A combination of doxycycline and ivermectin is adulticidal in dogs with naturally acquired heartworm disease (Dirofilaria immitis)

Veterinary Parasitology

Volumn 169, Issue 3-4, 2010, Pages 347-351

  Grandi, G ^a   Quintavalla, C ^a   Mavropoulou, A ^a   Genchi, M ^b   Gnudi, G ^a   Bertoni, G ^a   Kramer, L ^a  

^a UNIVERSITY OF PARMA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Dirofilaria immitis; Doxycycline; Ivermectin; Wolbachia

Indexed keywords

ANTHELMINTIC AGENT; CARDOTEK PLUS; DOXYCYCLINE; IVERMECTIN PLUS PYRANTEL PAMOATE; PARASITE ANTIGEN; PREDNISONE; RONAXAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTHELMINTIC ACTIVITY; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; COUGHING; DIROFILARIA IMMITIS; DIROFILARIASIS; DOG DISEASE; DRUG EFFECT; DRUG EFFICACY; DRUG TOLERABILITY; ECHOCARDIOGRAPHY; FEMALE; FOLLOW UP; MALE; MICROFILARIASIS; NONHUMAN; PARASITE IDENTIFICATION; PROTEIN BLOOD LEVEL; SEROLOGY; THORAX RADIOGRAPHY; TREATMENT DURATION;

ANIMALS; ANTIGENS, HELMINTH; ANTIPARASITIC AGENTS; DIROFILARIA IMMITIS; DIROFILARIASIS; DOG DISEASES; DOGS; DOXYCYCLINE; DRUG THERAPY, COMBINATION; FEMALE; IVERMECTIN; MALE; MICROFILARIA;

CANIS FAMILIARIS; DIROFILARIA IMMITIS; WOLBACHIA;

EID: 77951257008     PISSN: 03044017     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetpar.2010.01.025     Document Type: Article

References (13)

1. Bazzocchi C., Mortasino M., Grandi G., Kramer L., Genchi C., Bandi C., Genchi M., Sacchi L., McCall J.W. Combined ivermectin and doxycycline treatment has microfilaricidal and adulticidal activity against Dirofilaria immitis in experimentally infected dogs. Int. J. Parasitol. 2008, 38(12):1401-1410.
2. Debrah A.Y., Mand S., Marfo-Debrekyei Y., Batsa L., Pfarr K., Buttner M., Adjei O., Buttner D., Hoerauf A. Macrofilaricidal effect of 4 weeks of treatment with doxycycline on Wuchereria bancrofti. Trop. Med. Int. Health 2007, 12:1433-1441.
3. Genchi C., Rinaldi L., Cascone C., Mortarino M., Cringoli G. Is heartworm disease really spreading in Europe?. Vet. Parasitol. 2005, 133:137-148.
4. Gilbert J., Nfon C.K., Makepeace B.L., Njongmeta L.M., Hastings I.M., Pfarr K.M., Renz A., Tanya V.N., Trees A.J. Antibiotic chemotherapy of onchocerciasis: in a bovine model, killing of adult parasites requires a sustained depletion of endosymbiotic bacteria (Wolbachia species). J. Infect. Dis. 2005, 192:1483-1493.
5. Hoerauf A., Specht S., Büttner M., Pfarr K., Mand S., Fimmers R., Marfo-Debrekyei Y., Konadu P., Debrah A.Y., Bandi C., Brattig N., Albers A., Larbi J., Batsa L., Adjei O., Büttner D.W. Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study. Med. Microbiol. Immunol. 2008, 197(3):295-311.
6. Kramer L.H., Passeri B., Corona S., Simoncini L., Casiraghi M. Immunohistochemical/immunogold detection and distribution of the endosymbiont Wolbachia of D. immitis and Brugia pahangi using a polyclonal antiserum raised against WSP (Wolbachia surface protein). Parasitol. Res. 2003, 89:381-386.
7. Kramer L., Grandi G., Leoni M., Passeri B., McCall J., Genchi C., Mortasino M., Bazzocchi C. Wolbachia and its influence on the pathology and immunology of Dirofilaria immitis infection. Vet. Parasitol. 2008, 158(3):191-195.
8. McCall J.W., McTier T.L., Supakorndej N., Ricketts R. Clinical prophylactic activity of macrolides on young adult heartworms. Proceedings of the Heartworm Symposium '95 1995, 187-195. American Heartworm Society, Batavia, IL. M.D. Soll, D.H. Knight (Eds.).
9. McCall J.W., McTier T.L., Ryan W.G., Gross S.J., Soll M.D. Evaluation of ivermectin and milbemycin oxime efficacy against Dirofilaria immitis infections of three and four months' duration in dogs. Am. J. Vet. Res. 1996, 57:1189-1192.
10. McCall J.W., Ryan W.G., Roberts R.E., Dzimianski M.T. Heartworm adulticidal activity of prophylactic doses of ivermectin (6μg/kg) plus pyrantel administered monthly to dogs. Recent Advances in Heartworm Disease: Symposium '98 1998, 209-215. American Heartworm Society, Batavia, IL. R.L. Seward (Ed.).
11. McCall J.W., Guerrero J., Roberts R.E., Supakorndej N., Mansour A.E., Dzimianski M.T., McCall S.D. Further evidence of clinical prophylactic, retro-active (reach-back) and adulticidal activity of monthly administrations of ivermectin (Heartgard Plus™) in dogs experimentally infected with heartworms. Recent Advances in Heartworm Disease: Symposium '01 2001, 189-200. American Heartworm Society, Batavia, IL. R.L. Seward (Ed.).
12. Nelson C.T., McCall J.W., Rubin S.B., Buzhardt L.F., Dorion D.W., Graham W., Longhofer S.L., Guerrero J., Robertson-Plouch C., Paul A. Guidelines for the diagnosis, prevention and management of heartworm (Dirofilaria immitis) infection in dogs. Vet. Parasitol. 2005, 133(2-3):255-266. Executive Board of the American Heartworm Society.
13. Venco L., McCall J.W., Guerrero J., Genchi C. Efficacy of long-term monthly administration of ivermectin on the progress of naturally acquired heartworm infections in dogs. Vet. Parasitol. 2004, 124(3-4):259-268.