메뉴 건너뛰기




Volumn 10, Issue 4, 2010, Pages 585-596

Patient-based strategy for systemic treatment of metastatic renal cell carcinoma

Author keywords

MTOR inhibitor; Patient based approach; Renal cell carcinoma; Sequence therapy; Targeted therapy; Treatment algorithm; Tyrosine kinase inhibitor

Indexed keywords

ALPHA INTERFERON; ANTINEOPLASTIC AGENT; AXITINIB; BAY 73 4506; BEVACIZUMAB; EVEROLIMUS; FLUOROURACIL; INTERLEUKIN 12; PAZOPANIB; PLACEBO; REGORAFENIB; SORAFENIB; SUNITINIB; TEMSIROLIMUS; UNCLASSIFIED DRUG;

EID: 77951226719     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/era.10.25     Document Type: Review
Times cited : (20)

References (95)
  • 3
    • 0033978220 scopus 로고    scopus 로고
    • Systemic therapy for renal cell carcinoma
    • Motzer RJ, Russo P. Systemic therapy for renal cell carcinoma. J. Urol. 163, 408-417 (2000). (Pubitemid 30060482)
    • (2000) Journal of Urology , vol.163 , Issue.2 , pp. 408-417
    • Motzer, R.J.1    Russo, P.2
  • 4
    • 45549105967 scopus 로고    scopus 로고
    • Targeted therapy for metastatic renal cell carcinoma: A home run or a work in progress?
    • Rini BI, Bukowski RM. Targeted therapy for metastatic renal cell carcinoma: a home run or a work in progress? Oncology 22, 388-396 (2008).
    • (2008) Oncology , vol.22 , pp. 388-396
    • Rini, B.I.1    Bukowski, R.M.2
  • 6
    • 39149138108 scopus 로고    scopus 로고
    • Differenzialtherapie beim metastasierenden Nierenzellkarzinom
    • Kirchner H, Heinzer H, Roigas J, Overkamp F. Differenzialtherapie beim metastasierenden Nierenzellkarzinom. Der Onkologe 14, 191-197 (2008).
    • (2008) Der Onkologe , vol.14 , pp. 191-197
    • Kirchner, H.1    Heinzer, H.2    Roigas, J.3    Overkamp, F.4
  • 9
    • 24044489895 scopus 로고    scopus 로고
    • Metastatic renal carcinoma long-term survivors treated with s.c. interferon-alpha and s.c. interleukin-2
    • DOI 10.1089/cbr.2005.20.410
    • Atzpodien J, Reitz M. Metastatic renal carcinoma long-term survivors treated with s.c. interferon-a and s.c. interleukin-2. Cancer Biother. Radiopharm. 20, 410-416 (2005). (Pubitemid 41216105)
    • (2005) Cancer Biotherapy and Radiopharmaceuticals , vol.20 , Issue.4 , pp. 410-416
    • Atzpodien, J.1    Reitz, M.2
  • 12
    • 62849127717 scopus 로고    scopus 로고
    • Interferon-a (IFN), interleukin-2 (IL2) and 5-fluorouracil (5FU) vs IFN alone in patients with metastatic renal cell carcinoma (mRCC): Results of the randomised MRC/EORTC RE04 trial
    • Gore ME. Interferon-a (IFN), interleukin-2 (IL2) and 5-fluorouracil (5FU) vs IFN alone in patients with metastatic renal cell carcinoma (mRCC): results of the randomised MRC/EORTC RE04 trial. J. Clin. Oncol. 26, (2008) (Abstract 5039a).
    • (2008) J. Clin. Oncol. , vol.26
    • Gore, M.E.1
  • 13
    • 37349080670 scopus 로고    scopus 로고
    • Bevacuzimab plus interferon a-2a for treatment of metastastic renal cell carcinoma: Survival and biomarker analysis
    • Escudier B, Pluzanska A, Koralewski P et al. Bevacuzimab plus interferon a-2a for treatment of metastastic renal cell carcinoma: survival and biomarker analysis. Lancet 370, 2103-2111 (2007).
    • (2007) Lancet , vol.370 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3
  • 14
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: Mechanisms of anti-tumour activity
    • Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat. Rev. Cancer 8, 579-591 (2008).
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 15
    • 0036718539 scopus 로고    scopus 로고
    • Molecular basis of the VHL hereditary cancer syndrome
    • Kaelin WG. Molecular basis of the VHL hereditary cancer syndrome. Nat. Rev. Cancer 2, 672-682 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 672-682
    • Kaelin, W.G.1
  • 18
    • 34548315347 scopus 로고    scopus 로고
    • Final results of the randomized Phase III trial of sorafenib in advanced renal cell carcinoma: Survival and biomarker analysis
    • Bukowski RM, Eisen T, Szczyklik C et al. Final results of the randomized Phase III trial of sorafenib in advanced renal cell carcinoma: survival and biomarker analysis. J. Clin. Oncol. 25 (2007) (Abstract 5023a).
    • (2007) J. Clin. Oncol. , vol.25
    • Bukowski, R.M.1    Eisen, T.2    Szczyklik, C.3
  • 19
    • 35548931472 scopus 로고    scopus 로고
    • Randomized Phase II trial of first-line treatment with sorafenib versus interferon in patients with advanced renal cell carcinoma: Final results
    • Szczylik C, Demkow T, Staehler M et al. Randomized Phase II trial of first-line treatment with sorafenib versus interferon in patients with advanced renal cell carcinoma: final results. J. Clin. Oncol. 25 (2007) (Abstract 5025a).
    • (2007) J. Clin. Oncol. , vol.25
    • Szczylik, C.1    Demkow, T.2    Staehler, M.3
  • 20
    • 35548959952 scopus 로고    scopus 로고
    • Randomized Phase II study of sorafenib with or without low-dose IFN in patients with metastatic renal cell carcinoma
    • Jonasch E, Corn P, Ashe RG et al. Randomized Phase II study of sorafenib with or without low-dose IFN in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 25 (2007) (Abstract 5104a).
    • (2007) J. Clin. Oncol. , vol.25
    • Jonasch, E.1    Corn, P.2    Ashe, R.G.3
  • 21
    • 34648863567 scopus 로고    scopus 로고
    • The advanced renal cell carcinoma sorafenib (ARCSS) expanded access trial in North America: Safety and efficacy
    • Knox JJ, Figlin RA, Stadler WM et al. The advanced renal cell carcinoma sorafenib (ARCSS) expanded access trial in North America: safety and efficacy. J. Clin. Oncol. 25 (2007) (Abstract 5011a).
    • (2007) J. Clin. Oncol. , vol.25
    • Knox, J.J.1    Figlin, R.A.2    Stadler, W.M.3
  • 22
    • 41149106110 scopus 로고    scopus 로고
    • A large open-label, non-comparative, Phase III study of the multi-targeted kinase inhibitor sorafenib in European patients with advanced renal cell carcinoma
    • Beck J, Bajetta E, Escudier B et al. A large open-label, non-comparative, Phase III study of the multi-targeted kinase inhibitor sorafenib in European patients with advanced renal cell carcinoma. Eur. J. Cancer Suppl. 5, 4506 (2007).
    • (2007) Eur. J. Cancer Suppl. , vol.5 , pp. 4506
    • Beck, J.1    Bajetta, E.2    Escudier, B.3
  • 25
    • 34548310217 scopus 로고    scopus 로고
    • Sunitinib versus interferon-a (IFN-a) as first-line treatment of metastatic renal cell carcinoma (mRCC): Updated results and analysis of prognostic factors
    • Motzer RJ, Figlin RA, Hutson TE et al. Sunitinib versus interferon-a (IFN-a) as first-line treatment of metastatic renal cell carcinoma (mRCC): updated results and analysis of prognostic factors. J. Clin. Oncol. 25 (2007) (Abstract 5024).
    • (2007) J. Clin. Oncol. , vol.25
    • Motzer, R.J.1    Figlin, R.A.2    Hutson, T.E.3
  • 26
    • 48649094719 scopus 로고    scopus 로고
    • Overall survival with sunitinib versus interferon (IFN)-a as first-line treatment of metastatic renal cell carcinoma (mRCC)
    • Figlin RA, Hutson TE, Tomczak P et al. Overall survival with sunitinib versus interferon (IFN)-a as first-line treatment of metastatic renal cell carcinoma (mRCC). J. Clin. Oncol. 26 (2008) (Abstract 5024).
    • (2008) J. Clin. Oncol. , vol.26
    • Figlin, R.A.1    Hutson, T.E.2    Tomczak, P.3
  • 27
    • 77949890945 scopus 로고    scopus 로고
    • Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized Phase III trial
    • DOI: 10.1200/JCO.2009.23.9764 (2010), (Epub ahead of print)
    • Sternberg CN, Davis ID, Mardiak J et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized Phase III trial. J. Clin. Oncol. DOI: 10.1200/JCO.2009.23.9764 (2010) (Epub ahead of print).
    • J. Clin. Oncol.
    • Sternberg, C.N.1    Davis, I.D.2    Mardiak, J.3
  • 29
    • 70349264943 scopus 로고    scopus 로고
    • Final results of the Phase III, randomized, double-blind AVOREN trial of first-line bevacizumab (BEV) + interferon-a2a (IFN) in metastatic renal cell carcinoma (mRCC)
    • 2009 ASCO Annual Meeting; May 29-June 2; Orlando, FL, (Abstract 5020a)
    • Escudier B, Bellmunt J, Negrier S et al. Final results of the Phase III, randomized, double-blind AVOREN trial of first-line bevacizumab (BEV) + interferon-a2a (IFN) in metastatic renal cell carcinoma (mRCC). 2009 ASCO Annual Meeting; May 29-June 2; Orlando, FL. J. Clin. Oncol. 27(Suppl.) 15s (2009) (Abstract 5020a).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.SUPPL.
    • Escudier, B.1    Bellmunt, J.2    Negrier, S.3
  • 30
    • 77951215148 scopus 로고    scopus 로고
    • CALGB 90206: A Phase III trial of bevacizumab plus interferon-a versus interferon-a monotherapy in metastatic renal cell carcinoma
    • 2009 ASCO Annual Meeting; May 29-June 2; Orlando, FL, (Abstract 5019a)
    • Rini BI, Halabi S, Rosenberg JE et al. CALGB 90206: a Phase III trial of bevacizumab plus interferon-a versus interferon-a monotherapy in metastatic renal cell carcinoma. 2009 ASCO Annual Meeting; May 29-June 2; Orlando, FL. J. Clin. Oncol. 27(Suppl.) 15s (2009) (Abstract 5019a).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.SUPPL.
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3
  • 32
    • 0036138580 scopus 로고    scopus 로고
    • Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
    • DOI 10.1200/JCO.20.1.289
    • Motzer RJ, Bacik J, Murphy BA et al. Interferon-a as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J. Clin. Oncol. 20, 289-296 (2002). (Pubitemid 34032623)
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.1 , pp. 289-296
    • Motzer, R.J.1    Bacik, J.2    Murphy, B.A.3    Russo, P.4    Mazumdar, M.5
  • 33
    • 14144252047 scopus 로고    scopus 로고
    • Validation and extension of the Memorial Sloan-Kettering Prognostic Factors Model for Survival in patients with previously untreated metastatic renal cell carcinoma
    • Mekhail TM, Abou-Jawde RM, BouMerhi G et al. Validation and extension of the Memorial Sloan-Kettering Prognostic Factors Model for Survival in patients with previously untreated metastatic renal cell carcinoma. J. Clin. Oncol. 23, 832-841 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 832-841
    • Mekhail, T.M.1    Abou-Jawde, R.M.2    Boumerhi, G.3
  • 35
    • 55249103589 scopus 로고    scopus 로고
    • RAD001 vs placebo in patients with metastatic renal cell carcinoma (RCC) after progression on VEGFr-TKI therapy: Results from a randomized, double-blind, multicenter Phase-III study
    • Motzer R, Escudier B, Oudard S et al. RAD001 vs placebo in patients with metastatic renal cell carcinoma (RCC) after progression on VEGFr-TKI therapy: results from a randomized, double-blind, multicenter Phase-III study. J. Clin. Oncol. 26, (2008) (Abstract LBA5026).
    • (2008) J. Clin. Oncol. , vol.26
    • Motzer, R.1    Escudier, B.2    Oudard, S.3
  • 36
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in adavanced renal cell carcinoma: A double-blind, randomised, placebo-controlled Phase III trial
    • Motzer R, Escudier B, Oudard S et al. Efficacy of everolimus in adavanced renal cell carcinoma: a double-blind, randomised, placebo-controlled Phase III trial. Lancet 372, 449-456 (2008).
    • (2008) Lancet , vol.372 , pp. 449-456
    • Motzer, R.1    Escudier, B.2    Oudard, S.3
  • 37
    • 66649115302 scopus 로고    scopus 로고
    • Phase-3 randomized trial of everolimus (RAD001) vs placebo in metastatic renal cell carcinoma
    • Escudier B, Ravaud A, Oudard S et al. Phase-3 randomized trial of everolimus (RAD001) vs placebo in metastatic renal cell carcinoma. Ann. Oncol. 19, 72O (2008).
    • (2008) Ann. Oncol. , vol.19
    • Escudier, B.1    Ravaud, A.2    Oudard, S.3
  • 38
    • 70349253166 scopus 로고    scopus 로고
    • A randomized, double-blind Phase III study of pazopanib in treatment-naive and cytokine-pretreated patients with advanced renal cell carcinoma (RCC)
    • Abstract 5021a
    • Sternberg CN, Szczylik C, Lee E et al. A randomized, double-blind Phase III study of pazopanib in treatment-naive and cytokine-pretreated patients with advanced renal cell carcinoma (RCC). J. Clin. Oncol. 27(Suppl.), 15s (2009) (Abstract 5021a).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.SUPPL.
    • Sternberg, C.N.1    Szczylik, C.2    Lee, E.3
  • 39
    • 55249127491 scopus 로고    scopus 로고
    • Sequential axitinib (AG-013736) therapy of patients (pts) with metastatic clear cell renal cell cancer (RCC) refractory to sunitinib and sorafenib, cytokines and sorafenib, or sorafenib alone
    • Abstract 5127
    • Dutcher JP, Wilding G, Hudes GR et al. Sequential axitinib (AG-013736) therapy of patients (pts) with metastatic clear cell renal cell cancer (RCC) refractory to sunitinib and sorafenib, cytokines and sorafenib, or sorafenib alone. J. Clin. Oncol. 26, 5127 (2008) (Abstract 5127).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 5127
    • Dutcher, J.P.1    Wilding, G.2    Hudes, G.R.3
  • 40
    • 55349124241 scopus 로고    scopus 로고
    • Biomarker analysis and final efficacy and safety results of a Phase II renal cell carcinoma trial with pazopanib (GW786034), a multi-kinase angiogenesis inhibitor
    • Hutson TE, Davis ID, Machiels JH et al. Biomarker analysis and final efficacy and safety results of a Phase II renal cell carcinoma trial with pazopanib (GW786034), a multi-kinase angiogenesis inhibitor. J. Clin. Oncol. 26, (2008) (Abstract 5046).
    • (2008) J. Clin. Oncol. , vol.26
    • Hutson, T.E.1    Davis, I.D.2    MacHiels, J.H.3
  • 41
    • 84882538118 scopus 로고    scopus 로고
    • Cardiotoxicity associated with the cancer therapeutic agent sunitinib malate
    • Witteles RM, Telli ML, Fisher GA et al. Cardiotoxicity associated with the cancer therapeutic agent sunitinib malate. J. Clin. Oncol. 26, (2008) (Abstract 9597).
    • (2008) J. Clin. Oncol. , vol.26
    • Witteles, R.M.1    Telli, M.L.2    Fisher, G.A.3
  • 42
    • 77649289755 scopus 로고    scopus 로고
    • Thyroid dysfunction in patients (pts) with metastatic renal cell cancer (RCC) treated with sorafenib
    • Clement P, Wolter P, Stefan C et al. Thyroid dysfunction in patients (pts) with metastatic renal cell cancer (RCC) treated with sorafenib. J. Clin. Oncol. 26, (2008) (Abstract 16145).
    • (2008) J. Clin. Oncol. , vol.26
    • Clement, P.1    Wolter, P.2    Stefan, C.3
  • 43
    • 48349122489 scopus 로고    scopus 로고
    • The clinical implications of sunitinib-induced hypothyroidism: A prospective evaluation
    • Wolter P, Stefan C, Decallonne B et al. The clinical implications of sunitinib-induced hypothyroidism: a prospective evaluation. Br. J. Cancer 99, 448-454 (2008).
    • (2008) Br. J. Cancer , vol.99 , pp. 448-454
    • Wolter, P.1    Stefan, C.2    Decallonne, B.3
  • 44
    • 72449163966 scopus 로고    scopus 로고
    • Renal safety of sunitinib treatment: A prospective study for patients (pts) with metastatic renal cell carcinoma (mRCC)
    • Billemont B, Rixe O, Meric JB et al. Renal safety of sunitinib treatment: a prospective study for patients (pts) with metastatic renal cell carcinoma (mRCC). Ann. Oncol. 19, E01a (2008).
    • (2008) Ann. Oncol. , vol.19
    • Billemont, B.1    Rixe, O.2    Meric, J.B.3
  • 45
    • 57649111897 scopus 로고    scopus 로고
    • Characterization of hyperglycemia, hypercholesterolemia, and hyperlipidemia in patients with advanced renal cell carcinoma treated with temsirolimus or interferon-a
    • De Souza PL, Radulovic S, Beck J et al. Characterization of hyperglycemia, hypercholesterolemia, and hyperlipidemia in patients with advanced renal cell carcinoma treated with temsirolimus or interferon-a. J. Clin. Oncol. 26, (2008) (Abstract 5116).
    • (2008) J. Clin. Oncol. , vol.26
    • De Souza, P.L.1    Radulovic, S.2    Beck, J.3
  • 46
    • 48749101146 scopus 로고    scopus 로고
    • Temsirolimus in metastatic renal cell carcinoma
    • Negrier S. Temsirolimus in metastatic renal cell carcinoma. Ann. Oncol. 19, 1369-1370 (2008).
    • (2008) Ann. Oncol. , vol.19 , pp. 1369-1370
    • Negrier, S.1
  • 47
    • 48749128305 scopus 로고    scopus 로고
    • Temsirolimus safety profile and management of toxic effects in patients with advanced renal cell carcinoma and poor prognostic features
    • Bellmunt J, Szczylik C, Feingold J et al. Temsirolimus safety profile and management of toxic effects in patients with advanced renal cell carcinoma and poor prognostic features. Ann. Oncol. 19, 1387-1392 (2008).
    • (2008) Ann. Oncol. , vol.19 , pp. 1387-1392
    • Bellmunt, J.1    Szczylik, C.2    Feingold, J.3
  • 48
    • 41149108218 scopus 로고    scopus 로고
    • Toxicities associated with the administration of sorafenib, sunitinib, and temsirolimus and their management in patients with metastatic renal cell carcinoma
    • Bhojani N, Jeldres C, Patard JJ et al. Toxicities associated with the administration of sorafenib, sunitinib, and temsirolimus and their management in patients with metastatic renal cell carcinoma. Eur. Urol. 53, 917-930 (2008).
    • (2008) Eur. Urol. , vol.53 , pp. 917-930
    • Bhojani, N.1    Jeldres, C.2    Patard, J.J.3
  • 49
    • 74949126146 scopus 로고    scopus 로고
    • Temsirolimus (TEM) in metastatic renal cell carcinoma (mRCC): Safety and efficacy in patients (pts) previously treated with VEGF-targeted therapy
    • Wood L, Bukowski RM, Dreicer R et al. Temsirolimus (TEM) in metastatic renal cell carcinoma (mRCC): safety and efficacy in patients (pts) previously treated with VEGF-targeted therapy. J. Clin. Oncol. 26, (2008) (Abstract 16067a).
    • (2008) J. Clin. Oncol. , vol.26
    • Wood, L.1    Bukowski, R.M.2    Dreicer, R.3
  • 50
    • 67650569562 scopus 로고    scopus 로고
    • Efficacy and safety of first-line bevacizumab (BEV) plus interferon-a2a (IFN) in patients (pts) ≥ 65 years with metastatic renal cell carcinoma (mRCC)
    • Bajetta E, Ravaud A, Bracarda S et al. Efficacy and safety of first-line bevacizumab (BEV) plus interferon-a2a (IFN) in patients (pts) ≥ 65 years with metastatic renal cell carcinoma (mRCC). J. Clin. Oncol. 26, (2008) (Abstract 5095).
    • (2008) J. Clin. Oncol. , vol.26
    • Bajetta, E.1    Ravaud, A.2    Bracarda, S.3
  • 51
    • 67249099246 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in elderly pts: Results from a large open-label, non-comparative Phase III study of sorafenib in European pts with advanced RCC (EU-ARCCS)
    • Porta C, Bracarda S, Beck J et al. Efficacy and safety of sorafenib in elderly pts: results from a large open-label, non-comparative Phase III study of sorafenib in European pts with advanced RCC (EU-ARCCS). Ann. Oncol. 19 (2008) (Abstract 596P).
    • (2008) Ann. Oncol. , vol.19
    • Porta, C.1    Bracarda, S.2    Beck, J.3
  • 52
    • 60449099395 scopus 로고    scopus 로고
    • Safety and efficacy of sorafenib in elderly patients (pts) ≥ 65 years: A subset analysis from the advanced renal cell carcinoma sorafenib (ARCSS) expanded access program in North America
    • Bukowski RM, Stadler WM, Figlin RA et al. Safety and efficacy of sorafenib in elderly patients (pts) ≥ 65 years: a subset analysis from the advanced renal cell carcinoma sorafenib (ARCSS) expanded access program in North America. J. Clin. Oncol. 26 (2008) (Abstract 5045).
    • (2008) J. Clin. Oncol. , vol.26
    • Bukowski, R.M.1    Stadler, W.M.2    Figlin, R.A.3
  • 53
    • 35549012738 scopus 로고    scopus 로고
    • Treatment outcome for metastatic papillary and chromophobe renal cell carcinoma (RCC) patients treated with tyrosine-kinsase inhibitors
    • Plantade A, Choueiri T, Escudier B et al. Treatment outcome for metastatic papillary and chromophobe renal cell carcinoma (RCC) patients treated with tyrosine-kinsase inhibitors. J. Clin. Oncol. 25 (2007) (Abstract 5037).
    • (2007) J. Clin. Oncol. , vol.25
    • Plantade, A.1    Choueiri, T.2    Escudier, B.3
  • 54
    • 34648873387 scopus 로고    scopus 로고
    • Sunitinib in metastatic renal cell carcinoma (mRCC): Preliminary assessment of toxicity in an expanded access trial with subpopulation analysis
    • Gore Me, Porta C, Oudard S et al. Sunitinib in metastatic renal cell carcinoma (mRCC): preliminary assessment of toxicity in an expanded access trial with subpopulation analysis. J. Clin. Oncol. 25 (2007) (Abstract 5010).
    • (2007) J. Clin. Oncol. , vol.25
    • Me, G.1    Porta, C.2    Oudard, S.3
  • 55
    • 35548991359 scopus 로고    scopus 로고
    • The advanced renal cell carcinoma sorafenib (ARCSS) expanded access trial: Safety and efficacy in patients (pts) with non-clear cell (NCC) renal cell carcinoma (RCC)
    • Stadler WM, Figlin RA, Ernstoff MS et al. The advanced renal cell carcinoma sorafenib (ARCSS) expanded access trial: safety and efficacy in patients (pts) with non-clear cell (NCC) renal cell carcinoma (RCC). J. Clin. Oncol. 25 (2007) (Abstract 5036).
    • (2007) J. Clin. Oncol. , vol.25
    • Stadler, W.M.1    Figlin, R.A.2    Ernstoff, M.S.3
  • 56
    • 37849001813 scopus 로고    scopus 로고
    • Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma
    • Choueiri TK, Plantade A, Elson P et al. Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma. J. Clin. Oncol. 26, 127-131 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 127-131
    • Choueiri, T.K.1    Plantade, A.2    Elson, P.3
  • 57
    • 67649668650 scopus 로고    scopus 로고
    • Sunitinib in non-clear cell renal carcinoma (ncc-RCC): A Phase II study
    • Plimack ER, Jonasch E, Bekele BN et al. Sunitinib in non-clear cell renal carcinoma (ncc-RCC): a Phase II study. J. Clin. Oncol. 26 (2008) (Abstract 5112).
    • (2008) J. Clin. Oncol. , vol.26
    • Plimack, E.R.1    Jonasch, E.2    Bekele, B.N.3
  • 58
    • 49149102461 scopus 로고    scopus 로고
    • Efficacy of sunitinib and sorafenib in non-clear cell renal cell carcinoma: Results from expanded access studies
    • Strumberg D. Efficacy of sunitinib and sorafenib in non-clear cell renal cell carcinoma: results from expanded access studies. J. Clin. Oncol. 26, 3469-3471 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 3469-3471
    • Strumberg, D.1
  • 59
    • 0037093972 scopus 로고    scopus 로고
    • Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma
    • DOI 10.1002/cncr.10541
    • Schouten LJ, Rutten J, Huveneers HA et al. Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma. Cancer 94, 2698-2705 (2002). (Pubitemid 34478086)
    • (2002) Cancer , vol.94 , Issue.10 , pp. 2698-2705
    • Schouten, L.J.1    Rutten, J.2    Huveneers, H.A.M.3    Twijnstra, A.4
  • 60
    • 35549006671 scopus 로고    scopus 로고
    • The Advanced Renal Cell Carcinoma Sorafenib (ARCCS) expanded access trial: Subset analysis of patients (pts) with brain metastases (BM)
    • Henderson CA, Bukowski RM, Stadler WM et al. The Advanced Renal Cell Carcinoma Sorafenib (ARCCS) expanded access trial: subset analysis of patients (pts) with brain metastases (BM). J. Clin. Oncol. 25(18), (2007) (Abstract 15506).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.18
    • Henderson, C.A.1    Bukowski, R.M.2    Stadler, W.M.3
  • 61
    • 67649661872 scopus 로고    scopus 로고
    • Sunitinib in metastatic renal cell carcinoma (mRCC) patients (pts) with brain metastases (METS): Data from an expanded access trial
    • Hariharan S, Szczyklik C, Porta C et al. Sunitinib in metastatic renal cell carcinoma (mRCC) patients (pts) with brain metastases (METS): data from an expanded access trial. J. Clin. Oncol. 26 (2008) (Abstract 5094).
    • (2008) J. Clin. Oncol. , vol.26
    • Hariharan, S.1    Szczyklik, C.2    Porta, C.3
  • 62
    • 34547826118 scopus 로고    scopus 로고
    • Incidence of brain metastasis in advanced renal cell carcinoma among patients randomized in a Phase III trial of sorafenib, an oral multi-kinase inhibitor
    • Massard C, Zonierek J, Laplanche A et al. Incidence of brain metastasis in advanced renal cell carcinoma among patients randomized in a Phase III trial of sorafenib, an oral multi-kinase inhibitor. Ann. Oncol. 17 (2006) (Abstract 454P).
    • (2006) Ann. Oncol. , vol.17
    • Massard, C.1    Zonierek, J.2    Laplanche, A.3
  • 63
    • 37849054055 scopus 로고    scopus 로고
    • Brain metastases in patients with renal cell cancer receiving new targeted treatment
    • Helgason HH, Mallo HA, Droogendijk H et al. Brain metastases in patients with renal cell cancer receiving new targeted treatment. J. Clin. Oncol. 26, 152-154 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 152-154
    • Helgason, H.H.1    Mallo, H.A.2    Droogendijk, H.3
  • 64
    • 77951247120 scopus 로고    scopus 로고
    • Clinical prognostic and predictive markers for metastatic RCC therapeutic choices
    • Presented at: Chicago, IL, USA, 30 May-3 June
    • Rini BI. Clinical prognostic and predictive markers for metastatic RCC therapeutic choices. Presented at: ASCO Annual Meeting. Chicago, IL, USA, 30 May-3 June 2008.
    • (2008) ASCO Annual Meeting
    • Rini, B.I.1
  • 65
    • 67651172309 scopus 로고    scopus 로고
    • Rational therapeutic choices and strategies for patients with metastatic renal cancer
    • Rathmell WK, Stadler WM, Rini BI. Rational therapeutic choices and strategies for patients with metastatic renal cancer. Am. Soc. Clin. Oncol. Ed. Book 192-198 (2008).
    • (2008) Am. Soc. Clin. Oncol. Ed. Book , pp. 192-198
    • Rathmell, W.K.1    Stadler, W.M.2    Rini, B.I.3
  • 66
    • 50849111087 scopus 로고    scopus 로고
    • Will we be able to 'cure' metastatic renal cell carcinoma like we cure testicular tumours?
    • Kirkali Z. Will we be able to 'cure' metastatic renal cell carcinoma like we cure testicular tumours? Eur. Urol. 54, 712-714 (2008).
    • (2008) Eur. Urol. , vol.54 , pp. 712-714
    • Kirkali, Z.1
  • 67
    • 77951222257 scopus 로고    scopus 로고
    • Defining a new patient-focused treatment approach to renal cell carcinoma (RCC)
    • Bellmunt J, Mulders P, Szczylik C et al. Defining a new patient-focused treatment approach to renal cell carcinoma (RCC). Ann. Oncol. 19 (2008) (Abstract 612P).
    • (2008) Ann. Oncol. , vol.19
    • Bellmunt, J.1    Mulders, P.2    Szczylik, C.3
  • 68
    • 77951236137 scopus 로고    scopus 로고
    • What are the problems that are to be solved in the future?
    • Presented at: Stockholm 12-16 September Sweden
    • Gore M. What are the problems that are to be solved in the future? Presented at: ESMO Annual Meeting. Stockholm, Sweden, 12-16 September (2008).
    • (2008) ESMO Annual Meeting
    • Gore, M.1
  • 69
    • 67349163859 scopus 로고    scopus 로고
    • Sequential sorafenib and sunitinib for renal carcinoma
    • Sablin MP, Negrier S, Ravaud A et al. Sequential sorafenib and sunitinib for renal carcinoma. J. Urol. 182, 29-34 (2009).
    • (2009) J. Urol. , vol.182 , pp. 29-34
    • Sablin, M.P.1    Negrier, S.2    Ravaud, A.3
  • 70
    • 58949092548 scopus 로고    scopus 로고
    • Sequential therapy with sorafenib and sunitinib in renal cell carcinoma
    • Dudek AZ, Zolnierek J, Dham A, Lindgren BR, Szczylik C. Sequential therapy with sorafenib and sunitinib in renal cell carcinoma. Cancer 115(1), 61-67 (2009).
    • (2009) Cancer , vol.115 , Issue.1 , pp. 61-67
    • Dudek, A.Z.1    Zolnierek, J.2    Dham, A.3    Lindgren, B.R.4    Szczylik, C.5
  • 71
    • 55649103188 scopus 로고    scopus 로고
    • Sequential use of the tyrosine kinase inhibitors sorafenib and sunitinib in metastatic renal cell carcinoma: A retrospective outcome analysis
    • Eichelberg C, Heuer R, Chun FK et al. Sequential use of the tyrosine kinase inhibitors sorafenib and sunitinib in metastatic renal cell carcinoma: a retrospective outcome analysis. Eur. Urol. 54, 1373-1378 (2008).
    • (2008) Eur. Urol. , vol.54 , pp. 1373-1378
    • Eichelberg, C.1    Heuer, R.2    Chun, F.K.3
  • 72
    • 36749064602 scopus 로고    scopus 로고
    • Antitumor effects of sunitinib or sorafenib in patients with metastatic renal cell carcinoma who received prior antiangiogenic therapy
    • DOI 10.1016/j.juro.2007.08.127, PII S0022534707022938
    • Tamaskar A, Garcia JA, Elson P et al. Antitumor effects of sunitinib or sorafenib in patients with metastatic renal cell carcinoma who received prior antiangiogenic therapy. J. Urol. 179, 81-86 (2008). (Pubitemid 350216728)
    • (2008) Journal of Urology , vol.179 , Issue.1 , pp. 81-86
    • Tamaskar, I.1    Garcia, J.A.2    Elson, P.3    Wood, L.4    Mekhail, T.5    Dreicer, R.6    Rini, B.I.7    Bukowski, R.M.8
  • 73
    • 70350602665 scopus 로고    scopus 로고
    • Treatment and dosing patterns for angiogenesis inhibitor (AIS) therapies in patients with metastatic renal cell carcinoma (MRCC)
    • Choueiri TK, Brick AJ, McDermott S et al. Treatment and dosing patterns for angiogenesis inhibitor (AIS) therapies in patients with metastatic renal cell carcinoma (MRCC). Ann. Oncol. 19(Suppl. 8), (2008) (Abstract 593P).
    • (2008) Ann. Oncol. , vol.19 , Issue.SUPPL. 8
    • Choueiri, T.K.1    Brick, A.J.2    McDermott, S.3
  • 74
    • 67650659867 scopus 로고    scopus 로고
    • Retrospective analysis of the sequential use of sorafenib and sunitinib in patients with advanced renal cell carcinoma (RCC)
    • Porta C, Procopio G, Sabbatini R et al. Retrospective analysis of the sequential use of sorafenib and sunitinib in patients with advanced renal cell carcinoma (RCC). Eur. Urol. Suppl. 8(4), 183(252) (2009).
    • (2009) Eur. Urol. Suppl. 8(4) , vol.183 , Issue.252
    • Porta, C.1    Procopio, G.2    Sabbatini, R.3
  • 75
    • 74949130690 scopus 로고    scopus 로고
    • Failure of initial VEGF-targeted therapy in metastatic renal cell carcinoma (mRCC): What next?
    • Abstract 5098a
    • Vickers MM, Choueiri TK, Percy A et al. Failure of initial VEGF-targeted therapy in metastatic renal cell carcinoma (mRCC): what next? J. Clin. Oncol. 27(Suppl.), 15s (2009) (Abstract 5098a).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.SUPPL.
    • Vickers, M.M.1    Choueiri, T.K.2    Percy, A.3
  • 76
    • 65549155468 scopus 로고    scopus 로고
    • A multicenter prospective trial of sorafenib in patients with metastatic clear cell carcinoma refractory to prior sunitinib and bevacizumab
    • Shepard DR, Rini BI, Garcia JA et al. A multicenter prospective trial of sorafenib in patients with metastatic clear cell carcinoma refractory to prior sunitinib and bevacizumab. J. Clin. Oncol. 26 (2008) (Abstract 5123a).
    • (2008) J. Clin. Oncol. , vol.26
    • Shepard, D.R.1    Rini, B.I.2    Garcia, J.A.3
  • 77
    • 48249107432 scopus 로고    scopus 로고
    • Predictive factors for severe toxicity of sunitinib in unselected patients with advanced renal cell cancer
    • Van der Veeldt AAM, Boven E, Helgason HH et al. Predictive factors for severe toxicity of sunitinib in unselected patients with advanced renal cell cancer. Br. J. Cancer 99, 259-265 (2008).
    • (2008) Br. J. Cancer , vol.99 , pp. 259-265
    • Van Der Veeldt, A.A.M.1    Boven, E.2    Helgason, H.H.3
  • 78
    • 55249108426 scopus 로고    scopus 로고
    • First-line bevacizumab improves progression-free survival with lower doses of interferon a2a in the treatment of patients with metastastic renal cell carcinoma (AVOREN)
    • Melichar B, Koralewski P, Pluzanska A et al. First-line bevacizumab improves progression-free survival with lower doses of interferon a2a in the treatment of patients with metastastic renal cell carcinoma (AVOREN). Eur. J. Cancer Suppl. 5, 304-304 (2007).
    • (2007) Eur. J. Cancer Suppl. , vol.5 , pp. 304-304
    • Melichar, B.1    Koralewski, P.2    Pluzanska, A.3
  • 79
    • 34547636060 scopus 로고    scopus 로고
    • Correlation of survival with tumor histology, age, and prognostic-risk group for previously untreated patients with advanced renal cell carcinoma receiving temsirolimus or interferon a
    • Dutcher J, Szczylik C, Tannir N et al. Correlation of survival with tumor histology, age, and prognostic-risk group for previously untreated patients with advanced renal cell carcinoma receiving temsirolimus or interferon a. J. Clin. Oncol. 25 (2007) (Abstract 5033a).
    • (2007) J. Clin. Oncol. , vol.25
    • Dutcher, J.1    Szczylik, C.2    Tannir, N.3
  • 80
    • 70350602664 scopus 로고    scopus 로고
    • Second line treatment of progressive metastatic renal cell cancer with temsirolimus following first-line therapy with sunitinib or sorafenib
    • Richter S, Pfister D, Thüer D et al. Second line treatment of progressive metastatic renal cell cancer with temsirolimus following first-line therapy with sunitinib or sorafenib. Onkologie 31 (2008) (Abstract V684a).
    • (2008) Onkologie , vol.31
    • Richter, S.1    Pfister, D.2    Thüer, D.3
  • 81
    • 57449104977 scopus 로고    scopus 로고
    • Phase i trial of bevacizumab plus sunitinib in patients with metastatic renal cell carcinoma
    • Feldman DR, Ginsberg MS, Baum M et al. Phase I trial of bevacizumab plus sunitinib in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 26 (2008) (Abstract 5100a).
    • (2008) J. Clin. Oncol. , vol.26
    • Feldman, D.R.1    Ginsberg, M.S.2    Baum, M.3
  • 82
    • 60849086414 scopus 로고    scopus 로고
    • Phase i study combining treatment with temsirolimus and sunitinib malate in patients with advanced renal cell carcinoma
    • Fischer P, Patel P, Carducci MA et al. Phase I study combining treatment with temsirolimus and sunitinib malate in patients with advanced renal cell carcinoma. J. Clin. Oncol. 26, (2008) (Abstract 16020a).
    • (2008) J. Clin. Oncol. , vol.26
    • Fischer, P.1    Patel, P.2    Carducci, M.A.3
  • 83
    • 50849108567 scopus 로고    scopus 로고
    • Phase II study of bevacizumab and everolimus (RAD001) in the treatment of advanced renal cell carcinoma (RCC)
    • Whorf RC, Hainsworth JD, Spigel DR et al. Phase II study of bevacizumab and everolimus (RAD001) in the treatment of advanced renal cell carcinoma (RCC). J. Clin. Oncol. 26 (2008) (Abstract 5010a).
    • (2008) J. Clin. Oncol. , vol.26
    • Whorf, R.C.1    Hainsworth, J.D.2    Spigel, D.R.3
  • 84
    • 67249106104 scopus 로고    scopus 로고
    • Phase i study of sorafenib and RAD001 for metastatic clear cell renal cell carcinoma
    • Abstract 5109a
    • Rosenberg JE, Weinberg VK, Claros C et al. Phase I study of sorafenib and RAD001 for metastatic clear cell renal cell carcinoma. J. Clin. Oncol. 26 (2008) (Abstract 5109a).
    • (2008) J. Clin. Oncol. , vol.26
    • Rosenberg, J.E.1    Weinberg, V.K.2    Claros, C.3
  • 85
    • 67249111611 scopus 로고    scopus 로고
    • A Phase i study with a daily regimen of the mTOR inhibitor RAD001 (everolimus) plus sorafenib for patients with metastatic renal cell cancer (mRCC)
    • Abstract 14603a
    • Giessinger S, Amato RJ, Jac J et al. A Phase I study with a daily regimen of the mTOR inhibitor RAD001 (everolimus) plus sorafenib for patients with metastatic renal cell cancer (mRCC). J. Clin. Oncol. 26 (2008) (Abstract 14603a).
    • (2008) J. Clin. Oncol. , vol.26
    • Giessinger, S.1    Amato, R.J.2    Jac, J.3
  • 86
    • 49249113484 scopus 로고    scopus 로고
    • Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity
    • Azad NS, Posadas EM, Kwitkowski VE et al. Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity. J. Clin. Oncol. 26, 3709-3714 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 3709-3714
    • Azad, N.S.1    Posadas, E.M.2    Kwitkowski, V.E.3
  • 87
    • 55349098735 scopus 로고    scopus 로고
    • Final results of a Phase i trial of sorafenib and bevacizumab in patients with metastatic renal cell cancer
    • Abstract 5011a
    • Sosman JA, Flaherty KT, Atkins MB et al. Final results of a Phase I trial of sorafenib and bevacizumab in patients with metastatic renal cell cancer. J. Clin. Oncol. 26 (2008) (Abstract 5011a).
    • (2008) J. Clin. Oncol. , vol.26
    • Sosman, J.A.1    Flaherty, K.T.2    Atkins, M.B.3
  • 88
    • 36749098248 scopus 로고    scopus 로고
    • Phase I/II trial of CCI-779 and bevacizumab in stage IV renal cell carcinoma: Phase i safety and activity results
    • Abstract 5034a
    • Merchan JR, Liu G, Fitch T et al. Phase I/II trial of CCI-779 and bevacizumab in stage IV renal cell carcinoma: Phase I safety and activity results. J. Clin. Oncol. 25 (2007) (Abstract 5034a).
    • (2007) J. Clin. Oncol. , vol.25
    • Merchan, J.R.1    Liu, G.2    Fitch, T.3
  • 89
    • 66249106478 scopus 로고    scopus 로고
    • Sunitinib in elderly patients (>=70 years) with metatsatic renal cell carcinoma (mRCC): Multicenter analysis of tolerability and efficacy
    • Abstract 657P
    • Brunello A, Sacco C, Barile C et al. Sunitinib in elderly patients (>=70 years) with metatsatic renal cell carcinoma (mRCC): multicenter analysis of tolerability and efficacy. Ann. Oncol. 19 (2008) (Abstract 657P).
    • (2008) Ann. Oncol. , vol.19
    • Brunello, A.1    Sacco, C.2    Barile, C.3
  • 90
    • 71949124261 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in pts with brain and bone metastases: Results from a large openlabel, non-comparative Phase III study of sorafenib in European pts with advanced rcc (EU-ARCCS)
    • Abstract 595P
    • Bokemeyer C, Porta C, Beck J et al. Efficacy and safety of sorafenib in pts with brain and bone metastases: Results from a large openlabel, non-comparative Phase III study of sorafenib in European pts with advanced rcc (EU-ARCCS). Ann. Oncol. 19 (2008) (Abstract 595P).
    • (2008) Ann. Oncol. , vol.19
    • Bokemeyer, C.1    Porta, C.2    Beck, J.3
  • 91
    • 70349391784 scopus 로고    scopus 로고
    • Large open label, non-comparative Phase III study of sorafenib in European pts with advanced RCC (EU-ARCCS): Subgroup analysis of pts with and without baseline clinical cardiovascular diseases (CCD)
    • Abstract 602P
    • Eisen T, Beck J, Procopio G et al. Large open label, non-comparative Phase III study of sorafenib in European pts with advanced RCC (EU-ARCCS): subgroup analysis of pts with and without baseline clinical cardiovascular diseases (CCD). Ann. Oncol. 19 (2008) (Abstract 602P).
    • (2008) Ann. Oncol. , vol.19
    • Eisen, T.1    Beck, J.2    Procopio, G.3
  • 92
    • 67349121786 scopus 로고    scopus 로고
    • Effect of sorafenib treatment on left ventricular ejection fraction in cancer patients: An open-label, Phase i study
    • Abstract 552P
    • Tolcher A, Appleman L, Mita A et al. Effect of sorafenib treatment on left ventricular ejection fraction in cancer patients: an open-label, Phase I study. Ann. Oncol. 19 (2008) (Abstract 552P).
    • (2008) Ann. Oncol. , vol.19
    • Tolcher, A.1    Appleman, L.2    Mita, A.3
  • 93
    • 77951211638 scopus 로고    scopus 로고
    • Sorafenib is not associated with a high incidence of cardiovascular events in many tumor types
    • Abstract 553P
    • Snow H, Brueckner A, Gelder M et al. Sorafenib is not associated with a high incidence of cardiovascular events in many tumor types. Ann. Oncol. 19 (2008) (Abstract 553P).
    • (2008) Ann. Oncol. , vol.19
    • Snow, H.1    Brueckner, A.2    Gelder, M.3
  • 94
    • 62849099971 scopus 로고    scopus 로고
    • Sunitinib treatment for patients with advanced clear-cell renal-cell carcinoma after progression on sorafenib
    • Zimmermann K, Schmittel A, Steiner U et al. Sunitinib treatment for patients with advanced clear-cell renal-cell carcinoma after progression on sorafenib. Oncology 76(5), 350-354 (2009).
    • (2009) Oncology , vol.76 , Issue.5 , pp. 350-354
    • Zimmermann, K.1    Schmittel, A.2    Steiner, U.3
  • 95
    • 36849031075 scopus 로고    scopus 로고
    • A Phase I, pharmacokinetic and pharmacodynamic study of sorafenib (S), a multi-targeted kinase inhibitor in combination with temsirolimus (T), an mTOR inhibitor in patients with advanced solid malignancies
    • Abstract 3512a
    • Patnaik A, Ricart A, Cooper J et al. A Phase I, pharmacokinetic and pharmacodynamic study of sorafenib (S), a multi-targeted kinase inhibitor in combination with temsirolimus (T), an mTOR inhibitor in patients with advanced solid malignancies. J. Clin. Oncol. 25 (2007) (Abstract 3512a).
    • (2007) J. Clin. Oncol. , vol.25
    • Patnaik, A.1    Ricart, A.2    Cooper, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.