RepD-mediated recruitment of PcrA helicase at the Staphylococcus aureus pC221 plasmid replication origin, oriD

Nucleic Acids Research

Volumn 38, Issue 6, 2009, Pages 1874-1888

  Machon C ^a   Lynch, G P ^b   Thomson, N H ^b   Scott, D J ^a   Thomas, C D ^b   Soultanas, P ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; DEOXYRIBONUCLEASE I; HELICASE; PCRA HELICASE; PROTEIN ORID; REPLICATION PROTEIN D; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; BACTERIAL DNA; DNA BINDING PROTEIN; EXODEOXYRIBONUCLEASE; EXODEOXYRIBONUCLEASE III; PCRA PROTEIN, BACTERIA; REPD PROTEIN, STAPHYLOCOCCUS AUREUS;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA FOOTPRINTING; DNA PROTEIN COMPLEX; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; STAPHYLOCOCCUS AUREUS; STOICHIOMETRY; CHEMISTRY; CONFORMATION; DNA REPLICATION ORIGIN; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; ULTRASTRUCTURE;

STAPHYLOCOCCUS AUREUS;

ADENOSINE TRIPHOSPHATE; BACTERIAL PROTEINS; BASE SEQUENCE; DEOXYRIBONUCLEASE I; DNA FOOTPRINTING; DNA HELICASES; DNA, BACTERIAL; DNA-BINDING PROTEINS; EXODEOXYRIBONUCLEASES; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PLASMIDS; PROTEIN BINDING; REPLICATION ORIGIN; STAPHYLOCOCCUS AUREUS;

EID: 77951240674     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkp1153     Document Type: Article

References (31)

1. Gillespie, M.T. and Skurray, R.A. (1988) Structural relationships among chloramphenicol-resistance plasmids of Staphylococcus aureus. FEMS Microbiol. Lett., 51, 205-210.
2. Daini, O.A. and Akano, S.A. (2009) Plasmid-mediated antibiotic resistance in Staphylococcus aureus from patients and non-patients. Sci. Res. Essay, 4, 346-350.
3. Del Solar, G., Giraldo, R., Ruiz-Echevarria, M.J., Espinosa, M. and Diaz-Orejas, R. (1998) Replication and control of circular bacterial plasmids. Microbiol. Mol. Biol. Rev., 62, 434-464.
4. Khan, S.A. (2000) Plasmid rolling-circle replication: recent developments. Mol. Microbiol., 37, 477-484.
5. Novick, R.P. (1989) Staphylococcal plasmids and their replication. Ann. Rev. Microbiol., 43, 537-565.
6. Koepsel, R.R., Murray, R.W., Rosenblum, W.D. and Khan, S.A. (1985) The replication initiator protein of plasmid pT181 has sequence-specific endonuclease and topoisomerase-like activities. Proc. Natl Acad. Sci. USA, 82, 6845-6849.
7. Thomas, C.D., Balson, D.F. and Shaw, W.V. (1990) In vitro studies of the initiation of staphylococcal plasmid replication. Specificity of RepD for its origin (oriD), and characterization of the Rep-ori tyrosyl ester intermediate. J. Biol. Chem., 265, 5519-5530.
8. Zock, J.M., Birch, P. and Khan, S.A. (1990) Specificity of RepC protein in plasmid pT181 DNA replication. J. Biol. Chem., 265, 3484-3488.
9. Khan, S.A. (2005) Plasmid rolling-circle replication: highlights of two decades of research. Plasmid, 53, 126-136.
10. Zhang, W., Dillingham, M.S., Thomas, C.D., Allen, S., Roberts, C.J. and Soultanas, P. (2007) Directional loading and stimulation of PcrA helicase by the replication initiator protein RepD. J. Mol. Biol., 371, 336-348.
11. Soultanas, P., Dillingham, M.S., Papadopoulos, F., Phillips, S.E.V., Thomas, C.D. and Wigley, D.B. (1999) Plasmid replication initiator protein RepD increases the processivity of PcrA DNA helicase. Nucleic Acids Res., 27, 1421-1428.
12. Slatter, A.F., Thomas, C.D. and Webb, M.R. (2009) PcrA helicase tightly couples ATP hydrolysis to unwinding double-stranded DNA, modulated by the initiator protein for plasmid replication, RepD. Biochem., 48, 6326-6334.
13. Petit, M.A., Dervyn, E., Rose, M., Entian, K.D., McGovern, S.D., Ehrlich, S.D. and Bruand, C. (1998) PcrA is an essential DNA helicase of Bacillus subtilis fulfilling functions both in repair and rolling-circle replication. Mol. Microbiol., 29, 261-273.
14. Petit, M.A. and Ehrlich, S.D. (2002) Essential bacterial helicases that counteract the toxicity of recombination proteins. EMBO J., 21, 3137-3147.
15. Iordanescu, S. and Bargonetti, J. (1989) Staphylococcus aureus chromosomal mutations that decrease efficiency of Rep utilization in replication of pT181 and related plasmids. J. Bacteriol., 171, 4501-4503.
16. Iordanescu, S. and Basheer, R. (1991) The Staphylococcus aureus mutation pcrA3 leads to the accumulation of pT181 replication initiation complexes. J. Mol. Biol., 221, 1183-1189.
17. Iordanescu, S. (1993) Plasmid pT181-linked suppressors of the Staphylococcus aureus pcrA3 chromosomal mutation. J. Bacteriol., 175, 3916-3917. 1888 Nucleic Acids Research, 2010, Vol. 38, No. 6
18. Iordanescu, S. (1993) Characterization of the Staphylococcus aureus chromosomal gene pcrA, identified by mutations affecting plasmid pT181 replication. Mol. Gen. Genet., 241, 185-192.
19. Chang, T.-L., Naqvi, A., Anand, S.P., Kramer, G., Munshi, R. and Khan, S.A. (2002) Biochemical characterization of the Staphylococcus aureus PcrA helicase and its role in plasmid rolling circle replication. J. Biol. Chem., 277, 45880-45886.
20. Anand, S.P., Mitra, P., Naqvi, A. and Khan, S.A. (2004) Bacillus anthracis and Bacillus cereus PcrA helicases can support DNA unwinding and in vitro rolling-circle replication of plasmid pT181 of Staphylococcus aureus. J. Bacteriol., 186, 2195-2199.
21. Ruiz-Masó, J.A., Anand, S.P., Espinosa, M., Khan, S.A. and del Solar, G. (2006) Genetic and biochemical characterization of the Streptococcus pneumoniae PcrA helicase and its role in plasmid rolling circle replication. J. Bacteriol., 188, 7416-425.
22. Caryl, J.A. and Thomas, C.D. (2006) Investigating the basis of substrate recognition in the pC221 relaxosome. Mol. Microbiol., 60, 1302-1218.
23. Streeter, S.D., Papapanagiotou, I., McGeehan, J.E. and Kneale, G.G. (2004) DNA footprinting and biophysical characterization of the controller protein C.Ahdl suggests the basis of a genetic switch. Nucleic Acids Res., 32, 6445-6453.
24. Metzger, W. and Heumann, H. (1994) Footprinting with Exonuclease III. Methods Mol. Biol., 30, 11-20.
25. Schuck, P. (2000) Size distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and Lamm equation modeling. Biophys. J., 78, 1606-1619.
26. Koepsel, R.R. and Khan, S.A. (1986) Static and initiator protein-enhanced bending of DNA at a replication origin. Science, 233, 1316-1318.
27. Thomas, C.D., Nikiforov, T.T., Connolly, B.A. and Shaw, W.V. (1995) Determination of sequence specificity between a plasmid replication initiator protein and the origin of replication. J. Mol. Biol, 254, 381-391.
28. Higashitani, A., Greenstein, D., Hirokawa, H., Asano, S. and Horiuchi, K. (1994) Multiple DNA conformational changes induced by an initiator protein precede the nicking reaction in a rolling circle replication origin. J. Mol. Biol., 237, 388-400.
29. Toseland, C., Martinez-Senac, M.M., Slatter, A.F. and Webb, M.R. (2009) The ATPase cycle of PcrA helicase and its coupling to translocation on DNA. J. Mol. Biol., 392, 1020-1032.
30. Iordanescu, S. and Projan, S.J. (1988) Replication termination for staphylococcal plasmids: plasmids pT181 and pC221 cross-react in the termination process. J. Bacteriol., 170, 3427-3434.
31. Murray, R.W., Koepsel, R.R. and Khan, S.A. (1989) Synthesis of single-stranded plasmid pT181 DNA in vitro: initiation and termination of DNA replication. J. Biol. Chem., 264, 1051-1057.