Insulin receptor substrate-2 gene polymorphism: Is it associated with endometrial cancer?

Gynecological Endocrinology

Volumn 26, Issue 5, 2010, Pages 378-382

  Çayan, Filiz ^a   Tok, Ekrem ^a   Aras Ateş, Nurcan ^a   Ayaz, Lokman ^a   Akbay, Esen ^a   Gen, Ramazan ^a   Karakaş, Sevim ^a   Dilek, Saffet ^a  

^a MERSIN UNIVERSITY   (Turkey)

Author keywords

Endometrial cancer; G1057D variant; Insulin receptor substrate 2 gene

Indexed keywords

INSULIN RECEPTOR SUBSTRATE 2;

ADULT; AGED; ARTICLE; CANCER RISK; CONTROLLED STUDY; DNA EXTRACTION; DNA POLYMORPHISM; ENDOMETRIUM CANCER; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HUMAN; LEUKOCYTE; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADULT; AGED; CASE-CONTROL STUDIES; DNA; ENDOMETRIAL NEOPLASMS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH;

EID: 77951127354     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513591003632241     Document Type: Article

References (27)

1. Dearth RK, Cui X, Kim HJ, Hadsell DL, Lee AV. Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)- 1 and IRS-2. Cell Cycle 2007;6: 705-713.
2. Schubert M, Brazil DP, Burks DJ, Kushner JA, Ye J, Flint CL, Farhang-Fallah J, Dikkes P, Warot XM, Rio C, et al. Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 2003;18:7084-7092.
3. White MF. Regulating insulin signaling and beta-cell function through IRS proteins. Can J Physiol Pharmacol 2006;84:725-737.
4. WhiteMF. The insulin signalling system and the IRS proteins. Diabetologia 1997;40:2-17.
5. Dearth RK, Cui X, Kim HJ, Kuiatse I, Lawrence NA, Zhang X, Divisova J, Britton OL, Mohsin S, Allred DC, et al. Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2. Mol Cell Biol 2006;26:9302-9314.
6. Slattery ML, Samowitz W, Curtin K, Ma KN, Hoffman M, Caan B, Neuhausen S. Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer. Cancer Epidemiol Biomarkers Prev 2004;13:1206-1214.
7. Bergmann U, Funatomi H, Kornmann M, Beger HG, Korc M. Increased expression of insulin receptor substrate-1 in human pancreatic cancer. Biochem Biophys Res Commun 1996;220:886-890.
8. Boissan M, Beurel E, Wendum D, Rey C, Lécluse Y, Housset C, Lacombe ML, Desbois-Mouthon C. Overexpression of insulin receptor substrate-2 in human and murine hepatocellular carcinoma. Am J Pathol 2005;167:869-877.
9. Jemal A, Siegel R, Ward E, Hao Y, Xu J,Murray T, Thun MJ. Cancer statistics 2008. CA Cancer J Clin 2008;58:71-96.
10. Chia VM, Newcomb PA, Trentham-Dietz A, Hampton JM. Obesity, diabetes, and other factors in relation to survival after endometrial cancer diagnosis. Int J Gynecol Cancer 2007; 7:441-446.
11. Pavelić J, Radaković B, Pavelić K. Insulin-like growth factor 2 and its receptors (IGF 1R and IGF 2R/mannose 6-phosphate) in endometrial adenocarcinoma. Gynecol Oncol 2007;105: 727-735.
12. White MF. IRS proteins and the common path to diabetes. Am J Physiol Endocrinol Metab 2002;283:413-422.
13. Lautier C, El Mkadem SA, Renard E, Brun JF, Gris JC, Bringer J, Grigorescu F. Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutation. Hum Genet 2003; 113:34-43.
14. FIGO. Annual report on the results of treatment in gynecologic cancer. Int J Gynecol Obstet 1989;28:189-193.
15. WHO classification of tumors, pathology and genetics, tumours of the breast and female genital organs. In: Tavassoli FA, Devilee P, editors, Chapter 4. Tumors of the uterine corpus, Lyon: IARC press; 2000. pp 218.
16. Mardilovich K, Pankratz SL, Shaw LM. Expression and function of the insulin receptor substrate proteins in cancer. Cell Commun Signal 2009;7:14.
17. Neuhausen SL, Slattery ML, Garner CP, Ding YC, Hoffman M, Brothman AR. Prostate cancer risk and IRS1, IRS2, IGF1, and INS polymorphisms: strong association of IRS1 G972R variant and cancer risk. Prostate 2005;64:168-174.
18. Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 1998;391:900-904.
19. Nagle JA, Ma Z, Byrne MA, White MF, Shaw LM. Involvement of insulin receptor substrate 2 in mammary tumor metastasis. Mol Cell Biol 2004;24:9726-9735.
20. Almind K, Frederiksen SK, Bernal D, Hansen T, Ambye L, Urhammer S, Ekstrøm CT, Berglund L, Reneland R, Lithell H, et al. Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity. Diabetologia 1999;42:1244-1249.
21. McCampbell AS, Walker CL, Broaddus RR, Cook JD, Davies PJ. Developmental reprogramming of IGF signaling and susceptibility to endometrial hyperplasia in the rat. Lab Invest 2008;88:615-626.
22. Giudice LC, Dsupin BA, Gargosky SE, Rosenfeld RG, Irwin JC. The insulin-like growth factor system in human peritoneal fluid: its effects on endometrial stromal cells and its potential relevance to endometriosis. J Clin Endocrinol Metab 1994; 79:1284-1293.
23. Lacey JV Jr, Ioffe OB, Ronnett BM, Rush BB, Richesson DA, Chatterjee N, Langholz B, Glass AG, Sherman ME. Endometrial carcinoma risk among women diagnosed with endometrial hyperplasia: the 34-year experience in a large health plan. Br J Cancer 2008;98:45-53.
24. Ganeff C, Chatel G, Munaut C, Frankenne F, Foidart JM, Winkler R. The IGF system in in vitro human decidualization. Mol Hum Reprod 2009;15:27-38.
25. Chan BT, Lee AV. Insulin receptor substrates (IRSs) and breast tumorigenesis. J Mammary Gland Biol Neoplasia 2008; 13:415-422.
26. Khalili K, Del Valle L, Wang JY, Darbinian N, Lassak A, Safak M, Reiss K. T-antigen of human polyomavirus JC cooperates withIGF-IR signaling system in cerebellar tumors of the childhood-medulloblastomas. Anticancer Res 2003;23: 2035-2041.
27. Lannon CL, Martin MJ, Tognon CE, Jin W, Kim SJ, Sorensen PH. A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin receptor substrate- 1: an essential interaction for transformation. J Biol Chem 2004;279:6225-6234.