Decreased levels of Cx43 gap junctions result in ameloblast dysregulation and enamel hypoplasia in Gja1Jrt/+ mice

Journal of Cellular Physiology

Volumn 223, Issue 3, 2010, Pages 601-609

  Toth, K ^a   Shao, Q ^a   Lorentz, R ^a   Laird, D W ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMELOGENIN; CONNEXIN 43; GAP JUNCTION PROTEIN; GAP JUNCTION PROTEIN ALPHA 1; UNCLASSIFIED DRUG; CADHERIN;

ADULTHOOD; AMELOBLAST; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENAMEL HYPOPLASIA; GAP JUNCTION; INCISOR; MINERALIZATION; MOUSE; MOUTH CAVITY; NONHUMAN; OCULODENTODIGITAL SYNDROME; PERINATAL PERIOD; PHENOTYPE; PRIORITY JOURNAL; THICKNESS; TOOTH DEVELOPMENT; TOOTH DISEASE; TOOTH ERUPTION; TOOTH MALFORMATION; WEANING; ANIMAL; C57BL MOUSE; CELL JUNCTION; DISEASE MODEL; ENAMEL; METABOLISM; MOUSE MUTANT; PATHOLOGY; PROTEIN TRANSPORT; TOOTH PLAQUE;

MUS;

AMELOBLASTS; AMELOGENIN; ANIMALS; CADHERINS; CELL DIFFERENTIATION; CONNEXIN 43; DENTAL ENAMEL; DENTAL ENAMEL HYPOPLASIA; DENTAL PLAQUE; DISEASE MODELS, ANIMAL; GAP JUNCTIONS; INCISOR; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; PHENOTYPE; PROTEIN TRANSPORT;

EID: 77951223409     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22046     Document Type: Article

References (49)

1. About I, Proust JP, Raffo S, Mitsiadis TA, Franquin JC. 2002. In vivo and in vitro expression of connexin 43 in human teeth. Connect Tissue Res 43:232-237.
2. Bei M. 2009. Molecular genetics of ameloblast cell lineage. J Exp Zool 312B:437-444.
3. Boran T, Peterkova R, Lesot H, Lyons DB, Peterka M, Klein OD. 2009. Temporal analysis of ectopic enamel production in incisors from sprouty mutant mice. J Exp Zool 312B:473-485.
4. Brookes SJ, Kirkham J, Shore RC, Wood SR, Slaby I, Robinson C. 2001. Amelin extracellular processing and aggregation during rat incisor amelogenesis. Arch Oral Biol 46:201-208.
5. Castro C, Lecanda F, Sheikh S, Szejnfeld V, Willecke K, Theis M, Civitelli R. 2002.Osteoblast specific connexin43(Cx43) gene deletion in mice leads to reduced bone mass and osteoblast dysfunction. Mol Biol Cell 13:1609.
6. Crawford PJM, Aldred M, Bloch-Zupan A. 2007. Amelogenesis imperfecta. Orphanet J Rare Dis 2:17.
7. Debeer P, Van Esch H, Huysmans C, Pijkels E, De Smet L, Van de Ven W, Devriendt K, Fryns JP. 2005. Novel GJA1 mutations in patients with oculo-dento-digital dysplasia (ODDD). Eur J Med Genet 48:377-387.
8. Donahue HJ. 2000. Gap junctions and biophysical regulation of bone cell differentiation. Bone 26:417-422.
9. Evans WH, Martin PEM. 2002. Gap junctions: Structure and function (review). Mol Membr Biol 19:121-136.
10. Fleischmannova J, Matalova E, Tucker AS, Sharpe PT. 2008. Mouse models of tooth abnormalities. Eur J Oral Sci 116:1-10.
11. Flenniken AM, Osborne LR, Anderson N, Ciliberti N, Fleming C, Gittens JEI, Gong XQ, Kelsey LB, Lounsbury C, Moreno L, Nieman BJ, Peterson K, Qu DW, Roscoe W, Shao Q, Tong D, Veitch GIL, Voronina I, Vukobradovic I, Wood GA, Zhu YH, Zirngibl RA, Aubin JE, Bai DL, Bruneau BG, Grynpas M, Henderson JE, Henkelman RM, McKerlie C, Sled JG, Stanford WL, Laird DW, Kidder GM, Adamson SL, Rossant J. 2005. A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development 132:4375-4386.
12. Fried KAJ, Mitsiadis TA, Guerrier A, Haegerstrand A, Meister B. 1996. Combinatorial expression patterns of the connexins 26, 32 and 43 during development, homeostasis, and regeneration of rat teeth. Int J Dev Biol 40:985-995.
13. Fukumoto S, Yamada Y. 2005. Review: Extracellular matrix regulates tooth morphogenesis. Connect Tissue Res 46:220-226.
14. Gibson CW, Yuan ZA, Hall B, Longenecker G, Chen EH, Thyagarajan T, Sreenath T, Wright JT, Decker S, Piddington R, Harrison G, Kulkarni AB. 2001. Amelogenin-deficient mice display an amelogenesis imperfecta phenotype. J Biol Chem 276:31871-31875.
15. Gibson CW, Kulkarni AB, Wright JT. 2005. The use of animal models to explore amelogenin variants in amelogenesis imperfecta. Cells Tissues Organs 18:196-201.
16. Harada H, Ichimori Y, Yokohama-Tamaki T, Ohshima H, Kawano S, Katsube K, Wakisaka S. 2006. Stratum intermedium lineage diverges from ameloblast lineage via Notch signaling. Biochem Biophys Res Commun 340:611-616.
17. Hu JCC, Sun XL, Zhang CH, Simmer JP. 2001. A comparison of enamelin and amelogenin expression in developing mouse molars. Eur J Oral Sci 109:125-132.
18. Hu JCC, Hu Y, Smith CE, McKee MD, Wright JT, Yamakoshi Y, Papagerakis P, Hunter GK, Feng JQ, Yamakoshi F, Simmer JP. 2008. Enamel defects and ameloblast-specific expression in Enam knock-out/lacZ knock-in mice. J Biol Chem 283:10858-10871.
19. Ibuki N, Yamaoka Y, Sawa Y, Kawasaki T, Yoshida S. 2002. Different expressions of connexin 43 and 32 in the fibroblasts of human dental pulp. Tissue Cell 34:170-176.
20. Inai T, Nakamura K, Kurisu K, Shibata Y. 1997. Immunohistochemical localization of connexin43 in the enamel organ of the rat upper incisor during ameloblast development. Arch Histol Cytol 60:297-306.
21. Jiang JX, Siller-Jackson AJ, Burra S. 2007. Roles of gap junctions and hemichannels in bone cell functions and in signal transmission of mechanical stress. Front Biosci 12:1450-1462.
22. Joao SMA, Arana-Chavez VE. 2003. Expression of connexin 43 and Z0-1 in differentiating ameloblasts and odontoblasts from rat molar tooth germs. Histochem Cell Biol 119:21-26.
23. Kawano S, Saito M, Handa K, Morotomi T, Toyono T, Seta Y, Nakamura N, Uchida T, Toyoshima K, Ohishi M, Harada H. 2004. Characterization of dental epithelial progenitor cells derived from cervical-loop epithelium in a rat lower incisor. J Dent Res 83:129-133.
24. Laird DW. 2006. Life cycle of connexins in health and disease. Biochem J 394:527-543.
25. Langlois S, Maher AC, Manias JL, Shao Q, Kidder GM, Laird DW. 2007. Connexin levels regulate keratinocyte differentiation in the epidermis. J Biol Chem 282:30171-30180.
26. Lee SK, Kim SM, Lee YJ, Yamada KM, Yamada Y, Chi JG. 2003. The structure of the rat ameloblastin gene and its expression in amelogenesis. Mol Cells 15:216-225. (Pubitemid 41582926)
27. Lezot F, Thomas B, Greene SR, Hotton D, Yuan Z-A, Castaneda B, Bolanos A, Depew M, Sharpe P, Gibson CW, Berdall A. 2008. Physiological implications of DLX homeoproteins in enamel formation. J Cell Physiol 216:688-697.
28. Lu Y, Papagerakis P, Yamakoshi Y, Hu JCC, Bartlett JD, Simmer JP. 2008. Functions of KLK4 and MMP-20 in dental enamel formation. Biol Chem 389:695-700. (Pubitemid 352009413)
29. Manias JL, Plante I, Gong XQ, Shao Q, Churko J, Bai D, Laird DW. 2008. Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant. Cardiovasc Res 80:385-395.
30. McLachlan E, Manias JL, Gong XQ, Lounsbury CS, Shao Q, Bernier SM, Bai DL, Laird DW. 2005. Functional characterization of oculodentodigital dysplasia-associated Cx43 mutants. Cell Commun Adhes 12:279-292.
31. McLachlan E, Plante I, Shao Q, Tong D, Kidder GM, Bernier SM, Laird DW. 2008. ODDD-linked Cx43 mutants reduce endogenous Cx43 expression and function in osteoblasts and inhibit late stage differentiation. J Bone Miner Res 23:928-938. (Pubitemid 351768811)
32. Moinichen CB, Lyngstadaas SP, Risnes S. 1996. Morphological characteristics of mouse incisor enamel. J Anat 189:325-333. (Pubitemid 26364688)
33. Murakami S, Muramatsu T, Shimono M. 2001. Expression and localization of connexin 43 in rat incisor odontoblasts. Anat Embryol 203:367-374. (Pubitemid 32477306)
34. Nanci A, Ten Cate AR. 2007. Ten Cate's oral histology: Development, structure, and function. St. Louis, MO: Mosby. p. 432.
35. Neijssen J, Pang BX, Neefjes J. 2007. Gap junction-mediated intercellular communication in the immune system. Prog Biophys Mol Biol 94:207-218. (Pubitemid 46782984)
36. Pashley DH. 1990. Mechanisms of dentin sensitivity. Dent Clin North Am 34:449-473.
37. Pashley DH, Carvalho RM. 1997. Dentine permeability and dentine adhesion. J Dent 25:355-372.
38. Paznekas WA, Boyadjiev SA, Shapiro RE, Daniels O, Wollnik B, Keegan CE, Innis JW, Dinulos MB, Christian C, Hannibal MC, Jabs EW. 2003. Connexin 43 (GJA1) mutations cause the pleiotropic phenotype of oculodentodigital dysplasia. Am J Hum Genet 72:408-418.
39. Paznekas WA, Karczeski B, Vermeer S, Lowry RB, Delatycki M, Laurence F, Koivisto PA, Van Maldergem L, Boyadjiev SA, Bodurtha JN, Jabs EW. 2009. GJA1 mutations, variants, and connexin 43 dysfunction as it relates to the oculodentodigital dysplasia phenotype. Hum Mutat 30:724-733.
40. Risnes S, Septier D, Goldberg M. 1995. Accelerated eruption of rat lower incisor, relationship between impeded and unimpeded eruption rates, rate of attrition, tooth length, and production of dentin and enamel. Connect Tissue Res 32:183-189.
41. Satokata I, Ma L, Ohshima H, Bei M, Woo I, Nishizawa K, Maeda T, Takano Y, Uchiyama M, Heaney S, Peters H, Tang ZQ, Maxson R, Maas R. 2000. Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation. Nat Genet 24:391-395.
42. Shibayama J, Paznekas W, Seki A, Taffet S, Jabs EW, Delmar M, Musa H. 2005. Functional characterization of connexin43 mutations found in patients with oculodentodigital dysplasia. Circ Res 96:E83-E91.
43. Smith CE. 1998. Cellular and chemical events during enamel maturation. Crit Rev Oral Biol Med 9:128-161.
44. Thomas T, Jordan K, Simek J, Shao Q, Jedeszko C, Walton P, Laird DW. 2005. Mechanisms of Cx43 and Cx26 transport to the plasma membrane and gap junction regeneration. J Cell Sci 118:4451-4462. (Pubitemid 41556343)
45. Thyagarajan T, Totey S, Danton MJS, Kulkarni AB. 2003. Genetically altered mouse models: The good, the bad, and the ugly. Crit Rev Oral Biol Med 14:154-174.
46. Tompkins K. 2006. Molecular mechanisms of cytodifferentiation in mammalian tooth development. Connect Tissue Res 47:111-118.
47. Tziafas D. 1994. Mechanisms controlling secondary initiation of dentinogenesis-A review. Int Endod J 27:61-74.
48. Watkins M, Ornitz D, Wilecke K, Civitelli R. 2006. Connexin43 is required for normal skeletal development and bone mass acquisition. J Bone Miner Res 21:S56.
49. Wright JT, Hart TC, Hart PS, Simmons D, Suggs C, Daley B, Simmer J, Hu J, Bartlett JD, Li Y, Yuan ZA, Seow WK, Gibson CW. 2009. Human and mouse enamel phenotypes resulting from mutation or altered expression of AMEL, ENAM, MMP20 and KLK4. Cells Tissues Organs 189:224-229.