Towards resolving conflicting reports of radiation-induced genomic instability in populations exposed to ionizing radiation: Implications for the hibakusha

International Congress Series

Volumn 1299, Issue , 2007, Pages 128-134

  Morgan, William F ^a   Sowa, Marianne B ^b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

Author keywords

Chromosomal instability; Genomic instability; Hibakusha; Ionizing radiation

Indexed keywords

EID: 33847727858     PISSN: 05315131     EISSN: None     Source Type: Book Series    
DOI: 10.1016/j.ics.2006.10.003     Document Type: Article

References (31)

1. Morgan W.F. Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro. Radiat. Res. 159 (2003) 567-580
2. Day J.P., Limoli C.L., and Morgan W.F. Recombination involving interstitial telomere repeat-like sequences promotes chromosomal instability in Chinese hamster cells. Carcinogenesis 19 (1998) 259-265
3. Murnane J.P., and Sabatier L. Chromosome rearrangements resulting from telomere dysfunction and their role in cancer. Bioessays 26 (2004) 1164-1174
4. Morgan W.F. Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects. Radiat. Res. 159 (2003) 581-596
5. Kadhim M.A. Role of genetic background in induced instability. Oncogene 22 (2003) 6994-6999
6. Kadhim M.A., et al., Lorimore S.A., Hepburn M.D., Goodhead D.T., Buckle V.J., Wright E.G. Alpha-particle-induced chromosomal instability in human bone marrow cells. Lancet 344 (1994) 987-988
7. Kadhim M.A., et al., Lorimore S.A., Townsend K.M., Goodhead D.T., Buckle V.J., Wright E.G. Radiation-induced genomic instability: delayed cytogenetic aberrations and apoptosis in primary human bone marrow cells. Int. J. Radiat. Biol. 67 (1995) 287-293
8. Salomaa S., Holmberg K., Lindholm C., et al. Chromosomal instability in in vivo radiation exposed subjects. Int. J. Radiat. Biol. 74 (1998) 771-779
9. Holmberg K., et al., Meijer A.E., Auer G., Lambert B.O. Delayed chromosomal instability in human T-lymphocyte clones exposed to ionizing radiation. Int. J. Radiat. Biol. 68 (1995) 245-255
10. Holmberg K., et al., Meijer A.E., Harms-Ringdahl M., Lambert B. Chromosomal instability in human lymphocytes after low dose rate gamma-irradiation and delayed mitogen stimulation. Int. J. Radiat. Biol. 73 (1998) 21-34
11. Lambert B., et al., Holmberg K., Hackman P., Wennborg A. Radiation induced chromosomal instability in human T-lymphocytes. Mutat. Res. 405 (1998) 161-170
12. Tawn E.J., Whitehouse C.A., and Martin F.A. Sequential chromosome aberration analysis following radiotherapy-no evidence for enhanced genomic instability. Mutat. Res. 465 (2000) 45-51
13. Lefevre S.H., Vogt N., Dutrillaux A.M., et al. Genome instability in secondary solid tumors developing after radiotherapy of bilateral retinoblastoma. Oncogene 20 (2001) 8092-8099
14. Ryabchenko N., Nasonova V., Antoschina M., et al. Persistence of chromosome aberrations in peripheral lymphocytes from Hodgkin's lymphoma remission patients. Int. J. Radiat. Biol. 79 (2003) 251-257
15. Tawn E.J., Whitehouse C.A., Winther J.F., et al. Chromosome analysis in childhood cancer survivors and their offspring-no evidence for radiotherapy-induced persistent genomic instability. Mutat. Res. 583 (2005) 198-206
16. Iwamoto K.S., Fujii S., Kurata A., et al. p53 mutations in tumor and non-tumor tissues of thorotrast recipients: a model for cellular selection during radiation carcinogenesis in the liver. Carcinogenesis 20 (1999) 1283-1291
17. Wada I., et al. High rate of small TP53 mutations and infrequent loss of heterozygosity in malignant liver tumors associated with thorotrast: implications for alpha-particle carcinogenesis. Radiat. Res. 152 (1999) S125-S127
18. Liu D., et al. Microsatellite instability in thorotrast-induced human intrahepatic cholangiocarcinoma. Int. J. Cancer 102 (2002) 366-371
19. Liu D., et al. Allelotypic characteristics of thorotrast-induced intrahepatic cholangiocarcinoma: comparison to liver cancers not associated with thorotrast. Radiat. Res. 161 (2004) 235-243
20. Littlefield L.G., et al. Cumulative genetic damage in hematopoietic stem cells in a patient with a 40-year exposure to alpha particles emitted by thorium dioxide. Radiat. Res. 148 (1997) 135-144
21. Hande M.P., et al. Past exposure to densely ionizing radiation leaves a unique permanent signature in the genome. Am. J. Hum. Genet. 72 (2003) 1162-1170
22. Hande M.P., et al. Complex chromosome aberrations persist in individuals many years after occupational exposure to densely ionizing radiation: an mFISH study. Genes Chromosomes Cancer 44 (2005) 1-9
23. Mitchell C.R., et al. Stable intrachromosomal biomarkers of past exposure to densely ionizing radiation in several chromosomes of exposed individuals. Radiat. Res. 162 (2004) 257-263
24. Whitehouse C.A., Tawn E.J., and Riddell A.E. Chromosome aberrations in radiation workers with internal deposits of plutonium. Radiat. Res. 150 (1998) 459-468
25. Whitehouse C.A., and Tawn E.J. No evidence for chromosomal instability in radiation workers with in vivo exposure to plutonium. Radiat. Res. 156 (2001) 467-475
26. Tanaka K., and Kamada N. Leukemogenesis and chromosome aberrations: de novo leukemia in humans-with special reference to atomic bomb survivors. Nippon Ketsueki Gakkai Zasshi 48 (1985) 1830-1842
27. Nakanishi M., et al. Chromosomal instability in acute myelocytic leukemia and myelodysplastic syndrome patients among atomic bomb survivors. J. Radiat. Res. 40 (1999) 159-167
28. Nakanishi M., et al. Microsatellite instability in acute myelocytic leukaemia developed from A-bomb survivors. Int. J. Radiat. Biol. 77 (2001) 687-694
29. Little M.P. Comments on the paper: Microsatellite instability in acute myelocytic leukaemia developed from A-bomb survivors. Int. J. Radiat. Biol. 78 (2002) 441-443
30. Cox R., and Edwards A.A. Comments on the paper: Microsatellite instability in acute myelocytic leukaemia developed from A-bomb survivors-and related cytogenetic data. Int. J. Radiat. Biol. 78 (2002) 443-445
31. Plumb M. Comments on the paper: Microsatellite instability in acute myelocytic leukaemia developed from A-bomb survivors-a biological perspective. Int. J. Radiat. Biol. 79 (2003) 367-370