Effects of pentoxifylline on inflammation and lung dysfunction in ventilated septic animals

Journal of Trauma - Injury, Infection and Critical Care

Volumn 68, Issue 4, 2010, Pages 822-826

  Oliveira Júnior, Itamar Souza ^a   Oliveira, Wagner Rogério Souza ^a   Cavassani, Samia Santos ^a   Brunialti, Milena Karina Coló ^a   Salomao, Reinaldo ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

High tidal volume; Inflammatory response; Low tidal volume; Lung injury; Pentoxifylline; Sepsis; TNF alpha

Indexed keywords

MALONALDEHYDE; PENTOXIFYLLINE; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL OXYGEN SATURATION; ARTICLE; ARTIFICIAL VENTILATION; CELL COUNT; CONTROLLED STUDY; DRUG EFFECT; ESCHERICHIA COLI; GAS EXCHANGE; INFLAMMATION; LUNG ALVEOLUS CELL; LUNG LAVAGE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEPSIS; TIDAL VOLUME;

ACUTE DISEASE; ANALYSIS OF VARIANCE; ANIMALS; BRONCHOALVEOLAR LAVAGE; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI INFECTIONS; INFLAMMATION; LUNG DISEASES; MALE; MALONDIALDEHYDE; PENTOXIFYLLINE; PULMONARY GAS EXCHANGE; RANDOM ALLOCATION; RATS; RATS, WISTAR; RESPIRATION, ARTIFICIAL; SEPSIS; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77951052664     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e3181a5f4b5     Document Type: Article

References (34)

1. Fein AM, Lippman M, Holtzman H, Eliraz A, Goldberg SK. The risk factors, incidence, and prognosis of ARDS following septicemia. Chest. 1983;83:40-42.
2. Matthay MA. Conference summary: acute lung injury. Chest. 1999; 116(Suppl 1):119S-126S.
3. Irish Critical Care Trials Group. Acute lung injury and the acute respiratory distress syndrome in Ireland: a prospective audit of epidemiology and management. Crit Care. 2008;12:R30.
4. Bhatia M, Moochhala S. Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol. 2004;202: 145-156.
5. Balk RA. Optimum treatment of severe sepsis and septic shock: evidence in support of the recommendations. Dis Mon. 2004;50:168-213.
6. Choudhury S, Wilson MR, Goddard ME, O'Dea KP, Takata M. Mechanisms of early pulmonary neutrophil sequestration in ventilator-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2004;287: L902-L910.
7. Wilson MR, Choudhury S, Takata M: Pulmonary inflammation induced by high-stretch ventilation is mediated by tumor necrosis factor signaling in mice. Am J Physiol Lung Cell Mol Physiol. 2005;288:L599-L607.
8. Oliveira-Junior IS, Pinheiro BV, Silva ID, Salomão R, Zollner RL, Beppu OS. Pentoxifylline decreases tumor necrosis factor and interleukin-1 during high tidal volume. Braz J Med Biol Res. 2003;36:1349-1357.
9. Chamorro-Marín V, García-Delgado M, Touma-Fernández A, Aguilar-Alonso E, Fernández-Mondejar E. Intratracheal dopamine attenuates pulmonary edema and improves survival after ventilator-induced lung injury in rats. Crit Care. 2008;12:R39.
10. Aldridge AJ. Role of the neutrophil in septic shock and the adult respiratory distress syndrome. Eur J Surg. 2002;168:204-214.
11. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med. 2000;342:1301-1308.
12. Brackenbury AM, McCaig LA, Yao LJ, Veldhuizen RA, Lewis JF. Host response to intratracheally instilled bacteria in ventilated and nonventilated rats. Crit Care Med. 2004;32:2502-2507.
13. Jain M, Sznajder JI. Peripheral airways injury in acute lung injury/acute respiratory distress syndrome. Curr Opin Crit Care. 2008;14:37-43.
14. Dos Santos CC, Slutsky AS. Invited review: mechanisms of ventilatorinduced lung injury: a perspective. J Appl Physiol. 2000;89:1645-1655.
15. Parsons PE, Eisner MD, Thompson BT, et al. Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury. Crit Care Med. 2005;33:1-6.
16. Ricard JD, Dreyfuss D, Saumon G. Production of inflammatory cytokines in ventilator induced lung injury: a reappraisal. Am J Respir Crit Care Med. 2001;163:1176-1180.
17. Coimbra R, Melbostad H, Hoyt DB. Effects of phosphodiesterase inhibition on the inflammatory response after shock: role of pentoxifylline. J Trauma. 2004;56:442-449.
18. Lessa A, Suguihara C, Xianyu S, Hehre D, Devia C, Bancalari E. The effect of pentoxifylline on the pulmonary response to high tidal volume ventilation in rats. Pulm Pharmacol Ther. 2008;21:54-60.
19. Coimbra R, Melbostad H, Loomis WH, et al. LPS-induced acute lung injury is attenuated by phosphodiesterase inhibition: effects on proinflammatory mediators, metalloproteinases, NF-kB, and ICAM-1 expression. J Trauma. 2006;60:115-125.
20. Deree J, Martins J, de Campos T, et al. Pentoxifylline attenuates lung injury and modulates transcription factor activity in hemorrhagic shock. J Surg Res. 2007;143:99-108.
21. Oliveira-Júnior IS, Brunialti MKC, Koh IHJ, et al. Effect of pentoxifylline on lung inflammation and gas exchange in a sepsis-induced acute lung injury model. Braz J Med Biol Res. 2006;39:1455-1465.
22. Oliveira-Júnior IS, Maganhin CC, Carbonel AA, Monteiro CM, Cavassani SS, Oliveira-Filho RM. Effects of pentoxifylline on TNF-alpha and lung histopathology in HCL-induced lung injury. Clinics (Sao Paulo). 2008;63:77-84.
23. Schultz MJ, Haitsma JJ, Slutsky AS, Gajic O. What tidal volumes should be used in patients without acute lung injury? Anesthesiology. 2007;106: 1085-1087.
24. Altemeier WA, Matute-Bello G, Gharib SA, Glenny RW, Martin TR, Liles WC. Modulation of lipopolysaccharide-induced gene transcription and promotion of lung injury by mechanical ventilation. J Immunol. 2005;175:3369-3376.
25. Brunialti MK, Martins PS, Barbosa de Carvalho H, Machado FR, Barbosa LM, Salomao R. TLR2, TLR4, CD14, CD11B, and CD11C expressions on monocytes surface and cytokine production in patients with sepsis, severe sepsis, and septic shock. Shock. 2006;25:351-357.
26. Heller S, Weber K, Heller A, Urbaschek R, Koch T. Pentoxifylline improves bacterial clearance during hemorrhage and endotoxemia. Crit Care Med. 1999;27:756-763.
27. Voisin L, Breuillé D, Ruot B, et al. Cytokine modulation by PX differently affects specific acute phase proteins during sepsis in rats. Am J Physiol. 1998;275(5 Pt 2):R1412-R1419.
28. Krakauer T. Pentoxifylline inhibits ICAM-1 expression and chemokine production induced by proinflammatory cytokines in human pulmonary epithelial cells. Immunopharmacology. 2000;46:253-261.
29. Akgür FM, Zibari GB, McDonald JC, Granger DN, Brown MF. Effects of dextran and pentoxifylline on hemorrhagic shock-induced p-selectin expression. J Surg Res. 1999;87:232-238.
30. Wu CC, Liao MH, Chen SJ, Yen MH. Pentoxifylline improves circulatory failure and survival in murine models of endotoxaemia. Eur J Pharmacol 1999;373:41-49.
31. Sheridan BC, McIntyre RC, Meldrum DR, Fullerton DA. Pentoxifylline treatment attenuates pulmonary vasomotor dysfunction in acute lung injury. J Surg Res. 1997;71:150-154.
32. Yada-Langui MM, Coimbra R, Lancellotti C, et al. Hypertonic saline and pentoxifylline prevent lung injury and bacterial translocation after hemorrhagic shock. Shock. 2000;14:594-598.
33. Lattuada M, Hedenstierna G. Abdominal lymph flow in an endotoxin sepsis model: influence of spontaneous breathing and mechanical ventilation. Crit Care Med. 2006;34:2792-2798.
34. de Campos T, Deree J, Martins JO, et al. Pentoxifylline attenuates pulmonary inflammation and neutrophil activation in experimental acute pancreatitis. Pancreas. 2008;37:42-49.