Hypoxia induces differential translation of enolase/MBP-1

BMC Cancer

Volumn 10, Issue , 2010, Pages

  Sedoris, Kara C ^a   Thomas, Shelia D ^a   Miller, Donald M ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ENOLASE; GLUCOSE; MESSENGER RNA; MYC PROTEIN; OXYGEN; PROTEIN MBP 1; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; DENND4A PROTEIN, HUMAN; DNA BINDING PROTEIN; ENOLASE; EXCITATORY AMINO ACID TRANSPORTER 2; LACTIC ACID;

ACCLIMATIZATION; ANAEROBIC GLYCOLYSIS; APOPTOSIS; ARTICLE; BREAST CANCER; CELL FUNCTION; CELL GROWTH; CELL HYPOXIA; CELL METABOLISM; CELL PROLIFERATION; CELL STRAIN MCF 7; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; OXIDATIVE STRESS; PROMOTER REGION; PROTEIN DEPLETION; PROTEIN PROCESSING; TRANSCRIPTION REGULATION; TRANSLATION REGULATION; TUMOR MICROENVIRONMENT; BIOSYNTHESIS; BREAST TUMOR; CELL CYCLE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENE TRANSLOCATION; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE; UPREGULATION;

BREAST NEOPLASMS; CELL CYCLE; CELL GROWTH PROCESSES; CELL HYPOXIA; CELL LINE, TUMOR; DNA-BINDING PROTEINS; EXCITATORY AMINO ACID TRANSPORTER 2; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCOSE; HUMANS; LACTIC ACID; PHOSPHOPYRUVATE HYDRATASE; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TRANSLOCATION, GENETIC; UP-REGULATION;

EID: 77951081135     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-10-157     Document Type: Article

References (50)

1. Hoogsteen IJ, Marres HA, Kogel AJ, Kaanders JH. The hypoxic tumour microenvironment, patient selection and hypoxia-modifying treatments. Clin Oncol (R Coll Radiol) 2007, 19(6):385-396.
2. Tredan O, Galmarini CM, Patel K, Tannock IF. Drug resistance and the solid tumor microenvironment. J Natl Cancer Inst 2007, 99(19):1441-1454. 10.1093/jnci/djm135, 17895480.
3. Michaylira CZ, Nakagawa H. Hypoxic microenvironment as a cradle for melanoma development and progression. Cancer Biol Ther 2006, 5(5):476-479.
4. Blackburn RV, Spitz DR, Liu X, Galoforo SS, Sim JE, Ridnour LA, Chen JC, Davis BH, Corry PM, Lee YJ. Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells. Free Radic Biol Med 1999, 26(3-4):419-430. 10.1016/S0891-5849(98)00217-2, 9895234.
5. Shaw RJ. Glucose metabolism and cancer. Curr Opin Cell Biol 2006, 18(6):598-608. 10.1016/j.ceb.2006.10.005, 17046224.
6. Lundgren K, Holm C, Landberg G. Hypoxia and breast cancer: prognostic and therapeutic implications. Cell Mol Life Sci 2007, 64(24):3233-47. 10.1007/s00018-007-7390-6, 17957335.
7. Vleugel MM, Greijer AE, Shvarts A, Groep P, van Berkel M, Aarbodem Y, van Tinteren H, Harris AL, van Diest PJ, Wall E. Differential prognostic impact of hypoxia induced and diffuse HIF-1alpha expression in invasive breast cancer. J Clin Pathol 2005, 58(2):172-177. 10.1136/jcp.2004.019885, 1770566, 15677538.
8. Brown NS, Bicknell R. Hypoxia and oxidative stress in breast cancer. Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer. Breast Cancer Res 2001, 3(5):323-327. 10.1186/bcr315, 138696, 11597322.
9. Hennipman A, Smits J, van Oirschot B, van Houwelingen JC, Rijksen G, Neyt JP, Van Unnik JA, Staal GE. Glycolytic enzymes in breast cancer, benign breast disease and normal breast tissue. Tumour Biol 1987, 8(5):251-263. 10.1159/000217529, 3448771.
10. Warburg O. On respiratory impairment in cancer cells. Science 1956, 124(3215):269-270.
11. Kim JW, Dang CV. Cancer's molecular sweet tooth and the Warburg effect. Cancer Res 2006, 66(18):8927-8930. 10.1158/0008-5472.CAN-06-1501, 16982728.
12. Gordan JD, Thompson CB, Simon MC. HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell 2007, 12(2):108-113. 10.1016/j.ccr.2007.07.006, 17692803.
13. Hurlin PJ, Dezfouli S. Functions of myc:max in the control of cell proliferation and tumorigenesis. Int Rev Cytol 2004, 238:183-226. full_text, 15364199.
14. Osthus RC, Shim H, Kim S, Li Q, Reddy R, Mukherjee M, Xu Y, Wonsey D, Lee LA, Dang CV. Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem 2000, 275(29):21797-21800. 10.1074/jbc.C000023200, 10823814.
15. Ma SF, Grigoryev DN, Taylor AD, Nonas S, Sammani S, Ye SQ, Garcia JG. Bioinformatic identification of novel early stress response genes in rodent models of lung injury. Am J Physiol Lung Cell Mol Physiol 2005, 289(3):L468-477. 10.1152/ajplung.00109.2005, 15908477.
16. Kim JW, Dang CV. Multifaceted roles of glycolytic enzymes. Trends Biochem Sci 2005, 30(3):142-150. 10.1016/j.tibs.2005.01.005, 15752986.
17. Pancholi V. Multifunctional alpha-enolase: its role in diseases. Cell Mol Life Sci 2001, 58(7):902-920. 10.1007/PL00000910, 11497239.
18. Chang GC, Liu KJ, Hsieh CL, Hu TS, Charoenfuprasert S, Liu HK, Luh KT, Hsu LH, Wu CW, Ting CC, et al. Identification of alpha-enolase as an autoantigen in lung cancer: its overexpression is associated with clinical outcomes. Clin Cancer Res 2006, 12(19):5746-5754. 10.1158/1078-0432.CCR-06-0324, 17020980.
19. Takashima M, Kuramitsu Y, Yokoyama Y, Iizuka N, Fujimoto M, Nishisaka T, Okita K, Oka M, Nakamura K. Overexpression of alpha enolase in hepatitis C virus-related hepatocellular carcinoma: association with tumor progression as determined by proteomic analysis. Proteomics 2005, 5(6):1686-1692. 10.1002/pmic.200401022, 15800975.
20. Ray R, Miller DM. Cloning and characterization of a human c-myc promoter-binding protein. Mol Cell Biol 1991, 11(4):2154-2161. 359903, 2005901.
21. Feo S, Arcuri D, Piddini E, Passantino R, Giallongo A. ENO1 gene product binds to the c-myc promoter and acts as a transcriptional repressor: relationship with Myc promoter-binding protein 1 (MBP-1). FEBS Lett 2000, 473(1):47-52. 10.1016/S0014-5793(00)01494-0, 10802057.
22. Chaudhary D, Miller DM. The c-myc promoter binding protein (MBP-1) and TBP bind simultaneously in the minor groove of the c-myc P2 promoter. Biochemistry 1995, 34(10):3438-3445. 10.1021/bi00010a036, 7880838.
23. Potter M, Marcu KB. The c-myc story: where we've been, where we seem to be going. Curr Top Microbiol Immunol 1997, 224:1-17.
24. Ray RB, Steele R, Seftor E, Hendrix M. Human breast carcinoma cells transfected with the gene encoding a c-myc promoter-binding protein (MBP-1) inhibits tumors in nude mice. Cancer Res 1995, 55(17):3747-3751.
25. Ghosh AK, Steele R, Ryerse J, Ray RB. Tumor-suppressive effects of MBP-1 in non-small cell lung cancer cells. Cancer Res 2006, 66(24):11907-11912. 10.1158/0008-5472.CAN-06-2754, 17178888.
26. Sedoris KC, Thomas SD, Miller DM. c-myc Promoter Binding Protein Regulates the Cellular Response to an Altered Glucose Concentration. Biochemistry 2007, 46(29):8659-8668. 10.1021/bi7003558, 17595061.
27. Cooper JA, Esch FS, Taylor SS, Hunter T. Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro. J Biol Chem 1984, 259(12):7835-7841.
28. Mizukami Y, Iwamatsu A, Aki T, Kimura M, Nakamura K, Nao T, Okusa T, Matsuzaki M, Yoshida K, Kobayashi S. ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation. J Biol Chem 2004, 279(48):50120-50131. 10.1074/jbc.M402299200, 15459207.
29. Denko NC. Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat Rev Cancer 2008, 8(9):705-13. 10.1038/nrc2468, 19143055.
30. Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, Pfeiffer HK, Nissim I, Daikhin E, Yudkoff M, McMahon SB, et al. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci USA 2008, 105(48):18782-18787. 10.1073/pnas.0810199105, 2596212, 19033189.
31. Subramanian A, Miller DM. Structural analysis of alpha-enolase. Mapping the functional domains involved in down-regulation of the c-myc protooncogene. J Biol Chem 2000, 275(8):5958-5965. 10.1074/jbc.275.8.5958, 10681589.
32. Dang CV, Kim JW, Gao P, Yustein J. The interplay between MYC and HIF in cancer. Nat Rev Cancer 2008, 8(1):51-56. 10.1038/nrc2274, 18046334.
33. Dang CV, Lewis BC, Dolde C, Dang G, Shim H. Oncogenes in tumor metabolism, tumorigenesis, and apoptosis. J Bioenerg Biomembr 1997, 29(4):345-354. 10.1023/A:1022446730452, 9387095.
34. Ghosh AK, Steele R, Ray RB. Carboxyl-terminal repressor domain of MBP-1 is sufficient for regression of prostate tumor growth in nude mice. Cancer Res 2005, 65(3):718-721.
35. Gess B, Wolf K, Pfeifer M, Riegger GA, Kurtz A. In vivo carbon monoxide exposure and hypoxic hypoxia stimulate immediate early gene expression. Pflugers Arch 1997, 434(5):568-574. 10.1007/s004240050437, 9242720.
36. Vita M, Henriksson M. The Myc oncoprotein as a therapeutic target for human cancer. Semin Cancer Biol 2006, 16(4):318-330. 10.1016/j.semcancer.2006.07.015, 16934487.
37. Ray RB. Induction of cell death in murine fibroblasts by a c-myc promoter binding protein. Cell Growth Differ 1995, 6(9):1089-1096.
38. Ghosh AK, Majumder M, Steele R, Liu TJ, Ray RB. MBP-1 mediated apoptosis involves cytochrome c release from mitochondria. Oncogene 2002, 21(18):2775-2784. 10.1038/sj.onc.1205384, 11973636.
39. Cooper JA, Esch FS, Taylor SS, Hunter T. Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro. J Biol Chem 1984, 259:7835-7841.
40. Goonewardene TI, Sowter HM, Harris AL. Hypoxia-induced pathways in breast cancer. Microsc Res Tech 2002, 59(1):41-48. 10.1002/jemt.10175, 12242695.
41. Fruehauf JP, Meyskens FL. Reactive oxygen species: a breath of life or death?. Clin Cancer Res 2007, 13(3):789-794. 10.1158/1078-0432.CCR-06-2082, 17289868.
42. Simon AR, Rai U, Fanburg BL, Cochran BH. Activation of the JAK-STAT pathway by reactive oxygen species. Am J Physiol 1998, 275(6 Pt 1):C1640-1652.
43. Shi H, Liu KJ. Effects of glucose concentration on redox status in rat primary cortical neurons under hypoxia. Neurosci Lett 2006, 410(1):57-61. 10.1016/j.neulet.2006.09.066, 1865501, 17055160.
44. Liu Y, Song XD, Liu W, Zhang TY, Zuo J. Glucose deprivation induces mitochondrial dysfunction and oxidative stress in PC12 cell line. J Cell Mol Med 2003, 7(1):49-56. 10.1111/j.1582-4934.2003.tb00202.x, 12767261.
45. Liu J, Narasimhan P, Lee YS, Song YS, Endo H, Yu F, Chan PH. Mild hypoxia promotes survival and proliferation of SOD2-deficient astrocytes via c-Myc activation. J Neurosci 2006, 26(16):4329-4337. 10.1523/JNEUROSCI.0382-06.2006, 16624953.
46. Kim MH, Jung YS, Moon CH, Lee SH, Baik EJ, Moon CK. High-glucose induced protective effect against hypoxic injury is associated with maintenance of mitochondrial membrane potential. Jpn J Physiol 2003, 53(6):451-459. 10.2170/jjphysiol.53.451, 15038843.
47. Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis?. Nat Rev Cancer 2004, 4(11):891-899. 10.1038/nrc1478, 15516961.
48. Kunkel M, Reichert TE, Benz P, Lehr HA, Jeong JH, Wieand S, Bartenstein P, Wagner W, Whiteside TL. Overexpression of Glut-1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral squamous cell carcinoma. Cancer 2003, 97(4):1015-1024. 10.1002/cncr.11159, 12569601.
49. Royall JA, Ischiropoulos H. Evaluation of 2',7'-dichlorofluorescin and dihydrorhodamine 123 as fluorescent probes for intracellular H2O2 in cultured endothelial cells. Arch Biochem Biophys 1993, 302(2):348-355. 10.1006/abbi.1993.1222, 8387741.
50. Andrews NC, Faller DV. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res 1991, 19(9):2499. 10.1093/nar/19.9.2499, 329467, 2041787.