The structure of mammalian serine racemase: Evidence for conformational changes upon inhibitor binding

Journal of Biological Chemistry

Volumn 285, Issue 17, 2010, Pages 12873-12881

  Smith, Myron A ^a   Mack, Volker ^a   Ebneth, Andreas ^a   Moraes, Isabel ^a   Felicetti, Brunella ^a   Wood, Michael ^a   Schonfeld, Dorian ^a   Mather, Owen ^a   Cesura, Andrea ^a   Barker, John ^a  

^a EVOTEC UK LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CONFORMATIONAL CHANGE; D-SERINE; DRUG DESIGN; GLUTAMATE RECEPTOR; LARGE DOMAIN; MALONATES; MOLECULAR BASIS; N METHYL D ASPARTATE RECEPTOR; SERINE RACEMASE; X RAY CRYSTAL STRUCTURES;

ENZYMES; MAMMALS; PHOSPHATASES;

AMINO ACIDS;

DIMER; MALONIC ACID; PYRIDOXAL 5 PHOSPHATE; RACEMASE; SERINE RACEMASE; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CROSS LINKING; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ASSAY; ENZYME PURIFICATION; ENZYME STRUCTURE; HUMAN; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; MALONATES; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; PYRIDOXAL PHOSPHATE; RACEMASES AND EPIMERASES; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; SERINE;

MAMMALIA; RATTUS;

EID: 77951223140     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.050062     Document Type: Article

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