Transgenerational developmental effects and genomic instability after X-irradiation of preimplantation embryos: Studies on two mouse strains

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 687, Issue 1-2, 2010, Pages 54-62

  Jacquet, P ^a   Buset, J ^a   Neefs, M ^a   Vankerkom, J ^b   Benotmane, M A ^a   Derradji, H ^a   Hildebrandt, G ^c,d   Baatout, S ^a  

^a Molecular and Cellular Biology   (Belgium)

^b FLEMISH INSTITUTE FOR TECHNOLOGICAL RESEARCH VITO   (Belgium)

^c UNIVERSITY OF LEIPZIG   (Germany)

^d UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Anomalies; Embryos; Genomic instability; Irradiation; Malformations; Transgenerational

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DWARFISM; EMBRYO; EXENCEPHALY; FEMALE; FEMALE FERTILITY; FETUS WEIGHT; GASTROSCHISIS; GENOMIC INSTABILITY; INSTITUTE FOR CANCER RESEARCH MOUSE; LIMB DEFORMITY; MOUSE; NONHUMAN; POLYDACTYLY; PREGNANCY RATE; PREIMPLANTATION EMBRYO; PRIORITY JOURNAL; RADIATION DOSE; SEXUAL MATURATION; STRAIN DIFFERENCE; X IRRADIATION;

ABNORMALITIES, RADIATION-INDUCED; ANIMALS; BLASTOCYST; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; FEMALE; GENOMIC INSTABILITY; MICE; MICE, INBRED ICR; PREGNANCY;

EID: 77951297947     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2010.01.013     Document Type: Article

References (42)

1. Pampfer S., Streffer C. Prenatal death and malformations after irradiation of mouse zygotes with neutrons or X-rays. Teratology 1988, 37:599-607.
2. Müller W.U., Streffer C. Lethal and teratogenic effects after exposure to X-rays at various times of early murine gestation. Teratology 1990, 42:643-650.
3. Jacquet P., de Saint-Georges L., Vankerkom J., Baugnet-Mahieu L. Embryonic death, dwarfism and fetal malformations after irradiation of embryos at the zygote stage: studies on two mouse strains. Mutat. Res. 1995, 332:73-87.
4. Gu Y., Kai M., Kusama T. The embryonic and fetal effects in ICR mice irradiated in the various stages of the preimplantation period. Radiat. Res. 1997, 147:735-740.
5. Rutledge J.C. Developmental toxicity induced during early stages of mammalian embryogenesis. Mutat. Res. 1997, 36:113-127.
6. Rutledge J.C., Generoso W.M., Shourbaji A., Cain K.T., Gans M., Oliva J. Developmental anomalies derived from exposure of zygotes and first-cleavage embryos to mutagens. Mutat. Res. 1992, 296:167-177.
7. Iannaccone P.M. Long-term effects of exposure to methylnitrosourea on blastocysts following transfer to surrogate female mice. Cancer Res. 1984, 44:2785-2789.
8. Streffer C. Genetic predisposition and genomic instability in preimplantation mouse embryos. Effects of In Utero Exposure to Ionising Radiation During the Early Phases of Pregnancy 2002, 4-16. Office for Official Publications of the European Communities, L-2985, Luxembourg.
9. Pampfer S., Streffer C. Increased chromosome aberration levels in cells from mouse fetuses after zygote X-irradiation. Int. J. Radiat. Biol. 1989, 55:85-92.
10. Pils S., Müller W.U., Streffer C. Lethal and teratogenic effects in two successive generations of the HLG mouse strain after radiation exposure of zygotes: association with genomic instability?. Mutat. Res. 1999, 429:85-92.
11. Streffer C. Transgenerational transmission of radiation damage: genomic instability and congenital malformation. J. Radiat. Res. 2006, 47(Suppl. B):B19-B24.
12. Sharp C., Shrimpton J.A., Bury R.F. Diagnostic Medical Exposures: Advice on Exposure to Ionising Radiation During Pregnancy 1998, National Radiological Protection Board.
13. Ullrich R.L., Ponnaiya B. Radiation-induced instability and its relation to radiation carcinogenesis. Int. J. Radiat. Biol. 1998, 74:747-754.
14. Ullrich R.L., Davis C.M. Radiation-induced cytogenetic instability in vivo. Radiat. Res. 1999, 152:170-173.
15. West J.D., Kirk K.M., Goyder Y., Lyon M.F. Discrimination between the effects of X-ray irradiation of the mouse oocyte and uterus on the induction of dominant lethals and congenital anomalies. I. Embryo-transfer experiments. Mutat. Res. 1985, 149:221-230.
16. Czeizel A.E. Intrauterine growth retardation as a potential endpoint in mutation epidemiology. Mutat. Res. 1993, 296:211-219.
17. Kirk K.M., Lyon M.F. Induction of congenital anomalies in offspring of female mice exposed to varying doses of X rays. Mutat. Res. 1982, 106:73-74.
18. Kirk K.M., Lyon M.F. Induction of congenital anomalies in offspring of male mice treated with X-rays at premeiotic and post-meiotic stages. Mutat. Res. 1984, 125:75-85.
19. Nomura T. Parental exposure to X-rays and chemicals induces heritable tumours and anomalies in mice. Nature 1982, 296:575-577.
20. Nomura T. X-ray and chemically induced germ-line mutation causing phenotypical anomalies in mice. Mutat. Res. 1988, 198:309-320.
21. Cusic A.M., Dagg C.P. Spontaneous and retinoic acid-induced postaxial polydactyly in mice. Teratology 1985, 31:49-59.
22. Hayasaka I., Nakatsuka T., Fujii T., Naruse I., Oda S. Polydactyly Nagoya, Pdn: a new mutant gene in the mouse. Exp. Anim. 1980, 29:391-395.
23. Kalter H. A compendium of the genetically induced congenital malformations of the house mouse. Teratology 1980, 21:397-429.
24. Johnson D.R. Extra-toes: a new mutant gene causing multiple abnormalities in the mouse. J. Embryol. Exp. Morphol. 1967, 17:543-581.
25. Talamillo A., Bastida M.F., Fernandez-Teran M., Ros M.A. The developing limb and the control of the number of digits. Clin. Genet. 2005, 67:143-153.
26. Thien H., Rüther U. The mouse mutation Pdn (Polydactyly Nagoya) is caused by the integration of a retrotransposon into the Gli3 gene. Mamm. Genome 1999, 10:205-209.
27. Schimmang T., Lemaistre M., Vortkamp A., Rüther U. Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt). Development 1992, 116:799-804.
28. Heyer B.S., McAuley A., Behrendtsen O., Werb Z. Hypersensitivity to DNA damage leads to increased apoptosis during early mouse development. Genes Dev. 2000, 14:2072-2084.
29. Ponnaiya B., Cornforth M.N., Ullrich R.L. Radiation-induced chromosomal instability in BALB/c and C57BL/6 mice: the difference is as clear as black and white. Radiat. Res. 1997, 147:121-125.
30. Lord B., Woolford L., Wang L., Stones V., McDonald D., Lorimore S., Papworth D., Wright E., Scott D. Tumour induction by methyl-nitroso-urea, following preconceptional paternal contamination with plutonium-239. Br. J. Cancer 1998, 78:301-311.
31. Vorobtsova I. Irradiation of male rats increases the chromosomal sensitivity of progeny to genotoxic agents. Mutagenesis 2000, 15:33-38.
32. Kropakova K., Slovinska L., Misurova E. Cytogenetic changes in the liver of progeny of irradiated male rats. J. Radiat. Res. 2002, 43:125-133.
33. Luke G., Riches A., Bryant P. Genomic instability in haematopoietic cells of F1 generation mice of irradiated male parents. Mutagenesis 1997, 12:147-152.
34. Fomenko L., Vasiljeva G., Bezlepkin V. Elevated micronucleus frequency in bone marrow erythrocytes in the progeny of male mice exposed to chronic low-dose gamma irradiation. Biol. Bull. 2001, 28:419-423.
35. Carls N., Schiestl R. Effect of ionizing radiation on transgenerational appearance of pun reversions in mice. Carcinogenesis 1999, 20:2351-2354.
36. Shiraishi K., Shimura T., Taga M., Uematsu N., Gondo Y., Ohtaki M., Kominami R., Niwa O. Persistent induction of somatic reversions of the pink-eyed unstable mutation in F1 mice born to fathers irradiated at the spermatozoa stage. Radiat. Res. 2002, 157:661-667.
37. Dubrova Y., Plumb M., Gutierrez B., Boulton E., Jeffreys A.J. Transgenerational mutation by radiation. Nature 2000, 405:37.
38. Barber R., Plumb M.A., Boulton E., Roux I., Dubrova Y. Elevated mutation rates in the germ line of first- and second-generation offspring of irradiated male mice. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:6877-6882.
39. Dubrova Y. Radiation-induced transgenerational instability. Oncogene 2003, 22:7087-7093.
40. Tease C., Fisher G. Cytogenetic and genetic studies of radiation-induced chromosome damage in mouse oocytes. I. Numerical and structural chromosome anomalies in metaphase II oocytes, pre- and post-implantation embryos. Mutat. Res. 1996, 349:145-153.
41. Camats N., Garcia F., Parrilla J., Calaf J., Martin M., Caldés M. Trans-generational radiation-induced chromosomal instability in the female enhances the action of chemical mutagens. Mutat. Res. 2008, 640:16-26.
42. Barber R., Hardwick R., Shanks M., Glen C., Mughal S., Voutounou M., Dubrova Y. The effects of in utero irradiation on mutation induction and transgenerational instability in mice. Mutat. Res. 2009, 664:6-12.