Downregulation of Smad Transcriptional Corepressors SnoN and Ski in the Fibrotic Kidney: An Amplification Mechanism for TGF-β1 Signaling

Journal of the American Society of Nephrology

Volumn 14, Issue 12, 2003, Pages 3167-3177

  Yang, Junwei ^a,b   Zhang, Xianghong ^a   Li, Yingjian ^a   Liu, Youhua ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

SMAD PROTEIN; SMALL NUCLEOLAR RNA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERSTITIUM; KIDNEY DISEASE; KIDNEY FIBROSIS; KIDNEY TUBULE EPITHELIUM; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STIMULATION; URETER OBSTRUCTION;

EID: 0347282737     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ASN.0000099373.33259.B2     Document Type: Article

References (43)

1. Bottinger EP, Bitzer M: TGF-β1 signaling in renal disease. J Am Soc Nephrol 13: 2600-2610, 2002
2. Schnaper HW, Hayashida T, Hubchak SC, Poncelet AC: TGF-beta signal transduction and mesangial cell fibrogenesis. Am J Physiol Renal Physiol 284: F243-F252, 2003
3. Bissell DM, Roulot D, George J: Transforming growth factor beta and the liver. Hepatology 34: 859-867, 2001
4. Eddy AA: Molecular basis of renal fibrosis. Pediatr Nephrol 15: 290-301, 2000
5. Border WA, Noble NA: TGF-beta in kidney fibrosis: A target for gene therapy. Kidney Int 51: 1388-1396, 1997
6. Wolf G, Ziyadeh FN, Stahl RA: Angiotensin II stimulates expression of transforming growth factor beta receptor type II in cultured mouse proximal tubular cells. J Mol Med 77: 556-564, 1999
7. Border WA, Noble NA: Interaction of transforming growth factor-beta and angiotensin II in renal fibrosis. Hypertension 31: 181-188, 1998
8. Kopp JB, Factor VM, Mozes M, Nagy P, Sanderson N, Bottinger EP, Klotman PE, Thorgeirsson SS: Transgenic mice with increased plasma levels of TGF-beta I develop progressive renal disease. Lab Invest 74: 991-1003, 1996
9. Mozes MM, Bottinger EP, Jacot TA, Kopp JB: Renal expression of fibrotic matrix proteins and of transforming growth factor-beta (TGF-beta) isoforms in TGF-beta transgenic mice. J Am Soc Nephrol 10: 271-280, 1999
10. Isaka Y, Akagi Y, Ando Y, Tsujie M, Sudo T, Ohno N, Border WA, Noble NA, Kaneda Y, Hori M, Imai E: Gene therapy by transforming growth factor-beta receptor-IgG Fc chimera suppressed extracellular matrix accumulation in experimental glomerulonephritis. Kidney Int 55: 465-475, 1999
11. Ziyadeh FN, Hoffman BB, Han DC, Iglesias-De La Cruz MC, Hong SW, Isono M, Chen S, McGowan TA, Sharma K: Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice. Proc Natl Acad Sci U S A 97: 8015-8020, 2000
12. Isaka Y, Tsujie M, Ando Y, Nakamura H, Kaneda Y, Imai E, Hori M: Transforming growth factor-beta 1 antisense oligodeoxynucleotides block interstitial fibrosis in unilateral ureteral obstruction. Kidney Int 58: 1885-1892, 2000
13. Ling H, Li X, Jha S, Wang W, Karetskaya L, Pratt B, Ledbetter S: Therapeutic role of TGF-beta-neutralizing antibody in mouse cyclosporin A nephropathy: Morphologic improvement associated with functional preservation. J Am Soc Nephrol 14: 377-388, 2003
14. Miyazono K: TGF-beta/SMAD signaling and its involvement in tumor progression. Biol Pharm Bull 23: 1125-1130, 2000
15. Dai C, Yang J, Liu Y: Transforming growth factor-β1 potentiates renal tubular epithelial cell death by a mechanism independent of Smad signaling. J Biol Chem 278: 12537-12545, 2003
16. Massague J: How cells read TGF-beta signals. Nat Rev Mol Cell Biol 1: 169-178, 2000
17. Yang J, Liu Y: Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol 159: 1465-1475, 2001
18. Sutaria PM, Ohebshalom M, McCaffrey TA, Vaughan ED Jr, Felsen D: Transforming growth factor-beta receptor types I and II are expressed in renal tubules and are increased after chronic unilateral ureteral obstruction. Life Sci 62: 1965-1972, 1998
19. Kretzschmar M, Doody J, Timokhina I, Massague J: A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras. Genes Dev 13: 804-816, 1999
20. Lo RS, Wotton D, Massague J: Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF. EMBO J 20: 128-136, 2001
21. Yang J, Dai C, Liu Y: Hepatocyte growth factor suppresses renal interstitial myofibroblast activation and intercepts Smad signal transduction. Am J Pathol 163: 621-632, 2003
22. Massague J, Chen YG: Controlling TGF-beta signaling. Genes Dev 14: 627-644, 2000
23. Piek E, Heldin CH, Ten Dijke P: Specificity, diversity, and regulation in TGF-beta superfamily signaling. FASEB J 13: 2105-2124, 1999
24. ten Dijke P, Miyazono K, Heldin CH: Signaling inputs converge on nuclear effectors in TGF-beta signaling. Trends Biochem Sci 25: 64-70, 2000
25. Wotton D, Massague J: Smad transcriptional corepressors in TGF beta family signaling. Curr Top Microbiol Immunol 254: 145-164, 2001
26. Frederick JP, Wang XF: Smads "freeze" when they ski. Structure (Camb) 10: 1607-1611, 2002
27. Nomura N, Sasamoto S, Ishii S, Date T, Matsui M, Ishizaki R: Isolation of human cDNA clones of ski and the ski-related gene, sno. Nucleic Acids Res 17: 5489-5500, 1989
28. Sun Y, Liu X, Ng-Eaton E, Lodish HF, Weinberg RA: SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling. Proc Natl Acad Sci U S A 96:12442-12447, 1999
29. Stroschein SL, Wang W, Zhou S, Zhou Q, Luo K: Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein. Science 286: 771-774, 1999
30. Melhuish TA, Gallo CM, Wotton D: TGIF2 interacts with histone deacetylase 1 and represses transcription. J Biol Chem 276: 32109-32114, 2001
31. Wu JW, Krawitz AR, Chai J, Li W, Zhang F, Luo K, Shi Y: Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: Insights on Ski-mediated repression of TGF-beta signaling. Cell 111: 357-367, 2002
32. Pessah M, Marais J, Prunier C, Ferrand N, Lallemand F, Mauviel A, Atfi A: c-Jun associates with the oncoprotein Ski and suppresses Smad2 transcriptional activity. J Biol Chem 277: 29094-29100, 2002
33. Wotton D, Knoepfler PS, Laherty CD, Eisenman RN, Massague J: The Smad transcriptional corepressor TGIF recruits mSin3. Cell Growth Differ 12: 457-463, 2001
34. Yang J, Liu Y: Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis. J Am Soc Nephrol 13: 96-107, 2002
35. Yang J, Liu Y: Delayed administration of hepatocyte growth factor reduces renal fibrosis in obstructive nephropathy. Am J Physiol Renal Physiol 284: F349-F357, 2003
36. Scherr M, Morgan MA, Eder M: Gene silencing mediated by small interfering RNAs in mammalian cells. Curr Med Chem 10: 245-256, 2003
37. Wilson JA, Jayasena S, Khvorova A, Sabatinos S, Rodrigue-Gervais IG, Arya S, Sarangi F, Harris-Brandts M, Beaulieu S, Richardson CD: RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells. Proc Natl Acad Sci U S A 100: 2783-2788, 2003
38. Song E, Lee SK, Wang J, Ince N, Ouyang N, Min J, Chen J, Shankar P, Lieberman J: RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med 9: 347-351, 2003
39. Strutz F, Zeisberg M, Ziyadeh FN, Yang CQ, Kalluri R, Muller GA, Neilson EG: Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation. Kidney Int 61: 1714-1728, 2002
40. Wrana JL, Attisano L, Carcamo J, Zentella A, Doody J, Laiho M, Wang XF, Massague J: TGF beta signals through a heteromeric protein kinase receptor complex. Cell 71: 1003-1014, 1992
41. Isono M, Chen S, Hong SW, Iglesias-de la Cruz MC, Ziyadeh FN: Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-beta-induced fibronectin in mesangial cells. Biochem Biophys Res Commun 296: 1356-1365, 2002
42. Ziyadeh FN, Sharma K: Overview: Combating diabetic nephropathy. J Am Soc Nephrol 14: 1355-1357, 2003
43. Klahr S, Morrissey J: Obstructive nephropathy and renal fibrosis. Am J Physiol Renal Physiol 283: F861-F875, 2002