada)

^c Departments of Human Genetics   (Canada)

^d RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^e UNIVERSITY OF TURKU   (Finland)

^f MCGILL UNIVERSITY   (Canada)

Author keywords

Chemotherapy; Gene expression; Gene regulation; Jun protooncogene; Round spermatids; Spermatogenesis; Testicular cancer; Toxicology

Indexed keywords

BLEOMYCIN; CISPLATIN; ETOPOSIDE; MESSENGER RNA; TRANSCRIPTION FACTOR JUNB;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN NORWAY RAT; CANCER CHEMOTHERAPY; CELL SURVIVAL; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; GENE EXPRESSION PROFILING; GERM CELL; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SPERMATID; SPERMATOGENESIS; SPERMATOZOON COUNT; TESTIS CANCER;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BLEOMYCIN; CISPLATIN; CLUSTER ANALYSIS; ETOPOSIDE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REGULATORY NETWORKS; GERM CELLS; MALE; NEOPLASMS, GERM CELL AND EMBRYONAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, INBRED BN; SPERMATIDS; SPERMATOGENESIS; TESTICULAR NEOPLASMS; UROGENITAL SYSTEM;

RATTUS NORVEGICUS;

EID: 59949089765     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.108.072108     Document Type: Article

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