Marginal growth increase, altered bone quality and polycystic ovaries in female prepubertal rats after treatment with the aromatase inhibitor exemestane

Hormone Research in Paediatrics

Volumn 73, Issue 1, 2010, Pages 49-60

  Van Gool, Sandy A ^a   Wit, Jan M ^a   De Schutter, Tineke ^d   De Clerck, Nora ^d   Postnov, Andreï A ^d   Kremer Hovinga, Sandra ^a   Van Doorn, Jaap ^b   Veiga, Sergio J ^e   Garcia Segura, Luis Miguel ^e   Karperien, Marcel ^c  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY OF TWENTE   (Netherlands)

^d UNIVERSITY OF ANTWERP   (Belgium)

^e INSTITUTO CAJAL   (Spain)

Author keywords

Aromatase; Aromatase inhibition; Estrogen; Growth plate maturation; Longitudinal growth; Osteopenia; Polycystic ovary syndrome

Indexed keywords

EXEMESTANE; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY HEIGHT; BODY WEIGHT; BONE; CONTROLLED STUDY; DRUG MEGADOSE; ENZYME INHIBITION; EPIPHYSIS; FEMALE; FEMUR; GROWTH PLATE; GROWTH STIMULATION; HISTOPATHOLOGY; LEG LENGTHENING; METAPHYSIS; NONHUMAN; ORGAN WEIGHT; OSTEOPENIA; OVARIECTOMY; OVARY POLYCYSTIC DISEASE; PREPUBERTY; PRIORITY JOURNAL; RAT; TIBIA; WEIGHT GAIN;

ANDROSTADIENES; ANIMALS; AROMATASE INHIBITORS; BONE DENSITY; DRUG EVALUATION, PRECLINICAL; FEMALE; GROWTH AND DEVELOPMENT; INJECTIONS, INTRAMUSCULAR; OVARIAN CYSTS; PLACEBOS; QUALITY CONTROL; RATS; RATS, WISTAR; SEXUAL MATURATION; UP-REGULATION; X-RAY MICROTOMOGRAPHY;

EID: 77951472656     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000271916     Document Type: Article

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