Some important questions connected with non-targeted effects

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 687, Issue 1-2, 2010, Pages 84-88

  Baverstock, Keith ^a   Belyakov, Oleg V ^b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b STUK RADIATION AND NUCLEAR SAFETY AUTHORITY   (Finland)

Author keywords

Bystander effect; Genomic instability; Paradigm shift; Radiation biology

Indexed keywords

ARTICLE; ATOMIC BOMB SURVIVOR; BYSTANDER EFFECT; CHROMOSOME ABERRATION; DNA DAMAGE; EPIGENETICS; GENOMIC INSTABILITY; HEALTH HAZARD; HUMAN; IONIZING RADIATION; PRIORITY JOURNAL; RADIATION CARCINOGENESIS; RADIATION EXPOSURE; RADIATION HAZARD; RADIATION MUTAGENESIS; RADIATION PROTECTION; RADIOACTIVE WASTE; RISK ASSESSMENT; TANDEM REPEAT;

BYSTANDER EFFECT; DOSE-RESPONSE RELATIONSHIP, RADIATION; EPIGENESIS, GENETIC; FEMALE; GENOMIC INSTABILITY; HUMANS; MODELS, BIOLOGICAL; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RADIATION, IONIZING; RADIOBIOLOGY; RISK ASSESSMENT; TERMINOLOGY AS TOPIC;

EID: 77951296506     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2010.01.002     Document Type: Article

References (65)

1. Baverstock K., Belyakov O.V. Classical radiation biology, the bystander effect and paradigms: a reply. Hum. Exp. Toxicol. 2005, 24:537-542.
2. Baverstock K. Radiation-induced genomic instability: a paradigm-breaking phenomenon and its relevance to environmentally induced cancer. Mutat. Res. 2000, 454:89-109.
3. Morgan W.F. Genomic instability and bystander effects: a paradigm shift in radiation biology?. Mil. Med. 2002, 167:44-45.
4. Mothersill C., Seymour C. Genomic instability, bystander effects and radiation risks: implications for development of protection strategies for man and the environment. Radiat. Biol. Radioecol. 2000, 40:615-620.
5. Kadhim M.A., Macdonald D.A., Goodhead D.T., Lorimore S.A., Marsden S.J., Wright E.G. Transmission of chromosomal instability after plutonium alpha-particle irradiation. Nature 1992, 355:738-740.
6. Rosenow U.F. Notes on the legacy of the Rontgen rays. Med. Phys. 1995, 22:1855-1867.
7. Ward J. New paradigms for low-dose radiation response. Radiat. Res. 1999, 151:92-117.
8. Nagasawa H., Little J.B. Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Cancer Res. 1992, 52:6394-6396.
9. Lorimore S.A., Kadhim M.A., Pocock D.A., Papworth D., Stevens D.L., Goodhead D.T., Wright E.G. Chromosomal instability in the descendants of unirradiated surviving cells after alpha-particle irradiation. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:5730-5733.
10. Holmberg K., Falt S., Johansson A., Lambert B. Clonal chromosome aberrations and genomic instability in X-irradiated human T-lymphocyte cultures. Mutat. Res. 1993, 286:321-330.
11. Marder B.A., Morgan W.F. Delayed chromosomal instability induced by DNA damage. Mol. Cell Biol. 1993, 13:6667-6677.
12. Sabatier L., Lebeau J., Dutrillaux B. Chromosomal instability and alterations of telomeric repeats in irradiated human fibroblasts. Int. J. Radiat. Biol. 1994, 66:611-613.
13. Weissenborn U., Streffer C. The one-cell mouse embryo: cell cycle-dependent radiosensitivity and development of chromosomal anomalies in postradiation cell cycles. Int. J. Radiat. Biol. 1988, 54:659-674.
14. Seymour C.B., Mothersill C., Alper T. High yields of lethal mutations in somatic mammalian cells that survive ionizing radiation. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 1986, 50:167-179.
15. Luning K.G., Frolen H., Nilsson A. Genetic effects of 239Pu salt injections in male mice. Mutat. Res. 1976, 34:539-542.
16. Barber R., Plumb M.A., Boulton E., Roux I., Dubrova Y.E. Elevated mutation rates in the germ line of first- and second-generation offspring of irradiated male mice. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:6877-6882.
17. Barber R.C., Hardwick R.J., Shanks M.E., Glen C.D., Mughal S.K., Voutounou M., Dubrova Y.E. The effects of in utero irradiation on mutation induction and transgenerational instability in mice. Mutat. Res. 2009, 664:6-12.
18. Dubrova Y.E., Bersimbaev R.I., Djansugurova L.B., Tankimanova M.K., Mamyrbaeva Z., Mustonen R., Lindholm C., Hulten M., Salomaa S. Nuclear weapons tests and human germline mutation rate. Science 2002, 295:1037.
19. Dubrova Y.E., Grant G., Chumak A.A., Stezhka V.A., Karakasian A.N. Elevated minisatellite mutation rate in the post-chernobyl families from ukraine. Am. J. Hum. Genet. 2002, 71:801-809.
20. Dubrova Y.E., Nesterov V.N., Krouchinsky N.G., Ostapenko V.A., Neumann R., Neil D.L., Jeffreys A.J. Human minisatellite mutation rate after the Chernobyl accident. Nature 1996, 380:683-686.
21. Dubrova Y.E., Ploshchanskaya O.G., Kozionova O.S., Akleyev A.V. Minisatellite germline mutation rate in the Techa River population. Mutat. Res. 2006, 602:74-82.
22. Dubrova Y.E., Plumb M., Gutierrez B., Boulton E., Jeffreys A.J. Transgenerational mutation by radiation. Nature 2000, 405:37.
23. Barber R.C., Hickenbotham P., Hatch T., Kelly D., Topchiy N., Almeida G.M., Jones G.D., Johnson G.E., Parry J.M., Rothkamm K., Dubrova Y.E. Radiation-induced transgenerational alterations in genome stability and DNA damage. Oncogene 2006, 25:7336-7342.
24. Kennedy A.R., Fox M., Murphy G., Little J.B. Relationship between X-ray exposure and malignant transformation in C3H 10T1/2 cells. Proc. Natl. Acad. Sci. U.S.A. 1980, 77:7262-7266.
25. Kennedy A.R., Little J.B. Evidence that a second event in X-ray-induced oncogenic transformation in vitro occurs during cellular proliferation. Radiat. Res. 1984, 99:228-248.
26. Kennedy A.R., Troll W., Little J.B. Role of free radicals in the initiation and promotion of radiation transformation in vitro. Carcinogenesis 1984, 5:1213-1218.
27. Little J.B., Kennedy A.R. Promotion of X-ray transformation in vitro. Carcinog. Compr. Surv. 1982, 7:243-257.
28. Ehlers G., Fridman M. Abscopal effect of radiation in papillary adenocarcinoma. Br. J. Radiol. 1973, 46:220-222.
29. Nobler M.P. The abscopal effect in malignant lymphoma and its relationship to lymphocyte circulation. Radiology 1969, 93:410-412.
30. Robin H.I., AuBuchon J., Varanasi V.R., Weinstein A.B. The abscopal effect: demonstration in lymphomatous involvement of kidneys. Med. Pediatr. Oncol. 1981, 9:473-476.
31. Sham R.L. The abscopal effect and chronic lymphocytic leukemia. Am. J. Med. 1995, 98:307-308.
32. Moiseenko V.V., Battista J.J., Hill R.P., Travis E.L., Van Dyk J. In-field and out-of-field effects in partial volume lung irradiation in rodents: possible correlation between early DNA damage and functional endpoints. Int. J. Radiat. Oncol. Biol. Phys. 2000, 48:1539-1548.
33. Hollowell J.G., Littlefield L.G. Chromosome damage induced by plasma of X-rayed patients: an indirect effect of X-ray. Proc. Soc. Exp. Biol. Med. 1968, 129:240-244.
34. Littlefield L.G., Hollowell J.G., Pool W.H. Chromosomal aberrations induced by plasma from irradiated patients: an indirect effect of X radiation. Further observations and studies of a control population. Radiology 1969, 93:879-886.
35. Goh K., Sumner H. Breaks in normal human chromosomes: are they induced by a transferable substance in the plasma of persons exposed to total-body irradiation?. Radiat. Res. 1968, 35:171-181.
36. Emerit I. Reactive oxygen species, chromosome mutation, and cancer: possible role of clastogenic factors in carcinogenesis. Free Radic. Biol. Med. 1994, 16:99-109.
37. Emerit I., Levy A., Cernjavski L., Arutyunyan R., Oganesyan N., Pogosian A., Mejlumian H., Sarkisian T., Gulkandanian M., Quastel M. Transferable clastogenic activity in plasma from persons exposed as salvage personnel of the Chernobyl reactor. J. Cancer Res. Clin. Oncol. 1994, 120:558-561.
38. Emerit I., Oganesian N., Arutyunian R., Pogossian A., Sarkisian T., Cernjavski L., Levy A., Feingold J. Oxidative stress-related clastogenic factors in plasma from Chernobyl liquidators: protective effects of antioxidant plant phenols, vitamins and oligoelements. Mutat. Res. 1997, 377:239-246.
39. Emerit I., Oganesian N., Sarkisian T., Arutyunyan R., Pogosian A., Asrian K., Levy A., Cernjavski L. Clastogenic factors in the plasma of Chernobyl accident recovery workers: anticlastogenic effect of Ginkgo biloba extract. Radiat. Res. 1995, 144:198-205.
40. Khan M.A., Hill R.P., Van Dyk J. Partial volume rat lung irradiation: an evaluation of early DNA damage. Int. J. Radiat. Oncol. Biol. Phys. 1998, 40:467-476.
41. Auclair C., Gouyette A., Levy A., Emerit I. Clastogenic inosine nucleotide as components of the chromosome breakage factor in scleroderma patients. Arch. Biochem. Biophys. 1990, 278:238-244.
42. Morgan G.W., Breit S.N. Radiation and the lung: a reevaluation of the mechanisms mediating pulmonary injury. Int. J. Radiat. Oncol. Biol. Phys. 1995, 31:361-369.
43. Morgan W.F., Sowa M.B. Towards resolving conflicting reports of radiation-induced genomic instability in populations exposed to ionizing radiation: implications for the hibakusha. Int. Congr. Ser. 2007, 1299:128-134.
44. Bouffler S.D., Haines J.W., Edwards A.A., Harrison J.D., Cox R. Lack of detectable transmissible chromosomal instability after in vivo or in vitro exposure of mouse bone marrow cells to 224Ra alpha particles. Radiat. Res. 2001, 155:345-352.
45. Baverstock K. The Role of the WHO in questions relating to Public Health and Radioactive Waste Management. Proceedings of the International Conference on Safety of Radiation Waste Management, IAEA 2000.
46. Kovalchuk O., Baulch J.E. Epigenetic changes and nontargeted radiation effects-is there a link?. Environ. Mol. Mut. 2008, 49:16-25.
47. Weinhold B. Epigenetics: the science of change. Environ. Health Perspect. 2006, 114:A160-167.
48. Baverstock K. Implications of new radiobiological insights for the long term management of radioactive waste. Energy Environ. 2008, 19:497-514.
49. Huang S. Reprogramming cell fates: reconciling rarity with robustness. Bioessays 2009, 31:546-560.
50. Bouffler S.D., Bridges B.A., Cooper D.N., Dubrova Y., McMillan T.J., Thacker J., Wright E.G., Waters R. Assessing radiation-associated mutational risk to the germline: repetitive DNA sequences as mutational targets and biomarkers. Radiat. Res. 2006, 165:249-268.
51. Kodaira M., Satoh C., Hiyama K., Toyama K. Lack of effects of atomic bomb radiation on genetic instability of tandem-repetitive elements in human germ cells. Am. J. Hum. Genet. 1995, 57:1275-1283.
52. Kodama Y., Ohtaki K., Nakano M., Hamasaki K., Awa A.A., Lagarde F., Nakamura N. Clonally expanded T-cell populations in atomic bomb survivors do not show excess levels of chromosome instability. Radiat. Res. 2005, 164:618-626.
53. Vorobtsova I.E., Semenov A.V. Complex cytogenetic characteristic of people suffered from Chernobyl accident. Radiat. Biol. Radioecol. 2006, 46:140-151.
54. Vorobtsova I.E., Vorob'eva M.V., Korytova L.I., Shust V.F. The cytogenetic reaction of the lymphocytes to in-vitro irradiation in children born to patients after antitumor radio- and chemotherapy. Tsitologiia 1995, 37:449-457.
55. Vorobtsova I.E. Increased cancer risk as a genetic effect of ionising radiation in perinatal and multigenerational carcinogenesis. Perinatal and Multigenerational Carcinogenesis 1989, IARC, Lyon. Napalkov (Ed.).
56. Lord B.I., Hoyes K.P. Hemopoietic damage and induction of leukemia in offspring due to preconception paternal irradiation from incorporated plutonium-239. Radiat. Res. 1999, 152:S34-37.
57. Nomura T. Parental exposure to X rays and chemicals induces heritable tumours and anomalies in mice. Nature 1982, 296:575-577.
58. Nomura T. Transgenerational effects of radiation and chemicals in mice and humans. J. Radiat. Res. (Tokyo) 2006, 47(Suppl. B):B83-97.
59. Lord B.I., Woolford L.B., Wang L., McDonald D., Lorimore S.A., Stones V.A., Wright E.G., Scott D. Induction of lympho-haemopoietic malignancy: impact of preconception paternal irradiation. Int. J. Radiat. Biol. 1998, 74:721-728.
60. Lord B.I., Woolford L.B., Wang L., Stones V.A., McDonald D., Lorimore S.A., Papworth D., Wright E.G., Scott D. Tumour induction by methyl-nitroso-urea following preconceptional paternal contamination with plutonium-239. Br. J. Cancer 1998, 78:301-311.
61. Russell W.L., Bangham J.W., Russell L.B. Differential response of mouse male germ-cell stages to radiation-induced specific-locus and dominant mutations. Genetics 1998, 148:1567-1578.
62. Hoyes K.P., Lord B.I., McCann C., Hendry J.H., Morris I.D. Transgenerational effects of preconception paternal contamination with (55)Fe. Radiat. Res. 2001, 156:488-494.
63. Lord B.I. Transgenerational susceptibility to leukaemia induction resulting from preconception, paternal irradiation. Int. J. Radiat. Biol. 1999, 75:801-810.
64. Mancuso M., Pasquali E., Leonardi S., Tanori M., Rebessi S., Di Majo V., Pazzaglia S., Toni M.P., Pimpinella M., Covelli V., Saran A. Oncogenic bystander radiation effects in Patched heterozygous mouse cerebellum. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:12445-12450.
65. Baverstock K., Ronkko M. Epigenetic regulation of the mammalian cell. PLoS One 2008, 3:e2290.