Increased BACE1 mRNA and noncoding BACE1-antisense transcript in sporadic inclusion-body myositis muscle fibers-Possibly caused by endoplasmic reticulum stress

Neuroscience Letters

Volumn 474, Issue 3, 2010, Pages 140-143

  Nogalska, Anna ^a   Engel, W King ^a   Askanas, Valerie ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Amyloid ; Amyloid beta precursor protein (A PP); BACE1; Cultured human muscle fibers; Endoplasmic reticulum stress; Noncoding BACE1 antisense transcript; Sporadic inclusion body myositis

Indexed keywords

BETA SECRETASE 1; BETA SECRETASE 1 TRANSCRIPT; GENE PRODUCT; MESSENGER RNA; NONCODING BETA SECRETASE 1 ANTISENSE TRANSCRIPT; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELL CULTURE; CELL FUNCTION; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; INCLUSION BODY MYOSITIS; MUSCLE BIOPSY; MUSCLE CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; UPREGULATION;

AGED; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; DNA, ANTISENSE; ENDOPLASMIC RETICULUM; HUMANS; MIDDLE AGED; MUSCLE FIBERS, SKELETAL; MYOSITIS, INCLUSION BODY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STRESS, PHYSIOLOGICAL;

EID: 77951499020     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.03.023     Document Type: Article

References (34)

1. Askanas V., Engel W.K. Cultured normal and genetically abnormal human muscle. The Handbook of Clinical Neurology, Myopathies 1992, vol. 18:85-116. North Holland, Amsterdam.
2. Askanas V., Engel W.K. Inclusion-body myositis: muscle-fiber molecular pathology and possible pathogenic significance of its similarity to Alzheimer's and Parkinson's disease brains. Acta Neuropathol. 2008, 116:583-595.
3. Askanas V., Engel W.K., Alvarez R.B. Enhanced detection of Congo-red positive amyloid deposits in muscle fibers of inclusion-body myositis and brain of Alzheimer's disease using fluorescence technique. Neurology 1993, 43:1265-1267.
4. Askanas V., Engel W.K., Nogalska A. Inclusion body myositis: a degenerative muscle disease associated with intra-muscle fiber multi-protein aggregates, proteasome inhibition, endoplasmic reticulum stress and decreased lysosomal degradation. Brain Pathol. 2009, 19:493-506.
5. Bitan G., Kirkitadze M.D., Lomakin A., Vollers S.S., Benedek G.B., Teplow D.B. Amyloid beta-protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:330-335.
6. Chen Y-Ru., Glabe C. Distinct early folding and aggregation properties of Alzheimer amyloid-β peptides Aβ40 and Aβ42. J. Biol. Chem. 2006, 281:24414-24422.
7. Chromy B.A., Nowak R.J., Lambert M.P., Viola K.L., Chang L., Velasco P.T., Jones B.W., Fernandez S.J., Lacor P.N., Horowitz P., Finch C.E., Krafft G.A., Klein W.L. Self-assembly of Abeta (1-42) into globular neurotoxins. Biochemistry 2003, 42:12749-12760.
8. Costa F.F. Non-coding RNAs: new players in eucaryotic biology. Gene 2005, 357:83-94.
9. Dalakas M.C. Sporadic inclusion body myositis-diagnosis, pathogenesis and therapeutic strategies. Nat. Clin. Pract. Neurol. 2006, 2:437-447.
10. Engel W.K., Askanas V. Inclusion-body myositis: clinical, diagnostic, and pathologic aspects. Neurology 2006, 66:20-29.
11. LaFerla F.M., Green K.N., Oddo S. Intracellular amyloid-beta in Alzheimer's disease. Nat. Rev. Neurosci. 2007, 7:499-509.
12. Faghihi M.A., Modarresi F., Khalil A.M., Wood D.E., Sahagan B.G., Morgan T.E., Finch C.E., St Laurent G., Kenny P.J., Wahlestedt C. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Nat. Med. 2008, 14:723-730.
13. Faghihi M.A., Wahlestedt C. Regulatory roles of natural antisense transcripts. Nat. Rev. Mol. Cell. Biol. 2009, 10:637-643.
14. Lapidot M., Pilpel Y. Genome-wide natural antisense transcription: coupling its regulation to its different regulatory mechanisms. EMBO Rep. 2006, 7:1216-1222.
15. Lee A.S. The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress. Methods 2005, 35:373-381.
16. Li Y., Zhou W., Tong Y., He G., Song W. Control of APP processing and Abeta generation level by BACE1 enzymatic activity and transcription. FASEB J. 2006, 20:285-292.
17. Nogalska A., D'Agostino C., Engel W.K., Davies K.J., Askanas V. Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers. Neurobiol. Aging 2008, 10.1016/j.neurobiolaging.2008.08.021.
18. Nogalska A., Engel W.K., McFerrin J., Kokame K., Komano H., Askanas V. Homocysteine-induced endoplasmic reticulum protein (Herp) is up-regulated in sporadic inclusion-body myositis and in endoplasmic reticulum stress-induced cultured human muscle fibers. J. Neurochem. 2006, 96:1491-1499.
19. Nogalska A., Terracciano C., D'Agostino C., Engel W.K., Askanas V. p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis. Acta Neuropathol. 2009, 118:407-413.
20. Nogalska A., Wojcik S., Engel W.K., McFerrin J., Askanas V. Endoplasmic reticulum stress induces myostatin precursor protein and NF-kappaB in cultured human muscle fibers: relevance to inclusion body myositis. Exp. Neurol. 2007, 204:610-618.
21. Rossner S., Sastre M., Bourne K., Lichtenthaler S.F. Transcriptional and translational regulation of BACE1 expression-implications for Alzheimer's disease. Prog. Neurobiol. 2006, 79:95-111.
22. Smalheiser N.R., Lugli G., Torvik V.I., Mise N., Ikeda R., Abe K. Natural antisense transcripts are co-expressed with sense mRNAs in synaptoneurosomes of adult mouse forebrain. Neurosci. Res. 2008, 62:236-239.
23. St Laurent G., Wahlestedt C. Noncoding RNAs: couplers of analog and digital information in nervous system function?. Trends Neurosci. 2007, 30:612-621.
24. Stockley J.H., O'Neill C. Understanding BACE1: essential protease for amyloid-beta production in Alzheimer's disease. Cell. Mol. Life Sci. 2008, 65:3265-3289.
25. Terracciano C., Nogalska A., Engel W.K., Wojcik S., Askanas V. In inclusion-body myositis muscle fibers Parkinson-associated DJ-1 is increased and oxidized. Free Radic. Biol. Med. 2008, 45:773-779.
26. Vattemi G., Engel W.K., McFerrin J., Askanas V. Endoplasmic reticulum stress and unfolded protein response in inclusion body myositis muscle. Am. J. Pathol. 2004, 164:1-7.
27. Vattemi G., Engel W.K., McFerrin J., Buxbaum J.D., Pastorino L., Askanas V. Presence of BACE1 and BACE2 in muscle fibres of patients with sporadic inclusion-body myositis. Lancet 2001, 358:1962-1964.
28. Vattemi G., Engel W.K., McFerrin J., Pastorino L., Buxbaum J.D., Askanas V. BACE1 and BACE2 in pathologic and normal human muscle. Exp. Neurol. 2003, 179:150-158.
29. Vattemi G., Nogalska A., King Engel W., D'Agostino C., Checler F., Askanas V. Amyloid-beta42 is preferentially accumulated in muscle fibers of patients with sporadic inclusion-body myositis. Acta Neuropathol. 2009, 117:569-574.
30. Wahlestedt C. Natural antisense and noncoding RNA transcripts as potential drug targets. Drug Discov. Today 2006, 11:503-508.
31. Werner A., Carlile M., Swan D. What do natural antisense transcripts regulate?. RNA Biol. 2009, 6:43-48.
32. Wojcik S., Engel W.K., McFerrin J., Askanas V. Myostatin is increased and complexes with amyloid-beta within sporadic inclusion-body myositis muscle fibers. Acta Neuropathol. 2005, 110:173-177.
33. Wojcik S., Engel W.K., Yan R., McFerrin J., Askanas V. NOGO is increased and binds to BACE1 in sporadic inclusion-body myositis and in A beta PP-overexpressing cultured human muscle fibers. Acta Neuropathol. 2007, 114:517-526.
34. Yang C.C., Alvarez R.B., Engel W.K., Askanas V. Increase of nitric oxide synthases and nitrotyrosine in inclusion-body myositis. Neuroreport 1996, 8:153-158.