Complete nucleotide sequence and comparative analysis of pPR9, a 41.7-kilobase conjugative staphylococcal multiresistance plasmid conferring high-level mupirocin resistance

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 5, 2010, Pages 2252-2257

  Pérez Roth, Eduardo ^a   Kwong, Stephen M ^d   Alcoba Florez, Julia ^a,b   Firth, Neville ^d   Méndez Álvarez, Sebastián ^a,c  

^a Unidad de Investigacion   (Spain)

^b Servicio de Microbiología   (Spain)

^c HOSPITAL UNIVERSITARIO NUESTRA SEÑORA DE CANDELARIA   (Spain)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PSEUDOMONIC ACID;

ARTICLE; GENE INSERTION SEQUENCE; GENETIC CONSERVATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; STAPHYLOCOCCUS;

ANTI-BACTERIAL AGENTS; CHROMOSOME MAPPING; CONJUGATION, GENETIC; DRUG RESISTANCE, BACTERIAL; DRUG RESISTANCE, MULTIPLE; GENETIC HETEROGENEITY; MUPIROCIN; PLASMIDS; STAPHYLOCOCCUS AUREUS;

EID: 77951214214     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01074-09     Document Type: Article

References (32)

1. Altschul, S. F., T. L. Madden, A. A. Schaffer, J. Zhang, Z. Zhang, W. Miller, and D. J. Lipman. 1997. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25:3389-3402.
2. Badger, J. H., and G. J. Olsen. 1999. CRITICA: coding region identification tool invoking comparative analysis. Mol. Biol. Evol. 16:512-524.
3. Bateman, A., L. Coin, R. Durbin, R. D. Finn, V. Hollich, S. Griffiths-Jones, A. Khana, M. Marshall, S. Moxon, E. L. L. Sonnhammer, D. J. Studholme, C. Yeats, and S. R. Eddy. 2004. The Pfam protein families database. Nucleic Acids Res. 32:D138-D141.
4. Berg, T., N. Firth, S. Apisiridej, A. Hettiaratchi, A. Leelaporn, and R. A. Skurray. 1998. Complete nucleotide sequence of pSK41: evolution of staphylococcal conjugative multiresistance plasmids. J. Bacteriol. 180:4350-4359.
5. Berg, T. 2000. Conjugative and mobilisable antimicrobial resistance plasmids from staphylococci. Ph.D. thesis. University of Sydney, Sydney, NSW, Australia.
6. Caryl, J. A., and A. J. O'Neill. 2009. Complete nucleotide sequence of pGO1, the prototype conjugative plasmid from the staphylococci. Plasmid 62:35-38.
7. Climo, M. W., V. K. Sharma, and G. L. Archer. 1996. Identification and characterization of the origin of transfer (oriT) and a gene (nes) encoding a single-stranded endonuclease on the staphylococcal plasmid pGO1. J. Bacteriol. 178:4975-4983.
8. Cookson, B. D. 1998. The emergence of mupirocin resistance: a challenge to infection control and antibiotic prescribing practice. J. Antimicrob. Chemother. 41:11-18.
9. Delcher, A. L., D. Harmon, S. Kasif, O. White, and S. L. Salzberg. 1999. Improved microbial gene identification with GLIMMER. Nucleic Acids Res. 27:4636-4641.
10. Diep, B. A., S. R. Gill, R. F. Chang, T. H. Phan, J. H. Chen, M. G. Davidson, F. Lin, J. Lin, H. A. Carleton, E. F. Mongodin, G. F. Sensabaugh, and F. Perdreau-Remington. 2006. Complete genome sequence of USA300, an epidemic clone of community-acquired methicillin-resistant Staphylococcus aureus. Lancet 367:731-739.
11. Ewing, B., and P. Green. 1998. Base-calling of automated sequencer traces using phred. II. Error probabilities. Genome Res. 8:186-194.
12. Ewing, B., L. Hillier, M. C. Wendl, and P. Green. 1998. Base-calling of automated sequencer traces using phred. I. Accuracy assessment. Genome Res. 8:175-185.
13. Firth, N., and R. A. Skurray. 1998. Mobile elements in the evolution and spread of multiple-drug resistance in staphylococci. Drug Resist. Updat. 1:49-58.
14. Firth, N., and R. A. Skurray. 2006. Genetics: accessory elements and genetic exchange, p. 413-426. In V. A. Fischetti, R. P. Novick, J. J. Ferretti, D. A. Portnoy, and J. I. Rood (ed.), Gram-positive pathogens. ASM Press, Washington, DC.
15. Grkovic, S., M. H. Brown, K. M. Hardie, N. Firth, and R. A. Skurray. 2003. Stable low-copy-number Staphylococcus aureus shuttle vectors. Microbiology 149:785-794.
16. Hodgson, J. E., S. P. Curnock, K. G. H. Dyke, R. Morris, D. R. Sylvester, and M. S. Gross. 1994. Molecular characterization of the gene encoding high-level mupirocin resistance in Staphylococcus aureus J2870. Antimicrob. Agents Chemother. 38:1205-1208.
17. Hurdle, J. G., A. J. O'Neill, L. Mody, I. Chopra, and S. F. Bradley. 2005. In vivo transfer of high-level mupirocin resistance from Staphylococcus epidermidis to methicillin-resistant Staphylococcus aureus associated with failure of mupirocin prophylaxis. J. Antimicrob. Chemother. 56:1166-1168.
18. Kwong, S. M., R. A. Skurray, and N. Firth. 2004. Staphylococcus aureus multiresistance plasmid pSK41: analysis of the replication region, initiator protein binding and antisense RNA regulation. Mol. Microbiol. 51:497-509.
19. Kwong, S. M., R. A. Skurray, and N. Firth. 2006. Replication control of staphylococcal multiresistance plasmid pSK41: an antisense RNA mediates dual-level regulation of Rep expression. J. Bacteriol. 188:4404-4412.
20. LeBard, R. J., S. O. Jensen. I. A. Arnaiz, R. A. Skurray, and N. Firth. 2008. A multimer resolution system contributes to segregational stability of the prototypical staphylococcal conjugative multiresistance plasmid pSK41. FEMS Microbiol. Lett. 284:58-67.
21. Marchler-Bauer, A., J. B. Anderson, C. DeWeese-Scott, N. D. Fedorova, L. Y. Geer, S. He, D. I. Hurwitz, J. D. Jackson, A. R. Jacobs, C. J. Lanczycki, C. A. Liebert, C. Liu, T. Madej, G. H. Marchler, R. Mazumder, A. N. Nikolskaya, A. R. Panchenko, B. S. Rao, B. A. Shoemaker, V. Simonyan, J. S. Song, P. A. Thiessen, S. Vasudevan, Y. Wang, R. A. Yanashita, J. J. Yin, and S. H. Bryant. 2003. CDD: a curated Entrez database of conserved domain alignments. Nucleic Acids Res. 31:383-387.
22. Morton, T. M., J. L. Johnston, J. Patterson, and G. L. Archer. 1995. Characterization of a conjugative staphylococcal mupirocin resistance plasmid. Antimicrob. Agents Chemother. 39:1272-1280.
23. Pérez-Roth, E., C. López-Aguilar, J. Alcoba-Florez, and S. Méndez-Álvarez. 2006. High-level mupirocin resistance within methicillin-resistant Staphylococcus aureus pandemic lineages. Antimicrob. Agents Chemother. 50:3207-3211.
24. Pérez-Roth, E., F. Lorenzo-Díaz, N. Batista, A. Moreno, and S. Méndez- Álvarez. 2004. Tracking methicillin-resistant Staphylococcus aureus clones during a 5-year period (1998 to 2002) in a Spanish hospital. J. Clin. Microbiol. 42:4649-4656.
25. Rowland, S. J., and K. G. Dyke. 1990. Tn552, a novel transposable element from Staphylococcus aureus. Mol. Microbiol. 4:961-975.
26. Simor, A. E., T. L. Stuart, L. Louie, C. Watt, M. Ofner-Agostini, D. Gravel, M. Mulvey, M. Loeb, A. McGeer, E. Bryce, A. Matlow, and the Canadian Nosocomial Infection Surveillance Program. 2007. Mupirocin-resistant, methicillin-resistant Staphylococcus aureus strains in Canadian hospitals. Antimicrob. Agents Chemother. 51:3880-3886.
27. Simpson, A. E., R. A. Skurray, and N. Firth. 2000. An IS257-derived hybrid promoter directs transcription of a tetA(K) tetracycline resistance gene in the Staphylococcus aureus chromosomal mec region. J. Bacteriol. 182:3345-3352.
28. Tettelin, H., D. Radune, S. Kasif, H. Khouri, and S. L. Salzberg. 1999. Optimized multiplex PCR: efficiently closing a whole-genome shotgun sequencing project. Genomics 62:500-507.
29. Thomas, W. D., Jr., and G. L. Archer. 1989. Identification and cloning of the conjugative transfer region of Staphylococcus aureus plasmid pGO1. J. Bacteriol. 171:684-691.
30. Udo, E. E., and L. E. Jacob. 1998. Conjugative transfer of high-level mupirocin resistance and the mobilization of non-conjugative plasmids in Staphylococcus aureus. Microb. Drug Resist. 4:185-193.
31. Weaver, K. E., S. M. Kwong, N. Firth, and M. V. Francia. 2009. The RepA-N replicons of Gram-positive bacteria: a family of broadly distributed but narrow host range plasmids. Plasmid 61:94-109.
32. Weigel, L. M., D. B. Clewell, S. R. Gill, N. C. Clark, L. K. McDougal, S. E. Flannagan, J. F. Kolonay, J. Shetty, G. E. Killgore, and F. C. Tenover. 2003. Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus. Science 302:1569-1571.