The prognostic value of intraepithelial and stromal CD3-, CD117- and CD138-positive cells in non-small cell lung carcinoma

APMIS

Volumn 118, Issue 5, 2010, Pages 371-382

  Al Shibli, Khalid ^a,b   Al Saad, Samer ^b,c   Andersen, Sigve ^b,c   Donnem, Tom ^b,c   Bremnes, Roy M ^b,c   Busund, Lill Tove ^b,c  

^a NORDLAND HOSPITAL   (Norway)

^b UNIVERSITY OF TROMSØ   (Norway)

^c UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

Author keywords

CD138; Mast cells; NSCLC; T cells; Tumor stroma

Indexed keywords

CD3 ANTIGEN; CELL MARKER; STEM CELL FACTOR RECEPTOR; SYNDECAN 1;

ADULT; AGED; ARTICLE; CANCER STAGING; CELLULAR DISTRIBUTION; CLINICAL INDICATOR; CONTROLLED STUDY; DISEASE FREE SURVIVAL; EPITHELIUM CELL; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMAGE DISPLAY; IMMUNOHISTOCHEMISTRY; IMMUNOSURVEILLANCE; LUNG NON SMALL CELL CANCER; LYMPHOCYTE FUNCTION; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; STROMA CELL; T LYMPHOCYTE; TISSUE MICROARRAY;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD3; CARCINOMA, NON-SMALL-CELL LUNG; DISEASE-FREE SURVIVAL; EPITHELIAL CELLS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-KIT; STROMAL CELLS; SYNDECAN-1; TUMOR MARKERS, BIOLOGICAL;

EID: 77951095411     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/j.1600-0463.2010.02609.x     Document Type: Article

References (36)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. Cancer statistics, 2008. CA Cancer J Clin 2008 58 : 71 96.
2. Hotta K, Fujiwara Y, Matsuo K, Suzuki T, Kiura K, Tabata M, et al. Recent improvement in the survival of patients with advanced nonsmall cell lung cancer enrolled in phase III trials of first-line, systemic chemotherapy. Cancer 2007 109 : 939 948. (Pubitemid 46333536)
3. Kuo SH, Chang DB, Lee YC, Lee YT, Luh KT. Tumour-infiltrating lymphocytes in non-small cell lung cancer are activated T lymphocytes. Respirology 1998 3 : 55 9.
4. Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-pages C, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 2006 313 : 1960 1964.
5. Kataki A, Scheid P, Piet M, Marie B, Martinet N, Martinet Y, et al. Tumor infiltrating lymphocytes and macrophages have a potential dual role in lung cancer by supporting both host-defense and tumor progression. J Lab Clin Med 2002 140 : 320 328.
6. Blankenstein T. The role of tumor stroma in the interaction between tumor and immune system. Curr Opin Immunol 2005 17 : 180 186.
7. Donnem T, Al-Saad S, Al-Shibli K, Andersen S, Busund LT, Bremnes RM. Prognostic impact of platelet-derived growth factors in non-small cell lung cancer tumor and stromal cells. J Thorac Oncol 2008 3 : 963 970.
8. Donnem T, Al-Saad S, Al-Shibli K, Delghandi M, Persson M, Busund LT, et al. Inverse prognostic impact of angiogenic marker expression in tumor cells versus stromal cells in non small cell lung cancer. Clin Cancer Res 2007 13 (22 Pt 1 6649 6657.
9. Al-Shibli KI, Donnem T, Al-Saad S, Persson M, Bremnes RM, Busund LT. Prognostic effect of epithelial and stromal lymphocyte infiltration in non-small cell lung cancer. Clin Cancer Res 2008 14 : 5220 5227.
10. Mukunyadzi P, Liu K, Hanna EY, Suen JY, Fan CY. Induced expression of syndecan-1 in the stroma of head and neck squamous cell carcinoma. Mod Pathol 2003 16 : 796 801.
11. Yano H, Kinuta M, Tateishi H, Nakano Y, Matsui S, Monden T, et al. Mast cell infiltration around gastric cancer cells correlates with tumor angiogenesis and metastasis. Gastric Cancer 1999 2 (1 26 32.
12. Sihoe AD, Yim AP. Lung cancer staging. J Surg Res 2004 117 : 92 106.
13. Travis WD. Pathology of lung cancer. Clin Chest Med 2002 23 : 65 81.
14. Travis WD, Garg K, Franklin WA, Wistuba I. I., Sabloff B, Noguchi M, et al. Bronchioloalveolar carcinoma and lung adenocarcinoma: the clinical importance and research relevance of the 2004 World Health Organization pathologic criteria. J Thorac Oncol 2006 9 (Suppl S13 9.
15. Kallioniemi OP, Wagner U, Kononen J, Sauter G. Tissue microarray technology for high-throughput molecular profiling of cancer. Hum Mol Genet 2001 10 : 657 662.
16. Wakabayashi O, Yamazaki K, Oizumi S, Hommura F, kinoshita I, Ogura S, et al. CD4+ T cells in cancer stroma, not CD8+ T cells in cancer cell nests, are associated with favorable prognosis in human non-small cell lung cancers. Cancer Sci 2003 94 (11 1003 1009.
17. de Visser KE, Eichten A, Coussens LM. Paradoxical roles of the immune system during cancer development. Nat Rev Cancer 2006 6 : 24 37.
18. Tormanen-Napankangas U, Soini Y, Paakko P. High number of tumour-infiltrating lymphocytes is associated with apoptosis in non-small cell lung carcinoma. APMIS 2001 109 : 525 532.
19. Woo EY, Yeh H, Chu CS, Schlienger K, Carroll R. G., Riley J. L., et al. Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation. J Immunol 2002 168 : 4272 4276.
20. Galon J, Fridman WH, Pages F. The adaptive immunologic microenvironment in colorectal cancer: a novel perspective. Cancer Res 2007 67 : 883 886.
21. Arriagada R, Bergman B, Dunant A, Le CT, Pignon JP, Vansteenkiste J. Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. N Engl J Med 2004 350 : 351 360.
22. Norrby K. Mast cells and angiogenesis. APMIS 2002 110 : 355 371.
23. Dundar E, Oner U, Peker BC, Metintas M, Isiksoy S, Ak G. The significance and relationship between mast cells and tumour angiogenesis in non-small cell lung carcinoma. J Int Med Res 2008 36 : 88 95.
24. Ghiara P, Boraschi D, Villa L, Scapigliati G, Taddei C, Tagliabue A. In vitro generated mast cells express natural cytotoxicity against tumour cells. Immunology 1985 55 : 317 324.
25. Tomita M, Matsuzaki Y, Onitsuka T. Correlation between mast cells and survival rates in patients with pulmonary adenocarcinoma. Lung Cancer 1999 26 : 103 108.
26. Kawai O, Ishii G, Kubota K, Murata Y, Naito Y, Mizano T, et al. Predominant infiltration of macrophages and CD8(+) T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer. Cancer 2008 113 : 1387 1395.
27. Welsh TJ, Green RH, Richardson D, Waller DA, O'Byrne KJ, Bradding P. Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer. J Clin Oncol 2005 23 : 8959 8967.
28. Benitez-Bribiesca L, Wong A, Utrera D, Castellanos E. The role of mast cell tryptase in neoangiogenesis of premalignant and malignant lesions of the uterine cervix. J Histochem Cytochem 2001 49 : 1061 1062.
29. Gotte M, Kersting C, Radke I, Kiesel L, Wulfing P. An expression signature of syndecan-1 (CD138), E-cadherin and c-met is associated with factors of angiogenesis and lymphangiogenesis in ductal breast carcinoma in situ. Breast Cancer Res 2007 9 : R8.
30. Couchman JR, Vogt S, Lim ST, Lim Y, Oh E S, Prestwich GD, et al. Regulation of inositol phospholipid binding and signaling through syndecan-4. J Biol Chem 2002 277 : 49296 49303.
31. Kurokawa H, Zhang M, Matsumoto S, Yamashita Y, Tanaka T, Takamori K, et al. Reduced syndecan-1 expression is correlated with the histological grade of malignancy at the deep invasive front in oral squamous cell carcinoma. J Oral Pathol Med 2006 35 : 301 306.
32. Mukunyadzi P, Sanderson RD, Fan CY, Smoller BR. The level of syndecan-1 expression is a distinguishing feature in behavior between keratoacanthoma and invasive cutaneous squamous cell carcinoma. Mod Pathol 2002 15 : 45 9.
33. Shah L, Walter KL, Borczuk AC, Kawut SM, Sonett JR, Gorenstein LA, et al. Expression of syndecan-1 and expression of epidermal growth factor receptor are associated with survival in patients with nonsmall cell lung carcinoma. Cancer 2004 101 : 1632 1638.
34. Toyoshima E, Ohsaki Y, Nishigaki Y, Fujimoto Y, Kohgo Y, Kikuchi K. Expression of syndecan-1 is common in human lung cancers independent of expression of epidermal growth factor receptor. Lung Cancer 2001 31 : 193 202.
35. Johnson SK, Kerr KM, Chapman AD, Kennedy MM, King G, Cockburn JS, et al. Immune cell infiltrates and prognosis in primary carcinoma of the lung. Lung Cancer 2000 27 : 27 35.
36. Maeda T, Alexander CM, Friedl A. Induction of syndecan-1 expression in stromal fibroblasts promotes proliferation of human breast cancer cells. Cancer Res 2004 64 : 612 621.