Protective effect of bilberry (Vaccinium myrtillus L.) extracts on cultured Human Corneal Limbal Epithelial Cells (HCLEC)

Phytotherapy Research

Volumn 24, Issue 4, 2010, Pages 520-524

  Song, Juxian ^a   Li, Yiqing ^b   Ge, Jian ^b   Duan, Yongheng ^b   Sze, Stephen Cho Wing ^a   Tong, Yao ^a   Shaw, Pang Chui ^c   Ng, Tzi Bun ^c   Tsui, Kam Chuen ^d   Zhuo, Yehong ^b   Zhang, Kalin Yanbo ^a  

^a THE UNIVERSITY OF HONG KONG   (Hong Kong)

^b SUN YAT SEN UNIVERSITY   (China)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^d Oriental International Health Products Co Ltd   (Hong Kong)

Author keywords

Cell cycle; Cell viability; Glycosaminoglycans; Hyaluronic acid; Vaccinium myrtillus L.

Indexed keywords

GLYCOSAMINOGLYCAN; HYALURONIC ACID; VACCINIUM MYRTILLUS EXTRACT;

ARTICLE; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFECT; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; VACCINIUM MYRTILLUS;

ANTHOCYANINS; CELL CYCLE; CELL LINE; CELL PROLIFERATION; DRUG EVALUATION, PRECLINICAL; EPITHELIAL CELLS; GLYCOSAMINOGLYCANS; HUMANS; HYALURONIC ACID; LIMBUS CORNEAE; PLANT EXTRACTS; VACCINIUM MYRTILLUS;

VACCINIUM MYRTILLUS;

EID: 77951590163     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2974     Document Type: Article

References (43)

1. Bagchi D, Sen CK, Bagchi M, Atalay M. 2004. Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula. Biochemistry (Mosc) 69: 75-80.
2. Baj A, Bombardelli E, Gabetta B, Martinelli EM. 1983. Qualitative and quantitative evaluation of Vaccinium myrtillus anthocyanins by high-resolution gas chromatography and high-performance liquid chromatography. J Chromatogr A 279: 365-372.
3. Cai C, Ching A, Lagace C, Linsenmayer T. 2008. Nuclear ferritin-mediated protection of corneal epithelial cells from oxidative damage to DNA. Dev Dyn 237: 2676-2683.
4. Canter PH, Ernst E. 2004. Anthocyanosides of Vaccinium myrtillus (bilberry) for night vision - a systematic review of placebo-controlled trials. Surv Ophthalmol 49: 38-50. (Pubitemid 38056623)
5. Cao G, Muccitelli HU, Sanchez-Moreno C, Prior RL. 2001. Anthocyanins are absorbed in glycated forms in elderly women: a pharmacokinetic study. Am J Clin Nutr 73: 920-926. (Pubitemid 32405989)
6. Capo-Aponte JE, Wang Z, Akinci MA et al. 2007. Potassiumchloride cotransporter mediates cell cycle progression and proliferation of human corneal epithelial cells. Cell Cycle 6: 2709-2718. (Pubitemid 350224056)
7. Cazarolli LH, Zanatta L, Alberton EH et al. 2008. Flavonoids: prospective drug candidates. Mini Rev Med Chem 8: 1429-1440.
8. Durchschlag H, Fochler C, Abraham K, Kulawik B. 1999. Radiation effects on eye components. Radiat Phys Chem 55: 691-697.
9. Faria A, Oliveira J, Neves P et al. 2005. Antioxidant properties of prepared blueberry (Vaccinium myrtillus) extracts. J Agric Food Chem 53: 6896-6902. (Pubitemid 41263334)
10. Fitzsimmons TD, Molander N, Stenevi U, Fagerholm P, Schenholm M, von Malmborg A. 1994. Endogenous hyaluronan in corneal disease. Invest Ophthalmol Vis Sci 35: 2774-2782.
11. Fursova A, Gesarevich OG, Gonchar AM, Trofimova NA, Kolosova NG. 2005. Dietary supplementation with bilberry extract prevents macular degeneration and cataracts in senescence-accelerated OXYS rats. Adv Gerontol 16: 76-79.
12. Harfstrand A, Molander N, Stenevi U, Apple D, Schenholm M, Madsen K. 1992. Evidence of hyaluronic acid and hyaluronic acid binding sites on human corneal endothelium. J Cataract Refract Surg 18: 265-269. (Pubitemid 23230101)
13. Jang YP, Zhou J, Nakanishi K, Sparrow JR. 2005. Anthocyanins protect against A2E photooxidation and membrane permeabilization in retinal pigment epithelial cells. Photochem Photobiol 81: 529-536. (Pubitemid 40901324)
14. Kalea AZ, Lamari FN, Theocharis AD et al. 2006. Wild blueberry (Vaccinium angustifolium) consumption affects the composition and structure of glycosaminoglycans in Sprague-Dawley rat aorta. J Nutr Biochem 17: 109-116.
15. Knudson CB, Knudson W. 1993. Hyaluronan-binding proteins in development, tissue homeostasis, and disease. FASEB J 7: 1233-1241. (Pubitemid 23314358)
16. Kowalczyk E, Krzesinski P, Kura M, Szmigiel B, Blaszczyk J. 2003. Anthocyanins in medicine. Pol J Pharmacol 55: 699-702.
17. Laplaud PM, Lelubre A, Chapman MJ. 1997. Antioxidant action of Vaccinium myrtillus extract on human low density lipoproteins in vitro: initial observations. Fundam Clin Pharmacol 11: 35-40. (Pubitemid 27060239)
18. Larrosa M, Lodovici M, Morbidelli L, Dolara P. 2008. Hydrocaffeic and p-coumaric acids, natural phenolic compounds, inhibit UV-B damage in WKD human conjunctival cells in vitro and rabbit eye in vivo. Free Radic Res 42: 903-910.
19. Liu J, Song G, Wang Z et al. 2007. Establishment of a corneal epithelial cell line spontaneously derived from human limbal cells. Exp Eye Res 84: 599-609. (Pubitemid 46204700)
20. Lodovici M, Raimondi L, Guglielmi F, Gemignani S, Dolara P. 2003. Protection against ultraviolet B-induced oxidative DNA damage in rabbit corneal-derived cells (SIRC) by 4-coumaric acid. Toxicology 184: 141-147. (Pubitemid 36009296)
21. Lyu J, Joo CK. 2005. Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing. J Biol Chem 280: 21653-21660. (Pubitemid 40805735)
22. Maher P, Hanneken A. 2005. Flavonoids protect retinal ganglion cells from oxidative stress-induced death. Invest Ophthalmol Vis Sci 46: 4796-4803. (Pubitemid 44264586)
23. Matsumoto H, Nakamura Y, Tachibanaki S, Kawamura S, Hirayama M. 2003. Stimulatory effect of cyanidin 3-glycosides on the regeneration of rhodopsin. J Agric Food Chem 51: 3560-3563.
24. Milbury PE, Graf B, Curran-Celentano JM, Blumberg JB. 2007. Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in ARPE-19 cells. Invest Ophthalmol Vis Sci 48: 2343-2349. (Pubitemid 351261315)
25. Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63. (Pubitemid 14203433)
26. Nagai N, Murao T, Ito Y, Okamoto N, Sasaki M. 2009. Enhancing effects of sericin on corneal wound healing in rat debrided corneal epithelium. Biol Pharm Bull 32: 933-936.
27. Nakamura M, Sato N, Chikama TI, Hasegawa Y, Nishida T. 1997. Hyaluronan facilitates corneal epithelial wound healing in diabetic rats. Exp Eye Res 64: 1043-1050. (Pubitemid 27314780)
28. Oya T, Obata H, Miyata K, Tsuru T, Sawa M, Miyauchi S. 1994. Quantitative analysis of glycosaminoglycans in tear fluids during corneal epithelial wound healing in rabbits. Nippon Ganka Gakkai Zasshi 98: 1049-1055. (Pubitemid 24353772)
29. Pauloin T, Dutot M, Joly F, Warnet JM, Rat P. 2009. High molecular weight hyaluronan decreases UVB-induced apoptosis and inflammation in human epithelial corneal cells. Mol Vis 15: 577-583.
30. Paulsen K, Maile S, Giebel J, Tost FH. 2008. Lubricating agents differ in their protection of cultured human epithelial cells against desiccation. Med Sci Monit 14: PI12-PI16. (Pubitemid 351929698)
31. Price RD, Berry MG, Navsaria HA. 2007. Hyaluronic acid: the scientific and clinical evidence. J Plast Reconstr Aesthet Surg 60: 1110-1119. (Pubitemid 47342381)
32. Rahman MM, Ichiyanagi T, Komiyama T, Hatano Y, Konishi T. 2006. Superoxide radical- and peroxynitrite-scavenging activity of anthocyanins; structure-activity relationship and their synergism. Free Radic Res 40: 993-1002. (Pubitemid 44480564)
33. Roy S, Khanna S, Alessio HM et al. 2002. Anti-angiogenic property of edible berries. Free Radic Res 36: 1023-1031.
34. Saika S, Shiraishi A, Liu CY et al. 2000. Role of lumican in the corneal epithelium during wound healing. J Biol Chem 275: 2607-2612. (Pubitemid 30082027)
35. Schwager-Hubner ME, Gnadinger MC. 1976. Synthesis of sulfated glycosaminoglycans by the three cell types of the rabbit cornea in culture. Experientia 32: 15-16.
36. Sparrow JR, Vollmer-Snarr HR, Zhou J et al. 2003. A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation. J Biol Chem 278: 18207-18213. (Pubitemid 36799437)
37. Swann DA, Constable IJ. 1972. Vitreous structure. I. Distribution of hyaluronate and protein. Invest Ophthalmol 11: 159-163.
38. Thompson HW, Malter JS, Steinemann TL, Beuerman RW. 1991. Flow cytometry measurements of the DNA content of corneal epithelial cells during wound healing. Invest Ophthalmol Vis Sci 32: 433-436.
39. Valentov K, Ulrichov J, Cvak L, Simanek V. 2007. Cytoprotective effect of a bilberry extract against oxidative damage of rat hepatocytes. Food Chem 101: 912-917.
40. Wu X, Pittman HE, 3rd, Prior RL. 2006. Fate of anthocyanins and antioxidant capacity in contents of the gastrointestinal tract of weanling pigs following black raspberry consumption. J Agric Food Chem 54: 583-589. (Pubitemid 43301282)
41. Yao Y, Vieira A. 2007. Protective activities of Vaccinium antioxidants with potential relevance to mitochondrial dysfunction and neurotoxicity. Neurotoxicology 28: 93-100. (Pubitemid 46201950)
42. Youdim KA, Shukitt-Hale B, MacKinnon S, Kalt W, Joseph JA. 2000. Polyphenolics enhance red blood cell resistance to oxidative stress: in vitro and in vivo. Biochim Biophys Acta 1523: 117-122.
43. Zagon IS, Sassani JW, Ruth TB, McLaughlin PJ. 2000. Cellular dynamics of corneal wound re-epithelialization in the rat. III. Mitotic activity. Brain Res 882: 169-179.