Bile acids as possible human carcinogens: New tricks from an old dog

International Journal of Food Sciences and Nutrition

Volumn 60, Issue SUPPL. 6, 2009, Pages 116-125

  Costarelli, Vassiliki ^a  

^a HAROKOPIO UNIVERSITY   (Greece)

Author keywords

Bile acids; Cancer promoters; Carcinogens

Indexed keywords

BILE ACID; CARCINOGEN;

ANIMAL; ARTICLE; BLOOD; BREAST TUMOR; CHEMICALLY INDUCED DISORDER; COCARCINOGENESIS; DIGESTIVE SYSTEM TUMOR; DNA DAMAGE; ENTEROHEPATIC CIRCULATION; FEMALE; HUMAN; INTESTINE MUCOSA; LIVER; MALE; MAMMARY GLAND; METABOLISM; MICROBIOLOGY; SECRETION (PROCESS);

ANIMALS; BILE ACIDS AND SALTS; BREAST NEOPLASMS; CARCINOGENS; COCARCINOGENESIS; DIGESTIVE SYSTEM NEOPLASMS; DNA DAMAGE; ENTEROHEPATIC CIRCULATION; FEMALE; HUMANS; INTESTINAL MUCOSA; LIVER; MALE; MAMMARY GLANDS, HUMAN;

CANIS FAMILIARIS;

EID: 77951483050     PISSN: 09637486     EISSN: 14653478     Source Type: Journal    
DOI: 10.1080/09637480902970967     Document Type: Article

References (60)

1. Axelson M, Mork B, Sjovall J. 1988. Occurrence of 3 beta-hydroxy-5- cholestenoic acid, 3 beta,7 alphadihydroxy-5-cholestenoic acid, and 7 alpha-hydroxy-3-oxo-4-cholestenoic acid as normal constituents in human blood. J Lipid Res 29:629-641.
2. Bajpai M, Liu J, Geng X, Souza RF, Amenta PS, Das KM. 2008. Repeated exposure to acid and bile selectively induces colonic phenotype expression in a heterogeneous Barrett's epithelial cell line. Lab Invest 88:643-651.
3. Baker PR, Wilton JC, Jones CE, Stenzel DJ, Watson N, Smith GJ. 1992. Bile acids influence the growth, oestrogen receptor and oestrogen-regulated proteins of MCF-7 human breast cancer cells. Br J Cancer 65:566-572.
4. Baron JA, Beach MD, Mandel JS, Stolk RU, Haile RW, Sandler RS, Rothstein R, Summers RW, Snover DC, Beck GJ, Bond JH, Greenberg ER. 1999. Calcium supplements for the prevention of colorectal adenomas. The New England Journal of Medicine 340:101-107.
5. Bayerdorffer E, Mannes GA, Richter WO, Ochsenkuhn T, Wiebecke B, Kopcke W, Paumgartner G. 1993. Increased serum deoxycholic acid levels in men with colorectal adenomas. Gastroenterology 104:145-151.
6. Berkhout M, Roelofs HM, Friederich P, van Schaik A, Gosens MJ, Marian B, Pool-Zobel BL, van Krieken JH, Peters WH, Nagengast FM. 2007. Ursodeoxycholic acid intervention in patients with familial adenomatous polyposis: A pilot study. Transl Res 150:147-149.
7. Bernstein H, Bernstein C, Payne CM, Dvorakova K, Garewal H. 2005. Bile acids as carcinogens in human gastrointestinal cancers. Mutat Res 589:47-65.
8. Calvet X, Ponce J. 2006. Gastroesophageal reflux disease: Epidemiology, diagnosis and treatment. Gastroenterol Hepatol 29(Suppl 3):23-30.
9. Chaplin MF. 1998. Bile acids, fibre and colon cancer: The story unfolds. J R Soc Health 118:53-61.
10. Chen KH, Mukaisho K, Sugihara H, Araki Y, Yamamoto G, Hattori T. 2007. High animal-fat intake changes the bile-acid composition of bile juice and enhances the development of Barrett's esophagus and esophageal adenocarcinoma in a rat duodenal-contents reflux model. Cancer Sci 98:1683-1688.
11. Cook JW, Hazelwood GA. 1933. Conversion of a bile acid into a hydrocarbon derived from 1,2-benzanthracene. Chemical Industry Reviews 11:758-759.
12. Costarelli V, Sanders TA. 2001. Acute effects of dietary fat composition on postprandial plasma bile acid and cholecystokinin concentrations in healthy premenopausal women. Br J Nutr 86:471-477.
13. Costarelli V, Sanders TA. 2002. Plasma bile acids and risk of breast cancer. IARC Sci Publ 156:305-306.
14. Csendes A, Burdiles P. 2007. Scientific foundations for medical treatment based on modifying diet, lifestyle habits, and patient attitudes in chronic gastroesophageal reflux disease. Cir Esp 81:64-69.
15. Deschner EE, Cohen BI, Raicht RF. 1981. Acute and chronic effect of dietary cholic acid on colonic epithelial cell proliferation. Digestion 21:290-296.
16. Dore MP,Maragkoudakis E, Fraley K, Pedroni A, Tadeu V, Realdi G, Graham DY, Delitala G, Malaty HM. 2008. Diet, lifestyle and gender in gastro-esophageal reflux disease. Dig Dis Sci 53:2027-2032.
17. Flynn C, Montrose DC, Swank DL, Nakanishi M, Ilsley JN, Rosenberg DW. 2007. Deoxycholic acid promotes the growth of colonic aberrant crypt foci. Mol Carcinogen 46:60-70.
18. Gibson T. 1684. The Anatomy of Humane Bodies. 2nd ed. London: Flesher.
19. Hofmann AF. 1977. Enterohepatic circulation of bile acids and biliary lipid secretion. Minerva Med 68:3011-3017.
20. Hofmann AF. 1999a. Bile acids: The good, the bad, and the ugly. News Physiol Sci 14:24-29.
21. Hofmann AF. 1999b. The continuing importance of bile acids in liver and intestinal disease. Arch Intern Med 159:2647-2658.
22. Hsing AW, Gao YT, Han TQ, Rashid A, Sakoda LC, Wang BS, Shen MC, Zhang BH, Niwa S, Chen J, Fraumeni Jr JF. 2007. Gallstones and the risk of biliary tract cancer: A population-based study in China. Br J Cancer 97:1577-1582.
23. Jansen PL. 2007. Endogenous bile acids as carcinogens. J Hepatol 47:434-435.
24. Javitt NB, Budai K, Miller DG, Cahan AC, Raju U, Levitz M. 1994. Breast-gut connection: Origin of chenodeoxycholic acid in breast cyst fluid. Lancet 343:633-635.
25. Jenkins GJ, Harries K, Doak SH, Wilmes A, Griffiths AP, Baxter JN, Parry JM. 2004. The bile acid deoxycholic acid (DCA) at neutral pH activates NF-kappaB and induces IL-8 expression in oesophageal cells in vitro. Carcinogenesis 25:317-323.
26. Kauer WK, Peters JH, DeMeester TR, Feussner H, Ireland AP, Stein HJ, Siewert RJ. 1997. Composition and concentration of bile acid reflux into the esophagus of patients with gastroesophageal reflux disease. Surgery 122:874-881.
27. Kondo K. 2002. Duodenogastric reflux and gastric stump carcinoma. Gastric Cancer 5:16-22.
28. Korn WM. 2004. Prevention and management of early esophageal cancer. Curr Treat Options Oncol 5:405-416.
29. Kulkarni MS, Heidepriem PM, Yielding KL. 1980. Production by lithocholic acid of DNA strand breaks in L1210 cells. Cancer Res 40:2666-2669.
30. Lam KD, Phan JT, Garcia RT, Trinh H, Nguyen H, Nguyen K, Triadafilopoulos G, Vutien P, Nguyen L, Nguyen MH. 2008. Low proportion of Barrett's esophagus in Asian Americans. Am J Gastroenterol 103:1625-1630.
31. Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B. 2009. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 89:147-191.
32. Liebig J. 1843. Animal Chemistry or Chemistry in its Applications to Physiology and Pathology. 2nd ed. London: Taylor and Watton.
33. Micozzi MS, Carter CL, Albanes D, Taylor PR, Licitra LM. 1989. Bowel function and breast cancer in US women. Am J Public Health 79:73-75.
34. Ouatu-Lascar R, Fitzgerald RC, Triadafilopoulos G. 1999. Differentiation and proliferation in Barrett's esophagus and the effects of acid suppression. Gastroenterology 17:327-335.
35. Owen RW, Henly PJ, Thompson MH, Hill MJ. 1986. Steroids and cancer: Faecal bile acid screening for early detection of cancer risk. J Steroid Biochem 24:391-394.
36. Papatestas AE, Panvelliwalla D, Tartter PI, Miller S, Pertsemlidis D, Aufses Jr AH. 1982. Fecal steroid metabolites and breast cancer risk. Cancer 49:1201-1205.
37. Park JY, Park BK, Ko JS, Bang S, Song SY, Chung JB. 2006. Bile acid analysis in biliary tract cancer. Yonsei Med J 47:817-825.
38. Petrakis NL, King EB. 1981. Cytological abnormalities in nipple aspirates of breast fluid from women with severe constipation. Lancet 2:1203-1204.
39. Raju U, Levitz M, Javitt NB. 1990. Bile acids in human breast cyst fluid: The identification of lithocholic acid. J Clin Endocrinol Metab 70:1030-1034.
40. Rodrigo L, Riestra S. 2007. Diet and colon cancer. Rev Esp Enferm Dig 99:183-189.
41. Ross RK, Hartnett NM, Bernstein L, Henderson BE. 1991. Epidemiology of adenocarcinomas of the small intestine: Is bile a small bowel carcinogen? Br J Cancer 63:143-145.
42. Salemans JM, Nagengast FM, Tangerman A, van Schaik A, Hopman WP, de Haan AF, Jansen JB. 1993. Effect of ageing on postprandial conjugated and unconjugated serum bile acid levels in healthy subjects. Eur J Clin Invest 23:192-198.
43. Schweitzer EJ, Bass BL, Batzri S, Harmon JW. 1986. Bile acid accumulation by rabbit esophageal mucosa. Dig Dis Sci 31:1105-1113.
44. Setchell KDR, Ives JA, Cashmore GC, Lawson AM. 1987. On the homogeneity of stools with respect to bile acid composition and normal day-to-day variations: a detailed qualitative and quantitative study using capillary column gas chromatography-mass spectrometry. Clinical Chimica Acta 162:157-175.
45. Sharma V, Chauhan VS, Nath G, Kumar A, Shukla VK. 2007. Role of bile bacteria in gallbladder carcinoma. Hepatogastroenterology 54:1622-1625.
46. Sjovall J. 2004. Fifty years with bile acids and steroids in health and disease. Lipids 39:703-722.
47. Spigelman AD, Williams CB, Talbot IC, Domizio P, Phillips RK. 1989. Upper gastrointestinal cancer in patients with familial adenomatous polyposis. Lancet 2:783-785.
48. Stamp DH. 2002. Three hypotheses linking bile to carcinogenesis in the gastrointestinal tract: Certain bile salts have properties that may be used to complement chemotherapy. Med Hypotheses 59:398-405.
49. Sung MW, Roh JL, Park BJ, Park SW, Kwon TK, Lee SJ, Kim KH. 2003. Bile acid induces cyclooxygenase-2 expression in cultured human pharyngeal cells: A possible mechanism of carcinogenesis in the upper aerodigestive tract by laryngopharyngeal reflux. Laryngoscope 113:1059-1063.
50. Thao TD, Ryu HC, Yoo SH, Rhee DK. 2008. Antibacterial and anti-atrophic effects of a highly soluble, acid stable UDCA formula in Helicobacter pylori-induced gastritis. Biochem Pharmacol 75:2135-2146.
51. Triadafilopoulos G. 2001. Acid and bile reflux in Barrett's esophagus: A tale of two evils. Gastroenterology 121:1502-1506.
52. Tucker ON, Dannenberg AJ, Yang EK, Fahey 3rd TJ. 2004. Bile acids induce cyclooxygenase-2 expression in human pancreatic cancer cell lines. Carcinogenesis 25:419-423.
53. Van Tassel RL, MacDonald DK, Wilkins TD. 1982. Production of a fecal mutagen by Bacteroides spp. Infect Immun 37:975-980.
54. Vemulapalli R. 2008. Diet and lifestyle modifications in the management of gastroesophageal reflux disease. Nutr Clin Pract 23:293-298.
55. Wang YD, Chen WD, Moore DD, HuangW. 2008. FXR: A metabolic regulator and cell protector. Cell Res 18:1087-1095.
56. Weisburger JH. 2002. Lifestyle, health and disease prevention: the underlying mechanisms. Eur J Cancer Prev 11(Suppl 2):S1-S7.
57. Wu Z, Lu Y, Wang B, Liu C, Wang ZR. 2003. Effects of bile acids on proliferation and ultrastructural alteration of pancreatic cancer cell lines. World J Gastroenterol 9:2759-2763.
58. Yee SB, Song YS, Jeong SH, Lee HS, Seo SY, Kim JH, Suh H, Kim ND, Yoo YH. 2007. A novel chenodeoxycholic derivative HS-1200 enhances radiation-induced apoptosis in MCF-7 cells. Oncol Rep 17:919-923.
59. Yui S, Kanamoto R, Saeki T. 2008. Deoxycholic acid can induce apoptosis in the human colon cancer cell line HCT116 in the absence of Bax. Nutr Cancer 60:91-96.
60. Zhang F, Altorki NK, Wu YC, Soslow RA, Subbaramaiah K, Dannenberg AJ. 2001. Duodenal reflux induces cyclooxygenase-2 in the esophageal mucosa of rats: Evidence for involvement of bile acids. Gastroenterology 121:1391-1399.