VEGF in the muscular layer of placental blood vessels: Immuno-expression in preeclampsia and intrauterine growth restrictrion and its association with the antioxidant status

Cardiovascular and Hematological Agents in Medicinal Chemistry

Volumn 8, Issue 2, 2010, Pages 87-95

  Bosco, C ^a   Buffet, C ^a   Diaz E ^a   Rodrigo, R ^a   Morales, P ^a   Barja, P ^a   Terra, R ^b   Parra Cordero, M ^b  

^a UNIVERSITY OF CHILE   (Chile)

^b HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE   (Chile)

Author keywords

IUGR; Placenta; Preeclampsia; Sflt 1; sFlt1 14; Trophoblast; VEGF

Indexed keywords

CATALASE; FIBROBLAST GROWTH FACTOR RECEPTOR 1; GLUTATHIONE PEROXIDASE; ISOPROSTANE DERIVATIVE; MALONALDEHYDE; PLACENTAL GROWTH FACTOR; SUPEROXIDE DISMUTASE; VASCULOTROPIN;

ADULT; ANALYTIC METHOD; ARTICLE; BLOOD LEVEL; BLOOD VESSEL; CHORION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FERRIC REDUCING ABILITY OF PLASMA ASSAY; FETUS; HUMAN; HUMAN TISSUE; INTRAUTERINE GROWTH RETARDATION; LIPID PEROXIDATION; MATERNAL PLASMA; OXIDATIVE STRESS; PLACENTA BLOOD VESSEL; PREECLAMPSIA; REDUCTION;

ANTIOXIDANTS; BLOOD VESSELS; FEMALE; FETAL GROWTH RETARDATION; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT, NEWBORN; IRON; MALONDIALDEHYDE; MUSCLE, SMOOTH, VASCULAR; OXIDATIVE STRESS; PLACENTA DISEASES; PRE-ECLAMPSIA; PREGNANCY; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 77951549436     PISSN: 18715257     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152510791170951     Document Type: Article

References (51)

1. Redman, C.W. Current topic: pre-eclampsia and the placenta. Placenta, 1991, 12(4), 301-308.
2. Scott, J.S. Pregnancy toxaemia associated with hydrops foetalis, hydatidiform mole and hydramnios. J. Obstet. Gynaecol. Br. Empire., 1958, 65(5), 689-701.
3. Hou, H.L.; Wan, X.R.; Xiang, Y.; Qi, Q.W.; Yang, X.Y. Changes of clinical features in hydatidiform mole: analysis of 113 cases. J. Reprod. Med., 2008, 53(8), 629-633.
4. Roberts, J.M.; Lay, K.I. Recent insights into the pathogenesis of pre- eclampsia. Placenta, 2002, 23(5), 359-372.
5. Zhou, Y.; Damsky, C.H.; Chiu, K.; Roberts, J.M.; Fisher, S.J. Preeclampsia is associated with abnormal expression of adhesion molecules by invasive cytotrophoblast. J. Clin. Invest., 1993, 91(3), 950-960. (Pubitemid 23095269)
6. Di Federico, E.; Genbacev, O.; Fisher, S.J. Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall. Am. J. Pathol., 1999, 155(1), 293-301.
7. Many, A.; Hubel, C.A.; Fisher, S.J.; Roberts, J.M.; Zhou, Y. Invasive cytotrophoblasts manifest evidence of oxidative stress in preeclampsia. Am. J. Pathol., 2000, 156(1), 321-331. (Pubitemid 30644466)
8. Bosco, C.; Parra, M.; Barja, P.; Rodrigo, R.; Fernández, V.; Suarez, M.; Muñoz, H. Increased immunohistochemical expression of thrombomodulin at placental perivascular myofibroblast in severe preeclampsia (PE). Histol.Histophatol., 2005, 20(4), 1045-1055. (Pubitemid 41489148)
9. Khalil, R.A.; Granger, J.P. Vascular mechanisms of increased arterial pressure in preeclampsia: lessons from animal models. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2002, 283(1), R29-45.
10. Wathén, K-A.; Tuutti, E.; Stenman, U-H.; Alfthan, H.; Halmesmäki, E.; Finne, P.; Ylikorkala, O.; Vuorela, P. Maternal serumsoluble vascular endothelial growth factor receptor-1 in early pregnancy ending in preeclampsia or intrauterine growth retardation. J. Clin. Endocrinol. Metab., 2006, 91(1), 180-184. (Pubitemid 43069135)
11. Bowen, R.S.; Moodley, J.; Dutton, M.F.; Theron, A.J. Oxidative stress in pre-eclampsia. Acta Obstet. Gynecol. Scand., 2001, 80(8), 719-725.
12. Kharb, S. Vitamin E and C in preeclampsia. Eur. J. Obstet. Gynecol. Reprod. Biol., 2000, 93(1), 37-39.
13. Walsh, S.W.; Vaughan, J.E.; Wang, Y.; Roberts, L.J. Placental isoprostane is significantly increased in preeclampsia. FASEB J., 2000, 14(10), 1289-1296.
14. Zachary, I. Vascular endothelial growth factor. Int. J. Biochem. Cell Biol., 1998, 30(11), 1169-1174.
15. Zachary, I.; Gliki, G. Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiov. Res., 2001, 49(3), 568-581. (Pubitemid 32146420)
16. Lyall, F.; Yong, A.; Boswell, F.; Kingdom, J.C.P.; Greer, I.A. Placental expression of vascular endothelial growth factors in placentae from pregnancies complicated by pre-eclampsia and intrauterine growth restriction does not support placental hypoxia at delivery. Placenta, 1997, 18(4), 269-276.
17. Oh, M.J.; Lee, N.W.; Shin, J.H.; Yeo, M.K.; Kim, A.; Kim, I.S.; Kim, I.J. Vascular endothelial growth factor expression is unaltered in placentae and myometrial resistance arteries from pre-eclampsia patients. Acta. Obstet. Gynecol. Scandinav., 2006, 85(5), 545-550.
18. Sgambati, E.; Marini, M.; Zappoli Thyrion, G.D.; Parretti, E.; Mello, G.; Orlando, C.; Simi, L.; Tricarico, C.; Gheri, G.; Brizzi, E. VEGF expression in the placenta from pregnancies complicated by hypertensive disorders. BJOG., 2004, 111(6), 564-570. (Pubitemid 38746240)
19. Levine, R.J.; Maynard, S.E.; Qian, C.; Lim, K.H.; England, L.J.; Yu, K.F.; Schisterman, E.F.; Thadhani, R.; Sachs, B.P.; Epstein, F.H.; Sibai, B.M.; Sukhatme, V.P.; Karumanchi, S.A. Circulating angiogenic factors and the risk of preeclampsia. N. Engl. J. Med., 2004, 350(7), 672-683. (Pubitemid 38364626)
20. Sela, S.; Itin, A.; Natanson-Yaron, S.; Greenfield, C.; Goldman-Wohl, D.; Yagel, S.; Keshet, E. A novel human specific soluble vascular endothelial growth factor receptor 1. Circulation Res., 2008, 102(12), 1566-1584.
21. Juez, G. Intrauterine growth curve for the appropiate diagnosis of intrauterine growth retardation. Rev. Med. Chil., 1989, 117(11), 1311.
22. Parra, M.; Rodrigo, R.; Barja, P.; Bosco, C.; Fernández, V.; Sepúlveda, E.; Muñoz, H.; Soto-Chacón, E. Screening test for preeclampsia through assessment of uteroplacental blood flow and biochemical markers of oxidative stress and endothelial dysfunction. Am. J. Obstet. Gynecol., 2005, 193(4), 1486-1491. (Pubitemid 41395121)
23. Benzie, I.F.; Strain, J.J. The ferric reducing ability of plasma (FRAP) as measure of "antioxidant power": the FRAP assay. Anal. Biochem., 1996, 239(1), 70-76.
24. Ohkawa, H.; Ohishi, N.; Yagi, K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal.Biochem., 1979, 95(2), 351-358. (Pubitemid 9194347)
25. Pradelles, P.; Grassi, J.; Maclouf, J. Enzyme immunoassay of eicosanoids using AchE as label. An alternative to radioimmunoassay. Anal. Chem., 1985, 57(7), 1170-1173.
26. Rodrigo, R.; Rivera, G.; Orellana, M.; Araya, J.; Bosco, C. Rat kidney antioxidant response to long-term exposure to flavonol rich red wine. Life Sci., 2002, 71(24), 2881-2895.
27. Nebot, C.; Moutet, M.; Huet, P.; Xu, J.Z.; Yadan, J.C.; Chaudiere, J. Spectrophotometric assay of superoxide dismutase activity based on the activated autoxidation of a tetracyclic catechol. Anal. Biochem., 1993, 214(2), 442-451. (Pubitemid 23336403)
28. Aebi, H. In: Methods in Enzymatic Analysis. Bergmeyer, H.U. Ed.; Academic Press: New York, 1974; pp. 673-678.
29. Flohé, La.G.W.A. In: Methods in Enzymology. Colowic, S.P.; Kaplan, N.O. Eds.; Academic Press: New York, 1984; pp. 114-121.
30. Maynard, S.E.; Min, J.Y.; Merchan, J.; Lim, K.H.; Li, J.; Mondal, S.; Libermann T.A.; Morgan, J.P.; Sellke, F.W.; Stillman I.E.; Epstein, F.H.; Sukhatme, V.P.; Karumanchi, A. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J. Clin. Invest., 2003, 111(5), 649-658.
31. Myatt, L.; Rosenfield, R.B.; Eis, A.L.; Brockman, D.E.; Geer, I.; Lyall, F. Nytrotyrosine residues in placenta. Evidence of peroxynitrite formation and action. Hypertension , 1996, 28(3), 488-493. (Pubitemid 26296056)
32. Myatt, L.; Cui, X. Oxidative stress in the placenta. Histochem. Cell. Biol., 2004, 122(4), 369-382.
33. Webster, R.P.; Roberts, V.H.; Myatt, L. Protein nitration in placenta functional significance. Placenta, 2008, 29(12), 985-994.
34. Myatt, L. Control of vascular resistance in the human placenta. Placenta, 1992, 13(4), 329-341.
35. Sebire, N.J; Talbert, D.G. The dynamic placenta: a closer look at the pathophysiology of placental hemodynamics in uteroplacental compromise. Ultrasound. Obstet. Gynecol., 2001, 18(6), 357-361.
36. Feller, A.C.; Schneider, H.; Schmidt, D.; Parwaresch, M.R. Myofibroblast as a major cellular constituent of villous stroma in human placenta. Placenta, 1985, 6(5), 405-415.
37. Michel, J.B. Role of endothelial nitric oxide in the regulation of the vasomotor system. Pathol Biol., 1998, 46(3), 181-189. (Pubitemid 28160663)
38. Graf, R.; Langer, J.U.; Schonfelder, G.; Oney, T.; Hartel-Schenk, S.; Reutter, W.; Schmidt, H.H. The extravascular contractile system in the human placenta. Morphological and immunocytochemical investigations. Anat. Embryol. (Berl)., 1994, 190(6), 541-548. (Pubitemid 24359593)
39. Kroll, J.; Waltenberger, J. VEGF-A Induces expression of eNOS and iNOS in endothelial cells via VEGF receptor-2 (KDR). Biochem. Biophys. Res. Commun., 1998, 252(3), 743-746. (Pubitemid 28556847)
40. Dulak, J.; Józkowiz, A.; Dembinska-Kiec, A.; Guevara, I.; Zdzienicka, A.; Zmudzinska-Grochot, D.; Florek, I.; Wójtowicz, A.; Szuba, A.; Cooke, J.P. Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol., 2000, 20(3), 659-666. (Pubitemid 30151678)
41. Arroyo, J.A.; Anthony, R.V.; Parker, T.A.; Galan, H.L. Differential expression of placental and vascular endothelial nitric oxide synthase in an ovine model of fetal growth restriction. Am. J. Obstet. Gynecol., 2006, 195(3), 771-777. (Pubitemid 44292134)
42. El-Remessy, A.B.; Al-Shabrawey, M.; Platt, D.H.; Bartoli, M.; Behzadian, M.A.; Ghaly, N.; Tsai, N.; Motamed, K.; Caldwell, R.B. Peroxynitrite mediates VEGF's angiogenic signal and function via a nitration-independent mechanism in endothelial cells. FASEB J., 2007, 21(10), 2528-2539.
43. Kumazaki, K.; Nakamaya, M.; Suchara, N.; Wada, Y. Expression of Vascular endothelial growth factor, placental growth factor, and their receptors Flt-1 and KDR in human placenta under pathologic conditions. Human Pathol., 2002, 33(11), 1069-1077. (Pubitemid 35416703)
44. Santos, S.M; Peinado, V.I.; Ramírez, J.; Morales-Blanhir, J.; Bastos, R.; Roca, J.; Rodríguez-Roisin, R.; Barberà, A. Enhanced expression of vascular endothelial growth factor in pulmonary arteries of smokers and patients with moderate chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care. Med., 2003, 167(9), 1250-1256.
45. Simmons, L.A.; Hennessy, A.; Gillin, A.G.; Jeremy, R.W. Uteroplacental blood flow and placental vascular endothelial growth factor in normotensive and pre-eclamptic pregnancy. Br. J. Obstet. Gynaecol., 2000, 107(5), 678-685.
46. Lam, C.; Lim, K-H.; Karumanchi, S.A. Circulating angiogenic factors in the pathogenesis and prediction of preeclampsia. Hypertension, 2005, 46(5), 1077-1085. (Pubitemid 41533005)
47. Thomas, C.P.; Andrews, J.I.; Liu, K.Z. Intronic polyadenylation signal sequences and alternate splicing generate human soluble Flt1 variants and regulate the abundance of soluble Flt1 in the placenta. FASEB., 2007, 21(14), 3885-3895.
48. Kendall, R.L.; Thomas, K.A. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc. Natl. Acad. Sci., 1993, 90(22), 10705-10709.
49. Tsatsaris, V.; Goffin, F.; Munaut, C.; Brichant, J.F.; Pignon, M.R.; Noel, A.; Schaaps, J-P.; Cabrol, D.; Frankanne, F.; Foidart, J-M. Overexpression of the soluble vascular endothelial growth factor receptor in preeclamptic patients: pathophysiological consequences. J. Clin. Endocrinol. Metab., 2003, 88(11), 5555-5563. (Pubitemid 37452769)
50. Shibata, E.; Rajakumar, A.; Powers, R.W.; Larkin, R.; Gilmour, C.; Bodnar, L.M.; Crombieholme, W.R.; Ness, R.B.; Roberts, J.M.; Hubel, C.A. Soluble fms-like tyrosine kinase 1 is increased in preeclampsia but not in normotensive pregnancies with small-forgestational-age neonates: relationship to circulating placental growth factor. J. Clin. Endocrinol. Metab., 2005, 90(8), 4895-4903.
51. Burton, G.J.; Jones, C.J.P. Syncytial knots, sprouts, apoptosis, and trophoblast deportation from the human placenta. Taiwan J. Obstet. Gynecol., 2009, 48(1), 28-37.