Brain uptake of diazepam and phenytoin in a genetic animal model of absence epilepsy

Clinical and Experimental Pharmacology and Physiology

Volumn 37, Issue 5-6, 2010, Pages 647-649

  Nicolazzo, Joseph A ^a   Steuten, Jessica A ^a   Charman, Susan A ^a   Taylor, Nerida ^b   Davies, Philip J ^b   Petrou, Steven ^b  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Acute seizure; Blood brain barrier; Diazepam; Genetic absence epilepsy; Phenytoin

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR GAMMA2; CARBON 14; DIAZEPAM; INULIN; PENTETRAZOLE; PHENYTOIN; SODIUM CHLORIDE; 4 AMINOBUTYRIC ACID A RECEPTOR; ANTICONVULSIVE AGENT; GABRG2 PROTEIN, HUMAN; GABRG2 PROTEIN, MOUSE;

ABSENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG PENETRATION; DRUG UPTAKE; GENE MUTATION; GENETIC MODEL; HUMAN; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MOUSE; MOUSE MUTANT; NONHUMAN; PLASMA VOLUME; WILD TYPE; ANIMAL; BIOLOGICAL MODEL; BLOOD; BLOOD BRAIN BARRIER; BRAIN; BRAIN CIRCULATION; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; EPILEPSY, ABSENCE; GENETICS; METABOLISM; MICROCIRCULATION; MUTANT MOUSE STRAIN; MUTATION; VASCULARIZATION;

ANIMALS; ANTICONVULSANTS; BLOOD-BRAIN BARRIER; BRAIN; CEREBROVASCULAR CIRCULATION; CHROMATOGRAPHY, LIQUID; DIAZEPAM; DISEASE MODELS, ANIMAL; EPILEPSY, ABSENCE; HUMANS; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICROCIRCULATION; MODELS, GENETIC; MUTATION; PHENYTOIN; RECEPTORS, GABA-A;

EID: 77951119254     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2010.05362.x     Document Type: Article

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