Pentosan polysulfate treatment preserves renal autoregulation in ANG II-infused hypertensive rats via normalization of P2X1 receptor activation

American Journal of Physiology - Renal Physiology

Volumn 298, Issue 5, 2010, Pages

  Guan, Zhengrong ^a   Fuller, Barry S ^a   Yamamoto, Tatsuo ^a   Cook, Anthony K ^a   Pollock, Jennifer S ^b   Inscho, Edward W ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Afferent arteriole; Pentosan polysulfate

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA SMOOTH MUSCLE ACTIN; ANGIOTENSIN II; PENTOSAN POLYSULFATE; PURINERGIC P2X1 RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTERIOLE; ARTERY DIAMETER; ARTICLE; AUTOREGULATION; BLOOD SAMPLING; CONTROLLED STUDY; HYPERTENSION; IN VITRO STUDY; KIDNEY; KIDNEY DYSFUNCTION; KIDNEY INJURY; MALE; NONHUMAN; PERFUSION PRESSURE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; VASOCONSTRICTION;

EID: 77951518336     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00743.2009     Document Type: Article

References (54)

1. Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Knight GE, Fumagalli M, Gachet C, Jacobson KA, Weisman GA. International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev 58: 281-341, 2006.
2. Bailey MA, Turner CM, Hus-Citharel A, Marchetti J, Imbert-Teboul M, Milner P, Burnstock G, Unwin RJ. P2Y receptors present in the native and isolated rat glomerulus. Nephron Physiol 96: 79-90, 2004. (Pubitemid 38453107)
3. Bell PD, Lapointe JY, Sabirov R, Hayashi S, Peti-Peterdi J, Manabe K, Kovacs G, Okada Y. Macula densa cell signaling involves ATP release through a maxi anion channel. Proc Natl Acad Sci USA 100: 4322-4327, 2003. (Pubitemid 36418201)
4. Bidani AK, Griffin KA. Pathophysiology of hypertensive renal damage: implications for therapy. Hypertension 44: 595-601, 2004. (Pubitemid 39435221)
5. Bobadilla NA, Tack I, Tapia E, Sanchez-Lozada LG, Santamaria J, Jimenez F, Striker LJ, Striker GE, Herrera-Acosta J. Pentosan polysulfate prevents glomerular hypertension and structural injury despite persisting hypertension in 5/6 nephrectomy rats. J Am Soc Nephrol 12: 2080-2087, 2001. (Pubitemid 32880344)
6. Callera GE, Montezano AC, Yogi A, Tostes RC, Touyz RM. Vascular signaling through cholesterol-rich domains: implications in hypertension. Curr Opin Nephrol Hypertens 16: 90-104, 2007. (Pubitemid 46254928)
7. Ceol M, Gambaro G, Sauer U, Baggio B, Anglani F, Forino M, Facchin S, Bordin L, Weigert C, Nerlich A, Schleicher ED. Glycosaminoglycan therapy prevents TGF-beta1 overexpression and pathologic changes in renal tissue of long-term diabetic rats. J Am Soc Nephrol 11: 2324-2336, 2000.
8. 1 purinoceptors by autoradiography and immunohistochemistry in rat kidneys. Am J Physiol Renal Physiol 274: F799-F804, 1998.
9. Elliot SJ, Striker LJ, Connor E, Stetler-Stevenson W, McQuinn WC, Blagg CR, Striker GE. Pentosan polysulfate decreases proliferation and extracellular matrix deposition by vascular smooth muscle cells isolated from failed hemodialysis access grafts. Clin Nephrol 54: 121-127, 2000. (Pubitemid 30625629)
10. Elmarakby AA, Quigley JE, Imig JD, Pollock JS, Pollock DM. TNF-α inhibition reduces renal injury in DOCA-salt hypertensive rats. Am J Physiol Regul Integr Comp Physiol 294: R76-R83, 2008.
11. Elmarakby AA, Quigley JE, Olearczyk JJ, Sridhar A, Cook AK, Inscho EW, Pollock DM, Imig JD. Chemokine receptor 2b inhibition provides renal protection in angiotensin II-salt hypertension. Hypertension 50: 1069-1076, 2007. (Pubitemid 350172928)
12. Ghosh P. The pathobiology of osteoarthritis and the rationale for the use of pentosan polysulfate for its treatment. Semin Arthritis Rheum 28: 211-267, 1999. (Pubitemid 29094291)
13. Guan Z, Pollock JS, Cook AK, Hobbs JL, Inscho EW. Effect of epithelial sodium channel blockade on the myogenic response of rat juxtamedullary afferent arterioles. Hypertension, 2009.
14. Harrison DG, Guzik TJ, Goronzy J, Weyand C. Is hypertension an immunologic disease? Curr Cardiol Rep 10: 464-469, 2008.
15. Herbert JM, Maffrand JP. Effect of pentosan polysulphate, standard heparin and related compounds on protein kinase C activity. Biochim Biophys Acta 1091: 432-441, 1991.
16. Herrera-Acosta J, Tapia E, Sanchez-Lozada LG, Franco M, Striker LJ, Striker GE, Rodriguez IB. Restoration of glomerular haemodynamics and renal injury independent of arterial hypertension in rats with subtotal renal ablation. J Hypertens Suppl 20: S29-S35, 2002. (Pubitemid 34921158)
17. Imig JD, Passmore JC, Anderson GL, Jimenez AE. Chloride alters renal blood flow autoregulation in deoxycorticosterone-treated rats. J Lab Clin Med 121: 608-613, 1993. (Pubitemid 23112656)
18. Inscho EW. Mysteries of renal autoregulation. Hypertension 53: 299-306, 2009.
19. Inscho EW, Carmines PK, Cook AK, Navar LG. Afferent arteriolar responsiveness to altered perfusion pressure in renal hypertension. Hypertension 15: 748-752, 1990.
20. Inscho EW, Carmines PK, Navar LG. Juxtamedullary afferent arteriolar responses to P1 and P2 purinergic stimulation. Hypertension 17: 1033-1037, 1991.
21. 1 receptors in renal microvascular autoregulatory behavior. J Clin Invest 112: 1895-1905, 2003.
22. 1 knockout mice. Acta Physiol Scand 181: 445-453, 2004.
23. Inscho EW, Cook AK, Navar LG. Pressure-mediated vasoconstriction of juxtamedullary afferent arterioles involves P2-purinoceptor activation. Am J Physiol Renal Fluid Electrolyte Physiol 271: F1077-F1085, 1996.
24. Inscho EW, Imig JD, Deichmann PC, Cook AK. Candesartan cilexetil protects against loss of autoregulatory efficiency in angiotensin II-infused rats. J Am Soc Nephrol 10, Suppl 11: S178-S183, 1999.
25. Inscho EW, Ohishi K, Navar LG. Effects of ATP on pre- and postglomerular juxtamedullary microvasculature. Am J Physiol Renal Fluid Electrolyte Physiol 263: F886-F893, 1992.
26. Karlsen FM, Andersen CB, Leyssac PP, Holstein-Rathlou NH. Dynamic autoregulation and renal injury in Dahl rats. Hypertension 30: 975-983, 1997. (Pubitemid 27441132)
27. Komlosi P, Fintha A, Bell PD. Renal cell-to-cell communication via extracellular ATP. Physiology (Bethesda) 20: 86-90, 2005.
28. Komlosi P, Peti-Peterdi J, Fuson AL, Fintha A, Rosivall L, Bell PD. Macula densa basolateral ATP release is regulated by luminal [NaCl] and dietary salt intake. Am J Physiol Renal Physiol 286: F1054-F1058, 2004.
29. Lambrecht G. Agonists and antagonists acting at P2X receptors: selectivity profiles and functional implications. Naunyn Schmiedebergs Arch Pharmacol 362: 340-350, 2000.
30. Luft FC. Angiotensin, inflammation, hypertension, and cardiovascular disease. Curr Hypertens Rep 3: 61-67, 2001.
31. Maffrand JP, Herbert JM, Bernat A, Defreyn G, Delebassee D, Savi P, Pinot JJ, Sampol J. Experimental and clinical pharmacology of pentosan polysulfate. Semin Thromb Hemost 17, Suppl 2: 186-198, 1991.
32. Mori T, Cowley AW Jr. Role of pressure in angiotensin II-induced renal injury: chronic servo-control of renal perfusion pressure in rats. Hypertension 43: 752-759, 2004.
33. Mori T, Polichnowski A, Glocka P, Kaldunski M, Ohsaki Y, Liang M, Cowley AW Jr. High perfusion pressure accelerates renal injury in salt-sensitive hypertension. J Am Soc Nephrol 19: 1472-1482, 2008.
34. Navar LG, Inscho EW, Majid SA, Imig JD, Harrison-Bernard LM, Mitchell KD. Paracrine regulation of the renal microcirculation. Physiol Rev 76: 425-536, 1996.
35. Nishiyama A, Jackson KE, Majid DS, Rahman M, Navar LG. Renal interstitial fluid ATP responses to arterial pressure and tubuloglomerular feedback activation during calcium channel blockade. Am J Physiol Heart Circ Physiol 290: H772-H777, 2006.
36. Nishiyama A, Majid DS, Taher KA, Miyatake A, Navar LG. Relation between renal interstitial ATP concentrations and autoregulation-mediated changes in renal vascular resistance. Circ Res 86: 656-662, 2000.
37. North RA. Molecular physiology of P2X receptors. Physiol Rev 82: 1013-1067, 2002.
38. Parsons CL, Mulholland SG. Successful therapy of interstitial cystitis with pentosanpolysulfate. J Urol 138: 513-516, 1987.
39. Paul R, Herbert JM, Maffrand JP, Lansen J, Modat G, Pereillo JM, Gordon JL. Inhibition of vascular smooth muscle cell proliferation in culture by pentosan polysulphate and related compounds. Thromb Res 46: 793-801, 1987.
40. Peti-Peterdi J. Calcium wave of tubuloglomerular feedback. Am J Physiol Renal Physiol 291: F473-F480, 2006.
41. Ploth DW, Roy RN, Huang WC, Navar LG. Impaired renal blood flow and cortical pressure autoregulation in contralateral kidneys of Goldblatt hypertensive rats. Hypertension 3: 67-74, 1981.
42. Pollock CA, Poronnik P. Albumin transport and processing by the proximal tubule: physiology and pathophysiology. Curr Opin Nephrol Hypertens 16: 359-364, 2007.
43. Riou S, Mees B, Esposito B, Merval R, Vilar J, Stengel D, Ninio E, van Haperen R, de Crom R, Tedgui A, Lehoux S. High pressure promotes monocyte adhesion to the vascular wall. Circ Res 100: 1226-1233, 2007.
44. Russo LM, Sandoval RM, McKee M, Osicka TM, Collins AB, Brown D, Molitoris BA, Comper WD. The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: retrieval is disrupted in nephrotic states. Kidney Int 71: 504-513, 2007.
45. Sasser JM, Sullivan JC, Hobbs JL, Yamamoto T, Pollock DM, Carmines PK, Pollock JS. Endothelin A receptor blockade reduces diabetic renal injury via an anti-inflammatory mechanism. J Am Soc Nephrol 18: 143-154, 2007.
46. Savoia C, Schiffrin EL. Vascular inflammation in hypertension and diabetes: molecular mechanisms and therapeutic interventions. Clin Sci (Lond) 112: 375-384, 2007.
47. Schamhart DH, Kurth KH. Proteoglycans and glycosaminoglycans in tumor growth and migration: first experience with tumors of bladder and prostate origin. World J Urol 12: 55-61, 1994.
48. Schwiebert EM, Wallace DP, Braunstein GM, King SR, Peti-Peterdi J, Hanaoka K, Guggino WB, Guay-Woodford LM, Bell PD, Sullivan LP, Grantham JJ, Taylor AL. Autocrine extracellular purinergic signaling in epithelial cells derived from polycystic kidneys. Am J Physiol Renal Physiol 282: F763-F775, 2002.
49. Sharma K, Cook A, Smith M, Valancius C, Inscho EW. TGF-β impairs renal autoregulation via generation of ROS. Am J Physiol Renal Physiol 288: F1069-F1077, 2005.
50. Striker GE, Lupia E, Elliot S, Zheng F, McQuinn C, Blagg C, Selim S, Vilar J, Striker LJ. Glomerulosclerosis, arteriosclerosis, and vascular graft stenosis: treatment with oral heparinoids. Kidney Int Suppl 63: S120-S123, 1997.
51. Turner CM, Vonend O, Chan C, Burnstock G, Unwin RJ. The pattern of distribution of selected ATP-sensitive P2 receptor subtypes in normal rat kidney: an immunohistological study. Cells Tissues Organs 175: 105-117, 2003.
52. 1 receptor-mediated currents and arterial vasoconstriction. J Biol Chem 280: 30705-30711, 2005.
53. Wang CT, Chin SY, Navar LG. Impairment of pressure-natriuresis and renal autoregulation in ANG II-infused hypertensive rats. Am J Physiol Renal Physiol 279: F319-F325, 2000.
54. 2+ signaling attenuates P2X receptor-mediated vasoconstriction of afferent arterioles in angiotensin II hypertension. Hypertension 46: 562-568, 2005.