Synthesis and binding properties of novel selective 5-HT3 receptor ligands

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 14, 2004, Pages 3891-3901

  Modica, Maria ^a   Romeo, Giuseppe ^a   Materia, Luisa ^a   Russo, Filippo ^a   Cagnotto, Alfredo ^b   Mennini, Tiziana ^b   Gáspár, Róbert ^c   Falkay, George ^c   Fülöp, Ferenc ^d  

^a UNIVERSITY OF CATANIA   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^c UNIVERSITY OF SZEGED   (Hungary)

^d UNIVERSITY OF SZEGED   (Hungary)

Author keywords

5 HT3 receptor; Ligands; Thieno 2,3 d pyrimidine derivatives

Indexed keywords

2 METHYLTHIO 4 (1 PIPERAZINYL) 6,7 DIHYDRO 5H CYCLOPENTA[4,5]THIENO[2,3 D]PYRIMIDINE; 2 METHYLTHIO 4 (4 PHENYL 1 PIPERAZINYL) 6,7 DIHYDRO 5H CYCLOPENTA[4,5]THIENO[2,3 D]PYRIMIDINE; 2 METHYLTHIO 4 [4 (1 PHENYLMETHYL) 1 PIPERAZINYL] 6,7 DIHYDRO 5H CYCLOPENTA[4,5]THIENO[2,3 D]PYRIMIDINE; 2 METHYLTHIO 4 [4 (2 PYRIMIDYL) 1 PIPERAZINYL] 6,7 DIHYDRO 5H CYCLOPENTA[4,5]THIENO[2,3 D]PYRIMIDINE; 4 (4 METHYL 1 PIPERAZINYL) 2 METHYLTHIO 6,7 DIHYDRO 5H CYCLOPENTA[4,5]THIENO[2,3 D]PYRIMIDINE; 4 (4 METHYL 1 PIPERAZINYL) 6,7 DIHYDRO 5H CYCLOPENTA[4,5]THIENO[2,3 D]PYRIMIDINE; 4 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 METHYLTHIO 6,7 DIHYDRO 5H CYCLOPENTA[4,5]THIENO[2,3 D]PYRIMIDINE; 5,6 DIMETHYL 2 METHYLTHIO 4 (1 PIPERAZINYL)THIENO[2,3 D]PYRIMIDINE; 5,6 DIMETHYL 2 METHYLTHIO 4 (4 PHENYL 1 PIPERAZINYL)THIENO[2,3 D]PYRIMIDINE; 5,6 DIMETHYL 2 METHYLTHIO 4 [4 (1 PHENYLMETHYL) 1 PIPERAZINYL]THIENO[2,3 D]PYRIMIDINE; 5,6 DIMETHYL 2 METHYLTHIO 4 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]THIENO[2,3 D]PYRIMIDINE; 5,6 DIMETHYL 2 METHYLTHIO 4 [4 (2 PYRIMIDYL) 1 PIPERAZINYL]THIENO[2,3 D]PYRIMIDINE; 5,6 DIMETHYL 4 (4 METHYL 1 PIPERAZINYL) 2 METHYLTHIOTHIENO[2,3 D]PYRIMIDINE; 5,6 DIMETHYL 4 (4 METHYL 1 PIPERAZINYL)THIENO[2,3 D]PYRIMIDINE; ETHYL 2 METHYLTHIO 4 (1 PIPERAZINYL) 5,6,7,8 TETRAHYDRO[1]BENZOTHIENO[2,3 D]PYRIMIDINE 5 CARBOXYLATE; ETHYL 2 METHYLTHIO 4 (1 PIPERAZINYL) 6,7 DIHYDRO 5H CYCLOPENTA[4,5]THIENO[2,3 D]PYRIMIDINE 5 CARBOXYLATE; ETHYL 2 METHYLTHIO 4 (4 PHENYL 1 PIPERAZINYL) 5,6,7,8 TETRAHYDRO[1]BENZOTHIENO[2,3 D]PYRIMIDINE 5 CARBOXYLATE; ETHYL 2 METHYLTHIO 4 (4 PHENYL 1 PIPERAZINYL) 6,7 DIHYDRO 5H CYCLOPENTA[4,5]THIENO[2,3 D]PYRIMIDINE 5 CARBOXYLATE; ETHYL 2 METHYLTHIO 4 [4 (1 PHENYLMETHYL) 1 PIPERAZINYL] 5,6,7,8 TETRAHYDRO[1]BENZOTHIENO[2,3 D]PYRIMIDINE 5 CARBOXYLATE; ETHYL 2 METHYLTHIO 4 [4 (1 PHENYLMETHYL) 1 PIPERAZINYL] 6,7 DIHYDRO 5H CYCLOPENTA[4,5]THIENO[2,3 D]PYRIMIDINE 5 CARBOXYLATE; ETHYL 2 METHYLTHIO 4 [4 (2 PYRIMIDYL) 1 PIPERAZINYL] 5,6,7,8 TETRAHYDRO[1]BENZOTHIENO[2,3 D]PYRIMIDINE 5 CARBOXYLATE; ETHYL 2 METHYLTHIO 4 [4 (2 PYRIMIDYL) 1 PIPERAZINYL] 6,7 DIHYDRO 5H CYCLOPENTA[4,5]THIENO[2,3 D]PYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (4 METHYL 1 PIPERAZINYL) 2 METHYLTHIO 5,6,7,8 TETRAHYDRO[1]BENZOTHIENO[2,3 D]PYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (4 METHYL 1 PIPERAZINYL) 2 METHYLTHIO 6,7 DIHYDRO 5H CYCLOPENTA[4,5]THIENO[2,3 D]PYRIMIDINE 5 CARBOXYLATE; ETHYL 4 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 METHYLTHIO 5,6,7,8 TETRAHYDRO[1]BENZOTHIENO[2,3 D]PYRIMIDINE 5 CARBOXYLATE; ETHYL 4 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 METHYLTHIO 6,7 DIHYDRO 5H CYCLOPENTA[4,5]THIENO[2,3 D]PYRIMIDINE 5 CARBOXYLATE; PYRIMIDINE DERIVATIVE; SEROTONIN 3 RECEPTOR; SEROTONIN 4 RECEPTOR; SEROTONIN AGONIST; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GUINEA PIG; MALE; NONHUMAN; RAT;

ANIMALS; GUINEA PIGS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PROTEIN BINDING; RATS; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN AGENTS; SPECTROPHOTOMETRY, INFRARED;

EID: 2942729587     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.04.043     Document Type: Article

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