Systematic review: Accuracy of anti-citrullinated peptide antibodies for diagnosing rheumatoid arthritis

Annals of Internal Medicine

Volumn 152, Issue 7, 2010, Pages 456-464

  Whiting, Penny F ^a   Smidt, Nynke ^b   Sterne, Jonathan A C ^a   Harbord, Roger ^a   Burton, Anya ^a   Burke, Margaret ^a   Beynon, Rebecca ^a   Ben Shlomo, Yoav ^a   Axford, John ^c   Dieppe, Paul ^d  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY OF EXETER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CITRULLINATED PEPTIDE ANTIBODY; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; CYCLIC CITRULLINATED PEPTIDE ANTIBODY 2; PEPTIDE ANTIBODY; RHEUMATOID FACTOR; UNCLASSIFIED DRUG; AUTOANTIBODY; CYCLIC CITRULLINATED PEPTIDE; CYCLOPEPTIDE;

DIAGNOSTIC ACCURACY; EVIDENCE BASED PRACTICE; HUMAN; PRIORITY JOURNAL; QUALITY CONTROL; REVIEW; RHEUMATOID ARTHRITIS; SENSITIVITY AND SPECIFICITY; SYSTEMATIC REVIEW; BLOOD; FEMALE; IMMUNOLOGY; MALE;

ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; FEMALE; HUMANS; MALE; PEPTIDES, CYCLIC; SENSITIVITY AND SPECIFICITY;

EID: 77951246621     PISSN: 00034819     EISSN: 15393704     Source Type: Journal    
DOI: 10.7326/0003-4819-152-7-201004060-00010     Document Type: Review

References (182)

1. Kvien TK. Epidemiology and burden of illness of rheumatoid arthritis. Pharmacoeconomics. 2004;22:1-12. [PMID: 15157000]
2. Klareskog L, Catrina AI, Paget S. Rheumatoid arthritis. Lancet. 2009;373:659-672 [PMID: 19157532]
3. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31:315-324 [PMID: 3358796]
4. Nishimura K, Sugiyama D, Kogata Y, Tsuji G, Nakazawa T, Kawano S, et al. Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis. Ann Intern Med. 2007;146:797-808. [PMID: 17548411] (Pubitemid 351650500)
5. Levesque MC, Zhou Z, Moreland LW. Anti-cyclic citrullinated peptide testing for the diagnosis of rheumatoid arthritis and the quest for improved sensitivity and predictive value [Editorial]. Arthritis Rheum. 2009;60:2211-2215 [PMID: 19644881]
6. Bizzaro N, Mazzanti G, Tonutti E, Villalta D, Tozzoli R. Diagnostic accuracy of the anti-citrulline antibody assay for rheumatoid arthritis. Clin Chem. 2001;47:1089-1093 [PMID: 11375296] (Pubitemid 32493596)
7. György B, Tóth E, Tarcsa E, Falus A, Buzás EI. Citrullination: a posttranslational modification in health and disease. Int J Biochem Cell Biol. 2006;38:1662-1677 [PMID: 16730216]
8. Schellekens GA, Visser H, de Jong BA, van den Hoogen FH, Hazes JM, Breedveld FC, et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum. 2000;43:155-163 [PMID: 10643712] (Pubitemid 30368225)
9. Nienhuis RL, Mandema E. A new serum factor in patients with rheumatoid arthritis; the antiperinuclear factor. Ann Rheum Dis. 1964;23:302-305 [PMID: 14178016]
10. Young BJ, Mallya RK, Leslie RD, Clark CJ, Hamblin TJ. Anti-keratin antibodies in rheumatoid arthritis. Br Med J. 1979;2:97-99 [PMID: 111762]
11. Simon M, Girbal E, Sebbag M, Gomès-Daudrix V, Vincent C, Salama G, et al. The cytokeratin filament-aggregating protein filaggrin is the target of the so-called "antikeratin antibodies," autoantibodies specific for rheumatoid arthritis. J Clin Invest. 1993;92:1387-1393 [PMID: 7690781]
12. Vincent C, de Keyser F, Masson-Bessière C, Sebbag M, Veys EM, Serre G. Anti-perinuclear factor compared with the so called "antikeratin" antibodies and antibodies to human epidermis filaggrin, in the diagnosis of arthritides. Ann Rheum Dis. 1999;58:42-48 [PMID: 10343539]
13. Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ. Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest. 1998;101:273-281 [PMID: 9421490]
14. Bizzaro N, Tonutti E, Tozzoli R, Villalta D. Analytical and diagnostic characteristics of 11 2nd- and 3rd-generation immunoenzymatic methods for the detection of antibodies to citrullinated proteins. Clin Chem. 2007;53:1527-1533 [PMID: 17586589] (Pubitemid 47206351)
15. Correia ML, Carvalho S, Fortuna J, Pereira MH. Comparison of three anti-CCP antibody tests and rheumatoid factor in RA and control patients. Clin Rev Allergy Immunol. 2008;34:21-25 [PMID: 18270853]
16. Mutlu N, Bicakcigil M, Tasan DA, Kaya A, Yavuz S, Ozden AI. Comparative performance analysis of 4 different anti-citrullinated protein assays in the diagnosis of rheumatoid arthritis. J Rheumatol. 2009;36:491-500. [PMID: 19228660]
17. Bang H, Egerer K, Gauliard A, Lüthke K, Rudolph PE, Fredenhagen G, et al. Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis. Arthritis Rheum. 2007;56:2503-2511 [PMID: 17665451] (Pubitemid 47237269)
18. Lutteri L, Malaise M, Chapelle JP. Comparison of second- and third-generation anti-cyclic citrullinated peptide antibodies assays for detecting rheumatoid arthritis. Clin Chim Acta. 2007;386:76-81. [PMID: 17826752] (Pubitemid 47417966)
19. Riedemann JP, Muñoz S, Kavanaugh A. The use of second-generation anti-CCP antibody (anti-CCP2) testing in rheumatoid arthritis-a systematic review. Clin Exp Rheumatol. 2005;23:S69-76. [PMID: 16273788] (Pubitemid 46657513)
20. Harbord RM, Whiting P, Sterne JA, Egger M, Deeks JJ, Shang A, et al. An empirical comparison of methods for meta-analysis of diagnostic accuracy showed hierarchical models are necessary. J Clin Epidemiol. 2008;61:1095-1103 [PMID: 19208372]
21. Leeflang MM, Scholten RJ, Rutjes AW, Reitsma JB, Bossuyt PM. Use of methodological search filters to identify diagnostic accuracy studies can lead to the omission of relevant studies. J Clin Epidemiol. 2006;59:234-240 [PMID: 16488353]
22. Reitsma JB, Rutjes AW, Whiting P, Vlassov VV, Leeflang MM, Deeks JJ. Chapter 9: Assessing methodological quality. In: Deeks JJ, Bossuyt PM, Gatsonis C, eds. Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy. Version 1.0.0. The Cochrane Collaboration; 2009. Accessed at http://srdta.cochrane.org/en/authors.html on 19 February 2010.
23. Harbord RM, Deeks JJ, Egger M, Whiting P, Sterne JA. A unification of models for meta-analysis of diagnostic accuracy studies. Biostatistics. 2007;8:239-251 [PMID: 16698768] (Pubitemid 46569586)
24. Riley RD, Abrams KR, Sutton AJ, Lambert PC, Thompson JR. Bivariate random-effects meta-analysis and the estimation of between-study correlation. BMC Med Res Methodol. 2007;7:3. [PMID: 17222330]
25. Harbord R, Whiting P. Metandi: Meta-analysis of diagnostic accuracy using hierarchical logistic regression. Stata J. 2009;9:211-229.
26. Rutjes AW, Reitsma JB, Di Nisio M, Smidt N, van Rijn JC, Bossuyt PM. Evidence of bias and variation in diagnostic accuracy studies. CMAJ. 2006;174:469-476 [PMID: 16477057] (Pubitemid 43294861)
27. Banal F, Dougados M, Combescure C, Gossec L. Sensitivity and specificity of the American College of Rheumatology 1987 criteria for the diagnosis of rheumatoid arthritis according to disease duration: a systematic literature review and meta-analysis. Ann Rheum Dis. 2009;68:1184-1191 [PMID: 18728049]
28. Liao KP, Batra KL, Chibnik L, Schur PH, Costenbader KH. Anti-cyclic citrullinated peptide revised criteria for the classification of rheumatoid arthritis. Ann Rheum Dis. 2008;67:1557-1561 [PMID: 18234714]
29. Hyrich KL. Patients with suspected rheumatoid arthritis should be referred early to rheumatology. BMJ. 2008;336:215-216 [PMID: 18219044]
30. Combe B, Landewe R, Lukas C, Bolosiu HD, Breedveld F, Dougados M, et al. EULAR recommendations for the management of early arthritis: report of a task force of the European Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis. 2007;66:34-45. [PMID: 16396980] (Pubitemid 46044858)
31. Sutton AJ, Cooper NJ, Goodacre S, Stevenson M. Integration of metaanalysis and economic decision modeling for evaluating diagnostic tests. Med Decis Making. 2008;28:650-667 [PMID: 18753686]
32. Shmerling RH. Testing for anti-cyclic citrullinated peptide antibodies: is it time to set this genie free? Arch Intern Med. 2009;169:9-14. [PMID: 19139318]
33. Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig LM, et al; Standards for Reporting of Diagnostic Accuracy. The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration. Ann Intern Med. 2003;138:W1-12. [PMID: 12513067]
34. Aho K, Palosuo T, Lukka M, Kurki P, Isomäki H, Kautiainen H, et al. Antifilaggrin antibodies in recent-onset arthritis. Scand J Rheumatol. 1999;28: 113-116 [PMID: 10229141]
35. Ateş A, Karaaslan Y, Aksaray S. Predictive value of antibodies to cyclic citrullinated peptide in patients with early arthritis. Clin Rheumatol. 2007;26:499-504. [PMID: 16670828] (Pubitemid 46359287)
36. Baeten D, Kruithof E, De Rycke L, Vandooren B, Wyns B, Boullart L, et al. Diagnostic classification of spondylarthropathy and rheumatoid arthritis by synovial histopathology: a prospective study in 154 consecutive patients. Arthritis Rheum. 2004;50:2931-2941 [PMID: 15457462]
37. Boer AK, Weekamp HH, van der Lugt CP, van de Laar MA, van der Sluijs Veer G. [The diagnostic accuracy of anti-citrullin antibody assessment in the diagnosis of patients suspected of rheumatoid arthritis by a general practitioner]. Ned Tijdschr Geneeskd. 2008;152:91-95 [PMID: 18265799]
38. Coenen D, Verschueren P, Westhovens R, Bossuyt X. Technical and diagnostic performance of 6 assays for the measurement of citrullinated protein/peptide antibodies in the diagnosis of rheumatoid arthritis. Clin Chem. 2007;53: 498-504. [PMID: 17259232]
39. De Rycke L, Peene I, Hoffman IE, Kruithof E, Union A, Meheus L, et al. Rheumatoid factor and anticitrullinated protein antibodies in rheumatoid arthritis: diagnostic value, associations with radiological progression rate, and extraarticular manifestations. Ann Rheum Dis. 2004;63:1587-1593 [PMID: 15547083]
40. Dejaco C, Klotz W, Larcher H, Duftner C, Schirmer M, Herold M. Diagnostic value of antibodies against a modified citrullinated vimentin in rheumatoid arthritis. Arthritis Res Ther. 2006;8:R119. [PMID: 16859519]
41. Fernández-Suárez A, Reneses S, Wichmann I, Criado R, Núñez A. Efficacy of three ELISA measurements of anti-cyclic citrullinated peptide antibodies in the early diagnosis of rheumatoid arthritis. Clin Chem Lab Med. 2005;43:1234-1239 [PMID: 16232091]
42. Luis Caro-Oleas J, Fernández-Suárez A, Reneses Cesteros S, Porrino C, Núñez-Roldán A, Wichmann Schlipf I. Diagnostic usefulness of a thirdgeneration anti-cyclic citrulline antibody test in patients with recent-onset polyarthritis. Clin Chem Lab Med. 2007;45:1396-1401 [PMID: 17924851]
43. Goldbach-Mansky R, Lee J, McCoy A, Hoxworth J, Yarboro C, Smolen JS, et al. Rheumatoid arthritis|associated autoantibodies in patients with synovitis of recent onset. Arthritis Res. 2000;2:236-243 [PMID: 11056669]
44. Herold M, Boeser V, Russe E, Klotz W. Anti-CCP: history and its usefulness. Clin Dev Immunol. 2005;12:131-135 [PMID: 16050144]
45. Hoffman IE, Peene I, Pottel H, Union A, Hulstaert F, Meheus L, et al. Diagnostic performance and predictive value of rheumatoid factor, anticitrullinated peptide antibodies, and the HLA shared epitope for diagnosis of rheumatoid arthritis. Clin Chem. 2005;51:261-263 [PMID: 15388633]
46. Kudo-Tanaka E, Ohshima S, Ishii M, Mima T, Matsushita M, Azuma N, et al. Autoantibodies to cyclic citrullinated peptide 2 (CCP2) are superior to other potential diagnostic biomarkers for predicting rheumatoid arthritis in early undifferentiated arthritis. Clin Rheumatol. 2007;26:1627-1633 [PMID: 17286215]
47. Lee DM, Schur PH. Clinical utility of the anti-CCP assay in patients with rheumatic diseases. Ann Rheum Dis. 2003;62:870-874 [PMID: 12922961]
48. Miyamura T, Watanabe H, Takahama S, Sonomoto K, Nakamura M, Ando H, et al. [Diagnostic utility of anti-cyclic citrullinated peptide antibody in early rheumatoid arthritis]. Nihon Rinsho Meneki Gakkai Kaishi. 2009;32:102-109 [PMID: 19404008]
49. Narváez J, Sirvent E, Narváez JA, Bas J, Gómez-Vaquero C, Reina D, et al. Usefulness of magnetic resonance imaging of the hand versus anticyclic citrullinated peptide antibody testing to confirm the diagnosis of clinically suspected early rheumatoid arthritis in the absence of rheumatoid factor and radiographic erosions. Semin Arthritis Rheum. 2008;38:101-109 [PMID: 18221987]
50. Nell VP, Machold KP, Stamm TA, Eberl G, Heinzl H, Uffmann M, et al. Autoantibody profiling as early diagnostic and prognostic tool for rheumatoid arthritis. Ann Rheum Dis. 2005;64:1731-1736 [PMID: 15878904]
51. Nielen MM, van der Horst AR, van Schaardenburg D, van Schaardenburg D, van de Stadt RJ, van der Horst-Bruinsma I, et al. Antibodies to citrullinated human fibrinogen predict radiographic progression in early arthritis. Arthritis Rheum. 2004; 50:S162.
52. Nikolaisen C, Rekvig OP, Nossent HC. Diagnostic impact of contemporary biomarker assays for rheumatoid arthritis. Scand J Rheumatol. 2007;36:97-100. [PMID: 17476614]
53. Panchagnula R, Rajiv SR, Prakash J, Chandrashekara S, Suresh KP. Role of anticyclic citrullinated peptide in the diagnosis of early rheumatoid factornegative suspected rheumatoid arthritis: is it worthwhile to order the test? J Clin Rheumatol. 2006;12:172-175 [PMID: 16891919]
54. Raza K, Breese M, Nightingale P, Kumar K, Potter T, Carruthers DM, et al. Predictive value of antibodies to cyclic citrullinated peptide in patients with very early inflammatory arthritis. J Rheumatol. 2005;32:231-238 [PMID: 15693082]
55. Sauerland U, Becker H, Seidel M, Schotte H, Willeke P, Schorat A, et al. Clinical utility of the anti-CCP assay: experiences with 700 patients. Ann N Y Acad Sci. 2005;1050:314-318 [PMID: 16014547]
56. Silveira IG, Burlingame RW, von Mühlen CA, Bender AL, Staub HL. Anti-CCP antibodies have more diagnostic impact than rheumatoid factor (RF) in a population tested for RF. Clin Rheumatol. 2007;26:1883-1889 [PMID: 17410320]
57. Tamai M, Kawakami A, Uetani M, Takao S, Arima K, Iwamoto N, et al. A prediction rule for disease outcome in patients with undifferentiated arthritis using magnetic resonance imaging of the wrists and finger joints and serologic autoantibodies. Arthritis Rheum. 2009;61:772-778 [PMID: 19479686]
58. van der Linden MP, van der Woude D, Ioan-Facsinay A, Levarht EW, Stoeken-Rijsbergen G, Huizinga TW, et al. Value of anti-modified citrullinated vimentin and third-generation anti-cyclic citrullinated peptide compared with second-generation anti-cyclic citrullinated peptide and rheumatoid factor in predicting disease outcome in undifferentiated arthritis and rheumatoid arthritis. Arthritis Rheum. 2009;60:2232-2241 [PMID: 19644872]
59. van Gaalen FA, Visser H, Huizinga TW. A comparison of the diagnostic accuracy and prognostic value of the first and second anti-cyclic citrullinated peptides (CCP1 and CCP2) autoantibody tests for rheumatoid arthritis. Ann Rheum Dis. 2005;64:1510-1512 [PMID: 15800005]
60. Villaverde García V, Balsa A, Carmona L, Sanmarti R, Maese J, Pascual D, et al. What are patients with early rheumatoid arthritis like in Spain? Description of the PROAR cohort. Reumatologia Clin. 2009;5:115-120.
61. Vittecoq O, Jouen-Beades F, Krzanowska K, Bichon-Tauvel I, Ménard JF, Daragon A, et al. Rheumatoid factors, anti-filaggrin antibodies and low in vitro interleukin-2 and interferon-gamma production are useful immunological markers for early diagnosis of community cases of rheumatoid arthritis. A preliminary study. Joint Bone Spine. 2001;68:144-153 [PMID: 11324930]
62. Yamane T, Hashiramoto A, Tanaka Y, Tsumiyama K, Miura Y, Shiozawa K, et al. Easy and accurate diagnosis of rheumatoid arthritis using anti-cyclic citrullinated peptide 2 antibody, swollen joint count, and C-reactive protein/ rheumatoid factor. J Rheumatol. 2008;35:414-420 [PMID: 18203327]
63. Gao IK, Haas-Wöhrle A, Mueller KG, Lorenz HM, Fiehn C. Determination of anti-CCP antibodies in patients with suspected rheumatoid arthritis: does it help to predict the diagnosis before referral to a rheumatologist? [Letter]. Ann Rheum Dis. 2005;64:1516-1517 [PMID: 16162906]
64. Galati S, Beauvillain C, Renier G, Jeannin P, Masson C, Chevailler A. [Comparison and relevance of rheumatoid factors, antikeratin antibodies and anti-cyclic citrullinated peptides antibodies in rheumatoid arthritis]. Ann Biol Clin (Paris). 2008;66:157-164 [PMID: 18390426]
65. García-Berrocal B, González C, Pérez M, Navajo JA, Moreta I, Dávila C, et al. Anti-cyclic citrullinated peptide autoantibodies in IgM rheumatoid factorpositive patients. Clin Chim Acta. 2005;354:123-130 [PMID: 15748608]
66. Heidari B, Heidari P. Prevalence and predicted value of anti-cyclic citrullinated peptide in the diagnosis of rheumatoid arthritis. Rheumatology. 2006;45:I103.
67. Heidari B, Firouzjahi AR, Lotfi Z. Prevalence and discriminating ability of anti-cyclic citrullinated peptide antibody and rheumatoid factor in recognizing rheumatoid arthritis from non-rheumatoid arthritis musculoskeletal diseases. Rheumatology. 2007;46:I142-I143.
68. Hill JA, Al-Bishri J, Gladman DD, Cairns E, Bell DA. Serum autoantibodies that bind citrullinated fibrinogen are frequently found in patients with rheumatoid arthritis. J Rheumatol. 2006;33:2115-2119 [PMID: 16924693]
69. Hitchon CA, Alex P, Erdile LB, Frank MB, Dozmorov I, Tang Y, et al. A distinct multicytokine profile is associated with anti-cyclical citrullinated peptide antibodies in patients with early untreated inflammatory arthritis. J Rheumatol. 2004;31:2336-2346 [PMID: 15570632]
70. Lim MK, Sheen DH, Lee YJ, Mun YR, Park M, Shim SC. Anti-cyclic citrullinated peptide antibodies distinguish hepatitis B virus (HBV)-associated arthropathy from concomitant rheumatoid arthritis in patients with chronic HBV infection. J Rheumatol. 2009;36:712-716 [PMID: 19286846]
71. Limaye S, Carr V, Kirkpatrick P, Williams A, Adelstein S. Antibodies to cyclic citrullinated peptide in patients with chronic arthritis attending an arthritis-monitoring clinic. J Clin Rheumatol. 2005;11:150-152 [PMID: 16357734]
72. Marrone M, Chialà A, Tampoia M, Iannone F, Raho L, Covelli M, et al. [Prevalence of anti-CCP antibodies in systemic sclerosis]. Reumatismo. 2007;59:20-24 [PMID: 17435838]
73. Mettler S, Roch A, Langer H. Antibodies against cyclic citruillinated peptide (GGP; Filaggrin) in daily rheumatology practice: highly specific in diagnosis of rheumatoid arthritis. Ann Rheum Dis. 2003; 62(Suppl 1):385-386.
74. Vallbracht I, Oppermann M, Helmke K. Additional diagnostic and clinical value of anti-citrullinated peptide antibodies in early rheumatoid arthritis compared to rheumatoid factor-isotypes. Ann Rheum Dis. 2003;62:159.
75. van der Cruyssen B, Nogueira L, Van Praet J, Deforce D, Elewaut D, Serre G, et al. Do all anti-citrullinated protein/peptide antibody tests measure the same? Evaluation of discrepancy between anti-citrullinated protein/peptide antibody tests in patients with and without rheumatoid arthritis. Ann Rheum Dis. 2008;67:542-546 [PMID: 17644546]
76. Abdel Baky MS, Abdel-Mohsen D, Mansour H, Abdel-Hafeez M, Abdel-Ghany G. Use of anti-cyclic citrullinated peptide antibodies to distinguish between rheumatoid arthritis and hepatitis c virus infection associated polyarthritis. Arthritis Rheum. 2006;54:S631.
77. Abdel-Nasser AM, Mahmoud MH, El Mansoury TM, Osman AM. Anti-CCP2 is an adjunct to, not a surrogate for, rheumatoid factor in the diagnosis of rheumatoid arthritis: diagnostic utility of anti-CCP2 antibodies in Egyptian patients with rheumatoid arthritis. Scand J Rheumatol. 2008;37:329-336 [PMID: 18666028]
78. Aigner E, Schmid I, Osterreicher CH, Zwerina J, Schett G, Strasser M, et al. Contribution of anti-cyclic citrullinated peptide antibody and rheumatoid factor to the diagnosis of arthropathy in haemochromatosis. Ann Rheum Dis. 2007;66:1249-1251 [PMID: 17456529]
79. Aleksandrova EN, Chemeris NA, Karateev DE, Novikov AA, Brodetskaia KA, Nasonov EL. [Antibodies to cyclic citrullinized peptide in rheumatoid arthritis]. Ter Arkh. 2004;76:64-68 [PMID: 15724930]
80. Alexiou I, Germenis A, Ziogas A, Theodoridou K, Sakkas LI. Diagnostic value of anti-cyclic citrullinated peptide antibodies in Greek patients with rheumatoid arthritis. BMC Musculoskelet Disord. 2007;8:37. [PMID: 17448247]
81. Amezcua-Guerra LM, Springall R, Marquez-Velasco R, Gómez- García L, Vargas A, Bojalil R. Presence of antibodies against cyclic citrullinated peptides in patients with 'rhupus': a cross-sectional study. Arthritis Res Ther. 2006;8:R144. [PMID: 16934155]
82. Anzilotti C, Riente L, Pratesi F, Chimenti D, Delle Sedie A, Bombardieri S, et al. IgG, IgA, IgM antibodies to a viral citrullinated peptide in patients affected by rheumatoid arthritis, chronic arthritides and connective tissue disorders. Rheumatology (Oxford). 2007;46:1579-1582 [PMID: 17717033]
83. Aotsuka S, Okawa-Takatsuji M, Nagatani K, Nagashio C, Kano T, Nakajima K, et al. A retrospective study of the fluctuation in serum levels of anti-cyclic citrullinated peptide antibody in patients with rheumatoid arthritis. Clin Exp Rheumatol. 2005;23:475-481 [PMID: 16095115]
84. Aridoǧan BC, Kaya S, Savaş S, Cetin ES, Akkuş S, Demirci M. [The role of anti-cyclic citrullinated peptide (anti-CCP) antibodies in serologic diagnosis and evaluation of disease activity in rheumatoid arthritis]. Mikrobiyol Bul. 2008;42:669-674 [PMID: 19149089]
85. Atta AM, Carvalho EM, Jerônimo SM, Sousa Atta ML. Serum markers of rheumatoid arthritis in visceral leishmaniasis: rheumatoid factor and anti-cyclic citrullinated peptide antibody. J Autoimmun. 2007;28:55-58 [PMID: 17257811]
86. Bas S, Perneger TV, Mikhnevitch E, Seitz M, Tiercy JM, Roux-Lombard P, et al. Association of rheumatoid factors and anti-filaggrin antibodies with severity of erosions in rheumatoid arthritis. Rheumatology (Oxford). 2000;39: 1082-1088 [PMID: 11035127]
87. Bas S, Perneger TV, Seitz M, Tiercy JM, Roux-Lombard P, Guerne PA. Diagnostic tests for rheumatoid arthritis: comparison of anti-cyclic citrullinated peptide antibodies, anti-keratin antibodies and IgM rheumatoid factors. Rheumatology (Oxford). 2002;41:809-814 [PMID: 12096232]
88. Bas S, Genevay S, Meyer O, Gabay C. Anti-cyclic citrullinated peptide antibodies, IgM and IgA rheumatoid factors in the diagnosis and prognosis of rheumatoid arthritis. Rheumatology (Oxford). 2003;42:677-680 [PMID: 12709545]
89. Bassyouni IH, Ezzat Y, Hamdy S, Talaat RM. Clinical significance of anticyclic citrullinated peptide antibodies in Egyptian patients with chronic hepatitis C virus genotype IV infection. Clin Chem Lab Med. 2009;47:842-847 [PMID: 19575546]
90. Bongi SM, Manetti R, Melchiorre D, Turchini S, Boccaccini P, Vanni L, et al. Anti-cyclic citrullinated peptide antibodies are highly associated with severe bone lesions in rheumatoid arthritis anti-CCP and bone damage in RA. Autoimmunity. 2004;37:495-501. [PMID: 15621577]
91. Candia L, Marquez J, Gonzalez C, Santos AM, Londoño J, Valle R, et al. Low frequency of anticyclic citrullinated peptide antibodies in psoriatic arthritis but not in cutaneous psoriasis. J Clin Rheumatol. 2006;12:226-229 [PMID: 17023808]
92. Ceccato F, Roverano S, Barrionuevo A, Rillo O, Paira S. The role of anticyclic citrullinated peptide antibodies in the differential diagnosis of elderly-onset rheumatoid arthritis and polymyalgia rheumatica. Clin Rheumatol. 2006;25:854-857 [PMID: 16514472]
93. Cho SY, Kang SY, Lee HJ, Lee WI. [A comparative evaluation of the diagnostic value of anti-cyclic citrullinated peptide and rheumatoid factor in rheumatoid arthritis]. Korean J Lab Med. 2008;28:39-45. [PMID: 18309254]
94. Choi KH, Lee EB, Yoo CD, Baek HJ, Kang SW, Shin KC, et al. Clinical significance of anti-filaggrin antibody recognizing uncitrullinated filaggrin in rheumatoid arthritis. Exp Mol Med. 2005;37:546-552 [PMID: 16391515]
95. Choi SW, Lim MK, Shin DH, Park JJ, Shim SC. Diagnostic performances of anti-cyclic citrullinated peptides antibody and antifilaggrin antibody in Korean patients with rheumatoid arthritis. J Korean Med Sci. 2005;20:473-478 [PMID: 15953872]
96. da Silva AF, Matos AN, Lima AM, Lima EF, Gaspar AP, Braga JA, et al. Diagnostic value of anti-cyclic citrullinated peptide antibody in rheumatoid arthritis. Rev Bras Reumatol. 2006;46:174-180
97. Damjanovska L, Atanasovska V, Gruev T. The diagnostic value of anti-cyclic citrullinated peptide antibodies (anti-CCP) in patients with rheumatoid arthritis. J Med Biochem. 2007;26:285-288.
98. de Seny D, Fillet M, Meuwis MA, Geurts P, Lutteri L, Ribbens C, et al. Discovery of new rheumatoid arthritis biomarkers using the surface-enhanced laser desorption/ionization time-of-flight mass spectrometry ProteinChip approach. Arthritis Rheum. 2005;52:3801-3812 [PMID: 16320331]
99. Devauchelle-Pensec V, Saraux A, Youinou P, Le Goff P. Antiperinuclear factor and antikeratin/antifilaggrin antibodies for differentiating early rheumatoid arthritis from polymyalgia rheumatica. Joint Bone Spine. 2001;68:306-310.
100. dos Anjos LM, Pereira IA, d 'Orsi E, Seaman AP, Burlingame RW, Morato EF. A comparative study of IgG second- and third-generation anti-cyclic citrullinated peptide (CCP) ELISAs and their combination with IgA third-generation CCP ELISA for the diagnosis of rheumatoid arthritis. Clin Rheumatol. 2009;28:153-158 [PMID: 18795390]
101. Dos Santos WS, Da Silva NP, Atra E, Andrade LE. Diagnostic value of antiperinuclear factor and anti-stratum corneum antibody in rheumatoid arthritis. Part 1. Rev Bras Reumatol. 1997;37:251-259
102. Dubucquoi S, Solau-Gervais E, Lefranc D, Marguerie L, Sibilia J, Goetz J, et al. Evaluation of anti-citrullinated filaggrin antibodies as hallmarks for the diagnosis of rheumatic diseases. Ann Rheum Dis. 2004;63:415-419 [PMID: 15020336]
103. Erre GL, Tocco A, Longu MG, Fenu P, Sanna M, Faedda R, et al. Diagnostic value of antifilaggrine antibodies (antibodies to cyclic citrullinated peptide and anti-keratin antibodies) for rheumatoid arthritis. Trends Med. 2006;6:105-110.
104. Ferraro-Peyret C, Tebib J, Desbos A, Bihannic R, Genestier C, Letroublon MC, et al. Improvement in diagnosis of rheumatoid arthritis using dual indirect immunofluorescence and immunoblotting assays for antifilaggrin auto-antibodies: a retrospective 3 year study. J Rheumatol. 2002;29:276-281 [PMID: 11838844]
105. Fusconi M, Vannini A, Dall'Aglio AC, Pappas G, Cassani F, Ballardini G, et al. Anti-cyclic citrullinated peptide antibodies in type 1 autoimmune hepatitis. Aliment Pharmacol Ther. 2005;22:951-955 [PMID: 16268969]
106. Girelli F, Foschi FG, Bedeschi E, Calderoni V, Stefanini GF, Martinelli MG. Is anti cyclic citrullinated peptide a useful laboratory test for the diagnosis of rheumatoid arthritis? Eur Ann Allergy Clin Immunol. 2004;36:127-130 [PMID: 15180353]
107. Grillo ICC, Zimmerman B, Kadmon D. Anti-cyclic citrullinated peptide antibody and rheumatoid factor in patients older than 50 years with rheumatoid arthritis versus other rheumatic diseases. Arthritis Rheum. 2003;48:3633.
108. Gupta R, Thabah MM, Aneja R, Kumar A, Varghese T, Chandrasenan PJ. Usefulness of anti -CCP antibodies in rheumatic diseases in Indian patients. Indian J Med Sci. 2009;63:92-100. [PMID: 19359776]
109. Havemose-Poulsen A, Westergaard J, Stoltze K, Skjødt H, Danneskiold- Samsøe B, Locht H, et al. Periodontal and hematological characteristics associated with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis. J Periodontol. 2006;77:280-288 [PMID: 16460255]
110. Hayashi N, Kumagai S. [New diagnostic tests for rheumatoid arthritis]. Rinsho Byori. 2003;51:1030-1035 [PMID: 14653204]
111. Inanc N, Dalkilic E, Kamali S, Kasapoglu-Günal E, Elbir Y, Direskeneli H, et al. Anti-CCP antibodies in rheumatoid arthritis and psoriatic arthritis. Clin Rheumatol. 2007;26:17-23. [PMID: 16538391]
112. Innala L, Kokkonen H, Eriksson C, Jidell E, Berglin E, Dahlqvst SR. Antibodies against mutated citrullinated vimentin are a better predictor of disease activity at 24 months in early rheumatoid arthritis than antibodies against cyclic citrullinated peptides. J Rheumatol. 2008;35:1002-1008 [PMID: 18398946]
113. Ioan-Facsinay A, Willemze A, Robinson DB, Peschken CA, Markland J, van der Woude D, et al. Marked differences in fine specificity and isotype usage of the anti-citrullinated protein antibody in health and disease. Arthritis Rheum. 2008;58:3000-3008 [PMID: 18821680]
114. Jiang Z, Liu H, Liu Z. Diagnostic significance of combining detecting three antibodies including citrullinated protein antibodies for rheumatoid arthritis. Zhongguo Wuzhen Xue Zazhi. 2009;1:6-8.
115. Kamali S, Polat NG, Kasapoglu E, Gul A, Ocal L, Aral O, et al. Anti-CCP and antikeratin antibodies in rheumatoid arthritis, primary Sjögren's syndrome, and Wegener's granulomatosis [Letter]. Clin Rheumatol. 2005;24:673-676 [PMID: 15926038]
116. Karayev D, Morris RI, Metzger AL. Anti-cyclic citrullinated peptide antibodies (Anti-CCP) are highly specific for rheumatoid arthritis particularly in combination with IgM rheumatoid factor positivity. Arthritis Rheum. 2003;48:3654-3655.
117. Kastbom A, Strandberg G, Lindroos A, Skogh T. Anti-CCP antibody test predicts the disease course during 3 years in early rheumatoid arthritis (the Swedish TIRA project). Ann Rheum Dis. 2004;63:1085-1089 [PMID: 15308517]
118. Kelly P, Creagmile S, Brown N, Grant L, Taylor V, Torgersen A, et al. Performance of the AxSYM (R) anti-cyclic citrullinated peptide (CCP) assay as a diagnostic test for rheumatoid arthritis (RA) [Abstract]. Clin Chem. 2007;53:A148.
119. Kim KE, Kim KH, Woo KS, Han JY, Kim JM, Lee SW, et al. [Diagnostic utility of AxSYM anti-cyclic Citrullinated peptide antibody assay]. Korean J Lab Med. 2008;28:457-464 [PMID: 19127111]
120. Kitahara K, Takagi K, Kusunoki Y, Nishio S, Nozaki T, Inomata H, et al. Clinical value of second- and third-generation assays of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis [Letter]. Ann Rheum Dis. 2008;67:1059-1060 [PMID: 18556455]
121. Koivula MK, Savolainen E, Kaipiainen-Seppänen O, Kautiainen H, Luosujärvi R, Hakala M, et al. Sensitivity and specificity of autoantibodies binding to citrullinated carboxyterminal telopeptides of types I and II collagens in an early arthritis series. Rheumatology (Oxford). 2008;47:656-659 [PMID: 18356174]
122. Korkmaz C, Us T, Kaşifoǧlu T, Akgün Y. Anti-cyclic citrullinated peptide (CCP) antibodies in patients with long-standing rheumatoid arthritis and their relationship with extra-articular manifestations. Clin Biochem. 2006;39:961-965 [PMID: 16979149]
123. Kwok JS, Hui KH, Lee TL, Wong W, Lau YL, Wong RW, et al. Anticyclic citrullinated peptide: diagnostic and prognostic values in juvenile idiopathic arthritis and rheumatoid arthritis in a Chinese population. Scand J Rheumatol. 2005;34:359-366 [PMID: 16234183]
124. Kyriazis NC, Papalopoulou M, Balla M. Anti-cyclic citrullinated peptide antibodies and rheumatoid factor in the diagnosis of early versus established rheumatoid arthritis. Ann Rheum Dis. 2005;64:172.
125. Lemos A, Ramos MP, Furtado MJ, Carvalho C, Santos MJ, Silva JC, et al. [Diagnostic performance of anti-cyclic citrullinated antibodies and IgM rheumatoid factor in rheumatoid arthritis]. Acta Reumatol Port. 2007;32:345-349 [PMID: 18159201]
126. Liu FC, Chao YC, Hou TY, Chen HC, Shyu RY, Hsieh TY, et al. Usefulness of anti-CCP antibodies in patients with hepatitis C virus infection with or without arthritis, rheumatoid factor, or cryoglobulinemia. Clin Rheumatol. 2008;27:463-467 [PMID: 17876647]
127. Liu X, Jia R, Zhao J, Li Z. The role of anti-mutated citrullinated vimentin antibodies in the diagnosis of early rheumatoid arthritis. J Rheumatol. 2009;36:1136-1142 [PMID: 19447936]
128. Lopez-Hoyos M, Ruiz de Alegria C, Blanco R, Crespo J, Peña M, Rodriguez-Valverde V, et al. Clinical utility of anti-CCP antibodies in the differential diagnosis of elderly-onset rheumatoid arthritis and polymyalgia rheumatica. Rheumatology (Oxford). 2004;43:655-657 [PMID: 14970400]
129. López-Longo FJ, Rodríguez-Mahou M, Sánchez- Ramón S, Estecha A, Balsera M, Plaza R, et al. Anti-cyclic citrullinated peptide versus anti-Sa antibodies in diagnosis of rheumatoid arthritis in an outpatient clinic for connective tissue disease and spondyloarthritis. J Rheumatol. 2006;33:1476-1481 [PMID: 16881106]
130. Lundberg K, Kinloch A, Fisher BA, Wegner N, Wait R, Charles P, et al. Antibodies to citrullinated α-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase. Arthritis Rheum. 2008;58:3009-3019 [PMID: 18821669]
131. Merlini G, Anzilotti C, Chimenti D, Tommasi C, Bombardieri S, Migliorini P. A deiminated viral peptide to detect antibodies in rheumatoid arthritis. Ann N Y Acad Sci. 2005;1050:243-249 [PMID: 16014539]
132. Anzilotti C, Merlini G, Pratesi F, Tommasi C, Chimenti D, Migliorini P. Antibodies to viral citrullinated peptide in rheumatoid arthritis. J Rheumatol. 2006;33:647-651 [PMID: 16511941]
133. Mori S, Naito H, Ohtani S, Yamanaka T, Sugimoto M. Diagnostic utility of anti-cyclic citrullinated peptide antibodies for rheumatoid arthritis in patients with active lung tuberculosis. Clin Rheumatol. 2009;28:277-283 [PMID: 19002544]
134. Nakamura H, Kawakami A, Ida H, Origuchi T, Matsuoka N, Tsuboi M, et al. Clinical significance of anti-citrullinated peptide antibody in Japanese patients with established rheumatoid arthritis [Letter]. Scand J Rheumatol. 2005;34:489-490 [PMID: 16393775]
135. Nicaise RP, Grootenboer MS, Bruns A, Hurtado M, Palazzo E, Hayem G, et al. Antibodies to mutated citrullinated vimentin for diagnosing rheumatoid arthritis in anti-CCP-negative patients and for monitoring infliximab therapy. Arthritis Res Ther. 2008;10:R142.
136. Nicoloudi A, Renaudineau Y, Devauchelle V, Saraux A, Youinou P. Contribution of the new laboratory tests to the diagnosis of the rheumatoid arthritis. Immuno-Analyse et Biologie Specialisee. 2007;22:167-172.
137. Novikov AA, Aleksandrova EN, Karateev DE, Luchikhina EL, Demidova NV, Cherkasova MV, et al. [Diagnostic value of antibodies to modified citrullinized vimentin in early rheumatoid arthritis]. Klin Lab Diagn. 2008:27-29 [PMID: 18807510]
138. Parodi A, Drosera M, Seriolo B, Barbieri L, Rebora A. Anti-citrulline antibodies in psoriatic patients with and without arthritis [Letter]. Acta Derm Venereol. 2005;85:253-254 [PMID: 16040413]
139. Pengfei C, Yuanrui L, Shu C. Clinical evaluation of early marker in diagnosing rheumatoid arthritis. Wuhan Daxue Xuebao (Yixue Ban). 2005;26:529-532.
140. Pikner R, Suchy D, Zitkova J, Brabcova H, Beranova M, Kormunda S. Automated determination of citrullinated cyclic peptide antibodies on AxSYM analyser. Chemicke Listy. 2008;102:997-1002.
141. Qing YF, Zhang QB, Zhou JG, Yuan GH, Wei J, Xing Y, et al. The detecting and clinical value of anti-cyclic citrullinated peptide antibodies in patients with systemic lupus erythematosus. Lupus. 2009;18:713-717 [PMID: 19502267]
142. Quinn MA, Gough AK, Green MJ, Devlin J, Hensor EM, Greenstein A, et al. Anti-CCP antibodies measured at disease onset help identify seronegative rheumatoid arthritis and predict radiological and functional outcome. Rheumatology (Oxford). 2006;45:478-480 [PMID: 16287917]
143. Rodríguez-Mahou M, López-Longo FJ, Sánchez- Ramón S, Estecha A, García-Segovia A, Rodríguez-Molina JJ, et al. Association of anti-cyclic citrullinated peptide and anti-Sa/ citrullinated vimentin autoantibodies in rheumatoid arthritis. Arthritis Rheum. 2006;55:657-661 [PMID: 16874789]
144. Salvador G, Gomez A, Vinas O, Ercilla G, Canete JD, Munoz-Gomez J, et al. Prevalence and clinical significance of anti-cyclic citrullinated peptide and antikeratin antibodies in palindromic rheumatism. An abortive form of rheumatoid arthritis? Rheumatology (Oxford). 2003;42:972-975 [PMID: 12730510]
145. 312,314] filaggrin (306-324) analogue for the diagnosis of rheumatoid arthritis. Conformational study by circular dichroism and fourier transformed infrared spectroscopy. Lett Pept Sci. 2002;9:291-300.
146. Ribeiro SL, Pereira HL, Silva NP, Neves RM, Sato EI. Anti-cyclic citrullinated peptide antibodies and rheumatoid factor in leprosy patients with articular involvement. Braz J Med Biol Res. 2008;41:1005-1010 [PMID: 19099154]
147. Samanci N, Ozdem S, Akbas H, Mutlu D, Gultekin M, Arman M, et al. Diagnostic value and clinical significance of anti-CCP in patients with advanced rheumatoid arthritis. J Natl Med Assoc. 2005;97:1120-1126 [PMID: 16173327]
148. Santiago M, Baron M, Miyachi K, Fritzler MJ, Abu-Hakima M, Leclercq S, et al. A comparison of the frequency of antibodies to cyclic citrullinated peptides using a third generation anti-CCP assay (CCP3) in systemic sclerosis, primary biliary cirrhosis and rheumatoid arthritis. Clin Rheumatol. 2008;27:77-83. [PMID: 17570008]
149. Sedova L, Senolt L, Parkmanova P, Olejarova M, Vencovsky J. Antibodies against cyclic citrullinated peptide (anti-CCP) in serum and synovial fluid from patients with rheumatoid arthritis and osteoarthritis. Ceska Revmatologie. 2005;13:79-83. (Pubitemid 41245977)
150. Sène D, Ghillani-Dalbin P, Limal N, Thibault V, van Boekel T, Piette JC, et al. Anti-cyclic citrullinated peptide antibodies in hepatitis C virus associated rheumatological manifestations and Sjogren's syndrome. Ann Rheum Dis. 2006;65:394-397 [PMID: 16474032]
151. Sharif SK, Eghbal S, Gharibdoost F, Kbarian MA, Shahram F, Nadji A, et al. Comparative study of anti-CCP and RF for the diagnosis of rheumatoid arthritis. APLAR J Rheumatol. 2007;10:121-124.
152. Sghiri R, Bouagina E, ZaglaSghiri R, Bouagina E, Zaglaoui H, Mestiri H, Harzallah L, Harrabi I, et al. Diagnostic performances of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis. Rheumatol Int. 2007;27:1125-1130 [PMID: 17447069]
153. Sghiri R, Bouajina E, Bargaoui D, Harzallah L, Fredj HB, Sammoud S, et al. Value of anti-mutated citrullinated vimentin antibodies in diagnosing rheumatoid arthritis. Rheumatol Int. 2008;29:59-62. [PMID: 18496693]
154. Shibata S, Tada Y, Komine M, Hattori N, Osame S, Kanda N, et al. Anti-cyclic citrullinated peptide antibodies and IL-23p19 in psoriatic arthritis. J Dermatol Sci. 2009;53:34-39 [PMID: 18752933]
155. Snijders GF, Broeder AA, Bevers K, Jeurissen ME, van Eerd JE, van den Hoogen FH. Measurement characteristics of a new rapid anti-CCP2 test compared to the anti-CCP2 ELISA. Scand J Rheumatol. 2008;37:151-154 [PMID: 18415774]
156. Soós L, Szekanecz Z, Szabó Z, Fekete A, Zeher M, Horváth IF, et al. Clinical evaluation of anti-mutated citrullinated vimentin by ELISA in rheumatoid arthritis. J Rheumatol. 2007;34:1658-1663 [PMID: 17611988]
157. Soriano ER, Ceballos MF, Bustos D, Rosa J, Velozo E, Catoggio LJ. Sensitivity and specificity of anti-citrulline 3 antibodies in the diagnosis of seronegative rheumatoid artritis (RA). Rheumatology. 2008;47:II107-II108.
158. Spadaro A, Riccieri V, Alessandri C, Scrivo R, Valesini G. [Usefulness of anti-cyclic citrullinate peptide antibody determination in synovial fluid analysis of patients with rheumatoid arthritis]. Reumatismo. 2006;58:116-120 [PMID: 16829989]
159. Suzuki K, Sawada T, Murakami A, Matsui T, Tohma S, Nakazono K, et al. High diagnostic performance of ELISA detection of antibodies to citrullinated antigens in rheumatoid arthritis. Scand J Rheumatol. 2003;32:197-204. [PMID: 14626625]
160. Takasaki Y, Yamanaka K, Takasaki C, Matsushita M, Yamada H, Nawata M, et al. Anticyclic citrullinated peptide antibodies in patients with mixed connective tissue disease. Mod Rheumatol. 2004;14:367-375 [PMID: 17143695]
161. Tamai M, Kawakami A, Uetani M, Takao S, Rashid H, Tanaka F, et al. Early prediction of rheumatoid arthritis by serological variables and magnetic resonance imaging of the wrists and finger joints: results from prospective clinical examination [Letter]. Ann Rheum Dis. 2006;65:134-135 [PMID: 16344501]
162. Tampoia M, Brescia V, Fontana A, Maggiolini P, Lapadula G, Pansini N. Anti-cyclic citrullinated peptide autoantibodies measured by an automated enzyme immunoassay: analytical performance and clinical correlations. Clin Chim Acta. 2005;355:137-144 [PMID: 15820488]
163. Tobón GJ, Correa PA, Anaya JM. Anti-cyclic citrullinated peptide antibodies in patients with primary Sjögren's syndrome [Letter]. Ann Rheum Dis. 2005;64:791-792 [PMID: 15834066]
164. Tuchocka-Piotrowska A, Puszczewicz M, Zimmermann-Gorska I, Piotrowski A. The usefulness of anti-cyclic citrullinated peptide antibody testing for differentiation between ostheoarthritis or polymyalgia rheumatica and early rheumatoid arthritis in elderly. Ann Rheum Dis. 2005;64:554.
165. Union A, Meheus L, Humbel RL, Conrad K, Steiner G, Moereels H, et al. Identification of citrullinated rheumatoid arthritis-specific epitopes in natural filaggrin relevant for antifilaggrin autoantibody detection by line immunoassay. Arthritis Rheum. 2002;46:1185-1195 [PMID: 12115222]
166. Valladares GC, Rus MA, Sanchez-Molina Acosta MI, Muruzabal Sitges MV, Ibanez AE, Borque DL. Measurement of anti-CCP antibodies for the diagnosis of rheumatoid arthritis. Quimica Clinica. 2003;22:397-402.
167. Vasiliauskiene L, Wiik A, Høier-Madsen M. Prevalence and clinical significance of antikeratin antibodies and other serological markers in Lithuanian patients with rheumatoid arthritis. Ann Rheum Dis. 2001;60:459-466 [PMID: 11302867]
168. Vincent C, Nogueira L, Sebbag M, Chapuy-Regaud S, Arnaud M, Letourneur O, et al. Detection of antibodies to deiminated recombinant rat filaggrin by enzyme-linked immunosorbent assay: a highly effective test for the diagnosis of rheumatoid arthritis. Arthritis Rheum. 2002;46:2051-2058 [PMID: 12209508]
169. Vossenaar ER, Smeets TJ, Kraan MC, Raats JM, van Venrooij WJ, Tak PP. The presence of citrullinated proteins is not specific for rheumatoid synovial tissue. Arthritis Rheum. 2004;50:3485-3494 [PMID: 15529392]
170. Wagner E, Skoumal M, Bayer PM, Klaushofer K. Antibody against mutated citrullinated vimentin: a new sensitive marker in the diagnosis of rheumatoid arthritis. Rheumatol Int. 2009;29:1315-1321 [PMID: 19184032]
171. Wang Y, Fang YF, Zhong B. Significance of anti-cyclic citrullinase peptide antibody and rheumatoid factor in the diagnosis of rheumatoid arthritis. Zhongguo Linchuang Kangfu. 2004;8:1616-1617
172. Wei GL, Ding Y, Han YX. Preparation of ELISA kit for quantitative determination of antibody against cyclic citrulline peptide and its significance in diagnosis of rheumatoid arthritis. Chinese Journal of Biologicals. 2008;21:421-424
173. Wild N, Karl J, Grunert VP, Schmitt RI, Garczarek U, Krause F, et al. Diagnosis of rheumatoid arthritis: multivariate analysis of biomarkers. Biomarkers. 2008;13:88-105. [PMID: 18188726]
174. Wu R, Shovman O, Zhang Y, Gilburd B, Zandman-Goddard G, Shoenfeld Y. Increased prevalence of anti-third generation cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis and CREST syndrome. Clin Rev Allergy Immunol. 2007;32:47-56. [PMID: 17426360]
175. Yazdani-Biuki BJ, Brickmann K, Brezinschek RI, Muller T, Graninger W, Brezinschek H. The positive predictive value of anti-cyclic citrullinated peptide antibodies for rheumatoid arthritis compared with psoriatic arthritis and chronic lymphocytic B-cell leukemia. Ann Rheum Dis. 2006;65:159.
176. Guo Y, Chen Z, Gu M. Diagnostic value of citrullinated protein antibody and anti-RA∼3∼3 antibody in patients with rheumatoid arthritis. Jiangsu Medical Journal. 2006;32:112-113
177. Zeng X, Ai M, Tian X, Gan X, Shi Y, Song Q, et al. Diagnostic value of anti-cyclic citrullinated Peptide antibody in patients with rheumatoid arthritis. J Rheumatol. 2003;30:1451-1455 [PMID: 12858440]
178. Chibnik LB, Mandl LA, Costenbader KH, Schur PH, Karlson EW. Comparison of threshold cutpoints and continuous measures of anti-cyclic citrullinated peptide antibodies in predicting future rheumatoid arthritis. J Rheumatol. 2009;36:706-711 [PMID: 19228654]
179. Nielen MM, van Schaardenburg D, Reesink HW, van de Stadt RJ, van der Horst-Bruinsma IE, de Koning MH, et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum. 2004;50:380-386 [PMID: 14872479]
180. Rantapää-Dahlqvist S, de Jong BA, Berglin E, Hallmans G, Wadell G, Stenlund H, et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003;48:2741-2749 [PMID: 14558078]
181. Koivula MK, Heliövaara M, Ramberg J, Knekt P, Rissanen H, Palosuo T, et al. Autoantibodies binding to citrullinated telopeptide of type II collagen and to cyclic citrullinated peptides predict synergistically the development of seropositive rheumatoid arthritis. Ann Rheum Dis. 2007;66:1450-1455 [PMID: 17472989]
182. Jørgensen KT, Wiik A, Pedersen M, Hedegaard CJ, Vestergaard BF, Gislefoss RE, et al. Cytokines, autoantibodies and viral antibodies in premorbid and postdiagnostic sera from patients with rheumatoid arthritis: case-control study nested in a cohort of Norwegian blood donors. Ann Rheum Dis. 2008;67:860-866 [PMID: 17644543]