Specificity determinants in the interaction of apolipoprotein(a) kringles with tetranectin and LDL

Biological Chemistry

Volumn 383, Issue 11, 2002, Pages 1743-1750

  Caterer, Nigel R ^a   Graversen, Jonas H ^a   Jacobsen, Christian ^b   Moestrup, Søren K ^b   Sigurskjold, Bent W ^c   Etzerodt, Michael ^a   Thøgersen, Hans C ^a  

^a Laboratory of Gene Expression   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Binding site grafting; CTLD; Lys binding

Indexed keywords

APOLIPOPROTEIN A; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN; LYSINE; PLASMINOGEN; RECOMBINANT PROTEIN; TETRANECTIN;

AMINO TERMINAL SEQUENCE; CONTROLLED STUDY; COVALENT BOND; ESCHERICHIA COLI; KRINGLE DOMAIN; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; APOLIPOPROTEINS A; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, AGAROSE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENETIC VECTORS; KRINGLES; LECTINS, C-TYPE; LIPOPROTEINS, LDL; LYSINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN FOLDING; RECEPTORS, AMINO ACID; SWINE; THERMODYNAMICS;

ESCHERICHIA COLI;

EID: 0036868924     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2002.195     Document Type: Review

References (41)

1. Berg, K., Dahlen, G., and Frick, M. H. (1974). Lp(a) lipoprotein and pre-β1-lipoprotein in patients with coronary heart disease. Clin. Genet. 6, 230-235.
2. Bostom, A. G., Cupples, L. A., Jenner, J. L., Ordovas, J. M., Seman, L. J., Wilson, P. W., Schaefer, E. J., and Castelli, W. P. (1996). Elevated plasma lipoprotein(a) and coronary heart disease in men aged 55 years and younger. A prospective study. JAMA 276, 544-548.
3. Brown, M. S., and Goldstein, J. L. (1987). Plasma lipoproteins: teaching old dogmas new tricks. Nature 330, 113-114.
4. Callow, M. J., and Rubin, E. M. (1995). Site-specific mutagenesis demonstrates that cysteine 4326 of apolipoprotein B is required for covalent linkage with apolipoprotein (a) in vivo. J. Biol. Chem. 270, 23914-23917.
5. Clemmensen, I. (1989). Interaction of tetranectin with sulphated polysaccharides and trypan blue. Scand. J. Clin. Lab. Invest. 49, 719-725.
6. Clemmensen, I., Petersen, L. C., and Kluft, C. (1986). Purification and characterization of a novel, oligomeric, plasminogen kringle 4 binding protein from human plasma: tetranectin. Eur. J. Biochem. 156, 327-333.
7. Cremer, P., Nagel, D., Labrot, B., Mann, H., Muche, R., Elster, H., and Seidel, D. (1994). Lipoprotein Lp(a) as predictor of myocardial infarction in comparison to fibrinogen, LDL cholesterol and other risk factors: results from the prospective Gottingen Risk Incidence and Prevalence Study (GRIPS). Eur. J. Clin. Invest. 24, 444-453.
8. Cremer, P., Nagel, D., Mann, H., Labrot, B., Muller-Berninger, R., Elster, H., and Seidel, D. (1997). Ten-year follow-up results from the Goettingen Risk, Incidence and Prevalence Study (GRIPS). I. Risk factors for myocardial infarction in a cohort of 5790 men. Atherosclerosis 129, 221-230.
9. Ellgaard, L., Holtet, T. L., Nielsen, P. R., Etzerodt, M., Gliemann, J., and Thøgersen, H. C. (1997). Dissection of the domain architecture of the α2macroglobulin receptor-associated protein. Eur. J. Biochem. 244, 544-551.
10. Frank, S., and Kostner, G. M. (1997). The role of apo(a) kringle-IVs in the assembly of lipoprotein(a). Protein Eng. 10, 291-298.
11. Gabel, B. R., and Koschinsky, M. I. (1995). Analysis of the proteolytic activity of a recombinant form of apolipoprotein(a). Biochemistry 34, 15777-15784.
12. Gabel, B. R., and Koschinsky, M. L. (1998). Sequences within apolipoprotein(a) kringle IV types 6-8 bind directly to low-density lipoprotein and mediate noncovalent association of apolipoprotein(a) with apolipoprotein B-100. Biochemistry 37, 7892-7898.
13. Gabel, B.R., May, L.F, Marcovina, S.M., and Koschinsky, M.L. (1996). Lipoprotein(a) assembly. Quantitative assessment of the role of apo(a) kringle IV types 2-10 in particle formation. Arterioscler. Thromb. Vasc. Biol. 16, 1559-1567.
14. Gabel, B.R., McLeod, R.S., Yao, Z., and Koschinsky, M.L. (1998). Sequences within the amino terminus of ApoB100 mediate its noncovalent association with apo(a). Arterioscler. Thromb. Vasc. Biol. 18, 1738-1744.
15. Gaw, A., Brown, E. A., and Ford, I. (1998). Impact of apo(a) length polymorphism and the control of plasma Lp(a) concentrations: evidence for a threshold effect. Arterioscler. Thromb. Vasc. Biol. 18, 1870-1876.
16. Graversen, J. H., Lorentsen, R. H., Jacobsen, C., Moestrup, S. K., Sigurskjold, B. W., Thøgersen, H. C., and Etzerodt, M. (1998). The plasminogen binding site of the C-type lectin tetranectin is located in the carbohydrate recognition domain, and binding is sensitive to both calcium and lysine. J. Biol. Chem. 273, 29241-29246.
17. Graversen, J. H., Jacobsen, C., Sigurskjold, B. W., Lorentsen, R. H., Moestrup, S. K., Thøgersen, H. C., and Etzerodt, M. (2000a). Mutational analysis of affinity and selectivity of kringle-tetranectin interaction. Grafting novel kringle affinity onto the tetranectin lectin scaffold. J. Biol. Chem. 275, 37390-37396.
18. Graversen, J. H., Sigurskjold, B. W., Thøgersen, H. C., and Etzerodt, M. (2000b). Tetranectin-binding site on plasminogen kringle 4 involves the lysine-binding pocket and at least one additional amino acid residue. Biochemistry 39, 7414-7419.
19. Haibach, C., Kraft, H. G., Kochl, S., Abe, A., and Utermann, G. (1998). The number of kringle IV repeats 3-10 is invariable in the human apo(a) gene. Gene 208, 253-258.
20. Holtet, T. L., Graversen, J. H., Clemmensen, I., Thøgersen, H. C., and Etzerodt, M. (1997). Tetranectin, a trimeric plasminogen-binding C-type lectin. Protein Sci. 6, 1511-5.
21. Høgdall, C. K., Høgdall, E. V, Hording, U., Clemmensen, I., Nørgaard-Pedersen, B., and Toftager-Larsen, K. (1993a). Pre-operative plasma tetranectin as a prognostic marker in ovarian cancer patients. Scand. J. Clin. Lab. Invest. 53, 741-746.
22. Høgdall, C. K., Christensen, L., and Clemmensen, I. (1993b). The prognostic value of tetranectin immunoreactivity and plasma tetranectin in patients with ovarian cancer. Cancer 72, 2415-2422.
23. Høgdall, C. K., Hording, U., Nørgaard- Pedersen, B., Toftager-Larsen, K., and Clemmensen, I. (1994a). Serum tetranectin and CA-125 used to monitor the course of treatment in ovarian cancer patients. Eur. J. Obstet. Gynecol. Reprod. Biol. 57, 175-178.
24. Høgdall, C. K., Christensen, L., and Clemmensen, I. (1994b). [Tetranectin, a plasma and tissue protein - a prognostic marker of breast and ovarian cancer]. Ugeskr. Laeger. 156, 6190-6195.
25. Høgdall, C. K., Mogensen, O., Tabor, A., Mogensen, B., Jakobsen, A. K., Norgaard-Pedersen, B., Larsen, S. O., and Clemmensen, I. (1995). The role of serum tetranectin, CA 125, and a combined index as tumor markers in women with pelvic tumors. Gynecol. Oncol. 56, 22-28.
26. Høgdall, C. K., Høgdall, E. V., Hording, U., Toftager-Larsen, K., Arends, J., Norgaard-Pedersen, B., and Clemmensen, I. (1996). Use of tetranectin, CA-125 and CASA to predict residual tumor and survival at second- and third-look operations for ovarian cancer. Acta Oncol. 35, 63-69.
27. Kluft, C., Jie, A. F, Los, P., de Wit, E., and Havekes, L. (1989a). Functional analogy between lipoprotein(a) and plasminogen in the binding to the kringle 4 binding protein, tetranectin. Biochem. Biophys. Res. Commun. 161, 427-433.
28. Kluft, C., Los, P., and Clemmensen, I. (1989b). Calcium-dependent binding of tetranectin to fibrin. Thromb. Res. 55, 233-238.
29. Koschinsky, M. L., Cote, G. P., Gabel, B., and van der Hoek, Y. Y. (1993). Identification of the cysteine residue in apolipoprotein(a) that mediates extracellular coupling with apolipoprotein B-100. J. Biol. Chem. 268, 19819-19825.
30. Kraft, H. G., Lingenhel, A., Pang, R. W., Delport, R., Trommsdorff, M., Vermaak, H., Janus, E. D., and Utermann, G. (1996). Frequency distributions of apolipoprotein(a) kringle IV repeat alleles and their effects on lipoprotein(a) levels in Caucasian, Asian, and African populations: the distribution of null alleles is non-random. Eur. J. Hum. Genet. 4, 74-87.
31. Lackner, C., Cohen, J. C., and Hobbs, H. H. (1993). Molecular definition of the extreme size polymorphism in apolipoprotein(a). Hum. Mol. Genet. 2, 933-940.
32. LoGrasso, P. V., Cornell-Kennon, S., and Boettcher, B. R. (1994). Cloning, expression, and characterization of human apolipoprotein(a) kringle IV37. J. Biol. Chem. 269, 21820-21827.
33. Lorentsen, R. H., Graversen, J. H., Caterer, N. R., Thøgersen, H. C. and Etzerodt, M. (2000). The heparin-binding site in tetranectin is located in the N-terminal region and binding does not involve the carbohydrate recognition domain. Biochem. J. 347, 83-87.
34. Marcovina, S. M., Zhang, Z. H., Gaur, V. P., and Albers, J. J. (1993). Identification of 34 apolipoprotein(a) isoforms: differential expression of apolipoprotein(a) alleles; between American blacks and whites. Biochem. Biophys. Res. Commun. 191, 1192-1196.
35. McLean, J. W., Tomlinson, J. E., Kuang, W. J., Eaton, D. L., Chen, E. Y., Fless, G. M., Scanu, A. M., and Lawn, R. M. (1987). cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. Nature 330, 132-137.
36. Mihalich, A., Magnaghi, P, Sessa, L., Trubia, M., Acquati, F., and Taramelli, R. (1997). Genomic structure and organization of kringles type 3 to 10 of the apolipoprotein(a) gene in 6q26-27. Gene 196, 1-8.
37. Mulichak, A. M., Tulinsky, A., and Ravichandran, K. G. (1991). Crystal and molecular structure of human plasminogen kringle 4 refined at 1.9 Å resolution. Biochemistry 30, 10576-10588.
38. Nielsen, P. R., Einer-Jensen, K., Holtet, T. L., Andersen, B. D., Poulsen, F. M., and Thøgersen, H. C. (1993). Protein-ligand interactions in the lysine-binding site of plasminogen kringle 4 are different in crystal and solution. Electrostatic interactions studied by site-directed mutagenesis exclude Lys35 as an important acceptor in solution. Biochemistry 32, 13019-13025.
39. Rahman, M., Jia, Z., Gabel, B.R., Marcovina, S.M., and Koschinsky, M. L. (1998). Expression of apolipoprotein(a) kringle IV type 9 in Escherichia coli: demonstration of a specific interaction between kringle IV type 9 and apolipoproteinB-100. Protein Eng. 11, 1249-1256.
40. Wewer, U. M., Iba, K., Durkin, M. E., Nielsen, F. C., Loechel, F., Gilpin, B. J., Kuang, W., Engvall, E., and Albrechtsen, R. (1998). Tetranectin is a novel marker for myogenesis during embryonic development, muscle regeneration, and muscle cell differentiation in vitro. Dev. Biol. 200, 247-259.
41. Ye, Q., Rahman, M.N., Koschinsky, M.L., and Jia, Z. (2001). High-resolution crystal structure of aplipoprotein(a) kringle IV type 7: insights into ligand binding. Protein Sci. 10, 1124-1129.