Lipids to the top of hair biology

Journal of Investigative Dermatology

Volumn 130, Issue 5, 2010, Pages 1205-1207

  Stenn, Kurt S ^a   Karnik, Pratima ^b  

^a Aderans Research Institute Inc   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; STEAROYL COENZYME A;

ACNE; ALOPECIA; CHOLESTEROL SYNTHESIS; GENE ACTIVATION; HAIR; HAIR ANALYSIS; HAIR FOLLICLE; HAIR GROWTH; HAIR LOSS; LIPID METABOLISM; METABOLIC DISORDER; NONHUMAN; NOTE; PRIORITY JOURNAL; VIBRISSA;

EID: 77951063406     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.52     Document Type: Note

References (19)

1. Bazan J F, deSauvage FJ (2009) Structural ties between cholesterol transport and morphogen signaling. Cell 138:1055-1056
2. Bensinger SJ, Tontonoz P (2008) Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature 454:470-477
3. Colgan SM, Tang D, Werstuck GH et al. (2007) Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2. Int J Biochem Cell Biol 39:1843-1851
4. Demehri S, Kopan R (2009) Notch signaling in bulge stem cells is not required for selection of hair follicle fate. Development 136:891-896
5. Evers BM, Farooqi MS, Shelton JM et al. (2010) Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin. J Invest Dermatol 130:1237-1248
6. Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444:860-867
7. Karnik P, Tekeste Z, McCormick TS et al. (2009) Hair follicle stem cell-specific PPARγ deletion causes scarring alopecia. J Invest Dermatol 129:1243-1257
8. Lee L, DeBono CA, Campagna DR et al. (2007) Loss of the acyl-CoA binding protein (Acbp) results in fatty acid metabolism abnormalities in mouse hair and skin. J Invest Dermatol 127:16-23
9. Lewis PM, Dunn M P, McMahon JA et al. (2001) Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell 105:599-612
10. Moulson CL, Martin DR, Lugus JJ et al. (2003) Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development. Proc Natl Acad Sci USA 100: 5274-5279
11. Murphy S, Martin S, Parton RG (2009) Lipid droplet-organelle interactions; sharing the fats. Biochim Biophys Acta Mol Cell Biol Lipids 1791:441-447
12. Nusse R (2003) Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface. Development 130:5297-5305
13. Ron D, Walter P (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8:519-529
14. Shimomura Y, Wajid M, Petukhova L et al. (2009) Mutations in the lipase H gene underlie autosomal recessive woolly hair/hypotrichosis. J Invest Dermatol 129:622-628
15. ab2J): a new allele and a model for scarring alopecia. Am J Pathol 156:2067-2075
16. Todd DJ, Lee AH, Glimcher LH (2008) The endoplasmic reticulum stress response in immunity and autoimmunity. Nat Rev Immunol 8:663-674
17. Wan Y, Saghatelian A, Chong L-W et al. (2007) Maternal PPARγ protects nursing neonates by suppressing the production of inflammatory milk. Genes Dev 21:1895-1908
18. Wellen KE, Fucho R, Gregor MF et al. (2007) Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell 129:537-548
19. Westerberg R, Tvrdik P, Undén AB et al. (2004) Role for ELOVL3 and fatty acid chain length in development of hair and skin function. J Biol Chem 279:5621-5629