Wolbachia and its influence on the pathology and immunology of Dirofilaria immitis infection

Veterinary Parasitology

Volumn 158, Issue 3, 2008, Pages 191-195

  Kramer, L ^a   Grandi, G ^a   Leoni, M ^a   Passeri, B ^a   McCall, J ^b   Genchi, C ^c   Mortarino, M ^c   Bazzocchi, C ^c  

^a UNIVERSITY OF PARMA   (Italy)

^b UNIVERSITY OF GEORGIA   (United States)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Dirofilaria immitis; Immunohistochemistry; Lung; Pathology; Wolbachia

Indexed keywords

DOXYCYCLINE; IVERMECTIN; MELARSAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIROFILARIA IMMITIS; DOG; DRUG EFFECT; FEMALE; FILARIASIS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LUNG INFECTION; MALE; NONHUMAN; WOLBACHIA;

ANIMALS; ANTI-BACTERIAL AGENTS; ARSENICALS; BACTERIAL OUTER MEMBRANE PROTEINS; DIROFILARIA IMMITIS; DIROFILARIASIS; DOG DISEASES; DOGS; DOXYCYCLINE; FEMALE; FILARICIDES; IMMUNOHISTOCHEMISTRY; IVERMECTIN; LUNG; MALE; SEVERITY OF ILLNESS INDEX; TRIAZINES; WOLBACHIA;

BACTERIA (MICROORGANISMS); CANIS FAMILIARIS; DIROFILARIA IMMITIS; WOLBACHIA;

EID: 55249095740     PISSN: 03044017     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetpar.2008.09.014     Document Type: Article

References (11)

1. Bazzocchi C., Genchi C., Paltrinieri S., Lecchi C., Mortarino M., and Bandi C. Immunological role of the endosymbionts of Dirofilaria immitis: the Wolbachia surface protein activates canine neutrophils with production of IL-8. Vet. Parasitol. 117 (2003) 73-83
2. Bazzocchi C., Mortarino M., Grandi G., Kramer L.H., Genchi C., Bandi C., Genchi M., Sacchi L., and McCall J.W. Combined ivermectin-doxycycline treatment has microfilaricidal and adulticide activity against D. immitis in experimentally infected dogs. Int. J. Parasitol 38 (2008) 1401-1410
3. Brattig N.W., Bazzocchi C., Kirschning C.J., Reiling N., Buttner D.W., Ceciliani F., Geisinger F., Hochrein H., Ernst M., Wagner H., Bandi C., and Hoerauf A. The major surface protein of Wolbachia endosymbionts in filarial nematodes elicits immune responses through TLR2 and TLR4. J. Immunol. 73 (2004) 437-445
4. Chirgwin S.R., Coleman S.U., Porthouse K.H., Nowling J.M., Punkosdy G.A., and Klei T.R. Removal of Wolbachia from Brugia pahangi is closely linked to worm death and fecundity but does not result in altered lymphatic lesion formation in Mongolian gerbils (Meriones unguiculatus). Infect. Immun. 71 (2003) 6986-6994
5. Debrah A.Y., Mand S., Specht S., Marfo-Debrekyei Y., and Batsa L. Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis. PLoS Pathog. 2 (2006) e92
6. Grandi G., Kramer L.H., Bazzocchi C., Mortarino M., Venco L., and Genchi C. Dirofilaria immitis and the endosymbiont Wolbachia: inflammation and immune response in heartworm disease. Jpn. J. Vet. Parasitol. 4 (2005) 11-16
7. Hoerauf A., Volkmann L., Hamelmann C., Adjei O., Autenrieth I.B., Fleischer B., and Buttner D.W. Endosymbiotic bacteria in worms as targets for a novel chemotherapy in filariasis. Lancet 355 (2000) 1242-1243
8. Hoerauf A., Adjei O., and Buttner D.W. Antibiotics for the treatment of onchocerciasis and other filarial infections. Curr. Opin. Invest. Drugs 3 (2002) 533-537
9. Kramer L.H., Passeri B., Corona S., Simoncini L., and Casiraghi M. Immunohistochemical/immunogold detection and distribution of the endosymbiont Wolbachia of D. immitis and Brugia pahangi using a polyclonal antiserum raised against WSP (Wolbachia surface protein). Parasitol. Res. 89 (2003) 381-386
10. Saint André A., Blackwell N.M., May L.R., Hoerauf A., Brattig N.W., Volkmann L., Taylor M.J., Ford L., Hise A.G., Lass J.H., Diaconu E., and Pearlman E. The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness. Science 295 (2002) 1892-1895
11. Taylor M.J., Bandi C., and Hoerauf A. Wolbachia bacterial endosymbionts of filarial nematodes. Adv. Parasitol. 60 (2005) 245-284